Medical College of Wisconsin
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Kirkwood A. Pritchard PhD

Kirkwood A. Pritchard PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Surgery


Publications

  • Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID 23956444
  • N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID 23883583
  • Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER) Shock 2013 Mar;39(3):271-7 PMID 23364425
  • 4F decreases IRF5 expression and activation in hearts of tight skin mice. (Xu H, Krolikowski JG, Jones DW, Ge ZD, Pagel PS, Pritchard KA Jr, Weihrauch D) PLoS One 2012;7(12):e52046 PMID 23251680
  • Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. (Zaidi M, Krolikowki JG, Jones DW, Pritchard KA Jr, Struve J, Nandedkar SD, Lohr NL, Pagel PS, Weihrauch D) Photochem Photobiol 2013 May-Jun;89(3):709-13 PMID 23231468
  • Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2013 Feb;23(1):39-47 PMID 23165517
  • Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. (Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2013 Mar;180(1):21-6 PMID 23158403
  • A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. (Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H328-36 PMID 23125208
  • Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Pediatr Surg 2012 Jun;47(6):1135-42 PMID 22703783
  • Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM) J Surg Res 2012 Oct;177(2):228-34 PMID 22687880
  • The preventive effects of apolipoprotein mimetic D-4F from vibration injury-experiment in rats. (Rowe DJ, Yan JG, Zhang LL, Pritchard KA Jr, Kao DS, Matloub HS, Riley DA) Hand (N Y) 2011 Mar;6(1):64-70 PMID 22379441
  • Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice. (Pritchard KA Jr, Feroah TR, Nandedkar SD, Holzhauer SL, Hutchins W, Schulte ML, Strunk RC, Debaun MR, Hillery CA) Am J Respir Cell Mol Biol 2012 Mar;46(3):389-96 PMID 22033263
  • Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. (Teng RJ, Du J, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA Jr, Konduri GG) Am J Physiol Lung Cell Mol Physiol 2011 Sep;301(3):L334-45 PMID 21622842
  • Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. (Phillips SA, Das E, Wang J, Pritchard K, Gutterman DD) J Appl Physiol (1985) 2011 Apr;110(4):1013-20 PMID 21252216
  • Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. (Xu H, Zaidi M, Struve J, Jones DW, Krolikowski JG, Nandedkar S, Lohr NL, Gadicherla A, Pagel PS, Csuka ME, Pritchard KA, Weihrauch D) Am J Physiol Cell Physiol 2011 Mar;300(3):C550-6 PMID 21160034
  • D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. (Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Pritchard KA Jr) J Lipid Res 2011 Mar;52(3):499-508 PMID 21131532
  • Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs. (Teng RJ, Wu TJ, Bisig CG, Eis A, Pritchard KA, Konduri GG) Pediatr Res 2011 Feb;69(2):112-7 PMID 21057377
  • Endothelial microparticles induce inflammation in acute lung injury. (Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT) J Surg Res 2011 Mar;166(1):32-9 PMID 20828748
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Sep;163(1):79-85 PMID 20599220
  • Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. (Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard KA Jr) J Lipid Res 2010 Sep;51(9):2560-70 PMID 20498409
  • Increased resistance to LPS-induced myocardial dysfunction in the Brown Norway rats versus Dahl S rats: roles of inflammatory cytokines and nuclear factor kappaB pathway. (Du J, An J, Wei N, Guan T, Pritchard KA Jr, Shi Y) Shock 2010 Mar;33(3):332-6 PMID 20160611
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS et al.) J Surg Res 2010 Feb;158(2):201 PMID 20105777
  • Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. (Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Jun 1;161(1):1-8 PMID 19922948
  • Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. (Du J, Wei N, Xu H, Ge Y, Vásquez-Vivar J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y) Arterioscler Thromb Vasc Biol 2009 Dec;29(12):2161-8 PMID 19762783
  • Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. (An J, Du J, Wei N, Xu H, Pritchard KA Jr, Shi Y) Am J Physiol Heart Circ Physiol 2009 Nov;297(5):H1783-91 PMID 19717731
  • Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. (Du J, Wei N, Guan T, Xu H, An J, Pritchard KA Jr, Shi Y) Am J Physiol Cell Physiol 2009 Sep;297(3):C742-9 PMID 19553566
  • Identification of proteins interacting with GTP cyclohydrolase I. (Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard KA Jr, Shi Y) Biochem Biophys Res Commun 2009 Jul 24;385(2):143-7 PMID 19442649
  • Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. (Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD) Arterioscler Thromb Vasc Biol 2009 May;29(5):739-45 PMID 19213944
  • Targeted increases in endothelial cell superoxide anion production stimulate eNOS-dependent nitric oxide production, not uncoupled eNOS activity. (Xu H, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 2008 Sep;28(9):1580-1 PMID 18716321
  • Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles. (Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard KA Jr, Oldham KT) Shock 2008 Apr;29(4):504-11 PMID 18598005
  • Histopathology of experimentally induced asthma in a murine model of sickle cell disease. (Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA) Blood 2008 Sep 15;112(6):2529-38 PMID 18579795
  • Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. (Peterson DB, Sander T, Kaul S, Wakim BT, Halligan B, Twigger S, Pritchard KA Jr, Oldham KT, Ou JS) Proteomics 2008 Jun;8(12):2430-46 PMID 18563738
  • Vascular dysfunction in a murine model of severe hemolysis. (Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ) Blood 2008 Jul 15;112(2):398-405 PMID 18477769
  • Surfactant protein D: not just for the lung anymore. (Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2008 May;294(5):H1994 PMID 18390823
  • 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. (Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H1018-26 PMID 18156192
  • A heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function. (Xu H, Shi Y, Wang J, Jones D, Weilrauch D, Ying R, Wakim B, Pritchard KA Jr) J Biol Chem 2007 Dec 28;282(52):37567-74 PMID 17971446
  • PROTEIN COMPOSITION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1-DERIVED ENDOTHELIAL MICROPARTICLES. (Sander TL et al.) Shock 2007 Aug 16;Publish Ahead of Print: PMID 17704734
  • Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. (Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard KA) Am J Physiol Heart Circ Physiol 2007 Sep;293(3):H1432-41 PMID 17496220
  • Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury. (Densmore JC, Signorino PR, Ou J, Hatoum OA, Rowe JJ, Shi Y, Kaul S, Jones DW, Sabina RE, Pritchard KA Jr, Guice KS, Oldham KT) Shock 2006 Nov;26(5):464-71 PMID 17047516
  • Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. (Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT) Endothelium 2006 May-Jun;13(3):181-90 PMID 16840174
  • Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. (Klinkner DB, Densmore JC, Kaul S, Noll L, Lim HJ, Weihrauch D, Pritchard KA Jr, Oldham KT, Sander TL) Shock 2006 Jun;25(6):575-80 PMID 16721264
  • Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L378-85 PMID 16679377
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID 16478827
  • Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. (Ou J, Wang J, Xu H, Ou Z, Sorci-Thomas MG, Jones DW, Signorino P, Densmore JC, Kaul S, Oldham KT, Pritchard KA Jr) Circ Res 2005 Nov 25;97(11):1190-7 PMID 16224061
  • Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice. (Pritchard KA Jr, Shi Y, Konduri GG) Circulation 2005 Apr 26;111(16):2022-4 PMID 15851611
  • Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID 15808839
  • Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID 15611843
  • Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID 15388508
  • Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration. (Gendelman M, Halligan N, Komorowski R, Logan B, Murphy WJ, Blazar BR, Pritchard KA Jr, Drobyski WR) Blood 2005 Jan 1;105(1):428-31 PMID 15331451
  • Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID 15088102
  • Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. (Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2004 Feb;286(2):H561-9 PMID 14551044
  • Hypoxia-induced acute lung injury in murine models of sickle cell disease. (Pritchard KA Jr, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, Hillery CA) Am J Physiol Lung Cell Mol Physiol 2004 Apr;286(4):L705-14 PMID 12972407
  • Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. (Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC) J Biol Chem 2003 Nov 7;278(45):44719-26 PMID 12952971
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID 12937165
  • Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID 12794122
  • AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of Lipofectamine-mediated gene transfection in endothelial cells. (Ou J, Geiger T, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr) Biochem Biophys Res Commun 2003 Jun 6;305(3):605-10 PMID 12763037
