Medical College of Wisconsin
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John A. Corbett PhD

Chairman, Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the MCW Cancer Center


Publications

  • Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix. (Lim DJ, Andukuri A, Vines JB, Rahman SM, Hwang PT, Kim J, Shalev A, Corbett JA, Jun HW) Int J Nanomedicine 2014;9 Suppl 1:13-21 PMID 24872700
  • Amyloid and the macrophage: it's all about local production of IL-1β. (Broniowska KA, Corbett JA) Diabetes 2014 May;63(5):1448-50 PMID 24757195
  • Luminol-based chemiluminescent signals: clinical and non-clinical application and future uses. (Khan P, Idrees D, Moxley MA, Corbett JA, Ahmad F, von Figura G, Sly WS, Waheed A, Hassan MI) Appl Biochem Biotechnol 2014 May;173(2):333-55 PMID 24752935
  • Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell. (Salvatori AS, Elrick MM, Samson WK, Corbett JA, Yosten GL) Am J Physiol Endocrinol Metab 2014 Jun 1;306(11):E1257-63 PMID 24735892
  • Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. (Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA) J Biol Chem 2014 Apr 18;289(16):11454-64 PMID 24610783
  • β-cell responses to nitric oxide. (Broniowska KA, Oleson BJ, Corbett JA) Vitam Horm 2014;95:299-322 PMID 24559923
  • Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. (Afolayan AJ, Teng RJ, Eis A, Rana U, Broniowska KA, Corbett JA, Pritchard K, Konduri GG) Am J Physiol Lung Cell Mol Physiol 2014 Feb 15;306(4):L351-60 PMID 24375796
  • Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. (King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC) PLoS One 2013;8(10):e77452 PMID 24204831
  • Do β-cells generate peroxynitrite in response to cytokine treatment? (Broniowska KA, Mathews CE, Corbett JA) J Biol Chem 2013 Dec 20;288(51):36567-78 PMID 24194521
  • Improved MIN6 β-cell function on self-assembled peptide amphiphile nanomatrix inscribed with extracellular matrix-derived cell adhesive ligands. (Lim DJ, Antipenko SV, Vines JB, Andukuri A, Hwang PT, Hadley NT, Rahman SM, Corbett JA, Jun HW) Macromol Biosci 2013 Oct;13(10):1404-12 PMID 23966265
  • Immunoproteasome Activation During Early Antiviral Response in Mouse Pancreatic β-cells: New Insights into Auto-antigen Generation in Type I Diabetes? (Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA, Skowyra D) J Clin Cell Immunol 2013 Apr 23;4(2): PMID 23956946
  • The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. (Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ) Immunity 2013 Jul 25;39(1):111-22 PMID 23871208
  • Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. (Broniowska KA, Diers AR, Corbett JA, Hogg N) Biochemistry 2013 Jun 25;52(25):4364-72 PMID 23718265
  • Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. (Bai X, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Zaja I, Corbett JA, Bosnjak ZJ) Anesth Analg 2013 Apr;116(4):869-80 PMID 23460563
  • Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells. (Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA, Skowyra D) PLoS One 2013;8(2):e52408 PMID 23383295
  • The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. (Padgett LE, Broniowska KA, Hansen PA, Corbett JA, Tse HM) Ann N Y Acad Sci 2013 Apr;1281:16-35 PMID 23323860
  • Differential responses of pancreatic β-cells to ROS and RNS. (Meares GP, Fontanilla D, Broniowska KA, Andreone T, Lancaster JR Jr, Corbett JA) Am J Physiol Endocrinol Metab 2013 Mar 15;304(6):E614-22 PMID 23321474
  • Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. (Bosnjak ZJ, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Wells CW, Corbett JA, Bai X) Curr Drug Saf 2012 Apr;7(2):106-19 PMID 22873495
  • Cytokine-mediated β-cell damage in PARP-1-deficient islets. (Andreone T, Meares GP, Hughes KJ, Hansen PA, Corbett JA) Am J Physiol Endocrinol Metab 2012 Jul 15;303(2):E172-9 PMID 22535743
  • Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. (Mboko WP, Mounce BC, Wood BM, Kulinski JM, Corbett JA, Tarakanova VL) J Virol 2012 Jun;86(12):6899-912 PMID 22496235
