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Muthusamy Kunnimalaiyaan PhD

Muthusamy Kunnimalaiyaan PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Surgical Oncology

Member of the MCW Cancer Center


Publications

  • MK2206 inhibits hepatocellular carcinoma cellular proliferation via induction of apoptosis and cell cycle arrest. (Wilson JM, Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M) J Surg Res 2014 Jun 4: PMID 24996256
  • Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. (Carter YM, Kunnimalaiyaan S, Chen H, Gamblin TC, Kunnimalaiyaan M) Cancer Biol Ther 2014 May;15(5):510-5 PMID 24521712
  • MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (Burke JF, Schlosser L, Harrison AD, Kunnimalaiyaan M, Chen H) Ann Surg Oncol 2013 Nov;20(12):3862-8 PMID 23900743
  • Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma. (Dilip A, Cheng G, Joseph J, Kunnimalaiyaan S, Kalyanaraman B, Kunnimalaiyaan M, Gamblin TC) Anticancer Drugs 2013 Oct;24(9):881-8 PMID 23872912
  • Leflunomide suppresses growth in human medullary thyroid cancer cells. (Alhefdhi A, Burke JF, Redlich A, Kunnimalaiyaan M, Chen H) J Surg Res 2013 Nov;185(1):212-6 PMID 23816245
  • Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. (Yu XM, Jaskula-Sztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M, Chen H) Mol Cancer Ther 2013 Jul;12(7):1276-87 PMID 23594881
  • Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro. (Somnay Y, Simon K, Harrison AD, Kunnimalaiyaan S, Chen H, Kunnimalaiyaan M) Anticancer Drugs 2013 Jan;24(1):66-72 PMID 23147412
  • Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy. (Xiao Y, Jaskula-Sztul R, Javadi A, Xu W, Eide J, Dammalapati A, Kunnimalaiyaan M, Chen H, Gong S) Nanoscale 2012 Nov 21;4(22):7185-93 PMID 23070403
  • Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro. (Somnay Y, Chen H, Kunnimalaiyaan M) Neuroendocrinology 2013;97(2):183-92 PMID 22965070
  • Expression of the active Notch1 decreases MTC tumor growth in vivo. (Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M) J Surg Res 2011 Nov;171(1):23-7 PMID 21571316
  • Antiproliferative effect of chrysin on anaplastic thyroid cancer. (Phan T, Yu XM, Kunnimalaiyaan M, Chen H) J Surg Res 2011 Sep;170(1):84-8 PMID 21571321
  • Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. (Pinchot SN, Jaskula-Sztul R, Ning L, Peters NR, Cook MR, Kunnimalaiyaan M, Chen H) Cancer 2011 Apr 1;117(7):1386-98 PMID 21425138
  • A preclinical and clinical study of lithium in low-grade neuroendocrine tumors. (Lubner SJ, Kunnimalaiyaan M, Holen KD, Ning L, Ndiaye M, Loconte NK, Mulkerin DL, Schelman WR, Chen H) Oncologist 2011;16(4):452-7 PMID 21393344
  • Hesperetin, a potential therapy for carcinoid cancer. (Zarebczan B, Pinchot SN, Kunnimalaiyaan M, Chen H) Am J Surg 2011 Mar;201(3):329-32; discussion 333 PMID 21367373
  • Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. (Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H) Ann Surg Oncol 2011 May;18(5):1506-11 PMID 21184191
  • MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets. (Meyer-Rochow GY, Jackson NE, Conaglen JV, Whittle DE, Kunnimalaiyaan M, Chen H, Westin G, Sandgren J, Stålberg P, Khanafshar E, Shibru D, Duh QY, Clark OH, Kebebew E, Gill AJ, Clifton-Bligh R, Robinson BG, Benn DE, Sidhu SB) Endocr Relat Cancer 2010 Sep;17(3):835-46 PMID 20621999
  • Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids. (Alexander VM, Roy M, Steffens KA, Kunnimalaiyaan M, Chen H) Int J Clin Exp Med 2010;3(2):95-102 PMID 20607034
  • Lithium inhibits carcinoid cell growth in vitro. (Greenblatt DY, Ndiaye M, Chen H, Kunnimalaiyaan M) Am J Transl Res 2010;2(3):248-53 PMID 20589165
  • Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells. (Ning L, Chen H, Kunnimalaiyaan M) Mol Cancer Res 2010 May;8(5):775-82 PMID 20407018
  • Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer. (Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M) Am J Surg 2010 Mar;199(3):315-8; discussion 318 PMID 20226902
  • Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. (Cook MR, Pinchot SN, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H) Mol Cancer Ther 2010 Feb;9(2):429-37 PMID 20103603
  • Medullary thyroid carcinoma: targeted therapies and future directions. (Pinchot SN, Kunnimalaiyaan M, Sippel RS, Chen H) J Oncol 2009;2009:183031 PMID 20069043
  • Notch 1 signaling is active in ovarian cancer. (Rose SL, Kunnimalaiyaan M, Drenzek J, Seiler N) Gynecol Oncol 2010 Apr;117(1):130-3 PMID 20060575
  • ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. (Deming D, Geiger P, Chen H, Kunnimalaiyaan M, Holen K) J Surg Res 2010 Jun 1;161(1):28-32 PMID 20031160
  • AKT and PTEN expression in human gastrointestinal carcinoid tumors. (Pitt SC, Davis R, Kunnimalaiyaan M, Chen H) Am J Transl Res 2009;1(3):291-9 PMID 19956439
  • MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype. (Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H) J Surg Res 2010 Jan;158(1):15-9 PMID 19765735
  • Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. (Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H) World J Surg 2009 Nov;33(11):2452-7 PMID 19669229
  • Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells. (Pitt SC, Chen H, Kunnimalaiyaan M) J Am Coll Surg 2009 Jul;209(1):82-8 PMID 19651067
  • Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors. (Pitt SC, Chen H, Kunnimalaiyaan M) Ann Surg Oncol 2009 Oct;16(10):2936-42 PMID 19588205
  • Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies. (Goodell CA, Belisle JA, Gubbels JA, Migneault M, Rancourt C, Connor J, Kunnimalaiyaan M, Kravitz R, Tucker W, Zwick M, Patankar MS) J Ovarian Res 2009;2(1):8 PMID 19538730
  • Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. (Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H) J Surg Res 2010 Apr;159(2):640-4 PMID 19394967
  • Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. (Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H) Mol Cancer Ther 2009 Apr;8(4):914-20 PMID 19372564
  • Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. (Pinchot SN, Adler JT, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H) Am J Surg 2009 Mar;197(3):313-9 PMID 19245907
  • Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells. (Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H) Surgery 2008 Dec;144(6):956-61; discussion 961-2 PMID 19041003
  • Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. (Ning L, Kunnimalaiyaan M, Chen H) Surgery 2008 Dec;144(6):920-4; discussion 924-5 PMID 19040998
  • Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. (Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H) Ann Surg Oncol 2009 Feb;16(2):481-6 PMID 19030935
  • Valproic acid induces Notch1 signaling in small cell lung cancer cells. (Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H) J Surg Res 2008 Jul;148(1):31-7 PMID 18570928
  • Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. (Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H) Ann Surg Oncol 2008 Sep;15(9):2600-5 PMID 18563491
  • Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells. (Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H) Ann Surg 2008 Jun;247(6):1036-40 PMID 18520232
  • Current management of medullary thyroid cancer. (Sippel RS, Kunnimalaiyaan M, Chen H) Oncologist 2008 May;13(5):539-47 PMID 18515739
  • Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors. (Pinchot SN, Pitt SC, Sippel RS, Kunnimalaiyaan M, Chen H) Curr Opin Investig Drugs 2008 Jun;9(6):576-82 PMID 18516757
  • Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. (Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H) Oncologist 2008 Feb;13(2):98-104 PMID 18305053
  • ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. (Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K) J Gastrointest Surg 2008 May;12(5):852-7 PMID 18299943
  • Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. (Kunnimalaiyaan M, Ndiaye M, Chen H) Surgery 2007 Dec;142(6):959-64; discussion 959-64 PMID 18063082
  • Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. (Greenblatt DY, Cayo M, Ning L, Jaskula-Sztul R, Haymart M, Kunnimalaiyaan M, Chen H) J Gastrointest Surg 2007 Nov;11(11):1515-20; discussion 1520 PMID 17874277
  • Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. (Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, Chen H) Oncologist 2007 Aug;12(8):942-51 PMID 17766653
  • The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. (Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H) J Surg Res 2007 Oct;142(2):219-26 PMID 17612559
  • Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. (Kunnimalaiyaan M, Chen H) Oncologist 2007 May;12(5):535-42 PMID 17522241
  • Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. (Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H) Mol Cancer Ther 2007 Mar;6(3):1151-8 PMID 17363508
  • Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion. (Greenblatt DY, Kunnimalaiyaan M, Chen H) Am J Surg 2007 Mar;193(3):331-5; discussion 335 PMID 17320529
  • Lithium ions: a novel treatment for pheochromocytomas and paragangliomas. (Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H) Surgery 2007 Feb;141(2):161-5; discussion 165 PMID 17263970
  • Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells. (Kunnimalaiyaan M, Haymart MR, Chen H) Transl Oncogenomics 2007;2:43-7 PMID 23641144
  • Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. (Kunnimalaiyaan M, Ndiaye M, Chen H) Surgery 2006 Dec;140(6):1009-14; discussion 1014-5 PMID 17188151
  • Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. (Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H) J Biol Chem 2006 Dec 29;281(52):39819-30 PMID 17090547
