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Jeffrey M. Toth PhD

Jeffrey M. Toth PhD

Professor

Institution: Medical College of Wisconsin
Department: Orthopaedic Surgery
Program: Research


Research Experience

  • Arthroplasty
  • Biocompatible Materials
  • Bone Morphogenetic Proteins
  • Bone Substitutes
  • Bone Transplantation
  • Dental Materials
  • Materials Testing
  • Spinal Fusion
  • Spine
  • Orthopaedic and spine biomaterials
  • Methodologies and Techniques

  • Arthrodesis
  • Bone Cements
  • Bone Cements
  • Bone Development
  • Bone Morphogenetic Proteins
  • Bone Regeneration
  • Bone Resorption
  • Bone Substitutes
  • Bone Transplantation
  • Bone and Bones
  • Histology
  • Spine
  • MCW Program / Core Facilities

  • Research Faculty, Walter F. Joyce Jr. Memorial Biomaterials Laboratory, Marquette University

    Research Faculty, Materials Science and Technology Center, Marquette University

    Research Faculty, Orthopaedic Rehabilitation and Engineering Center, Medical College of Wisconsin and Marquette University
  • Educational Expertise

  • Biomaterials and Biological Response to Implant Materials; Bone Histology; Tissue Engineering
  • Publications

  • Bone properties by nanoindentation in mild and severe osteogenesis imperfecta. (Albert C, Jameson J, Toth JM, Smith P, Harris G) Clin Biomech (Bristol, Avon) 2013 Jan;28(1):110-6 PMID 23141422
  • Early-term and mid-term histologic events during single-level posterolateral intertransverse process fusion with rhBMP-2/collagen carrier and a ceramic bulking agent in a nonhuman primate model: implications for bone graft preparation. (Khan SN, Toth JM, Gupta K, Glassman SD, Gupta MC) J Spinal Disord Tech 2014 Jun;27(4):212-9 PMID 23073151
  • Altered hemodynamics, endothelial function, and protein expression occur with aortic coarctation and persist after repair. (Menon A, Eddinger TJ, Wang H, Wendell DC, Toth JM, LaDisa JF Jr) Am J Physiol Heart Circ Physiol 2012 Dec 1;303(11):H1304-18 PMID 23023871
  • Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats. (Everson CA, Folley AE, Toth JM) Exp Biol Med (Maywood) 2012 Sep;237(9):1101-9 PMID 22946089
  • The Latest Lessons Learned from Retrieval Analyses of Ultra-High Molecular Weight Polyethylene, Metal-on-Metal, and Alternative Bearing Total Disc Replacements. (Kurtz SM, Toth JM, Siskey R, Ciccarelli L, Macdonald D, Isaza J, Lanman T, Punt I, Steinbeck M, Goffin J, van Ooij A) Semin Spine Surg 2012 Mar 1;24(1):57-70 PMID 22904606
  • Biocompatibility of PEEK Polymers, Chapter 8. (Toth JM) The Peek Biomaterials Handbook. Ed by Stephen M. Kurtz Elsevier Publishing, Maryland Heights, MO, Pages 81-92, 2012
  • The Latest Lessons Learned from Retrieval Analyses of Ultra-High Molecular Weight Polyethylene, Metal-on-Metal, and Alternative Bearing Total Disc Replacements (Kurtz SM, Toth JM, Siskey R, Ciccarelli L, MacDonald D, Isaza J, Lanman T, Punt I, Steinbeck P, Goffin J and van Ooij A) Seminars in Spinal Surgery 24(1):57-70,March 2012
  • A coupled experimental and computational approach to quantify deleterious hemodynamics, vascular alterations, and mechanisms of long-term morbidity in response to aortic coarctation. (Menon A, Wendell DC, Wang H, Eddinger TJ, Toth JM, Dholakia RJ, Larsen PM, Jensen ES, Ladisa JF Jr) J Pharmacol Toxicol Methods 2012 Jan;65(1):18-28 PMID 22079597
  • Letters. (Toth JM et al.) Spine (Phila Pa 1976) 2010 Mar 1;35(5):597-8 PMID 20190627
  • Bioresorbable film for the prevention of adhesion to the anterior spine after anterolateral discectomy. (Klopp LS, Toth JM, Welch WC, Rao S, Tai JW, Thomas KA, Turner S) Spine J 2009 May;9(5):411-7 PMID 19272839
  • Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. (Toth JM, Boden SD, Burkus JK, Badura JM, Peckham SM, McKay WF) Spine (Phila Pa 1976) 2009 Mar 15;34(6):539-50 PMID 19240666
  • Biomechanical and radiographic evaluation of an ovine model for the human lumbar spine. (Easley NE, Wang M, McGrady LM, Toth JM) Proc Inst Mech Eng H 2008 Aug;222(6):915-22 PMID 18935808
