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Mitchell H. Grayson MD

Mitchell H. Grayson MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Allergy


I am willing to mentor a junior faculty member.


Research Experience

  • Allergy and Immunology
  • Asthma
  • Bronchiolitis, Viral
  • Dendritic Cells
  • Food Hypersensitivity
  • Immunoglobulin E
  • Models, Animal
  • Norovirus
  • Receptors, IgE
  • Clinical Expertise

  • Allergy and Immunology
  • Angioedema
  • Asthma
  • Drug Hypersensitivity
  • Food Hypersensitivity
  • Rhinitis, Allergic, Seasonal
  • Methodologies and Techniques

  • Adoptive Transfer
  • Bronchial Provocation Tests
  • Cell Separation
  • Flow Cytometry
  • Immunization, Passive
  • Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Publications

  • Mice matter. (Kelly BT, Grayson MH) Ann Allergy Asthma Immunol 2014 Feb;112(2):87-9 PMID 24468244
  • CD49d-expressing neutrophils differentiate atopic from nonatopic individuals. (Sigua JA, Buelow B, Cheung DS, Buell E, Hunter D, Klancnik M, Grayson MH) J Allergy Clin Immunol 2014 Mar;133(3):901-4.e5 PMID 24360325
  • Rhinovirus specific IgE can be detected in human sera. (Tam JS, Jackson WT, Hunter D, Proud D, Grayson MH) J Allergy Clin Immunol 2013 Nov;132(5):1241-3 PMID 23992751
  • Evidence mounts that viruses drive atopic development. (Sigua JA, Grayson MH) J Allergy Clin Immunol 2013 May;131(5):1340-1 PMID 23561800
  • Dendritic cells, viruses, and the development of atopic disease. (Tam JS, Grayson MH) J Allergy (Cairo) 2012;2012:936870 PMID 23118777
  • Role of viruses in the development of atopic disease in pediatric patients. (Cheung DS, Grayson MH) Curr Allergy Asthma Rep 2012 Dec;12(6):613-20 PMID 22911226
  • Ghosts in the annals: boo! (Grayson MH, Marshall GD Jr) Ann Allergy Asthma Immunol 2012 Jul;109(1):1-2 PMID 22727147
  • Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children. (Vasudev M, Cheung DS, Pincsak H, Li SH, Yan K, Simpson P, Dasu T, Grayson MH) PLoS One 2012;7(2):e32556 PMID 22384272
  • Evaluation of vomiting and regurgitation in the infant. (Tam JS, Grayson MH) Ann Allergy Asthma Immunol 2012 Jan;108(1):3-6 PMID 22192956
  • Characterization of intestinal dendritic cells in murine norovirus infection. (Chen X, Leach D, Hunter DA, Sanfelippo D, Buell EJ, Zemple SJ, Grayson MH) Open Immunol J 2011;4:22-30 PMID 22162983
  • Granzyme B regulates antiviral CD8+ T cell responses. (Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW) J Immunol 2011 Dec 15;187(12):6301-9 PMID 22084442
  • Can specific IgE discriminate between intrinsic and atopic asthma? (Camarda LE, Grayson MH) Am J Respir Crit Care Med 2011 Jul 15;184(2):152-3 PMID 21765028
  • Development of atopy by severe paramyxoviral infection in a mouse model. (Cheung DS, Ehlenbach SJ, Kitchens T, Riley DA, Grayson MH) Ann Allergy Asthma Immunol 2010 Dec;105(6):437-443.e1 PMID 21130381
  • Mechanisms of immunotherapy: a historical perspective. (Shakir EM, Cheung DS, Grayson MH) Ann Allergy Asthma Immunol 2010 Nov;105(5):340-7; quiz 348, 368 PMID 21055659
  • Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. (Cheung DS, Ehlenbach SJ, Kitchens RT, Riley DA, Thomas LL, Holtzman MJ, Grayson MH) J Immunol 2010 Nov 1;185(9):4983-7 PMID 20876348
  • The mannose-binding lectin gene in atopic dermatitis: lessons from genetics. (Shakir EM, Grayson MH) Ann Allergy Asthma Immunol 2010 Jul;105(1):1-2 PMID 20642196
  • Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. (Wright RJ, Visness CM, Calatroni A, Grayson MH, Gold DR, Sandel MT, Lee-Parritz A, Wood RA, Kattan M, Bloomberg GR, Burger M, Togias A, Witter FR, Sperling RS, Sadovsky Y, Gern JE) Am J Respir Crit Care Med 2010 Jul 1;182(1):25-33 PMID 20194818
  • Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28. (Khan SH, Grayson MH) J Allergy Clin Immunol 2010 Jan;125(1):265-7 PMID 19962743
  • The role of viruses in the development and exacerbation of atopic disease. (Kumar A, Grayson MH) Ann Allergy Asthma Immunol 2009 Sep;103(3):181-6; quiz 186-7, 219 PMID 19788013
  • Immune pathways for translating viral infection into chronic airway disease. (Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC) Adv Immunol 2009;102:245-76 PMID 19477323
  • The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. (Zindl CL, Kim TH, Zeng M, Archambault AS, Grayson MH, Choi K, Schreiber RD, Chaplin DD) Immunity 2009 Mar 20;30(3):408-20 PMID 19303389
  • Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis. (Silver E, Yin-DeClue H, Schechtman KB, Grayson MH, Bacharier LB, Castro M) Pediatr Allergy Immunol 2009 Aug;20(5):471-6 PMID 19140903
  • Basic science for the practicing clinician. (Grayson MH) Ann Allergy Asthma Immunol 2008 Sep;101(3):225 PMID 18814443
  • IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection. (Gunsten S, Mikols CL, Grayson MH, Schwendener RA, Agapov E, Tidwell RM, Cannon CL, Brody SL, Walter MJ) Immunology 2009 Apr;126(4):500-13 PMID 18783467
  • Respiratory virus and asthma: the role of immunoglobulin E. (Khan SH, Park SS, Sirajuddin IA, Grayson MH) Clin Ther 2008;30 Spec No:1017-24 PMID 18640476
