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Lawrence M. Ryan MD Online Profile

Professor
Medical College of Wisconsin
Department: Medicine
Division: Rheumatology
Program: Administration


Publications

  • Hypophosphatasia: nonlethal disease despite skeletal presentation in utero (17 new cases and literature review). (Wenkert D, McAlister WH, Coburn SP, Zerega JA, Ryan LM, Ericson KL, Hersh JH, Mumm S, Whyte MP) J Bone Miner Res 2011 Oct;26(10):2389-98 PMID 21713987
  • Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID 21532639
  • Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID 20709180
  • Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID 20604715
  • Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (Whyte MP, Wenkert D, McAlister WH, Mughal MZ, Freemont AJ, Whitehouse R, Baildam EM, Coburn SP, Ryan LM, Mumm S) J Bone Miner Res 2009 Aug;24(8):1493-505 PMID 19335222
  • Effects of retinoic acid on Dominant hemimelia expression in mice. (Owen MH, Ryan LM, Holmes LB) Birth Defects Res A Clin Mol Teratol 2009 Jan;85(1):36-41 PMID 19086026
  • Combining individual- and group-level exposure information: child carbon monoxide in the Guatemala woodstove randomized control trial. (McCracken JP, Schwartz J, Bruce N, Mittleman M, Ryan LM, Smith KR) Epidemiology 2009 Jan;20(1):127-36 PMID 19057384
  • Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID 18821676
  • Acute inflammatory syndrome following introduction of mycophenolate mofetil in a patient with systemic lupus erythematosus. (Konon I, Cronin ME, Ryan LM) Arthritis Rheum 2008 May 15;59(5):754-6 PMID 18438909
  • Tidal lavage in Milwaukee shoulder syndrome: do crystals make the difference? (Halverson PB, Ryan LM) J Rheumatol 2007 Jul;34(7):1446-7 PMID 17611961
  • Cementum and dentin in hypophosphatasia. (van den Bos T, Handoko G, Niehof A, Ryan LM, Coburn SP, Whyte MP, Beertsen W) J Dent Res 2005 Nov;84(11):1021-5 PMID 16246934
  • Modulation of chondrocyte production of extracellular inorganic pyrophosphate. (Costello JC, Ryan LM) Curr Opin Rheumatol 2004 May;16(3):268-72 PMID 15103256
  • Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease. (Williams CJ, Pendleton A, Bonavita G, Reginato AJ, Hughes AE, Peariso S, Doherty M, McCarty DJ, Ryan LM) Arthritis Rheum 2003 Sep;48(9):2627-31 PMID 13130483
  • Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID 12707586
  • Marrow cell transplantation for infantile hypophosphatasia. (Whyte MP, Kurtzberg J, McAlister WH, Mumm S, Podgornik MN, Coburn SP, Ryan LM, Miller CR, Gottesman GS, Smith AK, Douville J, Waters-Pick B, Armstrong RD, Martin PL) J Bone Miner Res 2003 Apr;18(4):624-36 PMID 12674323
  • Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. (Hirose J, Ryan LM, Masuda I) Arthritis Rheum 2002 Dec;46(12):3218-29 PMID 12483726
  • Comparative calcification of native articular cartilage matrix vesicles and nitroprusside-generated vesicles. (Jaovisidha K, Hung J, Ning G, Ryan LM, Derfus BA) Osteoarthritis Cartilage 2002 Aug;10(8):646-52 PMID 12479387
  • The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID 11908575
  • Variations in site and levels of expression of chondrocyte nucleotide pyrophosphohydrolase with aging. (Masuda I, Iyama KI, Halligan BD, Barbieri JT, Haas AL, McCarty DJ, Ryan LM) J Bone Miner Res 2001 May;16(5):868-75 PMID 11341331
  • Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID 11300741
  • The ank gene story. (Ryan LM) Arthritis Res 2001;3(2):77-9 PMID 11178113
  • Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging. (Hirose J, Masuda I, Ryan LM) Arthritis Rheum 2000 Dec;43(12):2703-11 PMID 11145028
  • Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. (Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM, Weinstein RS, Waymire K, Narisawa S, Millán JL, MacGregor GR, Whyte MP) J Bone Miner Res 1999 Dec;14(12):2015-26 PMID 10620060
  • Cellular responses to whitlockite. (Ryan LM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR, McCarthy GM) Calcif Tissue Int 1999 Nov;65(5):374-7 PMID 10541763
