Medical College of Wisconsin
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John E. Baker PhD

John E. Baker PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Cardiothoracic
Program: Research

Member of the Cancer Center


Research Experience

  • Cardiovascular Agents
  • Cardiovascular Diseases
  • Cardiovascular Physiologic Phenomena
  • Cardiovascular Physiologic Processes
  • Cardiovascular Physiology
  • Cardiovascular System
  • Radiation Effects
  • Radiation Genetics
  • Radiation Injuries
  • Radiation Injuries, Experimental
  • Radiation Tolerance
  • Radiation, Ionizing
  • Radiation-Protective Agents
  • radiation effects
  • Clinical Expertise

  • Clinical Trial
  • Clinical Trials, Phase II as Topic
  • Drugs, Investigational
  • Leadership Positions

  • Chair, Institutional Animal Care and Use Committee
  • Publications

  • Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus. (Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF) J Biol Chem 2013 Jan 4;288(1):737-46 PMID 23148226
  • Response. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Nov;26(11):4388-9 PMID 23118151
  • Intestinal microbiota as novel biomarkers of prior radiation exposure. (Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE) Radiat Res 2012 May;177(5):573-83 PMID 22439602
  • Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID 22247331
  • Laminin 332 deposition is diminished in irradiated skin in an animal model of combined radiation and wound skin injury. (Jourdan MM, Lopez A, Olasz EB, Duncan NE, Demara M, Kittipongdaja W, Fish BL, M├Ąder M, Schock A, Morrow NV, Semenenko VA, Baker JE, Moulder JE, Lazarova Z) Radiat Res 2011 Nov;176(5):636-48 PMID 21854211
  • Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts. (Gross GJ, Baker JE, Moore J, Falck JR, Nithipatikom K) Cardiovasc Drugs Ther 2011 Dec;25(6):517-22 PMID 21786213
  • Radiation as a risk factor for cardiovascular disease. (Baker JE, Moulder JE, Hopewell JW) Antioxid Redox Signal 2011 Oct 1;15(7):1945-56 PMID 21091078
  • Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. (Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K) Am J Physiol Heart Circ Physiol 2010 Jun;298(6):H2201-7 PMID 20400686
  • Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. (Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE) J Inflamm (Lond) 2009;6:34 PMID 20003243
  • 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. (Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Allen Li X, Hopewell JW, Moulder JE) Int J Radiat Biol 2009 Dec;85(12):1089-100 PMID 19995235
  • Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. (Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF) Protein Sci 2009 Jul;18(7):1359-69 PMID 19551879
  • Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. (Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE) Cardiovasc Res 2009 Jul 15;83(2):325-34 PMID 19380418
  • Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. (Aggarwal NT, Pfister SL, Gauthier KM, Chawengsub Y, Baker JE, Campbell WB) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H678-88 PMID 19112096
  • Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. (Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE) J Mol Cell Cardiol 2008 Feb;44(2):345-51 PMID 18083188
  • Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) J Pharmacol Exp Ther 2008 Mar;324(3):1045-54 PMID 18055876
  • Mitochondrial big conductance KCa channel and cardioprotection in infant rabbit heart. (Shi Y, Jiang MT, Su J, Hutchins W, Konorev E, Baker JE) J Cardiovasc Pharmacol 2007 Nov;50(5):497-502 PMID 18030058
  • Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID 18006466
  • Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. (Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N) J Mol Cell Cardiol 2007 Oct;43(4):437-44 PMID 17765919
  • Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms. (Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ) J Cardiovasc Pharmacol 2007 Jun;49(6):337-45 PMID 17577097
  • SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) Basic Res Cardiol 2007 Jul;102(4):350-8 PMID 17468933
  • Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. (Cabigas BP, Su J, Hutchins W, Shi Y, Schaefer RB, Recinos RF, Nilakantan V, Kindwall E, Niezgoda JA, Baker JE) Cardiovasc Res 2006 Oct 1;72(1):143-51 PMID 16930572
  • Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants. (Nilakantan V, Zhou X, Hilton G, Shi Y, Baker JE, Khanna AK, Pieper GM) J Thorac Cardiovasc Surg 2006 Apr;131(4):898-906 PMID 16580450
