Michael W. Lawlor MD, PhD Online Profile
Assistant Professor
Medical College of Wisconsin
Department: Pathology
Division: Administration
Program: Pediatrics
Publications
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. (de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H) J Med Genet 2013 Jun;50(6):383-92 PMID 23572184 Selenoprotein N deficiency in mice is associated with abnormal lung development. (Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH) FASEB J 2013 Apr;27(4):1585-99 PMID 23325319 Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy. (Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O'Callaghan M, Pierson CR, Buj-Bello A, Beggs AH) Hum Mol Genet 2013 Apr 15;22(8):1525-38 PMID 23307925 Large duplication in MTM1 associated with myotubular myopathy. (Amburgey K, Lawlor MW, Del Gaudio D, Cheng YW, Fitzpatrick C, Minor A, Li X, Aughton D, Das S, Beggs AH, Dowling JJ) Neuromuscul Disord 2013 Mar;23(3):214-8 PMID 23273872 Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment. (Lawlor MW, Alexander MS, Viola MG, Meng H, Joubert R, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Buj-Bello A, Kunkel LM, Beggs AH, Gussoni E) Am J Pathol 2012 Sep;181(3):961-8 PMID 22841819 Oxygen gas-filled microparticles provide intravenous oxygen delivery. (Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX Jr) Sci Transl Med 2012 Jun 27;4(140):140ra88 PMID 22745438 Thermoresponsive nanogels for prolonged duration local anesthesia. (Hoare T, Young S, Lawlor MW, Kohane DS) Acta Biomater 2012 Oct;8(10):3596-605 PMID 22732383 Toxicogenomic analysis of a sustained release local anesthetic delivery system. (Shichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS) Biomaterials 2012 May;33(13):3586-93 PMID 22341215 Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. (Hoare T, Sivakumaran D, Stefanescu CF, Lawlor MW, Kohane DS) Acta Biomater 2012 Apr;8(4):1450-8 PMID 22244983 Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype. (Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, Beggs AH) Hum Mol Genet 2012 Feb 15;21(4):811-25 PMID 22068590 An in vivo rodent model of contraction-induced injury in the quadriceps muscle. (Pratt SJ, Lawlor MW, Shah SB, Lovering RM) Injury 2012 Jun;43(6):788-93 PMID 22001505 Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy. (Lawlor MW, Ottenheijm CA, Lehtokari VL, Cho K, Pelin K, Wallgren-Pettersson C, Granzier H, Beggs AH) Skelet Muscle 2011;1(1):23 PMID 21798101 Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. (Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer R, Kohane DS) Acta Biomater 2011 Aug;7(8):3150-7 PMID 21569875 Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. (Ottenheijm CA, Lawlor MW, Stienen GJ, Granzier H, Beggs AH) Hum Mol Genet 2011 May 15;20(10):2015-25 PMID 21357678 Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. (Lawlor MW, Read BP, Edelstein R, Yang N, Pierson CR, Stein MJ, Wermer-Colan A, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH) Am J Pathol 2011 Feb;178(2):784-93 PMID 21281811 Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. (Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A) Development 2010 Aug;137(16):2643-52 PMID 20610486 Functional muscle analysis of the Tcap knockout mouse. (Markert CD, Meaney MP, Voelker KA, Grange RW, Dalley HW, Cann JK, Ahmed M, Bishwokarma B, Walker SJ, Yu SX, Brown M, Lawlor MW, Beggs AH, Childers MK) Hum Mol Genet 2010 Jun 1;19(11):2268-83 PMID 20233748 Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. (Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD) Pediatr Dev Pathol 2010 Sep-Oct;13(5):397-403 PMID 20158377 Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion. (Lawlor MW, Dechene ET, Roumm E, Geggel AS, Moghadaszadeh B, Beggs AH) Hum Mutat 2010 Feb;31(2):176-83 PMID 19953533 Prolonged duration local anesthesia with minimal toxicity. (Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS) Proc Natl Acad Sci U S A 2009 Apr 28;106(17):7125-30 PMID 19365067 Effect of chemical permeation enhancers on nerve blockade. (Simons EJ, Bellas E, Lawlor MW, Kohane DS) Mol Pharm 2009 Jan-Feb;6(1):265-73 PMID 19105721 Three-dimensional conductive constructs for nerve regeneration. (George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS) J Biomed Mater Res A 2009 Nov;91(2):519-27 PMID 18985787 Malignant solitary fibrous tumour of the meninges with marked amianthoid fibre deposition. (Lawlor MW, Nielsen GP, Louis DN) Neuropathol Appl Neurobiol 2008 Oct;34(5):569-72 PMID 18298634 Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. (Stubbs EB Jr, Lawlor MW, Richards MP, Siddiqui K, Fisher MA, Bhoopalam N, Siegel GJ) Acta Neuropathol 2003 Feb;105(2):109-16 PMID 12536221 Antibodies to L-periaxin in sera of patients with peripheral neuropathy produce experimental sensory nerve conduction deficits. (Lawlor MW, Richards MP, De Vries GH, Fisher MA, Stubbs EB Jr) J Neurochem 2002 Nov;83(3):592-600 PMID 12390521 Sensory nerve conduction deficit in experimental monoclonal gammopathy of undetermined significance (MGUS) neuropathy. (Lawlor MW, Richards MP, Fisher MA, Stubbs EB Jr) Muscle Nerve 2001 Jun;24(6):809-16 PMID 11360265 Assessment of serum-mediated neurotoxicity in Navajo neuropathy. (Lawlor MW, Holve S, Stubbs EB Jr) Electromyogr Clin Neurophysiol 2000 Jun;40(4):211-4 PMID 10907598 Grants and Awards
Mechanisms and Efficacy of Myostatin Inhibition in Myotubular Myopathy (#9207326 12/02/2011 - 06/30/2015) Sponsor: NIH Arthritis and Musculoskeletal and Skin DiseaseCongenital Muscle Disease Tissue Repository (#9207928 03/14/2013 - 03/13/2014) Sponsor: Children's Hospital FoundationAdvancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of Inhibition of Activin Type IIB Receptor Signaling as a Treatment for Nemaline Myopathy (#5520261)
