Medical College of Wisconsin
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Mary F. Otterson MD

Mary F. Otterson MD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Colorectal Surgery
Program: Colorectal Surgery

Member of the MCW Cancer Center


Publications

  • Propagation of giant migrating contractions between the small intestine, cecum and colon during radiation. (Otterson MF, Leming SC, Fox CJ, Moulder JE) Neurogastroenterol Motil 2010 Aug;22(8):919-26 PMID 20529206
  • Animal models for medical countermeasures to radiation exposure. (Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH) Radiat Res 2010 Apr;173(4):557-78 PMID 20334528
  • Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. (Rafiee P, Binion DG, Wellner M, Behmaram B, Floer M, Mitton E, Nie L, Zhang Z, Otterson MF) Am J Physiol Gastrointest Liver Physiol 2010 Jun;298(6):G865-77 PMID 20299603
  • Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis. (Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, Miller HJ, Awad SS, Crosby CT, Mosier MC, Alsharif A, Berger DH) N Engl J Med 2010 Jan 7;362(1):18-26 PMID 20054046
  • Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC). (Rafiee P, Stein DJ, Nelson VM, Otterson MF, Shaker R, Binion DG) Am J Physiol Gastrointest Liver Physiol 2010 Feb;298(2):G167-76 PMID 19926820
  • Impact of autonomic dysfunction on inflammatory bowel disease. (Ananthakrishnan AN, Issa M, Barboi A, Jaradeh S, Zadvornova Y, Skaros S, Johnson K, Otterson MF, Binion DG) J Clin Gastroenterol 2010 Apr;44(4):272-9 PMID 19727003
  • Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. (Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2009 Aug;297(2):G259-68 PMID 19520742
  • Durability of infliximab in Crohn's disease: a single-center experience. (Gonzaga JE, Ananthakrishnan AN, Issa M, Beaulieu DB, Skaros S, Zadvornova Y, Johnson K, Otterson MF, Binion DG) Inflamm Bowel Dis 2009 Dec;15(12):1837-43 PMID 19462426
  • History of medical hospitalization predicts future need for colectomy in patients with ulcerative colitis. (Ananthakrishnan AN, Issa M, Beaulieu DB, Skaros S, Knox JF, Lemke K, Emmons J, Lundeen SH, Otterson MF, Binion DG) Inflamm Bowel Dis 2009 Feb;15(2):176-81 PMID 18680197
  • Budesonide induction and maintenance therapy for Crohn's disease during pregnancy. (Beaulieu DB, Ananthakrishnan AN, Issa M, Rosenbaum L, Skaros S, Newcomer JR, Kuhlmann RS, Otterson MF, Emmons J, Knox J, Binion DG) Inflamm Bowel Dis 2009 Jan;15(1):25-8 PMID 18680195
  • Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn's disease stricture formation. (Floer M, Binion DG, Nelson VM, Manley S, Wellner M, Sadeghi S, Behmaram B, Sewell C, Otterson MF, Kucharzik T, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2008 Sep;295(3):G581-90 PMID 18635600
  • Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. (Binion DG, Otterson MF, Rafiee P) Gut 2008 Nov;57(11):1509-17 PMID 18596194
  • Novel method for recolonoscopy after percutaneous cecostomy. (Berger WL, Kounev V, Otterson MF) Gastrointest Endosc 2008 May;67(6):1005-6 PMID 18243187
  • Permanent work disability in Crohn's disease. (Ananthakrishnan AN, Weber LR, Knox JF, Skaros S, Emmons J, Lundeen S, Issa M, Otterson MF, Binion DG) Am J Gastroenterol 2008 Jan;103(1):154-61 PMID 18076736
  • Clinical factors contributing to rapid reoperation for Crohn's disease patients undergoing resection and/or strictureplasty. (Binion DG, Theriot KR, Shidham S, Lundeen S, Hatoum O, Lim HJ, Otterson MF) J Gastrointest Surg 2007 Dec;11(12):1692-8; dicussion 1698 PMID 17940830
  • Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease. (Ananthakrishnan AN, Attila T, Otterson MF, Lipchik RJ, Massey BT, Komorowski RA, Binion DG) J Clin Gastroenterol 2007 Aug;41(7):682-8 PMID 17667053
  • Effects of radiation upon gastrointestinal motility. (Otterson MF) World J Gastroenterol 2007 May 21;13(19):2684-92 PMID 17569136
  • Tissue and fluid penetration of garenoxacin in surgical patients. (Edmiston CE, Krepel CJ, Seabrook GR, Towne JB, Smith TL, Loehrl TA, Wackym PA, Johnson CP, Otterson MF, Gajjar DA, Krishna G) Surg Infect (Larchmt) 2007 Apr;8(2):179-88 PMID 17437363
  • Clostridium difficile enteritis: an early postoperative complication in inflammatory bowel disease patients after colectomy. (Lundeen SJ, Otterson MF, Binion DG, Carman ET, Peppard WJ) J Gastrointest Surg 2007 Feb;11(2):138-42 PMID 17390162
