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Marilyn P. Merker PhD

Marilyn P. Merker PhD

Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Research
Program: Zablocki Veterans Affairs Medical Center


Research Experience

  • Pulmonary Circulation
  • Publications

  • Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung. (Bongard RD, Myers CR, Lindemer BJ, Baumgardt S, Gonzalez FJ, Merker MP) Am J Physiol Lung Cell Mol Physiol 2012 May 1;302(9):L949-58 PMID 22268123
  • Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation. (Lindemer BJ, Bongard RD, Hoffmann R, Baumgardt S, Gonzalez FJ, Merker MP) Am J Physiol Lung Cell Mol Physiol 2011 May;300(5):L773-80 PMID 21296895
  • Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells. (Bongard RD, Krenz GS, Gastonguay AJ, Williams CL, Lindemer BJ, Merker MP) Free Radic Biol Med 2011 Apr 15;50(8):953-62 PMID 21238579
  • Quantifying mitochondrial and plasma membrane potentials in intact pulmonary arterial endothelial cells based on extracellular disposition of rhodamine dyes. (Gan Z, Audi SH, Bongard RD, Gauthier KM, Merker MP) Am J Physiol Lung Cell Mol Physiol 2011 May;300(5):L762-72 PMID 21239539
  • Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells. (Bongard RD, Lindemer BJ, Krenz GS, Merker MP) Free Radic Biol Med 2009 Jan 1;46(1):25-32 PMID 18848878
  • Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia. (Audi SH, Merker MP, Krenz GS, Ahuja T, Roerig DL, Bongard RD) J Appl Physiol (1985) 2008 Oct;105(4):1114-26 PMID 18703762
  • Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia. (Merker MP, Audi SH, Lindemer BJ, Krenz GS, Bongard RD) Am J Physiol Lung Cell Mol Physiol 2007 Sep;293(3):L809-19 PMID 17601793
  • Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1. (Merker MP, Audi SH, Bongard RD, Lindemer BJ, Krenz GS) Am J Physiol Lung Cell Mol Physiol 2006 Mar;290(3):L607-19 PMID 16243901
  • Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs. (Audi SH, Bongard RD, Krenz GS, Rickaby DA, Haworth ST, Eisenhauer J, Roerig DL, Merker MP) Am J Physiol Lung Cell Mol Physiol 2005 Nov;289(5):L788-97 PMID 15994278
  • Impact of pulmonary arterial endothelial cells on duroquinone redox status. (Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH) Free Radic Biol Med 2004 Jul 1;37(1):86-103 PMID 15183197
  • Duroquinone reduction during passage through the pulmonary circulation. (Audi SH, Bongard RD, Dawson CA, Siegel D, Roerig DL, Merker MP) Am J Physiol Lung Cell Mol Physiol 2003 Nov;285(5):L1116-31 PMID 12882764
  • Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. (Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP) Free Radic Biol Med 2003 Apr 1;34(7):892-907 PMID 12654478
  • Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells. (Merker MP, Bongard RD, Kettenhofen NJ, Okamoto Y, Dawson CA) Am J Physiol Lung Cell Mol Physiol 2002 Jan;282(1):L36-43 PMID 11741813
  • Pulmonary reduction of an intravascular redox polymer. (Audi SH, Bongard RD, Okamoto Y, Merker MP, Roerig DL, Dawson CA) Am J Physiol Lung Cell Mol Physiol 2001 Jun;280(6):L1290-9 PMID 11350810
  • Transport and reaction at endothelial plasmalemma: distinguishing intra- from extracellular events. (Dawson CA, Audi SH, Bongard RD, Okamoto Y, Olson L, Merker MP) Ann Biomed Eng 2000 Aug;28(8):1010-8 PMID 11144662
