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Meetha M. Medhora PhD

Meetha M. Medhora PhD

Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology
Program: Clinical

Member of the Cancer Center
Member of the Cardiovascular Center


Publications

  • Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage. (Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Medhora M, Hill RP) Int J Radiat Oncol Biol Phys 2014 Jul 15;89(4):722-8 PMID 24867538
  • Enhanced survival from radiation pneumonitis by combined irradiation to the skin. (Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M) Int J Radiat Biol 2014 Sep;90(9):753-61 PMID 24827855
  • Hypoxia preconditioning increases survival and decreases expression of Toll-like receptor 4 in pulmonary artery endothelial cells exposed to lipopolysaccharide. (Ali I, Nanchal R, Husnain F, Audi S, Konduri GG, Densmore JC, Medhora M, Jacobs ER) Pulm Circ 2013 Sep;3(3):578-88 PMID 24618542
  • Safety and blood sample volume and quality of a refined retro-orbital bleeding technique in rats using a lateral approach. (Sharma A, Fish BL, Moulder JE, Medhora M, Baker JE, Mader M, Cohen EP) Lab Anim (NY) 2014 Feb;43(2):63-6 PMID 24451361
  • Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation. (Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2013 Nov;180(5):546-52 PMID 24131041
  • Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? (Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z) Radiat Res 2013 Aug;180(2):216-21 PMID 23819595
  • Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung. (Gao F, Narayanan J, Joneikis C, Fish BL, Szabo A, Moulder JE, Molthen RC, Jacobs ER, Rao RN, Medhora M) Radiat Res 2013 Apr;179(4):465-74 PMID 23480564
  • Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER) Shock 2013 Mar;39(3):271-7 PMID 23364425
  • Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation. (Gao F, Fish BL, Szabo A, Doctrow SR, Kma L, Molthen RC, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2012 Nov;178(5):468-80 PMID 23020094
  • Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril. (Molthen RC, Wu Q, Fish BL, Moulder JE, Jacobs ER, Medhora MM) Respirology 2012 Nov;17(8):1261-8 PMID 22882664
  • Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. (Harland DR, Lorenz LD, Fay K, Dunn BE, Gruenloh SK, Narayanan J, Jacobs ER, Medhora M) Prostaglandins Leukot Essent Fatty Acids 2012 Aug-Sep;87(2-3):79-89 PMID 22858445
  • Dose-modifying factor for captopril for mitigation of radiation injury to normal lung. (Medhora M, Gao F, Fish BL, Jacobs ER, Moulder JE, Szabo A) J Radiat Res 2012 Jul;53(4):633-40 PMID 22843631
  • Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. (Jacobs ER, Bodiga S, Ali I, Falck AM, Falck JR, Medhora M, Dhanasekaran A) Exp Cell Res 2012 Oct 1;318(16):2143-52 PMID 22687879
  • Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax. (Kma L, Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M) J Radiat Res 2012;53(1):10-7 PMID 22302041
  • Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. (Ali I, Gruenloh S, Gao Y, Clough A, Falck JR, Medhora M, Jacobs ER) Ann Thorac Surg 2012 Jan;93(1):282-8 PMID 22115333
  • Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. (Medhora M, Gao F, Jacobs ER, Moulder JE) Respirology 2012 Jan;17(1):66-71 PMID 22023053
  • Salen Mn complexes mitigate radiation injury in normal tissues. (Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR) Anticancer Agents Med Chem 2011 May 1;11(4):359-72 PMID 21453241
  • Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs. (Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D) Hypertens Res 2011 May;34(5):630-9 PMID 21307870
  • Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung. (Somberg L, Nirula R, Bousamra M 2nd, Friesema J, Zhu D, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):407-12 PMID 21075384
  • Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis. (Pfister S, Somberg L, Lowry T, Gao Y, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):425-31 PMID 21075383
  • Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. (Leverence JT, Medhora M, Konduri GG, Sampath V) Chem Biol Interact 2011 Jan 15;189(1-2):72-81 PMID 20920494
  • Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID 20604715
  • 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. (Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D) Exp Cell Res 2010 Aug 15;316(14):2340-53 PMID 20493836
  • Animal models for medical countermeasures to radiation exposure. (Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH) Radiat Res 2010 Apr;173(4):557-78 PMID 20334528
  • Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. (Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2010 Apr;173(4):545-56 PMID 20334527
  • 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. (Bodiga S, Gruenloh SK, Gao Y, Manthati VL, Dubasi N, Falck JR, Medhora M, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2010 Apr;298(4):L564-74 PMID 20061439
  • Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. (Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M) Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1528-36 PMID 19931735
  • 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. (Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR) Prostaglandins Other Lipid Mediat 2009 Jun;89(1-2):43-51 PMID 19480064
  • Vascular injury after whole thoracic x-ray irradiation in the rat. (Ghosh SN, Wu Q, Mäder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC) Int J Radiat Oncol Biol Phys 2009 May 1;74(1):192-9 PMID 19362237
  • Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID 19336274
  • 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. (Dhanasekaran A, Bodiga S, Gruenloh S, Gao Y, Dunn L, Falck JR, Buonaccorsi JN, Medhora M, Jacobs ER) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H777-86 PMID 19136601
  • Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. (Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M) J Mol Cell Cardiol 2009 Jan;46(1):4-14 PMID 18930064
  • Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. (Ionova IA, Vásquez-Vivar J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM) Am J Physiol Heart Circ Physiol 2008 Nov;295(5):H2178-87 PMID 18835915
  • Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. (Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M) Int J Radiat Biol 2008 Jun;84(6):487-97 PMID 18470747
  • Irradiation of varying volumes of rat lung to same mean lung dose: a little to a lot or a lot to a little? (Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM, Li XA) Int J Radiat Oncol Biol Phys 2008 Jul 1;71(3):838-47 PMID 18439765
  • 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 May;294(5):L902-11 PMID 18296498
  • Role of JNK in network formation of human lung microvascular endothelial cells. (Medhora M, Dhanasekaran A, Pratt PF Jr, Cook CR, Dunn LK, Gruenloh SK, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 Apr;294(4):L676-85 PMID 18263671
  • Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H724-35 PMID 18055514
  • Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29 PMID 17164129
  • VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. (Jacobs ER, Zhu D, Gruenloh S, Lopez B, Medhora M) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L369-77 PMID 16679379
  • Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L378-85 PMID 16679377
  • Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. (Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31 PMID 16617127
  • Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). (Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER, Medhora M) Anat Rec A Discov Mol Cell Evol Biol 2005 Aug;285(2):771-80 PMID 15952186
  • Mechanisms regulating cerebral blood flow as therapeutic targets. (Pratt PF, Medhora M, Harder DR) Curr Opin Investig Drugs 2004 Sep;5(9):952-6 PMID 15503650
  • Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. (Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER) Circ Res 2003 May 16;92(9):992-1000 PMID 12690037
  • Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR). (Michaelis UR, Fisslthaler B, Medhora M, Harder D, Fleming I, Busse R) FASEB J 2003 Apr;17(6):770-2 PMID 12586744
  • Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. (Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H215-24 PMID 12388259
  • Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. (Yu M, McAndrew RP, Al-Saghir R, Maier KG, Medhora M, Roman RJ, Jacobs ER) J Appl Physiol (1985) 2002 Oct;93(4):1391-9 PMID 12235040
  • CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. (Zhu D, Zhang C, Medhora M, Jacobs ER) J Appl Physiol (1985) 2002 Jul;93(1):330-7 PMID 12070222
  • Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling. (Medhora M, Bousamra M 2nd, Zhu D, Somberg L, Jacobs ER) Am J Physiol Heart Circ Physiol 2002 Feb;282(2):H414-22 PMID 11788387
  • Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids. (Medhora M, Narayanan J, Harder D, Maier KG) Jpn J Pharmacol 2001 Aug;86(4):369-75 PMID 11569609
  • Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. (Medhora M, Narayanan J, Harder D) Trends Cardiovasc Med 2001 Jan;11(1):38-42 PMID 11413051
  • Retinoic acid upregulates beta(1)-integrin in vascular smooth muscle cells and alters adhesion to fibronectin. (Medhora MM) Am J Physiol Heart Circ Physiol 2000 Jul;279(1):H382-7 PMID 10899079
  • Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). (Medhora M, Harder D) Int J Mol Med 1998 Dec;2(6):661-9 PMID 9850733
  • Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. (Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR) Stroke 1996 May;27(5):971-9 PMID 8623121
  • 1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3. (Medhora MM, Teitelbaum S, Chappel J, Alvarez J, Mimura H, Ross FP, Hruska K) J Biol Chem 1993 Jan 15;268(2):1456-61 PMID 7678259
  • Molecular and functional analysis of the mariner mutator element Mos1 in Drosophila. (Medhora M, Maruyama K, Hartl DL) Genetics 1991 Jun;128(2):311-8 PMID 1649068
  • Introduction of the transposable element mariner into the germline of Drosophila melanogaster. (Garza D, Medhora M, Koga A, Hartl DL) Genetics 1991 Jun;128(2):303-10 PMID 1649067
  • Drosophila nonsense suppressors: functional analysis in Saccharomyces cerevisiae, Drosophila tissue culture cells and Drosophila melanogaster. (Garza D, Medhora MM, Hartl DL) Genetics 1990 Nov;126(3):625-37 PMID 2174393
  • Excision of the Drosophila transposable element mariner: identification and characterization of the Mos factor. (Medhora MM, MacPeek AH, Hartl DL) EMBO J 1988 Jul;7(7):2185-9 PMID 2843360
  • Molecular structure of a somatically unstable transposable element in Drosophila. (Jacobson JW, Medhora MM, Hartl DL) Proc Natl Acad Sci U S A 1986 Nov;83(22):8684-8 PMID 3022302
  • The evolution of DNA sequences in Escherichia coli. (Hartl DL, Medhora M, Green L, Dykhuizen DE) Philos Trans R Soc Lond B Biol Sci 1986 Jan 29;312(1154):191-204 PMID 2870515
  • Construction of a gene library from the nitrogen-fixing aerobe Azotobacter vinelandii. (Medhora M, Phadnis SH, Das HK) Gene 1983 Nov;25(2-3):355-60 PMID 6319242
  • Grants and Awards

  • Development of Lisinopril for Post-Exposure Mitigation of Late Effects from a Radiation/Nuclear Incident (#9208087 06/01/2013 - 05/31/2018) Sponsor: NIH Allergy and Infectious Diseases
  • Innovative Biomarkers to Predict Radiation Lung Injury (#9207492 06/21/2012 - 05/31/2017) Sponsor: NIH Allergy and Infectious Diseases
  • Role of EETs in Growht of Human Endothelial Cells (#9202915 07/01/2003 - 06/30/2008) Sponsor: NIH Heart Lung and Blood Institute
  • Anesthetic-Induced Cardiac Preconditioning (#9202848 05/05/2003 - 04/30/2009) PI of Core Laboratory: Biochemical and Molecular Biology (#2204562)
  • Post-Irradiation Intervention to Mitigate and Treat Non* (#9203848 08/31/2005 - 07/31/2012) PI of Project 3: Post-Irridation Intervention to Mitigate and Treat Non-Hematological Injuries (#2204709)
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of New Hypoxia Radiosensitizers as Targeted Anticancer Agents (#5520262)