Medical College of Wisconsin
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James S. Tweddell MD

James S. Tweddell MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Cardiothoracic
Program: Pediatrics


Publications

  • Invited commentary. (Tweddell JS) Ann Thorac Surg 2014 Feb;97(2):665 PMID 24484802
  • Risk and prevalence of developmental delay in young children with congenital heart disease. (Mussatto KA, Hoffmann RG, Hoffman GM, Tweddell JS, Bear L, Cao Y, Brosig C) Pediatrics 2014 Mar;133(3):e570-7 PMID 24488746
  • Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass. (Abu-Sultaneh S, Hehir DA, Murkowski K, Ghanayem NS, Liedel J, Hoffmann RG, Cao Y, Mitchell ME, Jeromin A, Tweddell JS, Hoffman GM) Pediatr Crit Care Med 2014 Mar;15(3):219-28 PMID 24366505
  • Incidence and outcome of pediatric patients with intracranial hemorrhage while supported on ventricular assist devices. (Niebler RA, Lew SM, Zangwill SD, Woods RK, Mitchell ME, Tweddell JS, Ghanayem NS) Artif Organs 2014 Jan;38(1):73-8 PMID 24256117
  • Outcomes of systemic to pulmonary artery shunts in patients weighing less than 3 kg: analysis of shunt type, size, and surgical approach. (Myers JW, Ghanayem NS, Cao Y, Simpson P, Trapp K, Mitchell ME, Tweddell JS, Woods RK) J Thorac Cardiovasc Surg 2014 Feb;147(2):672-7 PMID 24252942
  • Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association. (Giglia TM, Massicotte MP, Tweddell JS, Barst RJ, Bauman M, Erickson CC, Feltes TF, Foster E, Hinoki K, Ichord RN, Kreutzer J, McCrindle BW, Newburger JW, Tabbutt S, Todd JL, Webb CL, American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Stroke Council) Circulation 2013 Dec 17;128(24):2622-703 PMID 24226806
  • Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. (Hidestrand M, Tomita-Mitchell A, Hidestrand PM, Oliphant A, Goetsch M, Stamm K, Liang HL, Castleberry C, Benson DW, Stendahl G, Simpson PM, Berger S, Tweddell JS, Zangwill S, Mitchell ME) J Am Coll Cardiol 2014 Apr 1;63(12):1224-6 PMID 24140666
  • Stenting of the right ventricular outflow tract in the high-risk infant with cyanotic teratology of Fallot. (Castleberry CD, Gudausky TM, Berger S, Tweddell JS, Pelech AN) Pediatr Cardiol 2014 Mar;35(3):423-30 PMID 24096718
  • Bilateral pulmonary artery banding as rescue intervention in high-risk neonates. (Russell RA, Ghanayem NS, Mitchell ME, Woods RK, Tweddell JS) Ann Thorac Surg 2013 Sep;96(3):885-90 PMID 23916808
  • Thromboelastography in the assessment of bleeding following surgery for congenital heart disease. (Niebler RA, Gill JC, Brabant CP, Mitchell ME, Nugent M, Simpson P, Tweddell JS, Ghanayem NS) World J Pediatr Congenit Heart Surg 2012 Oct 1;3(4):433-8 PMID 23804904
  • Bleeding and thrombotic emergencies in pediatric cardiac intensive care: unchecked balances. (Giglia TM, Dinardo J, Ghanayem NS, Ichord R, Niebler RA, Odegard KC, Massicotte MP, Yates AR, Laussen PC, Tweddell JS) World J Pediatr Congenit Heart Surg 2012 Oct 1;3(4):470-91 PMID 23804911
  • Restrictive versus nonrestrictive physiology following repair of tetralogy of Fallot: is there a difference? (Samyn MM, Kwon EN, Gorentz JS, Yan K, Danduran MJ, Cava JR, Simpson PM, Frommelt PC, Tweddell JS) J Am Soc Echocardiogr 2013 Jul;26(7):746-55 PMID 23623591
  • Mechanical support as failure intervention in patients with cavopulmonary shunts (MFICS): rationale and aims of a new registry of mechanical circulatory support in single ventricle patients. (Rossano JW, Woods RK, Berger S, Gaynor JW, Ghanayem N, Morales DL, Ravishankar C, Mitchell ME, Shah TK, Mahr C, Tweddell JS, Adachi I, Zangwill S, Wearden PD, Icenogle TB, Jaquiss RD, Rychik J) Congenit Heart Dis 2013 May-Jun;8(3):182-6 PMID 23510301
  • Short-term outcome of neonates with congenital heart disease and diaphragmatic hernia treated with extracorporeal membrane oxygenation. (Dyamenahalli U, Morris M, Rycus P, Bhutta AT, Tweddell JS, Prodhan P) Ann Thorac Surg 2013 Apr;95(4):1373-6 PMID 23465363
