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Ming You MD, PhD

Ming You MD, PhD

Sr Associate Dean, Center Director, Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the MCW Cancer Center


Research Experience

  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Small Cell
  • Chemoprevention
  • DNA Fingerprinting
  • Genes, Neoplasm
  • Molecular Biology
  • Tumor Suppressor Protein p53
  • Publications

  • Genome-wide association tests of inversions with application to psoriasis. (Ma J, Xiong M, You M, Lozano G, Amos CI) Hum Genet 2014 Aug;133(8):967-74 PMID 24623382
  • Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer. (Morrison CD, Liu P, Woloszynska-Read A, Zhang J, Luo W, Qin M, Bshara W, Conroy JM, Sabatini L, Vedell P, Xiong D, Liu S, Wang J, Shen H, Li Y, Omilian AR, Hill A, Head K, Guru K, Kunnev D, Leach R, Eng KH, Darlak C, Hoeflich C, Veeranki S, Glenn S, You M, Pruitt SC, Johnson CS, Trump DL) Proc Natl Acad Sci U S A 2014 Feb 11;111(6):E672-81 PMID 24469795
  • CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. (James MA, Vikis HG, Tate E, Rymaszewski AL, You M) Cancer Res 2014 Feb 15;74(4):1116-27 PMID 24366883
  • Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis. (Pan J, Zhang Q, Xiong D, Vedell P, Yan Y, Jiang H, Cui P, Ding F, Tichelaar JW, Wang Y, Lubet RA, You M) Mol Carcinog 2014 Jan;53(1):19-29 PMID 24343902
  • EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. (Wilson IM, Vucic EA, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, BanĂ¡th JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TP, Selamat SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, Macaulay CE, Karsan A, Gazdar AF, Lam S, Lam WL) Oncogene 2013 Oct 7: PMID 24096489
  • Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1. (Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M) PLoS One 2013;8(9):e74188 PMID 24073202
  • Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes. (Lu Y, You M, Ghazoui Z, Liu P, Vedell PT, Wen W, Bode AM, Grubbs CJ, Lubet RA) Cancer Prev Res (Phila) 2013 Nov;6(11):1151-61 PMID 24067424
  • Chemoprevention of lung squamous cell carcinoma by ginseng. (Pan J, Zhang Q, Li K, Liu Q, Wang Y, You M) Cancer Prev Res (Phila) 2013 Jun;6(6):530-9 PMID 23550152
  • Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA) J Biol Chem 2013 Apr 12;288(15):10265-74 PMID 23393131
  • Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene). (Vedell PT, Lu Y, Grubbs CJ, Yin Y, Jiang H, Bland KI, Muccio DD, Cvetkovic D, You M, Lubet R) Mol Pharmacol 2013 Mar;83(3):698-708 PMID 23292798
  • Mouse models of lung squamous cell carcinomas. (You MS, Rouggly LC, You M, Wang Y) Cancer Metastasis Rev 2013 Jun;32(1-2):77-82 PMID 23229817
  • Lung cancer chemoprevention: difficulties, promise and potential agents? (Dragnev K, You M, Wang Y, Lubet R) Expert Opin Investig Drugs 2013 Jan;22(1):35-47 PMID 23167766
  • Genomic landscape of non-small cell lung cancer in smokers and never-smokers. (Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J, McDonald S, Bose R, Ornitz D, Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK) Cell 2012 Sep 14;150(6):1121-34 PMID 22980976
  • Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer. (Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS) Cancer Res 2012 Sep 1;72(17):4311-7 PMID 22751136
  • WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. (Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM) Am J Respir Cell Mol Biol 2012 Oct;47(4):528-35 PMID 22700866
  • Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. (Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M) Carcinogenesis 2012 Sep;33(9):1797-805 PMID 22696596
  • Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. (James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M) PLoS One 2012;7(6):e36116 PMID 22675468
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID 22510280
  • Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. (Zhang Q, Pan J, Wang Y, Lubet R, You M) Mol Carcinog 2013 Sep;52(9):686-91 PMID 22456940
  • Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. (Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2012 May;5(5):717-25 PMID 22401980
  • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. (Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M) Carcinogenesis 2012 May;33(5):1046-54 PMID 22331473
  • Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. (Lu Y, Wang L, Liu P, Yang P, You M) PLoS One 2012;7(1):e30880 PMID 22292069
  • Quantitative monitoring of mouse lung tumors by magnetic resonance imaging. (Krupnick AS, Tidwell VK, Engelbach JA, Alli VV, Nehorai A, You M, Vikis HG, Gelman AE, Kreisel D, Garbow JR) Nat Protoc 2012 Jan;7(1):128-42 PMID 22222788
  • Animal models of lung cancer characterization and use for chemoprevention research. (Wang Y, Rouggly L, You M, Lubet R) Prog Mol Biol Transl Sci 2012;105:211-26 PMID 22137433
  • Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. (Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M) Mol Cancer Res 2012 Jan;10(1):66-74 PMID 22127497
  • Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. (Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M) Mol Carcinog 2013 Jan;52(1):49-56 PMID 22086836
  • Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. (Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, Liu P, Tichelaar JW, Krupnick AS, You M) Mol Carcinog 2012 Dec;51(12):993-1002 PMID 22006501
  • Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer. (Lu Y, Liu P, Van den Bergh F, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, You M) Cancer Prev Res (Phila) 2012 Feb;5(2):248-59 PMID 21982874
  • Principles for the post-GWAS functional characterization of cancer risk loci. (Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG) Nat Genet 2011 Jun;43(6):513-8 PMID 21614091
  • Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. (Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M) Mol Carcinog 2011 Dec;50(12):913-21 PMID 21374736
  • Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers. (Lubet RA, Lu Y, Bode AM, You M, Verney ZM, Steele VE, Townsend R, Juliana MM, Grubbs CJ) Oncol Rep 2011 May;25(5):1389-97 PMID 21369704
  • Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice. (Zhang Q, Pan J, Zhang J, Liu P, Chen R, Chen DR, Lubet R, Wang Y, You M) Cancer Prev Res (Phila) 2011 Feb;4(2):270-6 PMID 21163938
  • Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. (Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, Lubet RA, You M) Am J Transl Res 2010;3(1):8-27 PMID 21139803
  • Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. (James MA, Fu H, Liu Y, Chen DR, You M) Mol Carcinog 2011 Jan;50(1):1-7 PMID 21061266
  • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. (Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M) Mol Cancer Ther 2010 Nov;9(11):3074-82 PMID 21045137
  • Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q. (Fang S, Pinney SM, Bailey-Wilson JE, de Andrade MA, Li Y, Kupert E, You M, Schwartz AG, Yang P, Anderson MW, Amos CI) Cancer Epidemiol Biomarkers Prev 2010 Dec;19(12):3157-66 PMID 21030603
  • A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. (Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M) Cancer Prev Res (Phila) 2010 Sep;3(9):1148-56 PMID 20716630
  • Functional genomics of chlorine-induced acute lung injury in mice. (Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DR) Proc Am Thorac Soc 2010 Jul;7(4):294-6 PMID 20601635
  • Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. (Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M) Cancer Res 2010 Jun 15;70(12):4859-67 PMID 20501835
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M) Cancer Res 2010 Apr 15;70(8):3128-35 PMID 20395203
  • A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. (Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW) Cancer Res 2010 Mar 15;70(6):2359-67 PMID 20215501
  • Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. (Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M) Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):517-24 PMID 20142248
  • Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. (Zhang Q, Fu H, Pan J, He J, Ryota S, Hara Y, Wang Y, Lubet RA, You M) Pharm Res 2010 Jun;27(6):1066-71 PMID 20112129
  • Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer. (Wang Y, Wen W, Yi Y, Zhang Z, Lubet RA, You M) Cancer Prev Res (Phila) 2009 Dec;2(12):1059-64 PMID 19934342
  • Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. (Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, Franklin A, You M) Oncogene 2010 Feb 18;29(7):1041-9 PMID 19915612
  • Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. (Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M) Cancer Res 2009 Oct 1;69(19):7844-50 PMID 19789337
  • Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. (Lubet RA, Yao R, Grubbs CJ, You M, Wang Y) Chem Biol Interact 2009 Nov 10;182(1):22-8 PMID 19695238
  • Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. (Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M) Cancer Res 2009 Aug 1;69(15):6290-8 PMID 19622765
  • Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. (Wang Y, Zhang Z, Garbow JR, Rowland DJ, Lubet RA, Sit D, Law F, You M) Cancer Prev Res (Phila) 2009 Jul;2(7):634-40 PMID 19584077
  • Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E). (Fu H, He J, Mei F, Zhang Q, Hara Y, Ryota S, Lubet RA, Chen R, Chen DR, You M) Cancer Prev Res (Phila) 2009 Jun;2(6):531-7 PMID 19470785
  • Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, COGEND collaborators and GELCC collaborators) Hum Mol Genet 2009 Aug 15;18(16):3125-35 PMID 19443489
  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW) Clin Cancer Res 2009 Apr 15;15(8):2666-74 PMID 19351763
  • RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. (James MA, Lu Y, Liu Y, Vikis HG, You M) Cancer Res 2009 Mar 1;69(5):2108-16 PMID 19244110
  • Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M) J Natl Cancer Inst 2008 Sep 17;100(18):1326-30 PMID 18780872
  • Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice. (Anderson MW, Goodin C, Zhang Y, Kim S, Estensen RD, Wiedmann TS, Sekar P, Buncher CR, Khoury JC, Garbow JR, You M, Tichelaar JW) Carcinogenesis 2008 Aug;29(8):1594-600 PMID 18515278
  • Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. (Garbow JR, Wang M, Wang Y, Lubet RA, You M) Clin Cancer Res 2008 Mar 1;14(5):1363-7 PMID 18316556
  • Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation. (Wang Y, Zhang Z, Lu Y, Yao R, Jia D, Wen W, LaRegina M, Crist K, Lubet R, You M) Mol Cancer Res 2008 Jan;6(1):99-109 PMID 18234966
  • Common human cancer genes discovered by integrated gene-expression analysis. (Lu Y, Yi Y, Liu P, Wen W, James M, Wang D, You M) PLoS One 2007;2(11):e1149 PMID 17989776
  • Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. (Liu Y, Vikis HG, Yi Y, Futamura M, Wang Y, You M) Cancer Res 2007 Nov 1;67(21):10207-13 PMID 17974961
  • Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice. (Yan Y, Tan Q, Wang Y, Wang D, Jin M, Gordon T, Lubet RA, You M) Inhal Toxicol 2007;19 Suppl 1:183-7 PMID 17886066
  • Large-scale in silico mapping of complex quantitative traits in inbred mice. (Liu P, Vikis H, Lu Y, Wang D, You M) PLoS One 2007;2(7):e651 PMID 17653278
  • Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice. (Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS, You M) Neoplasia 2007 May;9(5):401-5 PMID 17534445
  • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M) Cancer Res 2007 May 15;67(10):4665-70 PMID 17510392
  • Gene expression profiling of chemically induced rat bladder tumors. (Yao R, Yi Y, Grubbs CJ, Lubet RA, You M) Neoplasia 2007 Mar;9(3):207-21 PMID 17401461
  • Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. (Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M) Cancer Res 2007 Mar 15;67(6):2508-16 PMID 17363568
  • Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. (Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Minna J, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson MW, You M) Cancer Res 2007 Jan 1;67(1):93-9 PMID 17210687
  • Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. (Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M) Mol Cancer Res 2006 Dec;4(12):971-81 PMID 17189387
  • Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. (Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M) Nat Genet 2006 Aug;38(8):888-95 PMID 16862160
  • p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. (Zhang Z, Wang Y, Yao R, Li J, Lubet RA, You M) Mol Cancer Res 2006 Jun;4(6):401-10 PMID 16778087
  • Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. (Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M) Mol Cancer Ther 2006 Apr;5(4):1060-72 PMID 16648578
  • Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. (Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M) Neoplasia 2006 Jan;8(1):52-8 PMID 16533426
  • A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. (Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M) Cancer Res 2006 Feb 15;66(4):1956-63 PMID 16488994
  • Chemoprevention of lung cancer by tea. (Clark J, You M) Mol Nutr Food Res 2006 Feb;50(2):144-51 PMID 16425282
  • Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets. (Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M) Carcinogenesis 2006 Jul;27(7):1420-31 PMID 16403772
  • Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. (Yan Y, Wang Y, Tan Q, Lubet RA, You M) Neoplasia 2005 Dec;7(12):1053-7 PMID 16354587
  • Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53. (Zhang Z, Yao R, Li J, Wang Y, Boone CW, Lubet RA, You M) Mol Cancer Res 2005 Oct;3(10):563-74 PMID 16254190
  • A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. (Wang Y, Zhang Z, Lubet RA, You M) Oncogene 2006 Feb 23;25(8):1277-80 PMID 16247444
  • Prevention of lung cancer progression by bexarotene in mouse models. (Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M) Oncogene 2006 Mar 2;25(9):1320-9 PMID 16247446
  • Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice. (Wang D, You M) Cancer Res 2005 Sep 15;65(18):8158-65 PMID 16166290
  • A moderate reduction of Bcl-x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury. (Henderson CC, Zhang Z, Manson SR, Riehm JJ, Kataoka M, Flye MW, Garbow JR, You M, Weintraub SJ) Oncogene 2005 Oct 27;24(47):7120-4 PMID 16007126
  • Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf. (Wang Y, Zhang Z, Lubet R, You M) Oncogene 2005 Apr 21;24(18):3042-9 PMID 15846305
  • Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility. (Wang M, Wang Y, You M) Exp Lung Res 2005 Mar;31(2):165-77 PMID 15824019
  • Characterization of two protein-binding sites in the second intron of the mouse K-ras gene. (Chen B, Wang Y, You M) Exp Lung Res 2005 Mar;31(2):179-92 PMID 15824020
  • K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke. (Yao R, Wang Y, D'Agostini F, Izzotti A, Lubet RA, You M, De Flora S) Exp Lung Res 2005 Mar;31(2):271-81 PMID 15824025
  • Mouse models incorporating alterations in the major tumor suppressor genes P53 and P16: their use in screening for potential carcinogens, developing further relevant mouse models, and screening for potential chemopreventive and chemotherapetutic agents. (Lubet R, Wang Y, Zhang Z, You M) Exp Lung Res 2005 Jan-Feb;31(1):117-33 PMID 15765922
  • Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice. (De Flora S, Izzotti A, D'Agostini F, Bennicelli C, You M, Lubet RA, Balansky RM) Exp Lung Res 2005 Jan-Feb;31(1):19-35 PMID 15765917
  • Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture. (Crist KA, Zhang Z, You M, Gunning WT, Conran PB, Steele VE, Lubet RA) Carcinogenesis 2005 May;26(5):951-7 PMID 15695234
  • Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. (Wang M, Futamura M, Wang Y, You M) Oncogene 2005 Mar 10;24(11):1958-63 PMID 15688036
  • Tumor susceptibility of Rassf1a knockout mice. (Tommasi S, Dammann R, Zhang Z, Wang Y, Liu L, Tsark WM, Wilczynski SP, Li J, You M, Pfeifer GP) Cancer Res 2005 Jan 1;65(1):92-8 PMID 15665283
  • Gene expression in the lung of p53 mutant mice exposed to cigarette smoke. (Izzotti A, Cartiglia C, Longobardi M, Bagnasco M, Merello A, You M, Lubet RA, De Flora S) Cancer Res 2004 Dec 1;64(23):8566-72 PMID 15574763
  • Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. (Yao R, Lemon WJ, Wang Y, Grubbs CJ, Lubet RA, You M) Neoplasia 2004 Sep-Oct;6(5):569-77 PMID 15548366
  • Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. (Yao R, Wang Y, Lemon WJ, Lubet RA, You M) Oncogene 2004 Oct 7;23(46):7746-52 PMID 15361829
  • A major lung cancer susceptibility locus maps to chromosome 6q23-25. (Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW) Am J Hum Genet 2004 Sep;75(3):460-74 PMID 15272417
  • Chemoprevention of lung cancer in transgenic mice. (Lubet RA, Zhang Z, Wang Y, You M) Chest 2004 May;125(5 Suppl):144S-7S PMID 15136469
  • Detection of primary lung tumors in rodents by magnetic resonance imaging. (Garbow JR, Zhang Z, You M) Cancer Res 2004 Apr 15;64(8):2740-2 PMID 15087388
  • Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. (Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M) Cancer Res 2004 Mar 15;64(6):1924-31 PMID 15026325
  • Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. (Zhang Z, Wang Y, Yao R, Li J, Yan Y, La Regina M, Lemon WL, Grubbs CJ, Lubet RA, You M) Oncogene 2004 May 6;23(21):3841-50 PMID 15021904
  • CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. (Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K) Oncogene 2004 May 13;23(22):3990-8 PMID 15007387
  • A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. (Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M) Cancer Res 2004 Mar 1;64(5):1647-54 PMID 14996723
  • Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression. (Herzog CR, Bodon N, Pittman B, Maronpot RR, Massey TE, Anderson MW, You M, Devereux TR) Oncogene 2004 Apr 15;23(17):3033-9 PMID 14755239
  • Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. (Bonner AE, Lemon WJ, Devereux TR, Lubet RA, You M) Oncogene 2004 Feb 5;23(5):1166-76 PMID 14647414
  • Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. (Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M) Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12642-7 PMID 14583591
  • Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. (Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M) Oncogene 2003 Sep 18;22(40):6257-65 PMID 13679864
  • Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. (Wang Y, Zhang Z, Kastens E, Lubet RA, You M) Cancer Res 2003 Aug 1;63(15):4389-95 PMID 12907609
  • Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. (Fischer M, You M, Matsumoto M, Crabb DW) J Biol Chem 2003 Jul 25;278(30):27997-8004 PMID 12791698
  • Differential gene expression in chemically induced mouse lung adenomas. (Yao R, Wang Y, Lubet RA, You M) Neoplasia 2003 Jan-Feb;5(1):41-52 PMID 12659669
  • LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. (Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M) Oncogene 2003 Feb 27;22(8):1243-6 PMID 12606951
  • Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas. (Herzog CR, Crist KA, Sabourin CL, Kelloff GJ, Boone CW, Stoner GD, You M) Mol Carcinog 2001 Mar;30(3):159-68 PMID 11301476
  • Chemopreventive efficacy of promising farnesyltransferase inhibitors. (Lantry LE, Zhang Z, Crist KA, Wang Y, Hara M, Zeeck A, Lubet RA, You M) Exp Lung Res 2000 Dec;26(8):773-90 PMID 11195470
  • Use of p53 transgenic mice in the development of cancer models for multiple purposes. (Lubet RA, Zhang Z, Wiseman RW, You M) Exp Lung Res 2000 Dec;26(8):581-93 PMID 11195457
  • Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis. (Shilkaitis A, Graves J, Mehta RR, Hu L, You M, Lubet R, Steele V, Kelloff G, Christov K) Cell Growth Differ 2000 Aug;11(8):437-45 PMID 10965848
  • A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. (Zhang Z, Liu Q, Lantry LE, Wang Y, Kelloff GJ, Anderson MW, Wiseman RW, Lubet RA, You M) Cancer Res 2000 Feb 15;60(4):901-7 PMID 10706103
  • Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M) Carcinogenesis 2000 Jan;21(1):113-6 PMID 10607742
  • Measurement of oxygen and carbon dioxide partial pressures in synovial fluid after tonometry. (Geborek P, Lindoff B, Valind SO) Clin Physiol 1988 Aug;8(4):427-32 PMID 3136967
  • Electrophysiology and dye-coupling are sexually dimorphic characteristics of individual laryngeal muscle fibers in Xenopus laevis. (Tobias ML, Kelley DB) J Neurosci 1988 Jul;8(7):2422-9 PMID 3249234
  • Grants and Awards

  • The Role of Deubiquitinating Enzyme USP33 in Slit-Robo Signaling in Lung Cancer (#9208657 03/07/2014 - 02/28/2019) Sponsor: Northwestern University
  • State of Wisconsin Prostate Cancer Tax Check-Off For Tax Year 2007 (#9950011 07/01/2008 - 06/30/2015) Sponsor: State of Wisconsin
  • State of Wisconsin Breast Cancer Tax Check-Off for 2009 Tax Year (#9950017 07/01/2010 - 06/30/2015) Sponsor: State of Wisconsin
  • Transplantation Biology & Immunotherapy Program (#9520212 11/01/2011 - 10/31/2016) Sponsor: AHW-Research and Education Program
  • State of Wisconsin Breast Cancer Tax Check-Off for Tax Year 2011 (#9950024 07/01/2012 - 06/30/2017) Sponsor: State of Wisconsin
  • Use of TERT Vaccine in Prevention of Lung Cancer in Animal Models (#9208410 02/20/2014 - 09/18/2015) Sponsor: Board of Regents of the University of Oklahoma
  • State of Wisconsin Cancer Tax Check-Off for 2012 Tax Year (#9950027 08/01/2013 - 06/30/2018) Sponsor: State of Wisconsin
  • Cancer Imaging Research Program (#9520223 02/01/2012 - 01/31/2017) Sponsor: AHW-Research and Education Program
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) Sponsor: AHW-Research and Education Program
  • Prevention, Control, and Population Sciences Research Program (#9520222 02/01/2012 - 01/31/2017) Sponsor: AHW-Research and Education Program
  • TY08 State of Wisconsin Prostate Cancer Research Tax Check-Off Program (#9950013 08/01/2009 - 06/30/2017) Sponsor: State of Wisconsin
  • Genome-Wide Association Studies of Inherited Predisposition to Lung Cancer (#9206768 01/14/2011 - 05/31/2015) Sponsor: NIH Cancer Institute
  • State of Wisconsin Prostate Cancer Tax Check-Off for Tax Year 2011 (#9950025 07/01/2012 - 06/30/2017) Sponsor: State of Wisconsin
  • Molecular Genetics of Lung Tumor Promotion in Mice (#9206769 01/24/2011 - 04/30/2015) Sponsor: NIH Cancer Institute
  • State of Wisconsin Breast Cancer Tax Check-Off for 2010 Tax Year (#9950020 07/01/2011 - 06/30/2016) Sponsor: State of Wisconsin
  • State of Wisconsin Prostate Cancer Tax Check-Off for 2009 Tax Year (#9950016 07/01/2010 - 06/30/2015) Sponsor: State of Wisconsin
  • Cancer Center Infrastructure Grant (#9520181 11/01/2010 - 10/31/2016) Sponsor: AHW-Research and Education Program
  • Cancer Cell Biology Research Program (#9520213 11/01/2011 - 10/31/2016) Sponsor: AHW-Research and Education Program
  • WI DOJ Lupon Pharmaceutical Settlement Check-Biomedical Research Building-Cancer Labs (#9204173 05/01/2006 - 06/30/2013) Sponsor: State of Wisconsin
  • State of Wisconsin Prostate Cancer Tax Check-Off for 2010 Tax Year (#9950019 07/01/2011 - 06/30/2016) Sponsor: State of Wisconsin
  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 04/30/2015) Sponsor: American Cancer Society National
  • Transdisciplinary Research in Cancer of the Lung (#9207954 09/01/2012 - 06/30/2014) Sponsor: Dartmouth College
  • State of Wisconsin Cancer Tax Check-Off for 2013 Tax Year (#9950028 08/01/2014 - 06/30/2019) Sponsor: State of Wisconsin