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID 16478827
  • Erythropoietin mimics ischemic preconditioning. (Baker JE) Vascul Pharmacol 2005 Apr-May;42(5-6):233-41 PMID 15922256
  • Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID 15808839
  • Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID 15611843
  • Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID 15388508
  • Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. (Fitzpatrick CM, Shi Y, Hutchins WC, Su J, Gross GJ, Ostadal B, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H62-8 PMID 15319200
  • Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID 15088102
  • Oxidative stress and adaptation of the infant heart to hypoxia and ischemia. (Baker JE) Antioxid Redox Signal 2004 Apr;6(2):423-9 PMID 15025944
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID 12937165
  • Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. (Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER) Circ Res 2003 May 16;92(9):992-1000 PMID 12690037
  • Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. (Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr) Circ Res 2002 Aug 23;91(4):300-6 PMID 12193462
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 9;106(2):239-45 PMID 12105165
  • Delayed cardioprotection by isoflurane: role of K(ATP) channels. (Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H61-8 PMID 12063275
  • Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. (Kong X, Tweddell JS, Gross GJ, Baker JE) J Mol Cell Cardiol 2001 May;33(5):1041-5 PMID 11343425
  • Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. (Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC) J Biol Chem 2001 May 25;276(21):17621-4 PMID 11278264
  • Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism. (Baker JE, Contney SJ, Singh R, Kalyanaraman B, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 2001 Feb;33(2):331-41 PMID 11162137
  • Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics? (Eells JT, Henry MM, Gross GJ, Baker JE) Circ Res 2000 Nov 10;87(10):915-21 PMID 11073888
  • Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID 11053770
  • Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? (Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400 PMID 10749737
  • Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID 10415535
  • Preconditioning in immature rabbit hearts: role of KATP channels. (Baker JE, Holman P, Gross GJ) Circulation 1999 Mar 9;99(9):1249-54 PMID 10069795
  • Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID 9889894
  • Myocardial protection of the hypoxic heart. (Baker JE, Olinger GN) J Thorac Cardiovasc Surg 1997 Jun;113(6):1123-4 PMID 9202700
  • Effect of exposure to hypoxia from birth on aldosterone in rabbits: role of unesterified fatty acids. (Raff H, Jankowski BM, Goodfriend TL, Baker JE, Papanek PE) Am J Physiol 1997 Apr;272(4 Pt 2):R1084-7 PMID 9140005
  • Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel. (Baker JE, Curry BD, Olinger GN, Gross GJ) Circulation 1997 Mar 4;95(5):1278-85 PMID 9054860
  • KATP channel activation in a rabbit model of chronic myocardial hypoxia. (Baker JE, Contney SJ, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 1997 Feb;29(2):845-8 PMID 9140841
  • Spin label oximetry to assess extracellular oxygen during myocardial ischemia. (Baker JE, Froncisz W, Joseph J, Kalyanaraman B) Free Radic Biol Med 1997;22(1-2):109-15 PMID 8958135
  • Postnatal developmental profiles of antioxidant enzymes in heart. (Maulik N, Baker JE, Engelman RM, Das DK) Ann N Y Acad Sci 1996 Sep 30;793:439-48 PMID 8906189
  • S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) J Pharmacol Exp Ther 1995 Jul;274(1):200-6 PMID 7616400
  • Direct effects of halothane and isoflurane in infant rabbit hearts with right ventricular hypertrophy secondary to chronic hypoxemia. (Palmisano BW, Mehner RW, Baker JE, Stowe DF, Bosnjak ZJ, Kampine JP) Anesth Analg 1995 Jun;80(6):1122-8 PMID 7762838
  • Tolerance of the developing heart to ischemia: impact of hypoxemia from birth. (Baker EJ, Boerboom LE, Olinger GN, Baker JE) Am J Physiol 1995 Mar;268(3 Pt 2):H1165-73 PMID 7900870
  • Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) Free Radic Biol Med 1995 Feb;18(2):169-77 PMID 7744299
  • Calcium and cardioplegic protection of the ischemic immature heart: impact of hypoxemia from birth. (Baker EJ, Baker JE) Ann Thorac Surg 1994 Oct;58(4):1123-30 PMID 7944763
