Medical College of Wisconsin
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John Paul Scott MD

John Paul Scott MD


Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Hematology


  • Intravenous magnesium for pediatric sickle cell vaso-occlusive crisis: methodological issues of a randomized controlled trial. (Badaki-Makun O, Scott JP, Panepinto JA, Casper TC, Hillery CA, Dean JM, Brousseau DC, Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group) Pediatr Blood Cancer 2014 Jun;61(6):1049-54 PMID 24443249
  • Repeated aortopulmonary shunt thrombosis in a neonatal patient with a low antithrombin level. (Niebler RA, Mitchell ME, Scott JP) World J Pediatr Congenit Heart Surg 2014 Jan 1;5(1):94-6 PMID 24403363
  • Vitamin B12 deficiency: the great masquerader. (Dobrozsi S, Flood VH, Panepinto J, Scott JP, Brandow A) Pediatr Blood Cancer 2014 Apr;61(4):753-5 PMID 24115632
  • Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. (Alvarez O, Yovetich NA, Scott JP, Owen W, Miller ST, Schultz W, Lockhart A, Aygun B, Flanagan J, Bonner M, Mueller BU, Ware RE, Investigators of the Stroke With Transfusions Changing to Hydroxyurea Clinical Trial (SWiTCH)) Am J Hematol 2013 Nov;88(11):932-8 PMID 23861242
  • Academic attainment findings in children with sickle cell disease. (Epping AS, Myrvik MP, Newby RF, Panepinto JA, Brandow AM, Scott JP) J Sch Health 2013 Aug;83(8):548-53 PMID 23834606
  • Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion. (Collins CL, Scott JP, Panepinto JA, Punzalan RC) J Pediatr Hematol Oncol 2013 Jul;35(5):e226-8 PMID 23459377
  • Stroke With Transfusions Changing to Hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload. (Ware RE, Schultz WH, Yovetich N, Mortier NA, Alvarez O, Hilliard L, Iyer RV, Miller ST, Rogers ZR, Scott JP, Waclawiw M, Helms RW) Pediatr Blood Cancer 2011 Dec 1;57(6):1011-7 PMID 21826782
  • Partial splenectomy for hereditary spherocytosis: a multi-institutional review. (Buesing KL, Tracy ET, Kiernan C, Pastor AC, Cassidy LD, Scott JP, Ware RE, Davidoff AM, Rescorla FJ, Langer JC, Rice HE, Oldham KT) J Pediatr Surg 2011 Jan;46(1):178-83 PMID 21238662
  • Hydroxurea and sickle cell disease: Its been a long, long time coming. (Scott JP) Pediatr Blood Cancer 2010 Feb;54(2):185-6 PMID 19908298
  • Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. (Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Buchanan GR, Bunin N, Dickerhoff R, Giller R, Haut PR, Horan J, Hsu LL, Kamani N, Levine JE, Margolis D, Ohene-Frempong K, Patience M, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sullivan KM, Multicenter Study of Bone Marrow Transplantation for Sickle Cell Disease) Biol Blood Marrow Transplant 2010 Feb;16(2):263-72 PMID 19822218
  • Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function. (Flood VH, Friedman KD, Gill JC, Morateck PA, Wren JS, Scott JP, Montgomery RR) J Thromb Haemost 2009 Nov;7(11):1832-9 PMID 19694940
  • Genetic endothelial systems biology of sickle stroke risk. (Chang Milbauer L, Wei P, Enenstein J, Jiang A, Hillery CA, Scott JP, Nelson SC, Bodempudi V, Topper JN, Yang RB, Hirsch B, Pan W, Hebbel RP) Blood 2008 Apr 1;111(7):3872-9 PMID 18156497
  • Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. (Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC, Dickerhoff R, Donfield S, Feig SA, Giller RH, Haight A, Horan J, Hsu LL, Kamani N, Lane P, Levine JE, Margolis D, Moore TB, Ohene-Frempong K, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sleight B, Thompson AA, Sullivan KM, Walters MC, Multicenter Study of HCT for SCA) Br J Haematol 2007 Feb;136(4):673-6 PMID 17223910
  • Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. (Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu JY, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, DeBaun MR) J Pediatr 2006 Nov;149(5):710-2 PMID 17095350