  • Lung dendritic cells and IgE: the link between virus and atopy. (Park SS, Ehlenbach SJ, Grayson MH) Future Microbiol 2008 Jun;3(3):241-5 PMID 18505388
  • Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. (Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polineni D, Patterson GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ) Nat Med 2008 Jun;14(6):633-40 PMID 18488036
  • Pulmonary defense mechanisms against pneumonia and sepsis. (Tsai KS, Grayson MH) Curr Opin Pulm Med 2008 May;14(3):260-5 PMID 18427251
  • Clinical research: protection of the "vulnerable"? (Park SS, Grayson MH) J Allergy Clin Immunol 2008 May;121(5):1103-7 PMID 18313131
  • Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. (Akk AM, Simmons PM, Chan HW, Agapov E, Holtzman MJ, Grayson MH, Pham CT) J Immunol 2008 Mar 1;180(5):3535-42 PMID 18292580
  • Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. (Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ) J Exp Med 2007 Oct 29;204(11):2759-69 PMID 17954569
  • Emerging role of dendritic cells in respiratory viral infection. (Grayson MH, Holtzman MJ) J Mol Med (Berl) 2007 Oct;85(10):1057-68 PMID 17891367
  • Controls for lung dendritic cell maturation and migration during respiratory viral infection. (Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ) J Immunol 2007 Aug 1;179(3):1438-48 PMID 17641009
  • The role of antileukotriene drugs in management of rhinitis and rhinosinusitis. (Grayson MH, Korenblat PE) Curr Allergy Asthma Rep 2007 Jun;7(3):209-15 PMID 17448333
  • Treating asthma in the older patient: is there a place for leukotriene modifiers? (Grayson MH, Korenblat PE) Drugs Aging 2006;23(6):451-9 PMID 16872230
  • Chemokine complexity: the case for CCL5. (Grayson MH, Holtzman MJ) Am J Respir Cell Mol Biol 2006 Aug;35(2):143-6 PMID 16847105
  • Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. (Schwulst SJ, Grayson MH, DiPasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA, Hotchkiss RS) J Immunol 2006 Jul 1;177(1):557-65 PMID 16785553
  • Lung dendritic cells and the inflammatory response. (Grayson MH) Ann Allergy Asthma Immunol 2006 May;96(5):643-51; quiz 652-3, 678 PMID 16729776
  • Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense. (Grayson MH, Holtzman MJ) Cell Cycle 2006 Feb;5(4):380-3 PMID 16479157
  • Occupational exposures as triggers of asthma. (Vigo PG, Grayson MH) Immunol Allergy Clin North Am 2005 Feb;25(1):191-205 PMID 15579371
  • "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease. (Holtzman MJ, Shornick LP, Grayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y) Pediatr Infect Dis J 2004 Nov;23(11 Suppl):S235-45 PMID 15577579
  • The emerging role of leukotriene modifiers in allergic rhinitis. (Grayson MH, Korenblat PE) Am J Respir Med 2003;2(6):441-50 PMID 14719983
  • Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. (Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC, Karl IE, Hotchkiss RS) J Immunol 2003 Jul 15;171(2):909-14 PMID 12847261
  • Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin. (Grayson MH, Chaplin DD) ScientificWorldJournal 2003 Jun 9;3:484-96 PMID 12847299
  • Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. (Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE) Proc Natl Acad Sci U S A 2003 May 27;100(11):6724-9 PMID 12736377
  • Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. (Grayson MH, Hotchkiss RS, Karl IE, Holtzman MJ, Chaplin DD) Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H2213-26 PMID 12586641
  • Depletion of dendritic cells, but not macrophages, in patients with sepsis. (Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C, Karl IE) J Immunol 2002 Mar 1;168(5):2493-500 PMID 11859143
  • Confocal fluorescent intravital microscopy of the murine spleen. (Grayson MH, Chaplin DD, Karl IE, Hotchkiss RS) J Immunol Methods 2001 Oct 1;256(1-2):55-63 PMID 11516755
  • The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. (Van der Vieren M, Crowe DT, Hoekstra D, Vazeux R, Hoffman PA, Grayson MH, Bochner BS, Gallatin WM, Staunton DE) J Immunol 1999 Aug 15;163(4):1984-90 PMID 10438935
  • alphadbeta2 integrin is a ligand for vascular cell adhesion molecule-1. (Grayson MH, Van der Vieren M, Sterbinsky SA, Gallantin WM, Hoffman P, Staunton D, Bochner BS) Int Arch Allergy Immunol 1999 Feb-Apr;118(2-4):263-4 PMID 10224405
  • alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). (Grayson MH, Van der Vieren M, Sterbinsky SA, Michael Gallatin W, Hoffman PA, Staunton DE, Bochner BS) J Exp Med 1998 Dec 7;188(11):2187-91 PMID 9841932
  • New concepts in the pathogenesis and treatment of allergic asthma. (Grayson MH, Bochner BS) Mt Sinai J Med 1998 Sep;65(4):246-56 PMID 9757744
  • Grants and Awards

  • A Phase III, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, & Tolerability of Lebrikizumab In Adolescent Patients w Uncontrolled Asthma Who are on Inhaled Corticosteroids & Second Controller Medication (#9306486 12/30/2013 - 12/29/2016) Sponsor: PPD Development, LP