Medical College of Wisconsin
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Monica Thakar MD

Monica Thakar MD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology

Member of the Cancer Center


Clinical Expertise

  • Fanconi Anemia
  • Hematopoietic Stem Cell Transplantation
  • Immunotherapy, Adoptive
  • Publications

  • Treosulfan-Based Conditioning and Hematopoietic Cell Transplantation for Nonmalignant Diseases: A Prospective Multicenter Trial. (Burroughs LM, Nemecek ER, Torgerson TR, Storer BE, Talano JA, Domm J, Giller RH, Shimamura A, Delaney C, Skoda-Smith S, Thakar MS, Baker KS, Rawlings DJ, Englund JA, Flowers ME, Deeg HJ, Storb R, Woolfrey AE) Biol Blood Marrow Transplant 2014 Sep 6: PMID 25196857
  • Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2014 Jan 21;15(2):205 PMID 24448581
  • Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2013 Nov;14(11):1127-36 PMID 24036998
  • Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. (Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, LeRademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP) J Clin Oncol 2013 May 1;31(13):1669-76 PMID 23547077
  • Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. (Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S) J Cancer 2013;4(1):25-35 PMID 23386902
  • IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. (Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S) J Cancer 2013;4(1):57-65 PMID 23386905
  • Cyclophosphamide-based in vivo T-cell depletion for HLA-haploidentical transplantation in Fanconi anemia. (Thakar MS, Bonfim C, Sandmaier BM, O'Donnell P, Ribeiro L, Gooley T, Deeg HJ, Flowers ME, Pasquini R, Storb R, Woolfrey AE, Kiem HP) Pediatr Hematol Oncol 2012 Sep;29(6):568-78 PMID 22839094
  • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. (Kumar P, Thakar MS, Ouyang W, Malarkannan S) Mucosal Immunol 2013 Jan;6(1):69-82 PMID 22739232
  • IQGAP1: a regulator of intracellular spacetime relativity. (Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS) J Immunol 2012 Mar 1;188(5):2057-63 PMID 22345702
  • High-throughput detection method for influenza virus. (Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S) J Vis Exp 2012(60): PMID 22331038
  • The Wisconsin approach to newborn screening for severe combined immunodeficiency. (Verbsky J, Thakar M, Routes J) J Allergy Clin Immunol 2012 Mar;129(3):622-7 PMID 22244594
  • Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation. (Chen Y, Fukuda T, Thakar MS, Kornblit BT, Storer BE, Santos EB, Storb R, Sandmaier BM) Cytotherapy 2011 Nov;13(10):1269-80 PMID 21846291
  • Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. (Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S) J Biol Chem 2011 Sep 9;286(36):31213-24 PMID 21771792
  • Evaluation of posttransplant methotrexate to facilitate engraftment in the canine major histocompatibility complex-haploidentical nonmyeloablative transplant model. (Thakar MS, Santos EB, Gooley TA, Sale G, Storb R, Kiem HP, Sandmaier BM) Transplantation 2010 Jul 15;90(1):14-22 PMID 20626083
  • Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation. (Thakar MS, Kurre P, Storb R, Kletzel M, Frangoul H, Pulsipher MA, Leisenring W, Flowers ME, Sandmaier BM, Woolfrey A, Kiem HP) Bone Marrow Transplant 2011 Apr;46(4):539-44 PMID 20581880
  • Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier. (Thakar MS, Santos EB, Fricker S, Bridger G, Storb R, Sandmaier BM) Blood 2010 Jan 28;115(4):916-7 PMID 20110438
  • ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse? (Thakar MS, Forman SJ) Hematology Am Soc Hematol Educ Program 2009:414-8 PMID 20008227
  • Reagents for astatination of biomolecules. 4. Comparison of maleimido-closo-decaborate(2-) and meta-[(211)At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [(211)At]astatine. (Wilbur DS, Thakar MS, Hamlin DK, Santos EB, Chyan MK, Nakamae H, Pagel JM, Press OW, Sandmaier BM) Bioconjug Chem 2009 Oct 21;20(10):1983-91 PMID 19731929
  • Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model. (Thakar MS, Zhang XB, Beard BC, Sale GE, Santos EB, Peterson L, Kiem HP, Sandmaier BM) Exp Hematol 2009 Oct;37(10):1157-66 PMID 19616601
  • Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth-213 or astatine-211. (Nakamae H, Wilbur DS, Hamlin DK, Thakar MS, Santos EB, Fisher DR, Kenoyer AL, Pagel JM, Press OW, Storb R, Sandmaier BM) Cancer Res 2009 Mar 15;69(6):2408-15 PMID 19244101
  • Grants and Awards

  • A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus plus Prednisone, Sirolimus/Extracorporeal Photopheresis plus Prednisone, and Sirolimus/Calcineurin Inhibitor plus Prednisone for the Treatment of Chronic Graft-versus-Host D (#9206901 03/15/2011 - 02/28/2015) Sponsor: National Marrow Donor Program
  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 09/30/2015) PI of NK Cell Immunotherapy in Relapsed and Refractory Solid Tumors (#2207968)
  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 09/30/2015) PI of NK Cell Immunotherapy in Relapsed and Refractory Solid Tumors (#2207968)
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of CTSI Cellular and Adoptive Immunotherapy Using Hematopeoietic Cell Transplantation and NK Cell Infusion for the Treatment of High-risk Pediatric and Adult Solid Tumors: a Phase I/II Study (#5520283)