  • L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID 12732610
  • Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension. (Konduri GG, Ou J, Shi Y, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H204-11 PMID 12663260
  • Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation. (Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard KA Jr) Toxicol Sci 2003 May;73(1):90-7 PMID 12657742
  • L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells. (Ou Z, Ou J, Ackerman AW, Oldham KT, Pritchard KA Jr) Circulation 2003 Mar 25;107(11):1520-4 PMID 12654610
  • Angiostatin: a negative regulator of endothelial-dependent vasodilation. (Koshida R, Ou J, Matsunaga T, Chilian WM, Oldham KT, Ackerman AW, Pritchard KA Jr) Circulation 2003 Feb 18;107(6):803-6 PMID 12591747
  • Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. (Ou J, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr) Free Radic Biol Med 2003 Jan 15;34(2):269-76 PMID 12521608
  • Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. (Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr) Circ Res 2002 Aug 23;91(4):300-6 PMID 12193462
  • Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ. (Stepp DW, Ou J, Ackerman AW, Welak S, Klick D, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H750-9 PMID 12124224
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 9;106(2):239-45 PMID 12105165
  • Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. (Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC) Free Radic Biol Med 2002 Jul 1;33(1):52-62 PMID 12086682
  • Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. (Go YM, Boo YC, Park H, Maland MC, Patel R, Pritchard KA Jr, Fujio Y, Walsh K, Darley-Usmar V, Jo H) J Appl Physiol (1985) 2001 Oct;91(4):1574-81 PMID 11568138
  • Attenuated expression of inducible nitric oxide synthase in lung microvascular endothelial cells is associated with an increase in ICAM-1 expression. (Lo HP, Ackland-Berglund CE, Pritchard KA Jr, Guice KS, Oldham KT) J Pediatr Surg 2001 Aug;36(8):1136-42 PMID 11479842
  • Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. (Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC) J Biol Chem 2001 May 25;276(21):17621-4 PMID 11278264
  • Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID 11053770
  • Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. (Pritchard KA Jr, Ackerman A, Kalyanaraman B) J Environ Pathol Toxicol Oncol 2000;19(3):251-60 PMID 10983891
  • Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide release. (Hanke CJ, O'Brien T, Pritchard KA Jr, Campbell WB) Hypertension 2000 Jan;35(1 Pt 2):324-8 PMID 10642319
  • Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):607-17 PMID 10630684
  • Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B) J Biol Chem 1999 Sep 17;274(38):26736-42 PMID 10480877
  • Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID 10415535
  • Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. (Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B) Methods Enzymol 1999;301:169-77 PMID 9919565
  • Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID 9889894
  • Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. (Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr) Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9220-5 PMID 9689061
  • Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. (Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3469-74 PMID 9437194
  • Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. (Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B) Biochemistry 1997 Sep 23;36(38):11293-7 PMID 9333325
  • Suppression of angiotensin-converting enzyme expression and activity by shear stress. (Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS) Circ Res 1997 Mar;80(3):312-9 PMID 9048650
  • Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. (Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B) FEBS Lett 1997 Feb 17;403(2):127-30 PMID 9042951
  • Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. (Smalley DM, Lin JH, Curtis ML, Kobari Y, Stemerman MB, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1996 Apr;16(4):585-90 PMID 8624781
  • Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. (Pritchard KA Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB) Circ Res 1995 Sep;77(3):510-8 PMID 7543827
  • Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein. (Fair A, Pritchard KA Jr) Biochem Biophys Res Commun 1994 Jun 15;201(2):1014-20 PMID 8002971
  • Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. (Wu M, Pritchard KA Jr, Kaminski PM, Fayngersh RP, Hintze TH, Wolin MS) Am J Physiol 1994 May;266(5 Pt 2):H2108-13 PMID 8203609
  • Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. (Pritchard KA Jr, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB) J Biol Chem 1994 Mar 18;269(11):8504-9 PMID 8132578
  • Lipid fluidity modulates platelet aggregation and agglutination in vitro. (Vlasic N, Medow MS, Schwarz SM, Pritchard KA Jr, Stemerman MB) Life Sci 1993;53(13):1053-60 PMID 8366768
  • Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. (Arnold JH, Pritchard KA Jr, Greco NJ, Panganamala RV) Prostaglandins Leukot Essent Fatty Acids 1992 Jul;46(3):215-7 PMID 1508954
  • Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. (Holland JA, Pritchard KA, Rogers NJ, Stemerman MB) Am J Pathol 1992 Mar;140(3):551-8 PMID 1546741
  • Native low density lipoprotein. Endothelial cell recruitment of mononuclear cells. (Pritchard KA Jr, Tota RR, Lin JH, Danishefsky KJ, Kurilla BA, Holland JA, Stemerman MB) Arterioscler Thromb 1991 Sep-Oct;11(5):1175-81 PMID 1911704
  • Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. (Pritchard KA Jr, Schwarz SM, Medow MS, Stemerman MB) Am J Physiol 1991 Jan;260(1 Pt 1):C43-9 PMID 1987780
  • Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products. (Pritchard KA Jr, Wong PY, Stemerman MB) Am J Pathol 1990 Jun;136(6):1383-91 PMID 2356865
  • Bradykinin induces superoxide anion release from human endothelial cells. (Holland JA, Pritchard KA, Pappolla MA, Wolin MS, Rogers NJ, Stemerman MB) J Cell Physiol 1990 Apr;143(1):21-5 PMID 2156873
  • 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. (Pritchard KA Jr, Tota RR, Stemerman MB, Wong PY) Biochem Biophys Res Commun 1990 Feb 28;167(1):137-42 PMID 2310385
  • Effect of lovastatin on serum lipids in patients with nonfamilial primary hypercholesterolemia. (Itskovitz HD, Flamenbaum W, De Gaetano C, Pritchard KA Jr, Stemerman MB) Clin Ther 1989 Nov-Dec;11(6):862-72 PMID 2611825
  • Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). (Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY) Biochim Biophys Acta 1989 Aug 22;1004(3):332-6 PMID 2503031
  • Low density lipoprotein-mediated endothelial cell perturbation: effects on endothelial cell eicosanoid metabolism. (Miano JM, Holland JA, Pritchard KA Jr, Rogers NJ, Stemerman MB) Adv Prostaglandin Thromboxane Leukot Res 1989;19:248-54 PMID 2526478
  • Formation of lipoxins by rat basophilic leukemia cells. (Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY) Adv Prostaglandin Thromboxane Leukot Res 1989;19:128-31 PMID 2526456
  • Low-density lipoprotein preparation by combined diafiltration and ultracentrifugation. (Pritchard KA Jr, Holland JA, Rogers NJ, Crean CC, Britton TE, Onigman P, Stemerman MB) Anal Biochem 1988 Oct;174(1):121-7 PMID 3218726
  • Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. (Holland JA, Pritchard KA, Rogers NJ, Stemerman MB) Am J Pathol 1988 Sep;132(3):474-8 PMID 3046368
  • Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography. (Morrel EM, Holland JA, Pritchard KA, Colton CK, Stemerman MB) Ann N Y Acad Sci 1987;516:412-7 PMID 3439738
  • Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E. (Pritchard KA Jr, Patel ST, Karpen CW, Newman HA, Panganamala RV) Diabetes 1986 Mar;35(3):278-81 PMID 3512338
  • Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE). (Pritchard KA, Greco NJ, Panganamala RV) Thromb Haemost 1986 Feb 28;55(1):6-7 PMID 3705009
  • Evaluation of the Coomassie Brilliant Blue G-250 method for urinary protein. (Lott JA, Stephan VA, Pritchard KA Jr) Clin Chem 1983 Nov;29(11):1946-50 PMID 6354513
  • Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit. (Pritchard KA Jr, Karpen CW, Merola AJ, Panganamala RV) Prostaglandins Leukot Med 1982 Oct;9(4):373-8 PMID 6757965
  • Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats. (Karpen CW, Pritchard KA Jr, Merola AJ, Panganamala RV) Prostaglandins Leukot Med 1982 Feb;8(2):93-103 PMID 6804992
  • Grants and Awards

  • Asthma Increases Vaso-Occlusion in Sickle Cell Disease (#9206500 09/05/2010 - 08/31/2014) Sponsor: NIH Heart Lung and Blood Institute
  • Hsp90 Mediates eNOS and Vascular Function (#9202536 08/01/2002 - 07/31/2008) Sponsor: NIH Heart Lung and Blood Institute
  • HDL Dysfunction and Vascular Inflammation (#9204082 04/01/2006 - 03/31/2012) Sponsor: NIH Heart Lung and Blood Institute
  • Biophysics of HDL Dysfunction (#9207684 07/16/2012 - 06/30/2016) Sponsor: NIH Heart Lung and Blood Institute
  • Asthma and Nocturnal Hypoxemia in Sickle Cell Disease (#9204744 07/01/2007 - 06/30/2008) Sponsor: Washington University in St Louis