  • Impact of Clostridium difficile on inflammatory bowel disease. (Issa M, Vijayapal A, Graham MB, Beaulieu DB, Otterson MF, Lundeen S, Skaros S, Weber LR, Komorowski RA, Knox JF, Emmons J, Bajaj JS, Binion DG) Clin Gastroenterol Hepatol 2007 Mar;5(3):345-51 PMID 17368234
  • Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. (Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, Andrekopoulos C, Kalyanaraman B, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1323-36 PMID 17218473
  • Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. (Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD) Arterioscler Thromb Vasc Biol 2006 Feb;26(2):287-94 PMID 16322529
  • Novel mechanism of vasodilation in inflammatory bowel disease. (Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD) Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2355-61 PMID 16141408
  • Radiation induced small bowel "web" formation is associated with acquired microvascular dysfunction. (Hatoum OA, Binion DG, Phillips SA, O'Loughlin C, Komorowski RA, Gutterman DD, Otterson MF) Gut 2005 Dec;54(12):1797-800 PMID 16127018
  • Transrectal and transvaginal sonographic intervention of infected pelvic fluid collections: a complete approach. (Sudakoff GS, Lundeen SJ, Otterson MF) Ultrasound Q 2005 Sep;21(3):175-85 PMID 16096614
  • Mesenteric venous thrombosis in inflammatory bowel disease. (Hatoum OA, Spinelli KS, Abu-Hajir M, Attila T, Franco J, Otterson MF, Telford GL, Binion DG) J Clin Gastroenterol 2005 Jan;39(1):27-31 PMID 15599206
  • Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. (Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P) Am J Physiol Cell Physiol 2005 Feb;288(2):C272-81 PMID 15483224
  • Radiographic underestimation of small bowel stricturing Crohn's disease: a comparison with surgical findings. (Otterson MF, Lundeen SJ, Spinelli KS, Sudakoff GS, Telford GL, Hatoum OA, Saeian K, Yun H, Binion DG) Surgery 2004 Oct;136(4):854-60 PMID 15467672
  • Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. (Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H48-54 PMID 15345486
  • Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling. (Rafiee P, Heidemann J, Ogawa H, Johnson NA, Fisher PJ, Li MS, Otterson MF, Johnson CP, Binion DG) Cell Commun Signal 2004 Jun 2;2(1):3 PMID 15175101
  • Antiangiogenic treatment of mesenteric desmoid tumors with toremifene and interferon alfa-2b: report of two cases. (Heidemann J, Ogawa H, Otterson MF, Shidham VB, Binion DG) Dis Colon Rectum 2004 Jan;47(1):118-22 PMID 14719159
  • Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. (Tay GS, Binion DG, Eastwood D, Otterson MF) Surgery 2003 Oct;134(4):565-72; discussion 572-3 PMID 14605616
  • Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. (Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG) FEBS Lett 2003 Nov 6;554(1-2):88-94 PMID 14596920
  • Sequelae of cryotherapy in breast tissue. (Otterson MF, Redlich PN, McDonald A, Kristin Thorsen M, Klaas KK, Clowry LJ, Walker AP) Cryobiology 2003 Oct;47(2):174-8 PMID 14580851
  • Butyrate modulates gene and protein expression in human intestinal endothelial cells. (Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG) Biochem Biophys Res Commun 2003 Sep 26;309(3):512-9 PMID 12963019
  • Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation. (Hatoum OA, Binion DG, Otterson MF, Gutterman DD) Gastroenterology 2003 Jul;125(1):58-69 PMID 12851871
  • Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID 12794122
  • Case report: magnetic resonance imaging in the diagnosis of epidural abscess complicating perirectal fistulizing Crohn's disease. (Heidemann J, Spinelli KS, Otterson MF, Binion DG) Inflamm Bowel Dis 2003 Mar;9(2):122-4 PMID 12769446
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. (Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, Binion DG) J Biol Chem 2003 Mar 7;278(10):8508-15 PMID 12496258
  • Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels. (Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM, Loberiza FR, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2002 Sep;283(3):H845-52 PMID 12181110
  • Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. (Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG) J Biol Chem 2002 Sep 20;277(38):35605-15 PMID 12110686
  • Does breast tumor location influence success of sentinel lymph node biopsy? (Ahrendt GM, Laud P, Tjoe J, Eastwood D, Walker AP, Otterson MF, Redlich PN) J Am Coll Surg 2002 Mar;194(3):278-84 PMID 11893131
  • Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. (Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT) Free Radic Biol Med 2000 Nov 1;29(9):881-8 PMID 11063913