  • A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. (Baldwin AC, Green CD, Olson LK, Moxley MA, Corbett JA) Am J Physiol Endocrinol Metab 2012 Jun 1;302(11):E1390-8 PMID 22436701
  • Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. (Christmann BS, Moran JM, McGraw JA, Buller RM, Corbett JA) Am J Pathol 2011 Dec;179(6):2941-51 PMID 22001348
  • IRE1-dependent activation of AMPK in response to nitric oxide. (Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA) Mol Cell Biol 2011 Nov;31(21):4286-97 PMID 21896783
  • FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. (Hughes KJ, Meares GP, Hansen PA, Corbett JA) J Biol Chem 2011 Mar 11;286(10):8338-48 PMID 21196578
  • Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. (Lim DJ, Antipenko SV, Anderson JM, Jaimes KF, Viera L, Stephen BR, Bryant SM, Yancey BD, Hughes KJ, Cui W, Thompson JA, Corbett JA, Jun HW) Tissue Eng Part A 2011 Feb;17(3-4):399-406 PMID 20807014
  • Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. (Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T) Diabetes 2010 Oct;59(10):2360-5 PMID 20622164
  • Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. (Freudenburg W, Buller RM, Corbett JA) J Gen Virol 2010 Sep;91(Pt 9):2278-85 PMID 20505008
  • Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. (Freudenburg W, Moran JM, Lents NH, Baldassare JJ, Buller RM, Corbett JA) J Innate Immun 2010;2(1):77-86 PMID 20375625
  • AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. (Meares GP, Hughes KJ, Jaimes KF, Salvatori AS, Rhodes CJ, Corbett JA) J Biol Chem 2010 Jan 29;285(5):3191-200 PMID 19933272
  • Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. (Evans SA, Doblado M, Chi MM, Corbett JA, Moley KH) Endocrinology 2009 Dec;150(12):5302-10 PMID 19808778
  • Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage. (Hughes KJ, Chambers KT, Meares GP, Corbett JA) Am J Physiol Endocrinol Metab 2009 Nov;297(5):E1187-96 PMID 19738038
  • Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression. (Hughes KJ, Meares GP, Chambers KT, Corbett JA) J Biol Chem 2009 Oct 2;284(40):27402-8 PMID 19648647
  • Glucose-modulated tyrosine nitration in beta cells: targets and consequences. (Koeck T, Corbett JA, Crabb JW, Stuehr DJ, Aulak KS) Arch Biochem Biophys 2009 Apr 15;484(2):221-31 PMID 19402213
  • The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. (Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H) Eur J Immunol 2009 Mar;39(3):820-5 PMID 19189309
  • Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development. (Bensch KG, Mott JL, Chang SW, Hansen PA, Moxley MA, Chambers KT, de Graaf W, Zassenhaus HP, Corbett JA) Am J Physiol Endocrinol Metab 2009 Apr;296(4):E672-80 PMID 19158322
  • Thioredoxin-interacting protein is killing my beta-cells! (Corbett JA) Diabetes 2008 Apr;57(4):797-8 PMID 18375442
  • Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication. (Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RM) J Gen Virol 2008 Mar;89(Pt 3):751-9 PMID 18272767
  • The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. (Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA) Diabetes 2008 Jan;57(1):124-32 PMID 17928398
  • A transgenic model to study the pathogenesis of somatic mtDNA mutation accumulation in beta-cells. (Bensch KG, Degraaf W, Hansen PA, Zassenhaus HP, Corbett JA) Diabetes Obes Metab 2007 Nov;9 Suppl 2:74-80 PMID 17919181
  • Induction of natural killer cell responses by ectromelia virus controls infection. (Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM) J Virol 2007 Apr;81(8):4070-9 PMID 17287257
  • PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. (Chambers KT, Weber SM, Corbett JA) Am J Physiol Endocrinol Metab 2007 Apr;292(4):E1052-61 PMID 17148750
  • Chemically chaperoning the actions of insulin. (Hansen PA, Waheed A, Corbett JA) Trends Endocrinol Metab 2007 Jan-Feb;18(1):1-3 PMID 17116401
  • Zinc induces ERK-dependent cell death through a specific Ras isoform. (Klein C, Creach K, Irintcheva V, Hughes KJ, Blackwell PL, Corbett JA, Baldassare JJ) Apoptosis 2006 Nov;11(11):1933-44 PMID 17013754