  • Lung redox homeostasis: emerging concepts. (Merker MP, Pitt BR, Choi AM, Hassoun PM, Dawson CA, Fisher AB) Am J Physiol Lung Cell Mol Physiol 2000 Sep;279(3):L413-7 PMID 10956613
  • Cyanide increases reduction but decreases sequestration of methylene blue by endothelial cells. (Olson LE, Merker MP, Patel MK, Bongard RD, Daum JM, Johns RA, Dawson CA) Ann Biomed Eng 2000 Jan;28(1):85-93 PMID 10645791
  • Kinetics of plasma membrane electron transport in a pulmonary endothelial cell-column. (Olson LE, Merker MP, Bongard RD, Brantmeier BM, Audi SH, Linehan JH, Dawson CA) Ann Biomed Eng 1998 Jan-Feb;26(1):117-27 PMID 10355556
  • Proline in vasoactive peptides: consequences for peptide hydrolysis in the lung. (Merker MP, Audi SH, Brantmeier BM, Nithipatikom K, Goldman RS, Roerig DL, Dawson CA) Am J Physiol 1999 Feb;276(2 Pt 1):L341-50 PMID 9950897
  • Ascorbate-mediated transplasma membrane electron transport in pulmonary arterial endothelial cells. (Merker MP, Olson LE, Bongard RD, Patel MK, Linehan JH, Dawson CA) Am J Physiol 1998 May;274(5 Pt 1):L685-93 PMID 9612283
  • Pulmonary endothelial thiazine uptake: separation of cell surface reduction from intracellular reoxidation. (Merker MP, Bongard RD, Linehan JH, Okamoto Y, Vyprachticky D, Brantmeier BM, Roerig DL, Dawson CA) Am J Physiol 1997 Apr;272(4 Pt 1):L673-80 PMID 9142941
  • Biotinylation of membrane proteins accessible via the pulmonary circulation in normal and hyperoxic rats. (De La Fuente EK, Dawson CA, Nelin LD, Bongard RD, McAuliffe TL, Merker MP) Am J Physiol 1997 Mar;272(3 Pt 1):L461-70 PMID 9124603
  • Impact of angiotensin-converting enzyme substrate conformation on fractional hydrolysis in lung. (Merker MP, Armitage IM, Audi SH, Kakalis LT, Linehan JH, Maehl JR, Roerig DL, Dawson CA) Am J Physiol 1996 Feb;270(2 Pt 1):L251-9 PMID 8779994
  • Cyclophilin-facilitated bradykinin inactivation in the perfused rat lung. (Merker MP, Dawson CA) Biochem Pharmacol 1995 Dec 22;50(12):2085-91 PMID 8849336
  • Reduction of thiazine dyes by bovine pulmonary arterial endothelial cells in culture. (Bongard RD, Merker MP, Shundo R, Okamoto Y, Roerig DL, Linehan JH, Dawson CA) Am J Physiol 1995 Jul;269(1 Pt 1):L78-84 PMID 7631818
  • Reduction and accumulation of methylene blue by the lung. (Bongard RD, Krenz GS, Linehan JH, Roerig DL, Merker MP, Widell JL, Dawson CA) J Appl Physiol (1985) 1994 Sep;77(3):1480-91 PMID 7836156
  • Angiotensin-converting enzyme preferentially hydrolyzes trans isomer of proline-containing substrate. (Merker MP, Dawson CA, Bongard RD, Roerig DL, Haworth ST, Linehan JH) J Appl Physiol (1985) 1993 Oct;75(4):1519-24 PMID 8282598
  • Molecular mapping of pulmonary endothelial membrane glycoproteins of the intact rabbit lung. (Merker MP, Carley WW, Gillis CN) FASEB J 1990 Sep;4(12):3040-8 PMID 2168327
  • Propranolol and serotonin removal in lung injury. (Merker MP, Gillis CN) J Appl Physiol (1985) 1988 Dec;65(6):2579-84 PMID 3063711
  • A protein from the marine mollusc Aplysia californica that is hemolytic and stimulates arachidonic acid metabolism in cultured mammalian cells. (Merker MP, Levine L) Toxicon 1986;24(5):451-65 PMID 3715907
  • Grants and Awards

  • Redox Activity of the Pulmonary Endothelial Surface (#9203583 03/01/2005 - 02/28/2011) Sponsor: NIH Heart Lung and Blood Institute