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Michael E. Widlansky MD

Michael E. Widlansky MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cardiovascular Center


Research Experience

  • Aging
  • Coronary Artery Disease
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • Endothelium-Dependent Relaxing Factors
  • Exercise
  • Hypertension
  • Hypoglycemia
  • Nitric Oxide
  • endothelial function
  • Clinical Expertise

  • Coronary Artery Disease
  • Echocardiography
  • Methodologies and Techniques

  • Microbubbles
  • Microscopy, Video
  • Plethysmography
  • Ultrasonography
  • arterial tonometry
  • digital pulse amplitude tonometry
  • flow mediate dilation
  • Leadership Positions

  • Member, Continuing Medical Education Committee
  • Associate Fellowship Director, Cardiovascular Diseases
  • Research Director, Division of Cardiovascular Medicine
  • Chair, Human Research Affairs Committee
  • Member, Reserach Affairs Committee
  • MCW Program / Core Facilities

  • Human Vascular Translational Reserach Core
  • Publications

  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 1;307(1):H25-32 PMID 24778165
  • Relative importance of step count, intensity, and duration on physical activity's impact on vascular structure and function in previously sedentary older adults. (Suboc TB, Strath SJ, Dharmashankar K, Coulliard A, Miller N, Wang J, Tanner MJ, Widlansky ME) J Am Heart Assoc 2014;3(1):e000702 PMID 24572255
  • Moderate Obesity and Endothelial Dysfunction in Humans: Influence of Gender and Systemic Inflammation. (Suboc TM, Dharmashankar K, Wang J, Ying R, Couillard A, Tanner MJ, Widlansky ME) Physiol Rep 2013 Aug 1;1(3): PMID 24187612
  • Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. (Whitsett J, Rangel Filho A, Sethumadhavan S, Celinska J, Widlansky M, Vasquez-Vivar J) Free Radic Biol Med 2013 Oct;63:143-50 PMID 23707606
  • Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. (Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Oct;32(10):2531-9 PMID 22879582
  • Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. (Thanassoulis G, Lyass A, Benjamin EJ, Larson MG, Vita JA, Levy D, Hamburg NM, Widlansky ME, O'Donnell CJ, Mitchell GF, Vasan RS) Circulation 2012 Jun 12;125(23):2836-43 PMID 22572915
  • Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. (Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF Jr, Vita JA, Hamburg NM) Vasc Med 2012 Apr;17(2):101-7 PMID 22496207
  • Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function. (Dharmashankar K, Welsh A, Wang J, Kizhakekuttu TJ, Ying R, Gutterman DD, Widlansky ME) Am J Hypertens 2012 May;25(5):528-34 PMID 22337207
  • Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. (Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):712-20 PMID 22207730
  • Arteriolar function in visceral adipose tissue is impaired in human obesity. (Farb MG, Ganley-Leal L, Mott M, Liang Y, Ercan B, Widlansky ME, Bigornia SJ, Fiscale AJ, Apovian CM, Carmine B, Hess DT, Vita JA, Gokce N) Arterioscler Thromb Vasc Biol 2012 Feb;32(2):467-73 PMID 22095978
  • Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. (Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA) Circulation 2011 Jul 26;124(4):444-53 PMID 21747057
  • Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Gutterman DD) PM R 2011 Nov;3(11):1005-12 PMID 21715240
  • Association between the female athlete triad and endothelial dysfunction in dancers. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Schimke JE, Gutterman DD) Clin J Sport Med 2011 Mar;21(2):119-25 PMID 21358502
  • Impaired endothelial function in preadolescent children with type 1 diabetes. (Babar GS, Zidan H, Widlansky ME, Das E, Hoffmann RG, Daoud M, Alemzadeh R) Diabetes Care 2011 Mar;34(3):681-5 PMID 21289230
  • Reply to "Letter to the editor: 'Assessment of flow-mediated dilation in humans: a methodological and physiological guideline'". (Thijssen DH et al.) Am J Physiol Heart Circ Physiol 2011 Feb;300(2):H713 PMID 21282475
  • Regulation of endothelial function by mitochondrial reactive oxygen species. (Widlansky ME, Gutterman DD) Antioxid Redox Signal 2011 Sep 15;15(6):1517-30 PMID 21194353
  • Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. (Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ) Am J Physiol Heart Circ Physiol 2011 Jan;300(1):H2-12 PMID 20952670