  • Insulin biosynthesis: the IREny of it all. (Corbett JA) Cell Metab 2006 Sep;4(3):175-6 PMID 16950132
  • Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. (Steer SA, Moran JM, Christmann BS, Maggi LB Jr, Corbett JA) J Immunol 2006 Sep 1;177(5):3413-20 PMID 16920983
  • Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. (Missall TA, Pusateri ME, Donlin MJ, Chambers KT, Corbett JA, Lodge JK) Eukaryot Cell 2006 Mar;5(3):518-29 PMID 16524907
  • Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. (Steer SA, Scarim AL, Chambers KT, Corbett JA) PLoS Med 2006 Feb;3(2):e17 PMID 16354107
  • Encephalomyocarditis virus induces PKR-independent mitogen-activated protein kinase activation in macrophages. (Moran JM, Moxley MA, Buller RM, Corbett JA) J Virol 2005 Aug;79(16):10226-36 PMID 16051816
  • Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages. (Moran JM, Buller RM, McHowat J, Turk J, Wohltmann M, Gross RW, Corbett JA) J Biol Chem 2005 Jul 29;280(30):28162-8 PMID 15946940
  • Incretin hormones and insulin sensitivity. (Hansen PA, Corbett JA) Trends Endocrinol Metab 2005 May-Jun;16(4):135-6 PMID 15860408
  • Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. (Missall TA, Moran JM, Corbett JA, Lodge JK) Eukaryot Cell 2005 Jan;4(1):202-8 PMID 15643075
  • Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. (Heitmeier MR, Kelly CB, Ensor NJ, Gibson KA, Mullis KG, Corbett JA, Maziasz TJ) J Biol Chem 2004 Dec 17;279(51):53145-51 PMID 15471850
  • PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. (Weber SM, Chambers KT, Bensch KG, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2004 Dec;287(6):E1171-7 PMID 15315910
  • Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. (Mosley AL, Corbett JA, Ozcan S) Mol Endocrinol 2004 Sep;18(9):2279-90 PMID 15166251
  • The role and regulation of COX-2 during viral infection. (Steer SA, Corbett JA) Viral Immunol 2003;16(4):447-60 PMID 14733733
  • PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2004 Mar;286(3):E329-36 PMID 14600076
  • Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage. (Scarim AL, Nishimoto SY, Weber SM, Corbett JA) Endocrinology 2003 Aug;144(8):3415-22 PMID 12865320
  • Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. (Martinson BD, Albert CJ, Corbett JA, Wysolmerski RB, Ford DA) J Lipid Res 2003 Sep;44(9):1686-91 PMID 12810819
  • Isolation of islets of Langerhans from rodent pancreas. (Kelly CB, Blair LA, Corbett JA, Scarim AL) Methods Mol Med 2003;83:3-14 PMID 12619711
  • ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages. (Maggi LB Jr, Moran JM, Buller RM, Corbett JA) J Biol Chem 2003 May 9;278(19):16683-9 PMID 12609986
  • Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. (Steer SA, Moran JM, Maggi LB Jr, Buller RM, Perlman H, Corbett JA) J Immunol 2003 Jan 15;170(2):1070-6 PMID 12517975
  • Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2003 May;284(5):E883-91 PMID 12517740
  • Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression. (Maggi LB Jr, Moran JM, Scarim AL, Ford DA, Yoon JW, McHowat J, Buller RM, Corbett JA) J Biol Chem 2002 Oct 11;277(41):38449-55 PMID 12167650
  • Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. (Thomas HE, Darwiche R, Corbett JA, Kay TW) Diabetes 2002 Feb;51(2):311-6 PMID 11812737
  • Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets. (Blair LA, Maggi LB Jr, Scarim AL, Corbett JA) J Biol Chem 2002 Jan 4;277(1):359-65 PMID 11694524
  • Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis. (Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA) Am J Pathol 2001 Jul;159(1):273-83 PMID 11438474
  • Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes. (Hudson TY, Corbett JA, Howlett AC, Klein C) J Neurochem 2001 Jun;77(5):1279-84 PMID 11389178
  • K cells: a novel target for insulin gene therapy for the prevention of diabetes. (Corbett JA) Trends Endocrinol Metab 2001 May-Jun;12(4):140-2 PMID 11295563