  • Nitric oxide production is diminished in colonic circular muscle from acquired megacolon. (Koch TR, Otterson MF, Telford GL) Dis Colon Rectum 2000 Jun;43(6):821-8 PMID 10859084
  • Decreased vasoactive intestinal peptide levels and glutathione depletion in acquired megacolon. (Koch TR, Schulte-Bockholt A, Otterson MF, Telford GL, Stryker SJ, Ballard T, Opara EC) Dig Dis Sci 1996 Jul;41(7):1409-16 PMID 8689918
  • Multidisciplinary management of altered body image in the patient with an ostomy. (Walsh BA, Grunert BK, Telford GL, Otterson MF) J Wound Ostomy Continence Nurs 1995 Sep;22(5):227-36 PMID 7550779
  • Fractionated irradiation alters enteric neuroendocrine products. (Otterson MF, Koch TR, Zhang Z, Leming SC, Moulder JE) Dig Dis Sci 1995 Aug;40(8):1691-702 PMID 7544259
  • Expression of mRNA for vasoactive intestinal peptide in normal human colon and during inflammation. (Schulte-Bockholt A, Fink JG, Meier DA, Otterson MF, Telford GL, Hopp K, Koch TR) Mol Cell Biochem 1995 Jan 12;142(1):1-7 PMID 7753037
  • Chronic intestinal pseudo-obstruction. (Engelsgjerd M, Otterson MF, Condon RE) Adv Surg 1995;28:397-405 PMID 7879688
  • Neural control of small intestinal giant migrating contractions. (Otterson MF, Sarna SK) Am J Physiol 1994 Apr;266(4 Pt 1):G576-84 PMID 8178996
  • Altered motility causes the early gastrointestinal toxicity of irradiation. (Erickson BA, Otterson MF, Moulder JE, Sarna SK) Int J Radiat Oncol Biol Phys 1994 Mar 1;28(4):905-12 PMID 8138444
  • Gene expression and transcript size of the prepro-peptide VIP/PHM-27 in normal human tissue. (Schulte-Bockholt A, Meier DA, Hopp K, Stadelmann A, Otterson MF, Telford GL, Koch TR) Neurosci Lett 1993 Dec 24;164(1-2):101-4 PMID 8152582
  • Normal physiology of small intestinal motility. (Otterson MF, Sarr MG) Surg Clin North Am 1993 Dec;73(6):1173-92 PMID 8248833
  • Acquired megacolon is associated with alteration of vasoactive intestinal peptide levels and acetylcholinesterase activity. (Koch TR, Schulte-Bockholt A, Telford GL, Otterson MF, Murad TM, Stryker SJ) Regul Pept 1993 Nov 3;48(3):309-19 PMID 7506433
  • Nitric oxide regulates migrating motor complex cycling and its postprandial disruption. (Sarna SK, Otterson MF, Ryan RP, Cowles VE) Am J Physiol 1993 Oct;265(4 Pt 1):G749-66 PMID 7694478
  • Characterization of neuropeptides extracted from canine intestine. (Koch TR, Otterson MF, Roddy DR, Go VL) Neuropeptides 1993 Jun;24(6):359-65 PMID 7688877
  • Effects of fractionated doses of ionizing radiation on colonic motor activity. (Otterson MF, Sarna SK, Leming SC, Moulder JE, Fink JG) Am J Physiol 1992 Oct;263(4 Pt 1):G518-26 PMID 1415710
  • Fractionated doses of ionizing radiation alter postprandial small intestinal motor activity. (Otterson MF, Sarna SK, Lee MB) Dig Dis Sci 1992 May;37(5):709-15 PMID 1563312
  • Gastrointestinal motor effects of erythromycin. (Otterson MF, Sarna SK) Am J Physiol 1990 Sep;259(3 Pt 1):G355-63 PMID 2399980
  • Small intestinal amyogenesia and dysmyogenesia induced by morphine and loperamide. (Sarna SK, Otterson MF) Am J Physiol 1990 Feb;258(2 Pt 1):G282-9 PMID 1968317
  • Local effect of substance P on colonic motor activity in different experimental states. (Hou JY, Otterson MF, Sarna SK) Am J Physiol 1989 Jun;256(6 Pt 1):G997-1004 PMID 2472074
  • Small intestinal physiology and pathophysiology. (Sarna SK, Otterson MF) Gastroenterol Clin North Am 1989 Jun;18(2):375-404 PMID 2668175
  • Effects of fractionated doses of ionizing radiation on small intestinal motor activity. (Otterson MF, Sarna SK, Moulder JE) Gastroenterology 1988 Nov;95(5):1249-57 PMID 3169493
  • Gastrointestinal motility: some basic concepts. (Sarna SK, Otterson MF) Pharmacology 1988;36 Suppl 1:7-14 PMID 3285364
  • Grants and Awards

  • A Phase 3, Randomized, Double-Blind, Placebo Controlled, Parallel-Treatment Group, Multicenter Efficacy and Saftey Study of Topical Diltiazem Hydrochloride 2% Cream in Subjects with Anal Fissure (#9306225 08/21/2013 - 08/20/2014) Sponsor: Ventrus Biosciences
  • Intestinal Alkaline Phosphatase is a Mitigator of the Acute Radiation Syndrome (#9306230 10/01/2013 - 09/30/2014) Sponsor: Digestive Disease Center
  • Post Irradiation Modulation of Gastrointestinal Injury (#9206606 08/01/2010 - 07/31/2014) Sponsor: Wisconsin Corporation for Biomedical Research
  • Post-Irradiation Intervention to Mitigate and Treat Non* (#9203848 08/31/2005 - 07/31/2012) PI of Project 1: Post-Irridation Intervention to Mitigate and Treat Non-Hematological Injuries (#2204707)