  • 13th Annual C. Walton Lillehei Memorial Lecture--Invisible problems in cardiovascular surgery: what we can learn from prospective observational studies? (Tweddell JS) Cardiol Young 2012 Dec;22(6):823-30 PMID 23331608
  • Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. (Hoffman GM, Brosig CL, Mussatto KA, Tweddell JS, Ghanayem NS) J Thorac Cardiovasc Surg 2013 Nov;146(5):1153-64 PMID 23317941
  • Atrial tachyarrhythmias and the Cox-maze procedure in congenital heart disease. (Gutierrez SD, Earing MG, Singh AK, Tweddell JS, Bartz PJ) Congenit Heart Dis 2013 Sep-Oct;8(5):434-9 PMID 23280242
  • Long-term outcomes of the neoaorta after arterial switch operation for transposition of the great arteries. (Co-Vu JG, Ginde S, Bartz PJ, Frommelt PC, Tweddell JS, Earing MG) Ann Thorac Surg 2013 May;95(5):1654-9 PMID 23218968
  • Leftward displacement of septum primum in hypoplastic left heart syndrome. (Park MV, Fedderly RT, Frommelt PC, Frommelt MA, Pelech AN, Jaquiss RD, Mussatto K, Tweddell JS) Pediatr Cardiol 2013 Apr;34(4):942-7 PMID 23179423
  • Restrictive lung disease is an independent predictor of exercise intolerance in the adult with congenital heart disease. (Ginde S, Bartz PJ, Hill GD, Danduran MJ, Biller J, Sowinski J, Tweddell JS, Earing MG) Congenit Heart Dis 2013 May-Jun;8(3):246-54 PMID 23075089
  • Fontan fenestration closure and event-free survival. (Imielski BR, Woods RK, Mussatto KA, Cao Y, Simpson PM, Tweddell JS) J Thorac Cardiovasc Surg 2013 Jan;145(1):183-7 PMID 23062415
  • Predicting left ventricular recovery after replacement of a regurgitant aortic valve in pediatric and young adult patients: is it ever too late? (Cox DA, Walton K, Bartz PJ, Tweddell JS, Frommelt PC, Earing MG) Pediatr Cardiol 2013 Mar;34(3):694-9 PMID 23052669
  • Protecting the infant brain during cardiac surgery: a systematic review. (Hirsch JC, Jacobs ML, Andropoulos D, Austin EH, Jacobs JP, Licht DJ, Pigula F, Tweddell JS, Gaynor JW) Ann Thorac Surg 2012 Oct;94(4):1365-73; discussion 1373 PMID 23006704
  • Aortic valve replacement in neonates and infants: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database. (Woods RK, Pasquali SK, Jacobs ML, Austin EH, Jacobs JP, Krolikowski M, Mitchell ME, Pizarro C, Tweddell JS) J Thorac Cardiovasc Surg 2012 Nov;144(5):1084-89 PMID 22921819
  • Cause, timing, and location of death in the Single Ventricle Reconstruction trial. (Ohye RG, Schonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, Frank DU, Graham EM, Hill KD, Jacobs JP, Kanter KR, Kirsh JA, Lambert LM, Lewis AB, Ravishankar C, Tweddell JS, Williams IA, Pearson GD, Pediatric Heart Network Investigators) J Thorac Cardiovasc Surg 2012 Oct;144(4):907-14 PMID 22901498
  • Prospective trial of a pediatric ventricular assist device. (Fraser CD Jr, Jaquiss RD, Rosenthal DN, Humpl T, Canter CE, Blackstone EH, Naftel DC, Ichord RN, Bomgaars L, Tweddell JS, Massicotte MP, Turrentine MW, Cohen GA, Devaney EJ, Pearce FB, Carberry KE, Kroslowitz R, Almond CS, Berlin Heart Study Investigators) N Engl J Med 2012 Aug 9;367(6):532-41 PMID 22873533
  • Aortic aneurysms remain a significant source of morbidity and mortality after use of Dacron(┬«) patch aortoplasty to repair coarctation of the aorta: results from a single center. (Cramer JW, Ginde S, Bartz PJ, Tweddell JS, Litwin SB, Earing MG) Pediatr Cardiol 2013 Feb;34(2):296-301 PMID 22843204
  • Valve-sparing aortic root reconstruction in children, teenagers, and young adults. (Tweddell JS, Earing MG, Bartz PJ, Dunham-Ingles JL, Woods RK, Mitchell ME) Ann Thorac Surg 2012 Aug;94(2):587-90; discussion 590-1 PMID 22748646
  • Renal dysfunction is common among adults after palliation for previous tetralogy of Fallot. (Buelow MW, Dall A, Bartz PJ, Tweddell JS, Sowinski J, Rudd N, Katzmark L, Earing MG) Pediatr Cardiol 2013 Jan;34(1):165-9 PMID 22673967
  • Abnormal mitral valve anatomy in d-transposition of the great arteries: anatomic characterization and surgical outcomes. (Camarda JA, Harris SE, Hambrook J, Frommelt MA, Tweddell JS, Frommelt PC) Pediatr Cardiol 2013 Jan;34(1):70-4 PMID 22660521