  • Phosphocitrate blocks nitric oxide-induced calcification of cartilage and chondrocyte-derived apoptotic bodies. (Cheung HS, Ryan LM) Osteoarthritis Cartilage 1999 Jul;7(4):409-12 PMID 10419783
  • The role of crystals in osteoarthritis. (Ryan LM, Cheung HS) Rheum Dis Clin North Am 1999 May;25(2):257-67 PMID 10356416
  • Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (Ryan LM, Kurup IV, Cheung HS) Arthritis Rheum 1999 Mar;42(3):555-60 PMID 10088779
  • Serum nucleotide pyrophosphohydrolase activity; elevated levels in osteoarthritis, calcium pyrophosphate crystal deposition disease, scleroderma, and fibromyalgia. (Cardenal A, Masuda I, Ono W, Haas AL, Ryan LM, Trotter D, McCarty DJ) J Rheumatol 1998 Nov;25(11):2175-80 PMID 9818661
  • Basic calcium phosphate crystal-induced collagenase production: role of intracellular crystal dissolution. (McCarthy GM, Cheung HS, Abel SM, Ryan LM) Osteoarthritis Cartilage 1998 May;6(3):205-13 PMID 9682787
  • Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts. (McCarthy GM, Macius AM, Christopherson PA, Ryan LM, Pourmotabbed T) Ann Rheum Dis 1998 Jan;57(1):56-60 PMID 9536826
  • Milwaukee shoulder with massive bilateral cysts: effective therapy for hydrops of the shoulder. (Patel KJ, Weidensaul D, Palma C, Ryan LM, Walker SE) J Rheumatol 1997 Dec;24(12):2479-83 PMID 9415663
  • Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase. (Masuda I, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ) Gene 1997 Sep 15;197(1-2):277-87 PMID 9332376
  • Inhibition of calcium pyrophosphate dihydrate crystal formation in articular cartilage vesicles and cartilage by phosphocitrate. (Cheung HS, Kurup IV, Sallis JD, Ryan LM) J Biol Chem 1996 Nov 8;271(45):28082-5 PMID 8910421
  • Adenosine triphosphate levels in human plasma. (Ryan LM, Rachow JW, McCarty BA, McCarty DJ) J Rheumatol 1996 Feb;23(2):214-9 PMID 8882021
  • Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. (Derfus BA, Kurtin SM, Camacho NP, Kurup I, Ryan LM) Connect Tissue Res 1996;35(1-4):337-42 PMID 9084673
  • Understanding inorganic pyrophosphate metabolism: toward prevention of calcium pyrophosphate dihydrate crystal deposition. (Ryan LM, McCarty DJ) Ann Rheum Dis 1995 Dec;54(12):939-41 PMID 8546522
  • Correction: A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles. (Masuda I, Hamada J, Haas AL, Ryan LM, McCarthy DJ) J Clin Invest 1995 Aug;96(2):1179 PMID 7635956
  • Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy. (Whyte MP, Landt M, Ryan LM, Mulivor RA, Henthorn PS, Fedde KN, Mahuren JD, Coburn SP) J Clin Invest 1995 Apr;95(4):1440-5 PMID 7706447
  • A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles. (Masuda I, Hamada J, Haas AL, Ryan LM, McCarty DJ) J Clin Invest 1995 Feb;95(2):699-704 PMID 7860751
  • Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID 7732165
  • Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID 11550674
  • Synovial fluid and plasma levels of cartilage matrix glycoprotein in arthritis. (Fife RS, Rachow JW, Ryan LM) Calcif Tissue Int 1994 Aug;55(2):100-2 PMID 7953973
  • Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID 9128752
  • Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID 7520501
  • Calcium pyrophosphate dihydrate crystal deposition and other crystal deposition diseases. (Ryan LM) Curr Opin Rheumatol 1993 Jul;5(4):517-21 PMID 8357748
  • Acute calcific periarthritis of the finger joints: a syndrome of women. (McCarthy GM, Carrera GF, Ryan LM) J Rheumatol 1993 Jun;20(6):1077-80 PMID 8350318
  • A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID 7681284
  • Evidence that a 550,000-dalton cartilage matrix glycoprotein is a chondrocyte membrane-associated protein closely related to ceruloplasmin. (Fife RS, Kluve-Beckerman B, Houser DS, Proctor C, Liepnieks J, Masuda I, McCarty DJ, Ryan LM) J Biol Chem 1993 Feb 25;268(6):4407-11 PMID 8440723
  • ATP-induced chondrocalcinosis. (Ryan LM, Kurup IV, Derfus BA, Kushnaryov VM) Arthritis Rheum 1992 Dec;35(12):1520-5 PMID 1472129