  • Bioresorbable polylactide interbody implants in an ovine anterior cervical discectomy and fusion model: three-year results. (Thomas KA, Toth JM, Crawford NR, Seim HB 3rd, Shi LL, Harris MB, Turner AS) Spine (Phila Pa 1976) 2008 Apr 1;33(7):734-42 PMID 18379399
  • Mechanical behavior and failure analysis of prosthetic retaining screws after long-term use in vivo. Part 4: Failure analysis of 10 fractured retaining screws retrieved from three patients. (Al Jabbari YS, Fournelle R, Ziebert G, Toth J, Iacopino AM) J Prosthodont 2008 Apr;17(3):201-10 PMID 18205736
  • Mechanical behavior and failure analysis of prosthetic retaining screws after long-term use in vivo. Part 3: Preload and tensile fracture load testing. (Al Jabbari YS, Fournelle R, Ziebert G, Toth J, Iacopino AM) J Prosthodont 2008 Apr;17(3):192-200 PMID 18205737
  • Mechanical behavior and failure analysis of prosthetic retaining screws after long-term use in vivo. Part 2: Metallurgical and microhardness analysis. (Al Jabbari Y, Fournelle R, Ziebert G, Toth J, Iacopino A) J Prosthodont 2008 Apr;17(3):181-91 PMID 18047489
  • Mechanical behavior and failure analysis of prosthetic retaining screws after long-term use in vivo. Part 1: Characterization of adhesive wear and structure of retaining screws. (Al Jabbari YS, Fournelle R, Ziebert G, Toth J, Iacopino AM) J Prosthodont 2008 Apr;17(3):168-80 PMID 18005336
  • Mineral trioxide aggregate material use in endodontic treatment: a review of the literature. (Roberts HW, Toth JM, Berzins DW, Charlton DG) Dent Mater 2008 Feb;24(2):149-64 PMID 17586038
  • Effect on bone induction of using contrast media to reconstitute recombinant human bone morphogenetic protein-2 in an ectopic model in rats. (Zanella JM, Oliver C, Peckham SM, McKay B, Toth JM, Boden SD) J Neurosurg Spine 2006 Nov;5(5):434-9 PMID 17120893
  • Resistance to fracture of two all-ceramic crown materials following endodontic access. (Wood KC, Berzins DW, Luo Q, Thompson GA, Toth JM, Nagy WW) J Prosthet Dent 2006 Jan;95(1):33-41 PMID 16399273
  • A 1-year study of hydroxyapatite-derived biomaterials in an adult sheep model: III. Comparison with autogenous bone graft for facial augmentation. (Gosain AK, Riordan PA, Song L, Amarante MT, Kalantarian B, Nagy PG, Wilson CR, Toth JM, McIntyre BL) Plast Reconstr Surg 2005 Sep 15;116(4):1044-52 PMID 16163093
  • Polyetheretherketone as a biomaterial for spinal applications. (Toth JM, Wang M, Estes BT, Scifert JL, Seim HB 3rd, Turner AS) Biomaterials 2006 Jan;27(3):324-34 PMID 16115677
  • An in vitro comparison of the rake angles between K3 and ProFile endodontic file systems. (Chow DY, Stover SE, Bahcall JK, Jaunberzins A, Toth JM) J Endod 2005 Mar;31(3):180-2 PMID 15735464
  • Long-term BMP-2-induced bone formation in rat island and free flaps. (Cooley BC, Daley RA, Toth JM) Microsurgery 2005;25(2):167-73 PMID 15696516
  • A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: part II. Bioengineering implants to optimize bone replacement in reconstruction of cranial defects. (Gosain AK, Riordan PA, Song L, Amarante MT, Kalantarian B, Nagy PG, Wilson CR, Toth JM, McIntyre BL) Plast Reconstr Surg 2004 Oct;114(5):1155-63; discussion 1164-5 PMID 15457027
  • A comparison of simulator-tested and -retrieved cervical disc prostheses. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. (Anderson PA, Rouleau JP, Toth JM, Riew KD) J Neurosurg Spine 2004 Sep;1(2):202-10 PMID 15347007
  • Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model. (Klopp LS, Welch WC, Tai JW, Toth JM, Cornwall GB, Turner AS) Neurosurg Focus 2004 Mar 15;16(3):E2 PMID 15198490
  • Evaluation of 70/30 poly (L-lactide-co-D,L-lactide) for use as a resorbable interbody fusion cage. (Toth JM, Estes BT, Wang M, Seim HB 3rd, Scifert JL, Turner AS, Cornwall GB) J Neurosurg 2002 Nov;97(4 Suppl):423-32 PMID 12449196
