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Neil Hogg PhD

Neil Hogg PhD

Assistant Dean, Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Administration

Member of the MCW Cancer Center

I am willing to mentor a junior faculty member.


Research Experience

  • Anemia, Sickle Cell
  • Nitric Oxide
  • Nitric Oxide Donors
  • Nitric Oxide Synthase
  • Oxidative Stress
  • Peroxynitrous Acid
  • Reactive Nitrogen Species
  • S-Nitroso-N-Acetylpenicillamine
  • S-Nitrosoglutathione
  • Methodologies and Techniques

  • Electron Spin Resonance Spectroscopy
  • Nitric Oxide
  • Reactive Nitrogen Species
  • Leadership Positions

  • Director, Biophysics Graduate Program
  • Director, Redox Biology Program
  • Assistant Dean for Recruitment, Graduate School
  • Publications

  • Circulating membrane-derived microvesicles in redox biology. (Larson MC, Hillery CA, Hogg N) Free Radic Biol Med 2014 Aug;73C:214-228 PMID 24751526
  • S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells. (Diers AR, Broniowska KA, Chang CF, Hill RB, Hogg N) Free Radic Biol Med 2014 Apr;69:229-38 PMID 24486553
  • Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells. (Diers AR, Broniowska KA, Hogg N) Redox Biol 2013;1(1):1-7 PMID 24024132
  • Detection of S-nitrosothiols. (Diers AR, Keszler A, Hogg N) Biochim Biophys Acta 2014 Feb;1840(2):892-900 PMID 23988402
  • Nitric oxide expands scope to cover hydrogen sulfide and carbon monoxide. (Hogg N) Nitric Oxide 2013 Nov 30;35:1 PMID 23769947
  • Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. (Broniowska KA, Diers AR, Corbett JA, Hogg N) Biochemistry 2013 Jun 25;52(25):4364-72 PMID 23718265
  • S-nitrosoglutathione. (Broniowska KA, Diers AR, Hogg N) Biochim Biophys Acta 2013 May;1830(5):3173-81 PMID 23416062
  • LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation. (Menden H, Tate E, Hogg N, Sampath V) Am J Physiol Lung Cell Mol Physiol 2013 Mar 15;304(6):L445-55 PMID 23333803
  • Calcium-phosphate microprecipitates mimic microparticles when examined with flow cytometry. (Larson MC, Luthi MR, Hogg N, Hillery CA) Cytometry A 2013 Feb;83(2):242-50 PMID 23125136
  • A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. (Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H328-36 PMID 23125208
  • Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. (Cortese-Krott MM, Rodriguez-Mateos A, Sansone R, Kuhnle GG, Thasian-Sivarajah S, Krenz T, Horn P, Krisp C, Wolters D, Heiß C, Kröncke KD, Hogg N, Feelisch M, Kelm M) Blood 2012 Nov 15;120(20):4229-37 PMID 23007404
  • Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin. (Tejero J, Basu S, Helms C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT) J Biol Chem 2012 May 25;287(22):18262-74 PMID 22493289
  • The chemical biology of S-nitrosothiols. (Broniowska KA, Hogg N) Antioxid Redox Signal 2012 Oct 1;17(7):969-80 PMID 22468855
  • Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition. (Diers AR, Broniowska KA, Chang CF, Hogg N) Biochem J 2012 Jun 15;444(3):561-71 PMID 22458763
  • Cytochrome c-mediated formation of S-nitrosothiol in cells. (Broniowska KA, Keszler A, Basu S, Kim-Shapiro DB, Hogg N) Biochem J 2012 Feb 15;442(1):191-7 PMID 22070099
  • Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells. (Diers AR, Broniowska KA, Darley-Usmar VM, Hogg N) Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H803-12 PMID 21685262
  • Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. (Hanson MS, Piknova B, Keszler A, Diers AR, Wang X, Gladwin MT, Hillery CA, Hogg N) Br J Haematol 2011 Aug;154(4):502-11 PMID 21595649
  • The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress. (Ahmed MN, Codipilly C, Hogg N, Auten RL) Exp Lung Res 2011 Feb;37(1):10-7 PMID 21077778