  • Double-stranded RNA-dependent protein kinase is not required for double-stranded RNA-induced nitric oxide synthase expression or nuclear factor-kappaB activation by islets. (Blair LA, Heitmeier MR, Scarim AL, Maggi LB Jr, Corbett JA) Diabetes 2001 Feb;50(2):283-90 PMID 11272138
  • Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes. (Heitmeier MR, Arnush M, Scarim AL, Corbett JA) J Biol Chem 2001 Apr 6;276(14):11151-8 PMID 11108714
  • Adoptive transfer of acute lung injury. (Moxley MA, Baird TL, Corbett JA) Am J Physiol Lung Cell Mol Physiol 2000 Nov;279(5):L985-93 PMID 11053036
  • Potential role of PKR in double-stranded RNA-induced macrophage activation. (Maggi LB Jr, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA) EMBO J 2000 Jul 17;19(14):3630-8 PMID 10899117
  • Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. (Maggi LB Jr, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA) Diabetes 2000 Mar;49(3):346-55 PMID 10868955
  • Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. (Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG) Cell 2000 Mar 17;100(6):645-54 PMID 10761930
  • Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible nitric-oxide synthase expression by islets of Langerhans. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1999 Oct 8;274(41):29266-73 PMID 10506184
  • Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. (Thomas HE, Darwiche R, Corbett JA, Kay TW) J Immunol 1999 Aug 1;163(3):1562-9 PMID 10415060
  • Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1999 Apr 30;274(18):12531-6 PMID 10212230
  • Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats. (Cruz WS, Corbett JA, Longmore WJ, Moxley MA) Am J Physiol 1999 Feb;276(2 Pt 1):L263-8 PMID 9950888
  • Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets. (Scarim AL, Heitmeier MR, Corbett JA) Endocrinology 1998 Dec;139(12):5050-7 PMID 9832444
  • Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion. (Parkkila AK, Scarim AL, Parkkila S, Waheed A, Corbett JA, Sly WS) J Biol Chem 1998 Sep 18;273(38):24620-3 PMID 9733757
  • IL-1 produced and released endogenously within human islets inhibits beta cell function. (Arnush M, Heitmeier MR, Scarim AL, Marino MH, Manning PT, Corbett JA) J Clin Invest 1998 Aug 1;102(3):516-26 PMID 9691088
  • Double-stranded RNA-induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1998 Jun 12;273(24):15301-7 PMID 9614147
  • Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. (Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML) Diabetes 1998 Apr;47(4):583-91 PMID 9568691
  • Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. (Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA) J Immunol 1998 Mar 15;160(6):2684-91 PMID 9510167
  • Inhibition of nitric oxide synthase attenuates NNMU-induced alveolar injury in vivo. (Cruz WS, Moxley MA, Corbett JA, Longmore WJ) Am J Physiol 1997 Dec;273(6 Pt 1):L1167-73 PMID 9435571
  • Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans. (Scarim AL, Arnush M, Hill JR, Marshall CA, Baldwin A, McDaniel ML, Corbett JA) Biochim Biophys Acta 1997 Oct 24;1361(3):313-20 PMID 9375806
  • Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta. (Scarim AL, Heitmeier MR, Corbett JA) Endocrinology 1997 Dec;138(12):5301-7 PMID 9389514
  • Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets. (Kwon G, Hill JR, Corbett JA, McDaniel ML) Mol Pharmacol 1997 Sep;52(3):398-405 PMID 9281601
  • Phorbol esters stimulate muscle glucose transport by a mechanism distinct from the insulin and hypoxia pathways. (Hansen PA, Corbett JA, Holloszy JO) Am J Physiol 1997 Jul;273(1 Pt 1):E28-36 PMID 9252476
  • Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1997 May 23;272(21):13697-704 PMID 9153221
  • Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. (Carroll SL, Miller ML, Frohnert PW, Kim SS, Corbett JA) J Neurosci 1997 Mar 1;17(5):1642-59 PMID 9030624
  • A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction. (McDaniel ML, Corbett JA, Kwon G, Hill JR) Adv Exp Med Biol 1997;426:313-9 PMID 9544288
  • Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells. (Meredith M, Rabaglia ME, Corbett JA, Metz SA) Diabetes 1996 Dec;45(12):1783-91 PMID 8922366