  • Lack of protection of PBN in isolated heart during ischemia and reperfusion: implications for radical scavenging mechanism. (Baker JE, Konorev EA, Tse SY, Joseph J, Kalyanaraman B) Free Radic Res 1994 Mar;20(3):145-63 PMID 8019639
  • Protection of the ischemic immature heart--effect of perfusate reinfusion and composition. (Baker JE, Olinger GN, Boerboom LE) Thorac Cardiovasc Surg 1993 Oct;41(5):274-9 PMID 8303694
  • Recovery of hypoxic neonatal hearts after cardioplegic arrest. (Baker JE) Cardiovasc Res 1993 Jun;27(6):1135-6 PMID 8221776
  • Age and protection of the ischemic myocardium: is alkaline cardioplegia appropriate? (Baker JE, Boerboom LE, Olinger GN) Ann Thorac Surg 1993 Mar;55(3):747-55 PMID 8452442
  • Vasodilatory and toxic effects of spin traps on aerobic cardiac function. (Konorev EA, Baker JE, Joseph J, Kalyanaraman B) Free Radic Biol Med 1993 Feb;14(2):127-37 PMID 8425719
  • Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries. (Konorev EA, Struck AT, Baker JE, Ramanujam S, Thomas JP, Radi R, Kalyanaraman B) Free Radic Res Commun 1993;19(6):397-407 PMID 8168729
  • Calcium content of St. Thomas' II cardioplegic solution damages ischemic immature myocardium. (Baker EJ 5th, Olinger GN, Baker JE) Ann Thorac Surg 1991 Oct;52(4):993-9 PMID 1929665
  • Cardioplegia-induced damage to ischemic immature myocardium is independent of oxygen availability. (Baker JE, Boerboom LE, Olinger GN) Ann Thorac Surg 1990 Dec;50(6):934-9 PMID 2241386
  • On the detection of paramagnetic species in the adriamycin-perfused rat heart: a reappraisal. (Kalyanaraman B, Baker JE) Biochem Biophys Res Commun 1990 May 31;169(1):30-8 PMID 2161659
  • Is protection of ischemic neonatal myocardium by cardioplegia species dependent? (Baker JE, Boerboom LE, Olinger GN) J Thorac Cardiovasc Surg 1990 Feb;99(2):280-7 PMID 2299865
  • Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. (Baker JE, Kalyanaraman B) FEBS Lett 1989 Feb 27;244(2):311-4 PMID 2537756
  • Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID 2905005
  • Age-related changes in the ability of hypothermia and cardioplegia to protect ischemic rabbit myocardium. (Baker JE, Boerboom LE, Olinger GN) J Thorac Cardiovasc Surg 1988 Nov;96(5):717-24 PMID 3184966
  • Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy. (Baker JE, Felix CC, Olinger GN, Kalyanaraman B) Proc Natl Acad Sci U S A 1988 Apr;85(8):2786-9 PMID 2833754
  • Differing potencies and dose-response characteristics in the ability of slow-calcium-channel blockers to reduce enzyme leakage in the calcium paradox. (Baker JE, Hearse DJ) Adv Myocardiol 1985;6:637-46 PMID 2581302
  • Calcium delivery and time: factors affecting the progression of cellular damage during the calcium paradox in the rat heart. (Baker JE, Kemmenoe BH, Hearse DJ, Bullock GR) Cardiovasc Res 1984 Jun;18(6):361-70 PMID 6331667
  • The temperature-sensitivity of slow channel calcium blockers in relation to their effect upon the calcium paradox. (Baker JE, Hearse DJ) Eur Heart J 1983 Dec;4 Suppl H:97-103 PMID 6662136
  • Slow calcium channel blockers and the calcium paradox: comparative studies in the rat with seven drugs. (Baker JE, Hearse DJ) J Mol Cell Cardiol 1983 Jul;15(7):475-85 PMID 6312058
  • The temperature dependence of the calcium paradox: enzymatic, functional and morphological correlates of cellular injury. (Baker JE, Bullock GR, Hearse DJ) J Mol Cell Cardiol 1983 Jun;15(6):393-411 PMID 6876188
  • Verapamil and the calcium paradox: a reaffirmation. (Hearse DJ, Baker JE) J Mol Cell Cardiol 1981 Dec;13(12):1087-90 PMID 7328668
  • Verapamil and the calcium paradox. (Hearse DJ, Baker JE, Humphrey SM) J Mol Cell Cardiol 1980 Jul;12(7):733-9 PMID 7411649
  • Grants and Awards

  • Chronic Hypoxia and Resistance to Myocardial Ischemia (#9204684 04/16/2007 - 03/31/2012) Sponsor: NIH Heart Lung and Blood Institute
  • Chronic Hypoxia and Resistance to Myocardial Ischemia (#9202299 12/01/2001 - 11/30/2006) Sponsor: NIH Heart Lung and Blood Institute
  • SCOR - Ischemic Heart Disease in Blacks (#9201867 09/30/2000 - 08/31/2005) PI of SCOR - Ischemic Heart Disease in Blacks - Project 4 (#2203367)
  • Post-Irradiation Intervention to Mitigate and Treat Non* (#9203848 08/31/2005 - 07/31/2012) PI of Pilot: Pharmacological Treatment for Radiation Injury to the Cardiovascular System in Children after Radiation Exposure (#2204715)
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of Intestinal Microbiota and the Pathogenesis of Cardiovascular Disease (#5520281)