Matthew Budde PhD Online Profile

Matthew Budde PhD

Assistant Professor
Medical College of Wisconsin
Department: Neurosurgery
Program: Clinical Research


Research Experience

  • Brain Concussion
  • Brain Injuries
  • Diffuse Axonal Injury
  • Diffusion Magnetic Resonance Imaging
  • Disease Models, Animal
  • Histology
  • Hypoxia-Ischemia, Brain
  • Magnetic Resonance Imaging
  • Microscopy
  • Multiple Sclerosis
  • Neurosciences
  • Spinal Cord Injuries
  • Diffusion Tensor Imaging
  • MCW Program / Core Facilities

  • Center for Imaging Research
    Neuroscience Research Center
    Neuroscience Research Labs
  • Publications

  • Quantification of anisotropy and fiber orientation in human brain histological sections. (Budde MD, Annese J) Front Integr Neurosci 2013;7:3 PMID 23378830
  • The evolution of traumatic brain injury in a rat focal contusion model. (Turtzo LC, Budde MD, Gold EM, Lewis BK, Janes L, Yarnell A, Grunberg NE, Watson W, Frank JA) NMR Biomed 2012 Dec 6: PMID 23225324
  • Diffusion tensor imaging and tractography in Brown-Sequard syndrome. (Vedantam A, Jirjis MB, Schmit BD, Budde MD, Ulmer JL, Wang MC, Kurpad SN) Spinal Cord 2012 Dec;50(12):928-30 PMID 23045298
  • Examining brain microstructure using structure tensor analysis of histological sections. (Budde MD, Frank JA) Neuroimage 2012 Oct 15;63(1):1-10 PMID 22759994
  • Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging. (Thu MS, Bryant LH, Coppola T, Jordan EK, Budde MD, Lewis BK, Chaudhry A, Ren J, Varma NR, Arbab AS, Frank JA) Nat Med 2012 Mar;18(3):463-7 PMID 22366951
  • Differential microstructure and physiology of brain and bone metastases in a rat breast cancer model by diffusion and dynamic contrast enhanced MRI. (Budde MD, Gold E, Jordan EK, Frank JA) Clin Exp Metastasis 2012 Jan;29(1):51-62 PMID 22042553
  • Phase contrast MRI is an early marker of micrometastatic breast cancer development in the rat brain. (Budde MD, Gold E, Jordan EK, Smith-Brown M, Frank JA) NMR Biomed 2012 May;25(5):726-36 PMID 21954124
  • The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. (Budde MD, Janes L, Gold E, Turtzo LC, Frank JA) Brain 2011 Aug;134(Pt 8):2248-60 PMID 21764818
  • Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model. (Kim JH, Wu TH, Budde MD, Lee JM, Song SK) NMR Biomed 2011 Feb;24(2):163-9 PMID 21344532
  • Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords. (Klawiter EC, Schmidt RE, Trinkaus K, Liang HF, Budde MD, Naismith RT, Song SK, Cross AH, Benzinger TL) Neuroimage 2011 Apr 15;55(4):1454-60 PMID 21238597
  • Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model. (Kim JH, Wu TH, Budde MD, Lee JM, Song SK) NMR Biomed 2010 Dec 8: PMID 21140522
  • Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke. (Budde MD, Frank JA) Proc Natl Acad Sci U S A 2010 Aug 10;107(32):14472-7 PMID 20660718
  • Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features. (Xie M, Tobin JE, Budde MD, Chen CI, Trinkaus K, Cross AH, McDaniel DP, Song SK, Armstrong RC) J Neuropathol Exp Neurol 2010 Jul;69(7):704-16 PMID 20535036
  • Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery. (Kim JH, Loy DN, Wang Q, Budde MD, Schmidt RE, Trinkaus K, Song SK) J Neurotrauma 2010 Mar;27(3):587-98 PMID 20001686
  • IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. (McCandless EE, Budde M, Lees JR, Dorsey D, Lyng E, Klein RS) J Immunol 2009 Jul 1;183(1):613-20 PMID 19535637
  • Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. (Budde MD, Xie M, Cross AH, Song SK) J Neurosci 2009 Mar 4;29(9):2805-13 PMID 19261876
  • Magnetic tagging of therapeutic cells for MRI. (Budde MD, Frank JA) J Nucl Med 2009 Feb;50(2):171-4 PMID 19164242
  • Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. (Budde MD, Kim JH, Liang HF, Russell JH, Cross AH, Song SK) NMR Biomed 2008 Jul;21(6):589-97 PMID 18041806
  • High-resolution MR metabolic imaging. (Haldar JP, Hernando D, Budde MD, Wang Q, Song SK, Liang ZP) Conf Proc IEEE Eng Med Biol Soc 2007;2007:4324-6 PMID 18002959
  • Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matter. (Kim JH, Trinkaus K, Ozcan A, Budde MD, Song SK) NMR Biomed 2007 May;20(3):352-9 PMID 17451177
  • Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. (Budde MD, Kim JH, Liang HF, Schmidt RE, Russell JH, Cross AH, Song SK) Magn Reson Med 2007 Apr;57(4):688-95 PMID 17390365
  • Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. (Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK) Neurobiol Dis 2006 Mar;21(3):626-32 PMID 16298135
  • Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm. (Cabeza R, Prince SE, Daselaar SM, Greenberg DL, Budde M, Dolcos F, LaBar KS, Rubin DC) J Cogn Neurosci 2004 Nov;16(9):1583-94 PMID 15622612
  • Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. (Cabeza R, Daselaar SM, Dolcos F, Prince SE, Budde M, Nyberg L) Cereb Cortex 2004 Apr;14(4):364-75 PMID 15028641
  • Grants and Awards

  • Neuroscience Translational Research Initiative (NTRI) (#9520195 03/01/2011 - 02/29/2016) PI of Advanced MRI in Acute Brain and Spinal Cord Injury (#5520207)