  • Nitric oxide regulates interleukin 1 bioactivity released from murine macrophages. (Hill JR, Corbett JA, Kwon G, Marshall CA, McDaniel ML) J Biol Chem 1996 Sep 13;271(37):22672-8 PMID 8798439
  • The Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes (Corbett JA, McDaniel ML) Methods 1996 Aug;10(1):21-30 PMID 8812641
  • Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. (Corbett JA, Kwon G, Marino MH, Rodi CP, Sullivan PM, Turk J, McDaniel ML) Am J Physiol 1996 Jun;270(6 Pt 1):C1581-7 PMID 8764139
  • Nitric oxide production by the rat insulinoma cell line, RINm5F, Is specific for IL-1: a spectrophotometric IL-1 bioassay. (Hill JR, Corbett JA, Baldwin AC, McDaniel ML) Anal Biochem 1996 Apr 5;236(1):14-9 PMID 8619479
  • Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide. (Kwon G, Bohrer A, Han X, Corbett JA, Ma Z, Gross RW, McDaniel ML, Turk J) Biochim Biophys Acta 1996 Mar 29;1300(1):63-72 PMID 8608164
  • Interleukin 1-induced Fos and Jun do not regulate inducible nitric oxide synthase in rat islets of Langerhans and RINm5F cells. (Kwon G, Corbett JA, McDaniel ML) Endocrinology 1996 Mar;137(3):825-30 PMID 8603591
  • Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. (Zhao W, Tilton RG, Corbett JA, McDaniel ML, Misko TP, Williamson JR, Cross AH, Hickey WF) J Neuroimmunol 1996 Feb;64(2):123-33 PMID 8632054
  • Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism. (Ma Z, Ramanadham S, Corbett JA, Bohrer A, Gross RW, McDaniel ML, Turk J) J Biol Chem 1996 Jan 12;271(2):1029-42 PMID 8557627
  • Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. (Denlinger LC, Fisette PL, Garis KA, Kwon G, Vazquez-Torres A, Simon AD, Nguyen B, Proctor RA, Bertics PJ, Corbett JA) J Biol Chem 1996 Jan 5;271(1):337-42 PMID 8550583
  • Selective inhibition of inducible nitric oxide synthase by aminoguanidine. (Corbett JA, McDaniel ML) Methods Enzymol 1996;268:398-408 PMID 8782606
  • Cytokines and nitric oxide in islet inflammation and diabetes. (McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett JA) Proc Soc Exp Biol Med 1996 Jan;211(1):24-32 PMID 8594615
  • Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. (Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML) Endocrinology 1995 Nov;136(11):4790-5 PMID 7588208
  • Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. (Corbett JA, McDaniel ML) J Exp Med 1995 Feb 1;181(2):559-68 PMID 7530759
  • Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans. (Corbett JA, Kwon G, Misko TP, Rodi CP, McDaniel ML) Am J Physiol 1994 Jul;267(1 Pt 1):C48-54 PMID 7519400
  • Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. (Tilton RG, Chang K, Corbett JA, Misko TP, Currie MG, Bora NS, Kaplan HJ, Williamson JR) Invest Ophthalmol Vis Sci 1994 Jul;35(8):3278-88 PMID 7519183
  • Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. (Corbett JA, McDaniel ML) Biochem J 1994 May 1;299 ( Pt 3):719-24 PMID 7514870
  • Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface. (Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santiago JV, McDaniel ML) Diabetes 1994 Mar;43(3):418-25 PMID 8314014
  • Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis. (Heiss LN, Lancaster JR Jr, Corbett JA, Goldman WE) Proc Natl Acad Sci U S A 1994 Jan 4;91(1):267-70 PMID 7506415
  • Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. (Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML) Biochem Biophys Res Commun 1993 Dec 30;197(3):1458-64 PMID 7904159
  • Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes. (Hewett SJ, Corbett JA, McDaniel ML, Choi DW) Neurosci Lett 1993 Dec 24;164(1-2):229-32 PMID 7512249
  • IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. (Corbett JA, Kwon G, Turk J, McDaniel ML) Biochemistry 1993 Dec 21;32(50):13767-70 PMID 7505613
  • Nitric oxide mediates interleukin-1-induced cellular cytotoxicity in the rat ovary. A potential role for nitric oxide in the ovulatory process. (Ellman C, Corbett JA, Misko TP, McDaniel M, Beckerman KP) J Clin Invest 1993 Dec;92(6):3053-6 PMID 7504698