  • Use of polylactide resorbable film as an adhesion barrier. (Welch WC, Thomas KA, Cornwall GB, Gerszten PC, Toth JM, Nemoto EM, Turner AS) J Neurosurg 2002 Nov;97(4 Suppl):413-22 PMID 12449195
  • Evaluation of 70/30 D,L-PLa for use as a resorbable interbody fusion cage. (Toth JM, Wang M, Scifert JL, Cornwall GB, Estes BT, Seim HB 3rd, Turner AS) Orthopedics 2002 Oct;25(10 Suppl):s1131-40 PMID 12401023
  • Use of polylactide resorbable film as an adhesion barrier. (Welch WC, Cornwall GB, Toth JM, Turner AS, Thomas KA, Gerszten PC, Nemoto EM) Orthopedics 2002 Oct;25(10 Suppl):s1121-30 PMID 12401022
  • Histologic evaluation of the efficacy of rhBMP-2 compared with autograft bone in sheep spinal anterior interbody fusion. (Sandhu HS, Toth JM, Diwan AD, Seim HB 3rd, Kanim LE, Kabo JM, Turner AS) Spine (Phila Pa 1976) 2002 Mar 15;27(6):567-75 PMID 11884903
  • A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: part I. (Gosain AK, Song L, Riordan P, Amarante MT, Nagy PG, Wilson CR, Toth JM, Ricci JL) Plast Reconstr Surg 2002 Feb;109(2):619-30 PMID 11818845
  • Effects of hydroxyapatite particulate debris on the production of cytokines and proteases in human fibroblasts. (Ninomiya JT, Struve JA, Stelloh CT, Toth JM, Crosby KE) J Orthop Res 2001 Jul;19(4):621-8 PMID 11518271
  • Direct current electrical stimulation increases the fusion rate of spinal fusion cages. (Toth JM, Seim HB 3rd, Schwardt JD, Humphrey WB, Wallskog JA, Turner AS) Spine (Phila Pa 1976) 2000 Oct 15;25(20):2580-7 PMID 11034641
  • Practical illustrations in tissue engineering: surgical considerations relevant to the implantation of osteoinductive devices. (Vögelin E, Jones NF, Huang JI, Brekke JH, Toth JM) Tissue Eng 2000 Aug;6(4):449-60 PMID 10992440
  • The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model. (Hecht BP, Fischgrund JS, Herkowitz HN, Penman L, Toth JM, Shirkhoda A) Spine (Phila Pa 1976) 1999 Apr 1;24(7):629-36 PMID 10209790
  • Principles of tissue engineering applied to programmable osteogenesis. (Brekke JH, Toth JM) J Biomed Mater Res 1998;43(4):380-98 PMID 9855197
  • Laparoscopic assisted fusion of the lumbosacral spine. A biomechanical and histologic analysis of the open versus laparoscopic technique in an animal model. (Riley LH 3rd, Eck JC, Yoshida H, Toth JM, Nguyen C, Lim TH, McGrady LM) Spine (Phila Pa 1976) 1997 Jun 15;22(12):1407-12 PMID 9201846
  • Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. (Sandhu HS, Kanim LE, Toth JM, Kabo JM, Liu D, Delamarter RB, Dawson EG) Spine (Phila Pa 1976) 1997 Jun 1;22(11):1171-80 PMID 9201852
  • Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. (Sandhu HS, Kanim LE, Kabo JM, Toth JM, Zeegen EN, Liu D, Delamarter RB, Dawson EG) Spine (Phila Pa 1976) 1996 Sep 15;21(18):2115-22 PMID 8893436
  • Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model. (Sandhu HS, Kanim LE, Kabo JM, Toth JM, Zeegan EN, Liu D, Seeger LL, Dawson EG) Spine (Phila Pa 1976) 1995 Dec 15;20(24):2669-82 PMID 8747245
  • Evaluation of porous biphasic calcium phosphate ceramics for anterior cervical interbody fusion in a caprine model. (Toth JM, An HS, Lim TH, Ran Y, Weiss NG, Lundberg WR, Xu RM, Lynch KL) Spine (Phila Pa 1976) 1995 Oct 15;20(20):2203-10 PMID 8545713
  • Preliminary experience with a novel model assessing in vivo mechanical strength of bone grafts and substitute materials. (Hamson KR, Toth JM, Stiehl JB, Lynch KL) Calcif Tissue Int 1995 Jul;57(1):64-8 PMID 7671168
  • Grants and Awards

  • Histological Evaluation of Retrieved Spinal Fusion Devices (#9302654 07/01/2003 - 01/20/2019) Sponsor: Sofamor Danek
  • Comparison of Bone Graft Formulations in a Primate Posterolateral Fusion Model: Radiographic and Histologic Evaluation (#9303955 03/01/2007 - 02/28/2010) Sponsor: Medtronic Inc
  • Rehabilitation Engineering Center on Technologies for Children with Orthopedic Disabilities (#9206720 10/01/2010 - 09/30/2015) PI of R1: Rehabilitation Engineering Center on Technologies for Children with Orthopedic Disabilities (#2206734)