  • Perioperative management of sickle cell disease children undergoing adenotonsillectomy. (Duke RL, Scott JP, Panepinto JA, Flanary VA) Otolaryngol Head Neck Surg 2006 Mar;134(3):370-3 PMID 16500429
  • Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. (Hankins JS, Ware RE, Rogers ZR, Wynn LW, Lane PA, Scott JP, Wang WC) Blood 2005 Oct 1;106(7):2269-75 PMID 16172253
  • Health-related quality of life in children with sickle cell disease: child and parent perception. (Panepinto JA, O'Mahar KM, DeBaun MR, Loberiza FR, Scott JP) Br J Haematol 2005 Aug;130(3):437-44 PMID 16042695
  • Variation in hospitalizations and hospital length of stay in children with vaso-occlusive crises in sickle cell disease. (Panepinto JA, Brousseau DC, Hillery CA, Scott JP) Pediatr Blood Cancer 2005 Feb;44(2):182-6 PMID 15390359
  • The effect of magnesium on length of stay for pediatric sickle cell pain crisis. (Brousseau DC, Scott JP, Hillery CA, Panepinto JA) Acad Emerg Med 2004 Sep;11(9):968-72 PMID 15347549
  • Validity of the child health questionnaire for use in children with sickle cell disease. (Panepinto JA, O'Mahar KM, DeBaun MR, Rennie KM, Scott JP) J Pediatr Hematol Oncol 2004 Sep;26(9):574-8 PMID 15342984
  • Patient-controlled analgesia for sickle cell pain crisis in a pediatric emergency department. (Melzer-Lange MD, Walsh-Kelly CM, Lea G, Hillery CA, Scott JP) Pediatr Emerg Care 2004 Jan;20(1):2-4 PMID 14716157
  • Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia. (Greenbaum LA, Kerlin BA, Van Why S, Punzalan RC, Trost BA, Pan CG, Scott JP) Pediatr Nephrol 2003 Dec;18(12):1301-3 PMID 14586676
  • Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease. (Talano JA, Hillery CA, Gottschall JL, Baylerian DM, Scott JP) Pediatrics 2003 Jun;111(6 Pt 1):e661-5 PMID 12777582
  • Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion. (Watkins NA, Du LM, Scott JP, Ouwehand WH, Hillery CA) Blood 2003 Jul 15;102(2):718-24 PMID 12663449
  • Cutaneous manifestations of hemophagocytic lymphohistiocytosis. (Morrell DS, Pepping MA, Scott JP, Esterly NB, Drolet BA) Arch Dermatol 2002 Sep;138(9):1208-12 PMID 12224982
  • Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke. (Scothorn DJ, Price C, Schwartz D, Terrill C, Buchanan GR, Shurney W, Sarniak I, Fallon R, Chu JY, Pegelow CH, Wang W, Casella JF, Resar LS, Berman B, Adamkiewicz T, Hsu LL, Ohene-Frempong K, Smith-Whitley K, Mahoney D, Scott JP, Woods GM, Watanabe M, Debaun MR) J Pediatr 2002 Mar;140(3):348-54 PMID 11953734
  • A two-year pilot trial of hydroxyurea in very young children with sickle-cell anemia. (Wang WC, Wynn LW, Rogers ZR, Scott JP, Lane PA, Ware RE) J Pediatr 2001 Dec;139(6):790-6 PMID 11743503
  • Bleeding disorders: A common cause of menorrhagia in adolescents. (Bevan JA, Maloney KW, Hillery CA, Gill JC, Montgomery RR, Scott JP) J Pediatr 2001 Jun;138(6):856-61 PMID 11391329
  • Hydroxyurea therapy decreases the in vitro adhesion of sickle erythrocytes to thrombospondin and laminin. (Hillery CA, Du MC, Wang WC, Scott JP) Br J Haematol 2000 May;109(2):322-7 PMID 10848818
  • Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. (Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GE, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong WY, Scott JP, Margolis D, Vichinsky E, Wall DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, Sullivan KM) Blood 2000 Mar 15;95(6):1918-24 PMID 10706855
  • The carboxy-terminal cell-binding domain of thrombospondin is essential for sickle red blood cell adhesion. (Hillery CA, Scott JP, Du MC) Blood 1999 Jul 1;94(1):302-9 PMID 10381526
  • A frameshift mutation at Gly975 in the transmembrane domain of GPIIb prevents GPIIb-IIIa expression--analysis of two novel mutations in a kindred with type I glanzmann thrombasthenia. (Scott JP 3rd, Scott JP 2nd, Chao YL, Newman PJ, Ward CM) Thromb Haemost 1998 Oct;80(4):546-50 PMID 9798966
  • Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. (Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Yeager A, Kurtzberg J, Bunin N, Scott JP, Wall DA, Wayne AS, Wiley J, Darbyshire PJ, Mentzer WC, Smith FO, Sullivan KM) Biol Blood Marrow Transplant 1997 Dec;3(6):310-5 PMID 9502298
  • Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition. (French JA 2nd, Kenny D, Scott JP, Hoffmann RG, Wood JD, Hudetz AG, Hillery CA) Blood 1997 Jun 15;89(12):4591-9 PMID 9192784
  • Is biliary sludge a stone-in-waiting? (Werlin SL, Scott JP) J Pediatr 1996 Sep;129(3):321-2 PMID 8804319
  • Bone marrow transplantation for sickle cell disease. (Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM) N Engl J Med 1996 Aug 8;335(6):369-76 PMID 8663884
  • Hydroxyurea therapy in children severely affected with sickle cell disease. (Scott JP, Hillery CA, Brown ER, Misiewicz V, Labotka RJ) J Pediatr 1996 Jun;128(6):820-8 PMID 8648542
  • Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. (Hillery CA, Du MC, Montgomery RR, Scott JP) Blood 1996 Jun 1;87(11):4879-86 PMID 8639862
  • Barriers to bone marrow transplantation for sickle cell anemia. (Walters MC, Patience M, Leisenring W, Eckman JR, Buchanan GR, Rogers ZR, Olivieri NE, Vichinsky E, Davies SC, Mentzer WC, Powars D, Scott JP, Bernaudin F, Ohene-Frempong K, Darbyshire PJ, Wayne A, Roberts IA, Dinndorf P, Brandalise S, Sanders JE, Matthews DC, Appelbaum FR, Storb R, Sullivan KM) Biol Blood Marrow Transplant 1996 May;2(2):100-4 PMID 9118298
  • Recombinant activated factor VII (rFVIIa) therapy for intracranial hemorrhage in hemophilia A patients with inhibitors. (Schmidt ML, Gamerman S, Smith HE, Scott JP, DiMichele DM) Am J Hematol 1994 Sep;47(1):36-40 PMID 8042614
  • Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. (Visentin GP, Ford SE, Scott JP, Aster RH) J Clin Invest 1994 Jan;93(1):81-8 PMID 8282825
  • Immunosuppressant combinations in primate cardiac xenografts. A review. (McManus RP, O'Hair DP, Komorowski R, Scott JP) Ann N Y Acad Sci 1993 Nov 30;696:281-4 PMID 8109832
  • Therapy of von Willebrand disease. (Scott JP, Montgomery RR) Semin Thromb Hemost 1993;19(1):37-47 PMID 8456322
  • Heparin-induced thrombocytopenia in a child. (Potter C, Gill JC, Scott JP, McFarland JG) J Pediatr 1992 Jul;121(1):135-8 PMID 1625071
  • Neurologic events after partial exchange transfusion for priapism in sickle cell disease. (Rackoff WR, Ohene-Frempong K, Month S, Scott JP, Neahring B, Cohen AR) J Pediatr 1992 Jun;120(6):882-5 PMID 1593347
  • Expressed full-length von Willebrand factor containing missense mutations linked to type IIB von Willebrand disease shows enhanced binding to platelets. (Kroner PA, Kluessendorf ML, Scott JP, Montgomery RR) Blood 1992 Apr 15;79(8):2048-55 PMID 1373334
  • The role of antiendothelial antibody in primate cardiac xenograft rejection. (O'Hair DP, McManus RP, Johnson CP, Scott JP) Transplant Proc 1992 Apr;24(2):506-7 PMID 1566407
  • The rapid differentiation of type IIb von Willebrand's disease from platelet-type (pseudo-) von Willebrand's disease by the "neutral" monoclonal antibody binding assay. (Scott JP, Montgomery RR) Am J Clin Pathol 1991 Dec;96(6):723-8 PMID 1746488
  • Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease. (Kroner PA, Friedman KD, Fahs SA, Scott JP, Montgomery RR) J Biol Chem 1991 Oct 15;266(29):19146-9 PMID 1918030
  • Prolonged recombinant activated factor VII (rFVIIa) treatment for severe bleeding in a factor-IX-deficient patient with an inhibitor. (Schmidt ML, Smith HE, Gamerman S, DiMichele D, Glazer S, Scott JP) Br J Haematol 1991 Jul;78(3):460-3 PMID 1873233
  • Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets. (Scott JP, Montgomery RR, Retzinger GS) J Biol Chem 1991 May 5;266(13):8149-55 PMID 2022635
  • Human factor IXLincoln Park: a molecular characterization. (Rao KJ, Lyman G, Hamsbhushanam K, Scott JP, Jagadeeswaran P) Mol Cell Probes 1990 Oct;4(5):335-40 PMID 1980717