  • Urinary interleukin-18 and urinary neutrophil gelatinase-associated lipocalin predict acute kidney injury following pulmonary valve replacement prior to serum creatinine. (Buelow MW, Dall A, Regner K, Weinberg C, Bartz PJ, Sowinski J, Rudd N, Katzmark L, Tweddell JS, Earing MG) Congenit Heart Dis 2012 Sep-Oct;7(5):441-7 PMID 22537138
  • Normal interstage growth after the norwood operation associated with interstage home monitoring. (Hehir DA, Rudd N, Slicker J, Mussatto KA, Simpson P, Li SH, Frommelt MA, Tweddell JS, Ghanayem NS) Pediatr Cardiol 2012 Dec;33(8):1315-22 PMID 22526219
  • Late complications after Takeuchi repair of anomalous left coronary artery from the pulmonary artery: case series and review of literature. (Ginde S, Earing MG, Bartz PJ, Cava JR, Tweddell JS) Pediatr Cardiol 2012 Oct;33(7):1115-23 PMID 22438016
  • Timing and technique of pulmonary valve replacement in the patient with tetralogy of Fallot. (Tweddell JS, Simpson P, Li SH, Dunham-Ingle J, Bartz PJ, Earing MG, Pelech AN) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2012;15(1):27-33 PMID 22424505
  • Noninvasive assessment of liver fibrosis in adult patients following the Fontan procedure. (Ginde S, Hohenwalter MD, Foley WD, Sowinski J, Bartz PJ, Venkatapuram S, Weinberg C, Tweddell JS, Earing MG) Congenit Heart Dis 2012 May-Jun;7(3):235-42 PMID 22360766
  • Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type. (Tweddell JS, Sleeper LA, Ohye RG, Williams IA, Mahony L, Pizarro C, Pemberton VL, Frommelt PC, Bradley SM, Cnota JF, Hirsch J, Kirshbom PM, Li JS, Pike N, Puchalski M, Ravishankar C, Jacobs JP, Laussen PC, McCrindle BW, Pediatric Heart Network Investigators) J Thorac Cardiovasc Surg 2012 Jul;144(1):152-9 PMID 22341427
  • Human gene copy number spectra analysis in congenital heart malformations. (Tomita-Mitchell A, Mahnke DK, Struble CA, Tuffnell ME, Stamm KD, Hidestrand M, Harris SE, Goetsch MA, Simpson PM, Bick DP, Broeckel U, Pelech AN, Tweddell JS, Mitchell ME) Physiol Genomics 2012 May 1;44(9):518-41 PMID 22318994
  • Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID 22247331
  • Hypoplastic left heart syndrome: current considerations and expectations. (Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT, Pahl E, Villafa├▒e J, Bhatt AB, Peng LF, Johnson BA, Marsden AL, Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD, Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG, Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR) J Am Coll Cardiol 2012 Jan 3;59(1 Suppl):S1-42 PMID 22192720
  • Quality measures for congenital and pediatric cardiac surgery. (Jacobs JP, Jacobs ML, Austin EH 3rd, Mavroudis C, Pasquali SK, Lacour-Gayet FG, Tchervenkov CI, Walters H 3rd, Bacha EA, Nido PJ, Fraser CD, Gaynor JW, Hirsch JC, Morales DL, Pourmoghadam KK, Tweddell JS, Prager RL, Mayer JE) World J Pediatr Congenit Heart Surg 2012 Jan 1;3(1):32-47 PMID 23804682
  • Intensive care of the pediatric ventricular assist device patient. (Hehir DA, Niebler RA, Brabant CC, Tweddell JS, Ghanayem NS) World J Pediatr Congenit Heart Surg 2012 Jan 1;3(1):58-66 PMID 23804685
  • Remote ischemic preconditioning for renal protection in children undergoing surgery for complex congenital heart disease: what do we know now and where do we go next? (Tweddell JS) J Thorac Cardiovasc Surg 2012 Mar;143(3):583-4 PMID 22104670
  • Antithrombin replacement during extracorporeal membrane oxygenation. (Niebler RA, Christensen M, Berens R, Wellner H, Mikhailov T, Tweddell JS) Artif Organs 2011 Nov;35(11):1024-8 PMID 22097980
  • Coarctectomy combined with an interdigitating arch reconstruction results in a lower incidence of recurrent arch obstruction after the Norwood procedure than coarctectomy alone. (Lamers LJ, Frommelt PC, Mussatto KA, Jaquiss RD, Mitchell ME, Tweddell JS) J Thorac Cardiovasc Surg 2012 May;143(5):1098-102 PMID 22050986
  • Aortopulmonary window. (Barnes ME, Mitchell ME, Tweddell JS) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2011;14(1):67-74 PMID 21444051
