Medical College of Wisconsin
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Nancy Wandersee PhD

Nancy Wandersee PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology


Research Experience

  • Cerebrovascular Trauma
  • Elliptocytosis, Hereditary
  • Hemoglobin, Sickle
  • Hemolysis
  • Spherocytosis, Hereditary
  • Thrombosis
  • Publications

  • A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. (Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H328-36 PMID 23125208
  • Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. (Hillery CA, Kerstein PC, Vilceanu D, Barabas ME, Retherford D, Brandow AM, Wandersee NJ, Stucky CL) Blood 2011 Sep 22;118(12):3376-83 PMID 21708890
  • The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. (Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE Jr) Blood 2011 Aug 11;118(6):1641-52 PMID 21566095
  • Ca2+-CaM activation of AMP deaminase contributes to adenine nucleotide dysregulation and phosphatidylserine externalization in human sickle erythrocytes. (Sabina RL, Wandersee NJ, Hillery CA) Br J Haematol 2009 Feb;144(3):434-45 PMID 19036100
  • Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. (Campanella ME, Chu H, Wandersee NJ, Peters LL, Mohandas N, Gilligan DM, Low PS) Blood 2008 Nov 1;112(9):3900-6 PMID 18698006
  • Vascular dysfunction in a murine model of severe hemolysis. (Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ) Blood 2008 Jul 15;112(2):398-405 PMID 18477769
  • Erythrocyte adhesion is modified by alterations in cellular tonicity and volume. (Wandersee NJ, Punzalan RC, Rettig MP, Kennedy MD, Pajewski NM, Sabina RL, Paul Scott J, Low PS, Hillery CA) Br J Haematol 2005 Nov;131(3):366-77 PMID 16225657
  • Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis. (Wandersee NJ, Olson SC, Holzhauer SL, Hoffmann RG, Barker JE, Hillery CA) Blood 2004 Jan 15;103(2):710-6 PMID 12947004
  • Mutations in the murine erythroid alpha-spectrin gene alter spectrin mRNA and protein levels and spectrin incorporation into the red blood cell membrane skeleton. (Wandersee NJ, Birkenmeier CS, Bodine DM, Mohandas N, Barker JE) Blood 2003 Jan 1;101(1):325-30 PMID 12393645
  • Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene. (Wandersee NJ, Birkenmeier CS, Gifford EJ, Mohandas N, Barker JE) Hematol J 2000;1(4):235-42 PMID 11920196
  • Reduced incidence of thrombosis in mice with hereditary spherocytosis following neonatal treatment with normal hematopoietic cells. (Wandersee NJ, Lee JC, Deveau SA, Barker JE) Blood 2001 Jun 15;97(12):3972-5 PMID 11389042
  • Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis. (Wandersee NJ, Roesch AN, Hamblen NR, de Moes J, van der Valk MA, Bronson RT, Gimm JA, Mohandas N, Demant P, Barker JE) Blood 2001 Jan 15;97(2):543-50 PMID 11154235
  • Amelioration of severe hereditary spherocytosis in nonablated adult mice by marrow transplantation. (Barker JE, Deveau S, Wandersee NJ) Exp Hematol 2000 Aug;28(8):985-92 PMID 10989199
  • Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia. (Wandersee NJ, Tait JF, Barker JE) Blood Cells Mol Dis 2000 Feb;26(1):75-83 PMID 10772878
  • Thrombosis in heritable hemolytic disorders. (Barker JE, Wandersee NJ) Curr Opin Hematol 1999 Mar;6(2):71-5 PMID 10088635
  • Hematopoietic cells from -spectrin-deficient mice are sufficient to induce thrombotic events in hematopoietically ablated recipients. (Wandersee NJ, Lee JC, Kaysser TM, Bronson RT, Barker JE) Blood 1998 Dec 15;92(12):4856-63 PMID 9845553
  • Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. (Kaysser TM, Wandersee NJ, Bronson RT, Barker JE) Blood 1997 Dec 1;90(11):4610-9 PMID 9373273
  • Intronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene. (Wandersee NJ, Ferris RC, Ginder GD) Mol Cell Biol 1996 Jan;16(1):236-46 PMID 8524301
  • 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. (Glauber JG, Wandersee NJ, Little JA, Ginder GD) Mol Cell Biol 1991 Sep;11(9):4690-7 PMID 1875947