  • Inhibition of nitric oxide formation by guanidines. (Hasan K, Heesen BJ, Corbett JA, McDaniel ML, Chang K, Allison W, Wolffenbuttel BH, Williamson JR, Tilton RG) Eur J Pharmacol 1993 Nov 2;249(1):101-6 PMID 7506664
  • Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity. (Hewett SJ, Corbett JA, McDaniel ML, Choi DW) Brain Res 1993 Oct 22;625(2):337-41 PMID 8275317
  • Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. (Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER) Proc Natl Acad Sci U S A 1993 Oct 1;90(19):8992-5 PMID 7692442
  • Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia--effect of diabetes and aging. (Schmidt RE, Dorsey DA, McDaniel ML, Corbett JA) Brain Res 1993 Jul 23;617(2):343-8 PMID 8104662
  • What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus? (Mandrup-Poulsen T, Corbett JA, McDaniel ML, Nerup J) Diabetologia 1993 May;36(5):470-1 PMID 7686111
  • Glucose-induced insulin secretion from purified beta-cells. A role for modulation of Ca2+ influx by cAMP- and protein kinase C-dependent signal transduction pathways. (Wang JL, Corbett JA, Marshall CA, McDaniel ML) J Biol Chem 1993 Apr 15;268(11):7785-91 PMID 8385120
  • Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. (Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamson JR, Currie MG) Eur J Pharmacol 1993 Mar 16;233(1):119-25 PMID 7682510
  • Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. (Corbett JA, Sweetland MA, Wang JL, Lancaster JR Jr, McDaniel ML) Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1731-5 PMID 8383325
  • A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism. (Corbett JA, Sweetland MA, Lancaster JR Jr, McDaniel ML) FASEB J 1993 Feb 1;7(2):369-74 PMID 8440413
  • Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. (Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML) Diabetes 1993 Feb;42(2):221-32 PMID 7678825
  • Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. (Beckerman KP, Rogers HW, Corbett JA, Schreiber RD, McDaniel ML, Unanue ER) J Immunol 1993 Feb 1;150(3):888-95 PMID 7678626
  • Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone. (Corbett JA, Wang JL, Misko TP, Zhao W, Hickey WF, McDaniel ML) Autoimmunity 1993;15(2):145-53 PMID 7692996
  • Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. (Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr, McDaniel ML) J Clin Invest 1992 Dec;90(6):2384-91 PMID 1334975
  • Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction. (Corbett JA, Wang JL, Hughes JH, Wolf BA, Sweetland MA, Lancaster JR Jr, McDaniel ML) Biochem J 1992 Oct 1;287 ( Pt 1):229-35 PMID 1384465
  • Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. (Corbett JA, McDaniel ML) Diabetes 1992 Aug;41(8):897-903 PMID 1378415
  • Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. (Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR Jr, Williamson JR, McDaniel ML) Diabetes 1992 Apr;41(4):552-6 PMID 1376704
  • Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. (Corbett JA, Lancaster JR Jr, Sweetland MA, McDaniel ML) J Biol Chem 1991 Nov 15;266(32):21351-4 PMID 1657959
  • Grants and Awards

  • Control of Beta-cell Fate by Nitric Oxide (#9208681 07/01/2014 - 06/30/2016) Sponsor: American Heart Association - Midwest Affiliate
  • Mechanisms of Viral-Inducted Beta Cell Damage (#9206247 02/03/2010 - 01/31/2014) Sponsor: NIH Allergy and Infectious Diseases
  • Differential Control of Cell Signaling by Reactive Oxygen and Nitrogen Species (#9208099 07/01/2013 - 06/30/2015) Sponsor: American Heart Association - Midwest Affiliate
  • Mechanisms of Viral-Induced Beta Cell Damage (#9208504 04/01/2014 - 03/31/2019) Sponsor: NIH Allergy and Infectious Diseases
  • Biomechanical Mechanisms of Beta-Cell Destruction (#9206194 01/01/2010 - 06/30/2013) Sponsor: NIH Diabetes, Digestive and Kidney Diseases
  • 2014 Diabetes Research Project (#9208675 04/28/2014 - 04/27/2015) Sponsor: Forest County Potawatomi Community Foundation
  • Biochemical Mechanism of Beta-Cell Destruction (#9208521 04/02/2014 - 03/31/2018) Sponsor: NIH Diabetes, Digestive and Kidney Diseases