  • Ten-year experience with surgical unroofing of anomalous aortic origin of a coronary artery from the opposite sinus with an interarterial course. (Frommelt PC, Sheridan DC, Berger S, Frommelt MA, Tweddell JS) J Thorac Cardiovasc Surg 2011 Nov;142(5):1046-51 PMID 21439578
  • The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. (Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ) Paediatr Anaesth 2011 Apr;21(4):441-53 PMID 21306473
  • Bridging children of all sizes to cardiac transplantation: the initial multicenter North American experience with the Berlin Heart EXCOR ventricular assist device. (Morales DL, Almond CS, Jaquiss RD, Rosenthal DN, Naftel DC, Massicotte MP, Humpl T, Turrentine MW, Tweddell JS, Cohen GA, Kroslowitz R, Devaney EJ, Canter CE, Fynn-Thompson F, Reinhartz O, Imamura M, Ghanayem NS, Buchholz H, Furness S, Mazor R, Gandhi SK, Fraser CD Jr) J Heart Lung Transplant 2011 Jan;30(1):1-8 PMID 21145473
  • Surgery and critical care for anomalous coronary artery from the pulmonary artery. (Fehrenbacher TA, Mitchell ME, Ghanayem NS, Tweddell JS) Cardiol Young 2010 Dec;20 Suppl 3:35-43 PMID 21087558
  • Medium-term outcomes of Kawashima and completion Fontan palliation in single-ventricle heart disease with heterotaxy and interrupted inferior vena cava. (Kutty S, Frommelt MA, Danford DA, Tweddell JS) Ann Thorac Surg 2010 Nov;90(5):1609-13 PMID 20971273
  • Unobstructive total anomalous pulmonary venous return: impact of early elective repair on the need for prolonged mechanical ventilatory support. (Frommelt PC, Sheridan DC, Deatsman S, Yan K, Simpson P, Frommelt MA, Litwin SB, Tweddell JS) Pediatr Cardiol 2010 Nov;31(8):1191-7 PMID 20848277
  • Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease. (Ghanayem NS, Hoffman GM, Mussatto KA, Frommelt MA, Cava JR, Mitchell ME, Tweddell JS) J Thorac Cardiovasc Surg 2010 Oct;140(4):857-63 PMID 20621312
  • Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. (Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME) Physiol Genomics 2010 Sep;42A(1):52-60 PMID 20551144
  • Pro: NIRS is "standard of care" for postoperative management. (Tweddell JS, Ghanayem NS, Hoffman GM) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2010;13(1):44-50 PMID 20307860
  • Performance of the CryoValve SG human decellularized pulmonary valve in 342 patients relative to the conventional CryoValve at a mean follow-up of four years. (Brown JW, Elkins RC, Clarke DR, Tweddell JS, Huddleston CB, Doty JR, Fehrenbacher JW, Takkenberg JJ) J Thorac Cardiovasc Surg 2010 Feb;139(2):339-48 PMID 20106397
  • Fontan palliation in the modern era: factors impacting mortality and morbidity. (Tweddell JS, Nersesian M, Mussatto KA, Nugent M, Simpson P, Mitchell ME, Ghanayem NS, Pelech AN, Marla R, Hoffman GM) Ann Thorac Surg 2009 Oct;88(4):1291-9 PMID 19766824
  • Invited commentary. (Tweddell JS) Ann Thorac Surg 2009 Aug;88(2):580 PMID 19632415
  • How we approach peripheral pulmonary stenosis in Williams-Beuren syndrome. (Gandy KL, Tweddell JS, Pelech AN) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2009:118-21 PMID 19349025
  • Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome. (Johnson BA, Hoffman GM, Tweddell JS, Cava JR, Basir M, Mitchell ME, Scanlon MC, Mussatto KA, Ghanayem NS) Ann Thorac Surg 2009 Feb;87(2):571-7; discussion 577-9 PMID 19161781
  • Invited commentary. (Tweddell JS) Ann Thorac Surg 2009 Feb;87(2):553-4 PMID 19161778
  • Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy: a prospective, multicenter experience. (Tabbutt S, Nicolson SC, Dominguez TE, Wells W, Backer CL, Tweddell JS, Bokesch P, Schreiner M) J Thorac Cardiovasc Surg 2008 Nov;136(5):1229-36 PMID 19026808
  • The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial. (Tabbutt S, Nicolson SC, Adamson PC, Zhang X, Hoffman ML, Wells W, Backer CL, McGowan FX, Tweddell JS, Bokesch P, Schreiner M) J Thorac Cardiovasc Surg 2008 Aug;136(2):321-8 PMID 18692637