  • Vascular endothelial function and hypertension: insights and directions. (Dharmashankar K, Widlansky ME) Curr Hypertens Rep 2010 Dec;12(6):448-55 PMID 20857237
  • Measuring FMD in the brachial artery: how important is QRS gating? (Kizhakekuttu TJ, Gutterman DD, Phillips SA, Jurva JW, Arthur EI, Das E, Widlansky ME) J Appl Physiol (1985) 2010 Oct;109(4):959-65 PMID 20671033
  • Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. (Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA) Transl Res 2010 Jul;156(1):15-25 PMID 20621033
  • The danger of sedenterism: endothelium at risk. (Widlansky ME) Am J Physiol Heart Circ Physiol 2010 Aug;299(2):H243-4 PMID 20511408
  • Natural antioxidants and hypertension: promise and challenges. (Kizhakekuttu TJ, Widlansky ME) Cardiovasc Ther 2010 Aug;28(4):e20-32 PMID 20370791
  • Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. (Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE) Cardiovasc Res 2009 Jul 15;83(2):325-34 PMID 19380418
  • Lifestyle choices and endothelial function: risk and relevance. (Wang J, Widlansky ME) Curr Vasc Pharmacol 2009 Apr;7(2):209-24 PMID 19356004
  • Shear stress and flow-mediated dilation: all shear responses are not created equally. (Widlansky ME) Am J Physiol Heart Circ Physiol 2009 Jan;296(1):H31-2 PMID 19028789
  • Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. (Hamburg NM, Larson MG, Vita JA, Vasan RS, Keyes MJ, Widlansky ME, Fox CS, Mitchell GF, Levy D, Meigs JB, Benjamin EJ) Am J Cardiol 2008 Jan 1;101(1):82-8 PMID 18157970
  • Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. (Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA) Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2650-6 PMID 17932315
  • Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study). (Widlansky ME, Vita JA, Keyes MJ, Larson MG, Hamburg NM, Levy D, Mitchell GF, Osypiuk EW, Vasan RS, Benjamin EJ) Am J Cardiol 2007 Aug 1;100(3):518-23 PMID 17659939
  • Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. (Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF Jr, Vita JA) J Am Coll Nutr 2007 Apr;26(2):95-102 PMID 17536120
  • Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. (McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA) J Clin Hypertens (Greenwich) 2007 Apr;9(4):249-55 PMID 17396066
  • Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. (Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, Keaney JF Jr, Frei B, Vita JA) Free Radic Biol Med 2005 Feb 15;38(4):499-506 PMID 15649652
  • Body mass index and total and cardiovascular mortality in men with a history of cardiovascular disease. (Widlansky ME, Sesso HD, Rexrode KM, Manson JE, Gaziano JM) Arch Intern Med 2004 Nov 22;164(21):2326-32 PMID 15557411
  • Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. (Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM) Curr Med Chem 2004 May;11(9):1135-46 PMID 15134511
  • Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid. (Widlansky ME, Biegelsen ES, Hamburg NM, Duffy SJ, Keaney JF Jr, Vita JA) Free Radic Biol Med 2004 Jan 1;36(1):123-30 PMID 14732296
  • The clinical implications of endothelial dysfunction. (Widlansky ME, Gokce N, Keaney JF Jr, Vita JA) J Am Coll Cardiol 2003 Oct 1;42(7):1149-60 PMID 14522472
  • Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. (Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF Jr, Morrow JD, Vita JA) Hypertension 2003 Sep;42(3):310-5 PMID 12874094
  • Grants and Awards

  • Impact of Low Glucose Exposure on Endothelial Function in Humans (#9208415 01/01/2014 - 12/31/2015) Sponsor: American Heart Association - Midwest Affiliate
  • Mitochondrial Morphology and Endothelial Function in Type 2 Diabetes (#9206896 04/01/2011 - 02/29/2016) Sponsor: Boston University
  • A Randomized, Crossover Design Study of Acute and Chronic Effects of Sitagliptin on Endothelial Function in Humans w Type 2 Diabetes on Background Metformin Therapy (#9306177 08/14/2013 - 08/13/2016) Sponsor: Merck Sharp & Dohme Corp.
  • Importance of Mitochondrial in the Endothelial Dysfunction of Type 2 Diabetes (#9205540 09/01/2009 - 06/30/2015) Sponsor: NIH Heart Lung and Blood Institute
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of The Effect of Moderate Intensity Physical Activity on Systemic and Local MicroRNA Expression in Older Adult Humans: Effects on Vascular Aging (#5520306)