  • In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer. (Vaccaro A, Chen H, Kunnimalaiyaan M) Anticancer Drugs 2006 Aug;17(7):849-53 PMID 16926634
  • ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. (Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H) J Surg Res 2006 Jun 1;133(1):42-5 PMID 16603190
  • The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? (Kunnimalaiyaan M, Chen H) Anticancer Drugs 2006 Feb;17(2):139-42 PMID 16428931
  • Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells. (Kunnimalaiyaan M, Yan S, Wong F, Zhang YW, Chen H) Surgery 2005 Dec;138(6):1137-42; discussion 1142 PMID 16360401
  • Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. (Kunnimalaiyaan M, Traeger K, Chen H) Am J Physiol Gastrointest Liver Physiol 2005 Oct;289(4):G636-42 PMID 16160079
  • Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1. (Chen H, Kunnimalaiyaan M, Van Gompel JJ) Thyroid 2005 Jun;15(6):511-21 PMID 16029117
  • ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. (Van Gompel JJ, Kunnimalaiyaan M, Holen K, Chen H) Mol Cancer Ther 2005 Jun;4(6):910-7 PMID 15956248
  • Molecular characterization of plasmid pBM300 from Bacillus megaterium QM B1551. (Kunnimalaiyaan M, Vary PS) Appl Environ Microbiol 2005 Jun;71(6):3068-76 PMID 15933003
  • A mouse model of carcinoid syndrome and heart disease. (Musunuru S, Carpenter JE, Sippel RS, Kunnimalaiyaan M, Chen H) J Surg Res 2005 Jun 1;126(1):102-5 PMID 15916982
  • Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. (Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW) J Clin Endocrinol Metab 2005 Jul;90(7):4350-6 PMID 15870121
  • The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. (Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H) Surgery 2003 Dec;134(6):866-71; discussion 871-3 PMID 14668716
  • Sequencing and characterization of pBM400 from Bacillus megaterium QM B1551. (Scholle MD, White CA, Kunnimalaiyaan M, Vary PS) Appl Environ Microbiol 2003 Nov;69(11):6888-98 PMID 14602653
  • Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. (Sippel RS, Carpenter JE, Kunnimalaiyaan M, Lagerholm S, Chen H) Am J Physiol Gastrointest Liver Physiol 2003 Aug;285(2):G245-54 PMID 12851216
  • Analysis of the replicon region and identification of an rRNA operon on pBM400 of Bacillus megaterium QM B1551. (Kunnimalaiyaan M, Stevenson DM, Zhou Y, Vary PS) Mol Microbiol 2001 Feb;39(4):1010-21 PMID 11251820
  • In vitro replication of mitochondrial plasmid mp1 from the higher plant Chenopodium album (L.): a remnant of bacterial rolling circle and conjugative plasmids? (Backert S, Kunnimalaiyaan M, Börner T, Nielsen BL) J Mol Biol 1998 Dec 11;284(4):1005-15 PMID 9837722
  • Characterization of a theta plasmid replicon with homology to all four large plasmids of Bacillus megaterium QM B1551. (Stevenson DM, Kunnimalaiyaan M, Müller K, Vary PS) Plasmid 1998 Nov;40(3):175-89 PMID 9806855
  • Fine mapping of replication origins (ori A and ori B) in Nicotiana tabacum chloroplast DNA. (Kunnimalaiyaan M, Nielsen BL) Nucleic Acids Res 1997 Sep 15;25(18):3681-6 PMID 9278490
  • Analysis of the tobacco chloroplast DNA replication origin (oriB) downstream of the 23 S rRNA gene. (Kunnimalaiyaan M, Shi F, Nielsen BL) J Mol Biol 1997 May 2;268(2):273-83 PMID 9159470
  • Characterization of replication origins flanking the 23S rRNA gene in tobacco chloroplast DNA. (Lu Z, Kunnimalaiyaan M, Nielsen BL) Plant Mol Biol 1996 Nov;32(4):693-706 PMID 8980521
  • Molecular characterization of the Azotobacter vinelandii recF gene. (Badran H, Venkatesh TV, Kunnimalaiyaan M, Sharma N, Das HK) Gene 1995 Aug 30;162(1):47-51 PMID 7557415
  • Genes for E1, E2, and E3 small nucleolar RNAs. (Nag MK, Thai TT, Ruff EA, Selvamurugan N, Kunnimalaiyaan M, Eliceiri GL) Proc Natl Acad Sci U S A 1993 Oct 1;90(19):9001-5 PMID 8415643
  • Integration ofhup cosmid pHU52 into the chromosomal DNA ofCicer-Rhizobium using Tn5 as an homologous sequence. (Kunnimalaiyaan M, Lodha ML, Sreekumar KR) World J Microbiol Biotechnol 1992 Nov;8(6):567-72 PMID 24425601
  • Grants and Awards

  • Chemoprevention of Liver cancer by Xanthohumol (#9306300 12/16/2013 - 12/15/2014) Sponsor: Research Affairs Committee
  • Pilot Studies on Notch3 and Hepatocellular Carcinoma (#9306234 10/01/2013 - 09/30/2014) Sponsor: Digestive Disease Center
  • Signaling Based Therapy for Hepatocellular Carcinoma (#9208245 10/01/2013 - 06/30/2014) Sponsor: Froedtert Hospital Foundation
  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 04/30/2015) PI of Interactions of GSK-3 and Notch Proteins in Pancreatic Cancer (#2208249)
  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 04/30/2015) PI of Interactions of GSK-3 and Notch Proteins in Pancreatic Cancer (#2208249)