  • Impact of mitral stenosis and aortic atresia on survival in hypoplastic left heart syndrome. (Glatz JA, Fedderly RT, Ghanayem NS, Tweddell JS) Ann Thorac Surg 2008 Jun;85(6):2057-62 PMID 18498820
  • Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID 18006466
  • Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. (Tweddell JS, Ghanayem NS, Mussatto KA, Mitchell ME, Lamers LJ, Musa NL, Berger S, Litwin SB, Hoffman GM) Ann Thorac Surg 2007 Oct;84(4):1301-10; discussion 1310-1 PMID 17888987
  • Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. (Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N) J Mol Cell Cardiol 2007 Oct;43(4):437-44 PMID 17765919
  • Medical management of the failing Fontan. (Ghanayem NS, Berger S, Tweddell JS) Pediatr Cardiol 2007 Nov-Dec;28(6):465-71 PMID 17763892
  • Aspirin: a treatment for the headache of shunt-dependent pulmonary blood flow and parallel circulation? (Tweddell JS) Circulation 2007 Jul 17;116(3):236-7 PMID 17638938
  • Effect of shunt type on echocardiographic indices after initial palliations for hypoplastic left heart syndrome: Blalock-Taussig shunt versus right ventricle-pulmonary artery conduit. (Frommelt PC, Sheridan DC, Mussatto KA, Hoffman GM, Ghanayem NS, Frommelt MA, Tweddell JS) J Am Soc Echocardiogr 2007 Dec;20(12):1364-73 PMID 17604955
  • Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms. (Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ) J Cardiovasc Pharmacol 2007 Jun;49(6):337-45 PMID 17577097
  • Psychosocial outcomes for preschool children and families after surgery for complex congenital heart disease. (Brosig CL, Mussatto KA, Kuhn EM, Tweddell JS) Pediatr Cardiol 2007 Jul-Aug;28(4):255-62 PMID 17486393
  • The vertical vein: to ligate or not to ligate. (Tweddell JS) J Thorac Cardiovasc Surg 2007 May;133(5):1135-6 PMID 17467419
  • Complex atrioventricular canal. (Mitchell ME, Litwin SB, Tweddell JS) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2007:32-41 PMID 17433989
  • The double patch repair for complete atrioventricularis communis. (Litwin SB, Tweddell JS, Mitchell ME, Mussatto KA) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2007:21-7 PMID 17433987
  • Monitoring the brain before, during, and after cardiac surgery to improve long-term neurodevelopmental outcomes. (Ghanayem NS, Mitchell ME, Tweddell JS, Hoffman GM) Cardiol Young 2006 Sep;16 Suppl 3:103-9 PMID 17378048
  • Neurodevelopmental outcome in preschool survivors of complex congenital heart disease: implications for clinical practice. (Brosig CL, Mussatto KA, Kuhn EM, Tweddell JS) J Pediatr Health Care 2007 Jan-Feb;21(1):3-12 PMID 17198894
  • Right ventricle-to-pulmonary artery conduit versus Blalock-Taussig shunt: a hemodynamic comparison. (Ghanayem NS, Jaquiss RD, Cava JR, Frommelt PC, Mussatto KA, Hoffman GM, Tweddell JS) Ann Thorac Surg 2006 Nov;82(5):1603-9; discussion 1609-10 PMID 17062213
  • Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome. (Jaquiss RD, Siehr SL, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS) Ann Thorac Surg 2006 Oct;82(4):1260-5; discussion 1265-6 PMID 16996918
  • Near infrared spectroscopy monitoring during pediatric aortic coarctation repair. (Berens RJ, Stuth EA, Robertson FA, Jaquiss RD, Hoffman GM, Troshynski TJ, Staudt SR, Cava JR, Tweddell JS, Bert Litwin S) Paediatr Anaesth 2006 Jul;16(7):777-81 PMID 16879521
  • Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. (Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT) Endothelium 2006 May-Jun;13(3):181-90 PMID 16840174
  • Characterizing the inflammatory response to cardiopulmonary bypass in children. (Kozik DJ, Tweddell JS) Ann Thorac Surg 2006 Jun;81(6):S2347-54 PMID 16731102
  • Ventricular septal defect and aortic valve regurgitation: pathophysiology and indications for surgery. (Tweddell JS, Pelech AN, Frommelt PC) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2006:147-52 PMID 16638560