  • Platelet collection during plasma exchange donation of cryoprecipitate. (McLeod BC, Sassetti RJ, Cole ER, Scott JP) Prog Clin Biol Res 1990;337:481-3 PMID 2112755
  • Plasma exchange donation of cryoprecipitate after DDAVP stimulation: an alternative source of factor VIII. (McLeod BC, Scott JP) Prog Clin Biol Res 1990;324:189-98 PMID 2106687
  • A human monoclonal autoantibody specific for human platelet glycoprotein IIb (integrin alpha IIb) heavy chain. (Kunicki TJ, Furihata K, Kekomaki R, Scott JP, Nugent DJ) Hum Antibodies Hybridomas 1990;1(2):83-95 PMID 1715776
  • Molecular characterization of human factor XSan Antonio. (Reddy SV, Zhou ZQ, Rao KJ, Scott JP, Watzke H, High KA, Jagadeeswaran P) Blood 1989 Oct;74(5):1486-90 PMID 2790181
  • Simultaneous collection of platelets and cryoprecipitate by plasma-exchange donation. (McLeod BC, Sassetti RJ, Owens EA, Scott JP) Transfusion 1989 May;29(4):332-6 PMID 2497567
  • Long-term frequent plasma exchange donation of cryoprecipitate. (McLeod BC, Sassetti RJ, Cole ER, Scott JP) Transfusion 1988 Jul-Aug;28(4):307-10 PMID 3133843
  • Liver transplantation in hemophilia A. (Bontempo FA, Lewis JH, Gorenc TJ, Spero JA, Ragni MV, Scott JP, Starzl TE) Blood 1987 Jun;69(6):1721-4 PMID 3107632
  • Activation of complement and coagulation in juvenile dermatomyositis. (Scott JP, Arroyave C) Arthritis Rheum 1987 May;30(5):572-6 PMID 3109444
  • A high-potency, single-donor cryoprecipitate of known factor VIII content dispensed in vials. (McLeod BC, Sassetti RJ, Cole ER, Scott JP) Ann Intern Med 1987 Jan;106(1):35-40 PMID 3098152
  • Is sickle cell crisis a thrombotic event? (Green D, Scott JP) Am J Hematol 1986 Dec;23(4):317-21 PMID 3788960
  • Neonatal aortic thrombosis: recent experience. (Vailas GN, Brouillette RT, Scott JP, Shkolnik A, Conway J, Wiringa K) J Pediatr 1986 Jul;109(1):101-8 PMID 3522831
  • The spectrum of Epstein-Barr virus hepatitis in children. (Lloyd-Still JD, Scott JP, Crussi F) Pediatr Pathol 1986;5(3-4):337-51 PMID 3024140
  • Septic arthritis in two teenaged hemophiliacs. (Scott JP, Maurer HS, Dias L) J Pediatr 1985 Nov;107(5):748-51 PMID 3903092
  • Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile rheumatoid arthritis. (Scott JP, Gerber P, Maryjowski MC, Pachman LM) Arthritis Rheum 1985 Mar;28(3):256-61 PMID 3977974
  • Use of 'single donor' factor VIII from plasma exchange donation. (McLeod BC, Scott JP) JAMA 1984 Nov 16;252(19):2726-9 PMID 6436520
  • Coagulopathy of disseminated neuroblastoma. (Scott JP, Morgan E) J Pediatr 1983 Aug;103(2):219-22 PMID 6875712
  • Gangrene in a neonate following dopamine therapy. (Maggi JC, Angelats J, Scott JP) J Pediatr 1982 Feb;100(2):323-5 PMID 7057344
  • Evaluation of neonatal neutrophil function using the combined immunobead/NBT dye reduction assay. (Loren AB, Maggi JC, Scott JP, Anderson CL, Niwa Y, Yokoyama MM) J Clin Lab Immunol 1982 Jan;7(1):71-4 PMID 7069780
  • Urokinase therapy for a catheter-related right atrial thrombus. (Delaplane D, Scott JP, Riggs TW, Silverman BL, Hunt CE) J Pediatr 1982 Jan;100(1):149-52 PMID 6799632
  • Platelet von Willebrand's antigen II: active release by aggregating agents and a marker of platelet release reaction in vivo. (Scott JP, Montgomery RR) Blood 1981 Dec;58(6):1075-80 PMID 6975640
  • The autoerythrocyte sensitization syndrome as the primary manifestation of systemic lupus erythematosus. (Scott JP, Schiff DW, Githens JH) J Pediatr 1981 Oct;99(4):598-600 PMID 7277104
  • Acquired von Willebrand's disease in association with Wilm's tumor: regression following treatment. (Scott JP, Montgomery RR, Tubergen DG, Hays T) Blood 1981 Oct;58(4):665-9 PMID 6268230
  • Grants and Awards

  • Wisconsin Sickle Cell Disease Comprehensive Program (#9208701 07/01/2014 - 06/30/2015) Sponsor: State of Wisconsin
  • Cost Based: Stroke with Transfusion Changing to Hydroxyurea (#9204764 08/01/2007 - 07/31/2008) Sponsor: St. Jude Children's Research Hospital