  • Severe arthropathy and osteopathy following combined renal/pancreas transplantation. (Derfus BA, Carrera GF, Komorowski RA, Ryan LM) Transplantation 1992 Mar;53(3):678-81 PMID 1549866
  • Articular cartilage vesicles generate calcium pyrophosphate dihydrate-like crystals in vitro. (Derfus BA, Rachow JW, Mandel NS, Boskey AL, Buday M, Kushnaryov VM, Ryan LM) Arthritis Rheum 1992 Feb;35(2):231-40 PMID 1734912
  • Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate. (Ryan LM, Kurup I, Cheung HS) Matrix 1991 Aug;11(4):276-81 PMID 1656174
  • Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID 1647773
  • Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate. (Ryan LM, Rachow JW, McCarty DJ) J Rheumatol 1991 May;18(5):716-20 PMID 1650841
  • Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID 2155981
  • Cartilage inorganic pyrophosphate elaboration is independent of sulfated glycosaminoglycan synthesis. (Ryan LM, Kurup I, McCarty DJ, Cheung HS) Arthritis Rheum 1990 Feb;33(2):235-40 PMID 2154998
  • Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. (Wortmann RL, Veum JA, Ryan LM, Cheung HS) Arthritis Rheum 1989 Aug;32(8):1014-21 PMID 2788422
  • Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 1;272(2):393-9 PMID 2546499
  • Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 1;272(2):386-92 PMID 2546498
  • Triple crystal disease: monosodium urate monohydrate, calcium pyrophosphate dihydrate, and basic calcium phosphate in a single joint. (Halverson PB, Ryan LM) Ann Rheum Dis 1988 Oct;47(10):864-5 PMID 2848460
  • Arthritis associated with calcium oxalate crystals in an anephric patient treated with peritoneal dialysis. (Rosenthal A, Ryan LM, McCarty DJ) JAMA 1988 Sep 2;260(9):1280-2 PMID 3404640
  • Inorganic pyrophosphate metabolism in arthritis. (Rachow JW, Ryan LM) Rheum Dis Clin North Am 1988 Aug;14(2):289-302 PMID 2845490
  • Synovial fluid inorganic pyrophosphate concentration and nucleotide pyrophosphohydrolase activity in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndrome. (Rachow JW, Ryan LM, McCarty DJ, Halverson PC) Arthritis Rheum 1988 Mar;31(3):408-13 PMID 2833903
  • Anterior pituitary involvement in Wegener's granulomatosis. (Lohr KM, Ryan LM, Toohill RJ, Anderson T) J Rheumatol 1988;15(5):855-7 PMID 3172100
  • Recurrent aseptic meningitis as a manifestation of mixed connective tissue disease (MCTD). (Harris GJ, Franson TR, Ryan LM) Wis Med J 1987 Mar;86(3):31-3 PMID 3564518
  • Rotator cuff tears: preliminary application of high-resolution MR imaging with counter rotating current loop-gap resonators. (Kneeland JB, Carrera GF, Middleton WD, Campagna NF, Ryan LM, Jesmanowicz A, Froncisz W, Hyde JS) Radiology 1986 Sep;160(3):695-9 PMID 3737908
  • Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease. (Ryan LM, Wortmann RL, Karas B, Lynch MP, McCarty DJ) J Clin Invest 1986 May;77(5):1689-93 PMID 3009553
  • Increased serum pyridoxal-5'-phosphate in pseudohypophosphatasia. (Cole DE, Salisbury SR, Stinson RA, Coburn SP, Ryan LM, Whyte MP) N Engl J Med 1986 Apr 10;314(15):992-3 PMID 3960066
  • Ecto-nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition disease. (Wortmann RL, Ryan LM, Karas B, McCarthy DJ) Adv Exp Med Biol 1986;195 Pt A:153-6 PMID 3014830
  • Partial characterization of synovial fluid nucleotide pyrophosphohydrolase. (Rachow JW, Ryan LM) Arthritis Rheum 1985 Dec;28(12):1377-83 PMID 2935159
  • Adenosine triphosphate pyrophosphohydrolase and neutral inorganic pyrophosphatase in pathologic joint fluids. Elevated pyrophosphohydrolase in calcium pyrophosphate dihydrate crystal deposition disease. (Rachow JW, Ryan LM) Arthritis Rheum 1985 Nov;28(11):1283-8 PMID 2998408
  • Cartilage nucleoside triphosphate pyrophosphohydrolase. II. Role in extracellular pyrophosphate generation and nucleotide metabolism. (Ryan LM, Wortmann RL, Karas B, McCarty DJ Jr) Arthritis Rheum 1985 Apr;28(4):413-8 PMID 2985090
  • Milwaukee Shoulder syndrome: eleven additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease). (Halverson PB, McCarty DJ, Cheung HS, Ryan LM) Semin Arthritis Rheum 1984 Aug;14(1):36-44 PMID 6484575