  • The virtual crossmatch--a screening tool for sensitized pediatric heart transplant recipients. (Zangwill SD, Ellis TM, Zlotocha J, Jaquiss RD, Tweddell JS, Mussatto KA, Berger S) Pediatr Transplant 2006 Feb;10(1):38-41 PMID 16499585
  • Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. (Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD) Cardiol Young 2006 Feb;16 Suppl 1:61-6 PMID 16401365
  • The neonate with congenital heart disease: what the cardiac surgeon needs to know from the neonatologist and the cardiologist. (Jaquiss RD, Tweddell JS) Clin Perinatol 2005 Dec;32(4):947-61, ix PMID 16325671
  • Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. (Hoffman GM, Mussatto KA, Brosig CL, Ghanayem NS, Musa N, Fedderly RT, Jaquiss RD, Tweddell JS) J Thorac Cardiovasc Surg 2005 Oct;130(4):1094-100 PMID 16214525
  • A medical strategy to reduce persistent chest tube drainage after the fontan operation. (Cava JR, Bevandic SM, Steltzer MM, Tweddell JS) Am J Cardiol 2005 Jul 1;96(1):130-3 PMID 15979451
  • Aortic valve repair. (Tweddell JS, Pelech AN, Jaquiss RD, Frommelt PC, Mussatto KA, Hoffman GM, Litwin SB) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2005:112-21 PMID 15818366
  • Noninvasive assessment of cardiac output. (Hoffman GM, Ghanayem NS, Tweddell JS) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2005:12-21 PMID 15818353
  • Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease. (Tweddell JS, Pelech AN, Frommelt PC, Jaquiss RD, Hoffman GM, Mussatto KA, Litwin SB) J Thorac Cardiovasc Surg 2005 Mar;129(3):551-8 PMID 15746738
  • Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID 15611843
  • Newborn heart surgery: reasonable expectations and outcomes. (Tweddell JS, Spray TL) Pediatr Clin North Am 2004 Dec;51(6):1611-23, ix PMID 15561176
  • Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID 15388508
  • Surgical therapy for sudden cardiac death in children. (Jaquiss RD, Tweddell JS, Litwin SB) Pediatr Clin North Am 2004 Oct;51(5):1389-400 PMID 15331290
  • Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. (Fitzpatrick CM, Shi Y, Hutchins WC, Su J, Gross GJ, Ostadal B, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H62-8 PMID 15319200
  • Home monitoring of infants after stage one palliation for hypoplastic left heart syndrome. (Ghanayem NS, Cava JR, Jaquiss RD, Tweddell JS) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004;7:32-8 PMID 15283350
  • Orthotopic heart transplantation in a child with histiocytoid cardiomyopathy. (Zangwill SD, Trost BA, Zlotocha J, Tweddell JS, Jaquiss RD, Berger S) J Heart Lung Transplant 2004 Jul;23(7):902-4 PMID 15261188
  • Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID 15088102
  • Extracorporeal membrane oxygenation for pediatric cardiac failure: limitations and future directions. (Tweddell JS) Crit Care Med 2004 Apr;32(4):1091-2 PMID 15071417
  • Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality. (Jaquiss RD, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS) J Thorac Cardiovasc Surg 2004 Apr;127(4):982-9 PMID 15052194
  • Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. (Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto KA, Stuth EA, Jaquis RD, Berger S) J Thorac Cardiovasc Surg 2004 Mar;127(3):738-45 PMID 15001902
  • Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion. (Hoffman GM, Stuth EA, Jaquiss RD, Vanderwal PL, Staudt SR, Troshynski TJ, Ghanayem NS, Tweddell JS) J Thorac Cardiovasc Surg 2004 Jan;127(1):223-33 PMID 14752434
  • Home surveillance program prevents interstage mortality after the Norwood procedure. (Ghanayem NS, Hoffman GM, Mussatto KA, Cava JR, Frommelt PC, Rudd NA, Steltzer MM, Bevandic SM, Frisbee SS, Jaquiss RD, Litwin SB, Tweddell JS) J Thorac Cardiovasc Surg 2003 Nov;126(5):1367-77 PMID 14666008
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID 12937165
  • Prospective echocardiographic diagnosis and surgical repair of anomalous origin of a coronary artery from the opposite sinus with an interarterial course. (Frommelt PC, Frommelt MA, Tweddell JS, Jaquiss RD) J Am Coll Cardiol 2003 Jul 2;42(1):148-54 PMID 12849675
