Medical College of Wisconsin
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Kathryn M. Gauthier PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology


Publications

  • Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension. (Kriska T, Cepura C, Magier D, Siangjong L, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2012 Jun 1;302(11):H2428-38 PMID 22467300
  • 11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries. (Bukhari IA, Shah AJ, Gauthier KM, Walsh KA, Koduru SR, Imig JD, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2012 Apr 15;302(8):H1574-83 PMID 22307677
  • Endothelial nitric oxide and 15-lipoxygenase-1 metabolites independently mediate relaxation of the rabbit aorta. (Aggarwal NT, Gauthier KM, Campbell WB) Vascul Pharmacol 2012 Jan-Feb;56(1-2):106-12 PMID 22197897
  • Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB) Am J Physiol Renal Physiol 2011 Oct;301(4):F765-72 PMID 21753077
  • Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide. (Gauthier KM, Zhang DX, Cui L, Nithipatikom K, Campbell WB) Hypertension 2008 Jul;52(1):150-5 PMID 18490519
  • 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits. (Aggarwal NT, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Jul;295(1):H89-96 PMID 18456739
  • Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. (Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K) Am J Physiol Heart Circ Physiol 2008 Jun;294(6):H2838-44 PMID 18441205
  • 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta. (Gauthier KM, Chawengsub Y, Goldman DH, Conrow RE, Anjaiah S, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1467-72 PMID 18203841
  • Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. (Chawengsub Y, Aggarwal NT, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1348-56 PMID 18192225
  • Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits. (Aggarwal NT, Chawengsub Y, Gauthier KM, Viita H, Yla-Herttuala S, Campbell WB) Hypertension 2008 Feb;51(2):246-51 PMID 18180398
  • Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning. (Gauthier KM, Yang W, Gross GJ, Campbell WB) J Cardiovasc Pharmacol 2007 Dec;50(6):601-8 PMID 18091575
  • Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. (Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD) Br J Pharmacol 2007 Nov;152(5):691-8 PMID 17891162
  • Steroid-producing cells regulate arterial tone of adrenal cortical arteries. (Zhang DX, Gauthier KM, Falck JR, Siddam A, Campbell WB) Endocrinology 2007 Aug;148(8):3569-76 PMID 17446179
  • ACh-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+. (Zhang DX, Gauthier KM, Chawengsub Y, Campbell WB) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H152-9 PMID 17337603
  • Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries. (Yi XY, Gauthier KM, Cui L, Nithipatikom K, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2007 May;292(5):H2265-74 PMID 17209008
  • Hypoxia-induced vascular smooth muscle relaxation: increased ATP-sensitive K+ efflux or decreased voltage-sensitive Ca2+ influx? (Gauthier KM) Am J Physiol Heart Circ Physiol 2006 Jul;291(1):H24-5 PMID 16565315
  • Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. (Campbell WB, Holmes BB, Falck JR, Capdevila JH, Gauthier KM) Am J Physiol Heart Circ Physiol 2006 Jan;290(1):H64-71 PMID 16143653
  • Novel mechanism of vasodilation in inflammatory bowel disease. (Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD) Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2355-61 PMID 16141408
  • Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries. (Zhang DX, Gauthier KM, Campbell WB) Am J Physiol Endocrinol Metab 2005 Dec;289(6):E1058-63 PMID 16076876
  • Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide. (Gauthier KM, Zhang DX, Edwards EM, Holmes B, Campbell WB) Endocrinology 2005 Aug;146(8):3319-24 PMID 15890772
  • Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation. (Yang W, Gauthier KM, Reddy LM, Sangras B, Sharma KK, Nithipatikom K, Falck JR, Campbell WB) Hypertension 2005 Apr;45(4):681-6 PMID 15699458
  • 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. (Gauthier KM, Edwards EM, Falck JR, Reddy DS, Campbell WB) Hypertension 2005 Apr;45(4):666-71 PMID 15699460
  • U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. (Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2694-701 PMID 15695564
  • Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. (Gauthier KM, Baewer DV, Hittner S, Hillard CJ, Nithipatikom K, Reddy DS, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1344-51 PMID 15528233
  • Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. (Zhang DX, Gauthier KM, Chawengsub Y, Holmes BB, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H302-9 PMID 15388505
  • Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Oct;145(10):4532-9 PMID 15231705
  • 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. (Gauthier KM, Falck JR, Reddy LM, Campbell WB) Pharmacol Res 2004 Jun;49(6):515-24 PMID 15026029
  • Characterization of vasoconstrictor responses in small bovine adrenal cortical arteries in vitro. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Apr;145(4):1571-8 PMID 14726440
  • Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta. (Gauthier KM, Spitzbarth N, Edwards EM, Campbell WB) Hypertension 2004 Feb;43(2):413-9 PMID 14691199
  • 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. (Gauthier KM, Jagadeesh SG, Falck JR, Campbell WB) Hypertension 2003 Oct;42(4):555-61 PMID 12953017
  • 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. (Campbell WB, Spitzbarth N, Gauthier KM, Pfister SL) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2648-56 PMID 12907422
  • Freshly isolated bovine coronary endothelial cells do not express the BK Ca channel gene. (Gauthier KM, Liu C, Popovic A, Albarwani S, Rusch NJ) J Physiol 2002 Dec 15;545(Pt 3):829-36 PMID 12482889
  • Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. (Falck JR, Krishna UM, Reddy YK, Kumar PS, Reddy KM, Hittner SB, Deeter C, Sharma KK, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H337-49 PMID 12388250
  • 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. (Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB) Circ Res 2002 May 17;90(9):1028-36 PMID 12016270
  • 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. (Campbell WB, Deeter C, Gauthier KM, Ingraham RH, Falck JR, Li PL) Am J Physiol Heart Circ Physiol 2002 May;282(5):H1656-64 PMID 11959628
  • What is new in endothelium-derived hyperpolarizing factors? (Campbell WB, Gauthier KM) Curr Opin Nephrol Hypertens 2002 Mar;11(2):177-83 PMID 11856910
  • Rat Coronary Endothelial Cell Membrane Potential Responses During Hypertension. (Gauthier KM, Rusch NJ) Hypertension 2001 Jan;37(1):66-71 PMID 11208758
  • Distinct endothelial impairment in coronary microvessels from hypertensive Dahl rats. (Gauthier-Rein KM, Rusch NJ) Hypertension 1998 Jan;31(1 Pt 2):328-34 PMID 9453324
  • Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries. (Gauthier-Rein KM, Bizub DM, Lombard JH, Rusch NJ) Am J Physiol 1997 Mar;272(3 Pt 2):H1462-9 PMID 9087625