  • Cartilage nucleoside triphosphate (NTP) pyrophosphohydrolase. I. Identification as an ecto-enzyme. (Ryan LM, Wortmann RL, Karas B, McCarty DJ Jr) Arthritis Rheum 1984 Apr;27(4):404-9 PMID 6143564
  • Acute erosive reactive arthritis associated with Campylobacter jejuni-induced colitis. (Ebright JR, Ryan LM) Am J Med 1984 Feb;76(2):321-3 PMID 6695953
  • Biological variation of rabbit chondrocyte 5'nucleotidase. (Wortmann RL, Ryan LM) Proc Soc Exp Biol Med 1983 Jul;173(3):349-54 PMID 6306674
  • The radiographic diagnosis of sacroiliitis. A comparison of different views with computed tomograms of the sacroiliac joint. (Ryan LM, Carrera GF, Lightfoot RW Jr, Hoffman RG, Kozin F) Arthritis Rheum 1983 Jun;26(6):760-3 PMID 6860377
  • Inorganic pyrophosphate levels in blood platelets from normal donors and patients with calcium pyrophosphate dihydrate crystal deposition disease. (Ryan LM, Lynch MP, McCarty DJ) Arthritis Rheum 1983 Apr;26(4):564-6 PMID 6301512
  • Infantile hypophosphatasia: enzyme replacement therapy by intravenous infusion of alkaline phosphatase-rich plasma from patients with Paget bone disease. (Whyte MP, Valdes R Jr, Ryan LM, McAlister WH) J Pediatr 1982 Sep;101(3):379-86 PMID 7108657
  • PRedominance of type II collagen in synovial chondromatosis. (Ryan LM, Cheung HS, Schwab JP, Johnson RP) Clin Orthop Relat Res 1982 Aug(168):173-7 PMID 7105543
  • Amyloid arthropathy: possible association with chondrocalcinosis. (Ryan LM, Liang G, Kozin F) J Rheumatol 1982 Mar-Apr;9(2):273-8 PMID 7097685
  • Computed tomography in the diagnosis of sacroiliitis. (Kozin F, Carrera GF, Ryan LM, Foley D, Lawson T) Arthritis Rheum 1981 Dec;24(12):1479-85 PMID 6976786
  • Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture. (Ryan LM, Cheung HS, McCarty DJ) Arthritis Rheum 1981 Dec;24(12):1522-7 PMID 6275863
  • A method for determining DNA and chondrocyte content of articular cartilage. (Cheung HS, Ryan LM) Anal Biochem 1981 Sep 1;116(1):93-7 PMID 6272614
  • Bone scintigraphy in the reflex sympathetic dystrophy syndrome. (Kozin F, Soin JS, Ryan LM, Carrera GF, Wortmann RL) Radiology 1981 Feb;138(2):437-43 PMID 7455127
  • The reflex sympathetic dystrophy syndrome (RSDS). III. Scintigraphic studies, further evidence for the therapeutic efficacy of systemic corticosteroids, and proposed diagnostic criteria. (Kozin F, Ryan LM, Carerra GF, Soin JS, Wortmann RL) Am J Med 1981 Jan;70(1):23-30 PMID 6109448
  • Identification of collagen subtypes in synovial fluid sediments from arthritic patients. (Cheung HS, Ryan LM, Kozin F, McCarty DJ) Am J Med 1980 Jan;68(1):73-9 PMID 7350807
  • Synovial origins of Rice bodies in joint fluid. (Cheung HS, Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1980 Jan;23(1):72-6 PMID 7352946
  • Concurrent linear scleroderma and systemic lupus erythematosus: a report of two cases. (Mackel SE, Kozin F, Ryan LM, Sheth KJ, Jordon RE) J Invest Dermatol 1979 Nov;73(5):368-72 PMID 315439
  • Quantification of human plasma inorganic pyrophosphate. II. Biologic variables. (Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1979 Aug;22(8):892-5 PMID 223578
  • Quantification of human plasma inorganic pyrophosphate. I. Normal values in osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease. (Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1979 Aug;22(8):886-91 PMID 223577
  • Rhabdomyolysis and renal failure in hypothyroidism. (Halverson PB, Kozin F, Ryan LM, Sulaiman AR) Ann Intern Med 1979 Jul;91(1):57-8 PMID 464456
  • High prevalence of HLA-Cw1 and Cw2 antigens in spondylarthritis. (Kozin F, Duquesnoy R, Rodey GE, Lightfoot RW, Ryan LM) Arthritis Rheum 1978 Nov-Dec;21(8):889-95 PMID 737012
  • Immune complex uveitis: a case. (Ryan LM, Kozin F, Eiferman R) Ann Intern Med 1978 Jan;88(1):62-3 PMID 619761
  • Phenformin and pancreatitis. (Ryan LM, Hankwitz P, Banasiak M) Ann Intern Med 1977 Dec;87(6):796 PMID 931225
  • Renal proximal tubular dysfunction and paroxysmal nocturnal hemoglobinuria. (Riley AL, Ryan LM, Roth DA) Am J Med 1977 Jan;62(1):125-9 PMID 13653