  • Complete staged palliation of hypoplastic left heart syndrome in a child with cystic fibrosis. (Stuth EA, Stucke AG, Fedderly RT, Tweddell JS) Paediatr Anaesth 2003 May;13(4):345-8 PMID 12753450
  • Safety of aprotinin use and re-use in pediatric cardiothoracic surgery. (Jaquiss RD, Ghanayem NS, Zacharisen MC, Mussatto KA, Tweddell JS, Litwin SB) Circulation 2002 Sep 24;106(12 Suppl 1):I90-4 PMID 12354715
  • Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients. (Tweddell JS, Hoffman GM, Mussatto KA, Fedderly RT, Berger S, Jaquiss RD, Ghanayem NS, Frisbee SJ, Litwin SB) Circulation 2002 Sep 24;106(12 Suppl 1):I82-9 PMID 12354714
  • Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. (Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr) Circ Res 2002 Aug 23;91(4):300-6 PMID 12193462
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 9;106(2):239-45 PMID 12105165
  • Delayed cardioprotection by isoflurane: role of K(ATP) channels. (Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H61-8 PMID 12063275
  • Postoperative management in patients with complex congenital heart disease. (Tweddell JS, Hoffman GM) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2002;5:187-205 PMID 11994879
  • Factors related to pleural effusions after Fontan procedure in the era of fenestration. (Fedderly RT, Whitstone BN, Frisbee SJ, Tweddell JS, Litwin SB) Circulation 2001 Sep 18;104(12 Suppl 1):I148-51 PMID 11568047
  • Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. (Kong X, Tweddell JS, Gross GJ, Baker JE) J Mol Cell Cardiol 2001 May;33(5):1041-5 PMID 11343425
  • Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome. (Hoffman GM, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB, Tweddell JS) Ann Thorac Surg 2000 Nov;70(5):1515-20; discussion 1521 PMID 11093480
  • Factors affecting longevity of homograft valves used in right ventricular outflow tract reconstruction for congenital heart disease. (Tweddell JS, Pelech AN, Frommelt PC, Mussatto KA, Wyman JD, Fedderly RT, Berger S, Frommelt MA, Lewis DA, Friedberg DZ, Thomas JP Jr, Sachdeva R, Litwin SB) Circulation 2000 Nov 7;102(19 Suppl 3):III130-5 PMID 11082375
  • Patients at risk for low systemic oxygen delivery after the Norwood procedure. (Tweddell JS, Hoffman GM, Fedderly RT, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB) Ann Thorac Surg 2000 Jun;69(6):1893-9 PMID 10892943
  • Partial left ventriculectomy for dilated cardiomyopathy in a newborn. (Berger S, Tweddell JS, Frommelt PC, Weinhaus L) J Thorac Cardiovasc Surg 1999 May;117(5):1017-8 PMID 10220698
  • Recent advances in the surgical management of the single ventricle pediatric patient. (Tweddell JS, Litwin SB, Thomas JP Jr, Mussatto K) Pediatr Clin North Am 1999 Apr;46(2):465-80, xii PMID 10218086
  • Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. (Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas JP Jr, Ghanayem NS, Kessel MW, Litwin SB) Ann Thorac Surg 1999 Jan;67(1):161-7; discussion 167-8 PMID 10086542
  • Advances in the care of children with heart disease. (Fedderly RT, Berger S, Frommelt PC, Lewis DA, Dhala A, Pelech AN, Frommelt MA, Friedberg DZ, Thomas JP Jr, Tweddell JS, Litwin SB) WMJ 1998 Sep;97(8):47-50 PMID 9775754
  • Valve repair and replacement in children. (Lewis DA, Tweddell JS) Curr Opin Cardiol 1997 Jan;12(1):63-9 PMID 9132083
  • Aprotinin improves outcome of single-ventricle palliation. (Tweddell JS, Berger S, Frommelt PC, Pelech AN, Lewis DA, Fedderly RT, Frommelt MA, McManus TS, Mussatto KA, Kessel MW, Litwin SB) Ann Thorac Surg 1996 Nov;62(5):1329-35; discussion 1335-6 PMID 8893564
  • Early and late morbidity in patients undergoing pulmonary resection with low diffusion capacity. (Bousamra M 2nd, Presberg KW, Chammas JH, Tweddell JS, Winton BL, Bielefeld MR, Haasler GB) Ann Thorac Surg 1996 Oct;62(4):968-74; discussion 974-5 PMID 8823074
  • Twenty-year experience with repair of complete atrioventricular septal defects. (Tweddell JS, Litwin SB, Berger S, Friedberg DZ, Thomas JP, Frommelt PC, Frommelt MA, Pelech AN, Lewis DA, Fedderly RT, Mussatto KA, Kessel MW) Ann Thorac Surg 1996 Aug;62(2):419-24 PMID 8694600
  • Pulmonary tuberculosis after lung-liver transplantation from cystic fibrosis. (Chusid MJ, Splaingard ML, Tweddell JS, Rice TR, Adams M, Havens PL, Kehl KS) Pediatr Infect Dis J 1996 May;15(5):462-4 PMID 8724073
  • Wire stent for tracheomalacia in a five-year-old girl. (Bousamra M 2nd, Tweddell JS, Wells RG, Splaingard ML, Sty JR) Ann Thorac Surg 1996 Apr;61(4):1239-40 PMID 8607691
  • Does an additional source of pulmonary blood flow alter outcome after a bidirectional cavopulmonary shunt? (Frommelt MA, Frommelt PC, Berger S, Pelech AN, Lewis DA, Tweddell JS, Litwin SB) Circulation 1995 Nov 1;92(9 Suppl):II240-4 PMID 7586416
  • Anterior septal coronary artery infarction in the canine: a model of ventricular tachycardia with a subendocardial origin. Ablation and activation sequence mapping. (Tweddell JS, Rokkas CK, Harada A, Pirolo JS, Branham BH, Schuessler RB, Boineau JP, Cox JL) Circulation 1994 Dec;90(6):2982-92 PMID 7994846
  • Predictors of operative mortality and morbidity after infant heart transplantation. (Tweddell JS, Canter CE, Bridges ND, Moorhead S, Huddleston CB, Spray TL) Ann Thorac Surg 1994 Oct;58(4):972-7 PMID 7944818
  • Hemodynamic effects of atrial interaction. (Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL) Coron Artery Dis 1993 Jun;4(6):545-53 PMID 8261233
  • Importance of left ventricular function and systolic ventricular interaction to right ventricular performance during acute right heart ischemia. (Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL) J Am Coll Cardiol 1992 Mar 1;19(3):704-11 PMID 1538031
  • Alternative approaches to abdominal wound closure in severely injured patients with massive visceral edema. (Smith PC, Tweddell JS, Bessey PQ) J Trauma 1992 Jan;32(1):16-20 PMID 1732567
  • Right atrial ischemia exacerbates hemodynamic compromise associated with experimental right ventricular dysfunction. (Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL) J Am Coll Cardiol 1991 Nov 15;18(6):1564-72 PMID 1939962
  • Influence of activation origin, lead number, and lead configuration on the noninvasive electrophysiologic detection of cardiac allograft rejection. (Pirolo JS, Tweddell JS, Brunt EM, Pyo R, Shuman TS, Cox JL, Ferguson TB) Circulation 1991 Nov;84(5 Suppl):III344-54 PMID 1934429
  • Computerized potential distribution mapping: a new intraoperative mapping technique for ventricular tachycardia surgery. (Harada A, Tweddell JS, Schuessler RB, Branham BH, Boineau JP, Cox JL) Ann Thorac Surg 1990 Apr;49(4):649-55 PMID 2322062
  • Pericardiocentesis guided by a pulse generator. (Tweddell JS, Zimmerman AN, Stone CM, Rokkas CK, Schuessler RB, Boineau JP, Cox JL) J Am Coll Cardiol 1989 Oct;14(4):1074-83 PMID 2794268
  • Potential mapping in septal tachycardia. Evaluation of a new intraoperative mapping technique. (Tweddell JS, Branham BH, Harada A, Stone CM, Rokkas CK, Schuessler RB, Boineau JP, Cox JL) Circulation 1989 Sep;80(3 Pt 1):I97-108 PMID 2670332
  • Renal vein thrombosis in burned children. (Waymack JP, Tweddell JS, Warden GD) J Burn Care Rehabil 1988 Sep-Oct;9(5):472-3 PMID 3192603
  • Hematuria in the burned child. (Tweddell JS, Waymack JP, Warden GD, Law EJ, Jenkins M, Alexander JW) J Pediatr Surg 1987 Oct;22(10):899-903 PMID 3681618
  • Renal calculi in the burned child. (Waymack JP, Warden GD, Tweddell JS) Burns Incl Therm Inj 1987 Jun;13(3):190-3 PMID 3607561
  • Effect of transfusion on immune function in a traumatized animal model. (Waymack JP, Rapien J, Garnett D, Tweddell JS, Alexander JW) Arch Surg 1986 Jan;121(1):50-5 PMID 3484624
  • Grants and Awards

  • S. Bert Litwin Chair in Pediatric Cardiothoracic Surgery (#9208544 01/01/2014 - 12/31/2014) Sponsor: Children's Hospital Foundation
  • CryoValve SG Pulmonary Human Heart Valve Post-Clearance Study (#9304916 11/18/2009 - 12/16/2013) Sponsor: CryoLife, Inc.