  • The potential role of the red blood cell in nitrite-dependent regulation of blood flow. (Patel RP, Hogg N, Kim-Shapiro DB) Cardiovasc Res 2011 Feb 15;89(3):507-15 PMID 20952416
  • Differential mechanisms of inhibition of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosothiols and NO in cellular and cell-free conditions. (Broniowska KA, Hogg N) Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1212-9 PMID 20675567
  • Detection of nitric oxide by electron paramagnetic resonance spectroscopy. (Hogg N) Free Radic Biol Med 2010 Jul 15;49(2):122-9 PMID 20304044
  • An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin. (Goetz BI, Shields HW, Basu S, Wang P, King SB, Hogg N, Gladwin MT, Kim-Shapiro DB) Nitric Oxide 2010 Feb 15;22(2):149-54 PMID 19895897
  • A novel role for cytochrome c: Efficient catalysis of S-nitrosothiol formation. (Basu S, Keszler A, Azarova NA, Nwanze N, Perlegas A, Shiva S, Broniowska KA, Hogg N, Kim-Shapiro DB) Free Radic Biol Med 2010 Jan 15;48(2):255-63 PMID 19879353
  • Reaction between nitric oxide, glutathione, and oxygen in the presence and absence of protein: How are S-nitrosothiols formed? (Keszler A, Zhang Y, Hogg N) Free Radic Biol Med 2010 Jan 1;48(1):55-64 PMID 19819329
  • Decreased S-nitrosation of peptide thiols in the membrane interior. (Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, Kalyanaraman B) Free Radic Biol Med 2009 Oct 1;47(7):962-8 PMID 19573593
  • Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L. (Riego JA, Broniowska KA, Kettenhofen NJ, Hogg N) Free Radic Biol Med 2009 Aug 1;47(3):269-74 PMID 19409484
  • Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. (Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N) J Mol Cell Cardiol 2009 Aug;47(2):256-63 PMID 19328206
  • Nitrite as regulator of hypoxic signaling in mammalian physiology. (van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A, Slama-Schwok A, Shiva S, Vanin AF, Weitzberg E, Zweier J, Gladwin MT) Med Res Rev 2009 Sep;29(5):683-741 PMID 19219851
  • Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia. (Sampath V, Radish AC, Eis AL, Broniowska K, Hogg N, Konduri GG) Free Radic Biol Med 2009 Mar 1;46(5):663-71 PMID 19135525
  • The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. (Piknova B, Keszler A, Hogg N, Schechter AN) Nitric Oxide 2009 Mar;20(2):88-94 PMID 19010434
  • Nitrite reductase activity of cytochrome c. (Basu S, Azarova NA, Font MD, King SB, Hogg N, Gladwin MT, Shiva S, Kim-Shapiro DB) J Biol Chem 2008 Nov 21;283(47):32590-7 PMID 18820338
  • In-gel detection of S-nitrosated proteins using fluorescence methods. (Kettenhofen NJ, Wang X, Gladwin MT, Hogg N) Methods Enzymol 2008;441:53-71 PMID 18554529
  • Vascular dysfunction in a murine model of severe hemolysis. (Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ) Blood 2008 Jul 15;112(2):398-405 PMID 18477769
  • Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins. (Wang X, Kettenhofen NJ, Shiva S, Hogg N, Gladwin MT) Free Radic Biol Med 2008 Apr 1;44(7):1362-72 PMID 18211831
  • The reaction between nitrite and oxyhemoglobin: a mechanistic study. (Keszler A, Piknova B, Schechter AN, Hogg N) J Biol Chem 2008 Apr 11;283(15):9615-22 PMID 18203719
  • Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. (Basu S, Grubina R, Huang J, Conradie J, Huang Z, Jeffers A, Jiang A, He X, Azarov I, Seibert R, Mehta A, Patel R, King SB, Hogg N, Ghosh A, Gladwin MT, Kim-Shapiro DB) Nat Chem Biol 2007 Dec;3(12):785-94 PMID 17982448
  • An electron paramagnetic resonance investigation of the oxygen dependence of the arterial-venous gradient of nitrosyl hemoglobin in blood circulation. (Jiang J, Corbett J, Hogg N, Mason RP) Free Radic Biol Med 2007 Oct 15;43(8):1208-15 PMID 17854716
  • Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. (Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N) J Mol Cell Cardiol 2007 Oct;43(4):437-44 PMID 17765919
  • Role of S-nitrosothiol transport in the cardioprotective effects of S-nitrosocysteine in rat hearts. (Hogg N, Broniowska KA, Novalija J, Kettenhofen NJ, Novalija E) Free Radic Biol Med 2007 Oct 1;43(7):1086-94 PMID 17761304
  • Red meat and colon cancer: heme proteins and nitrite in the gut. A commentary on "diet-induced endogenous formation of nitroso compounds in the GI tract". (Hogg N) Free Radic Biol Med 2007 Oct 1;43(7):1037-9 PMID 17761299
  • Proteomic methods for analysis of S-nitrosation. (Kettenhofen NJ, Broniowska KA, Keszler A, Zhang Y, Hogg N) J Chromatogr B Analyt Technol Biomed Life Sci 2007 May 15;851(1-2):152-9 PMID 17360249
  • Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. (Grubina R, Huang Z, Shiva S, Joshi MS, Azarov I, Basu S, Ringwood LA, Jiang A, Hogg N, Kim-Shapiro DB, Gladwin MT) J Biol Chem 2007 Apr 27;282(17):12916-27 PMID 17322300
  • Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. (Shiva S, Wang X, Ringwood LA, Xu X, Yuditskaya S, Annavajjhala V, Miyajima H, Hogg N, Harris ZL, Gladwin MT) Nat Chem Biol 2006 Sep;2(9):486-93 PMID 16906150
  • Requirement of transmembrane transport for S-nitrosocysteine-dependent modification of intracellular thiols. (Broniowska KA, Zhang Y, Hogg N) J Biol Chem 2006 Nov 10;281(45):33835-41 PMID 16893892
  • Methodological vexation about thiol oxidation versus S-nitrosation -- a commentary on "An ascorbate-dependent artifact that interferes with the interpretation of the biotin-switch assay". (Gladwin MT, Wang X, Hogg N) Free Radic Biol Med 2006 Aug 15;41(4):557-61 PMID 16863988
  • Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. (Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, Patel RP) Am J Physiol Heart Circ Physiol 2006 Nov;291(5):H2026-35 PMID 16798825
  • Immuno-spin trapping of hemoglobin and myoglobin radicals derived from nitrite-mediated oxidation. (Keszler A, Mason RP, Hogg N) Free Radic Biol Med 2006 Feb 1;40(3):507-15 PMID 16443166
  • The emerging biology of the nitrite anion. (Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR Jr, Feelisch M, Lundberg JO) Nat Chem Biol 2005 Nov;1(6):308-14 PMID 16408064
  • Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation. (Azarov I, Huang KT, Basu S, Gladwin MT, Hogg N, Kim-Shapiro DB) J Biol Chem 2005 Nov 25;280(47):39024-32 PMID 16186121
  • Electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during NO inhalation. (Piknova B, Gladwin MT, Schechter AN, Hogg N) J Biol Chem 2005 Dec 9;280(49):40583-8 PMID 16183646
  • Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. (Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, Huang KT, Ho C, Hogg N, Schechter AN, Gladwin MT) J Clin Invest 2005 Aug;115(8):2099-107 PMID 16041407
  • Hemoglobin mediated nitrite activation of soluble guanylyl cyclase. (Jeffers A, Xu X, Huang KT, Cho M, Hogg N, Patel RP, Kim-Shapiro DB) Comp Biochem Physiol A Mol Integr Physiol 2005 Oct;142(2):130-5 PMID 15936233
  • Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. (Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ) J Clin Invest 2005 May;115(5):1232-40 PMID 15841216
  • The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry. (Huang KT, Keszler A, Patel N, Patel RP, Gladwin MT, Kim-Shapiro DB, Hogg N) J Biol Chem 2005 Sep 2;280(35):31126-31 PMID 15837788
  • Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. (Schopfer FJ, Baker PR, Giles G, Chumley P, Batthyany C, Crawford J, Patel RP, Hogg N, Branchaud BP, Lancaster JR Jr, Freeman BA) J Biol Chem 2005 May 13;280(19):19289-97 PMID 15764811
  • Characterization and application of the biotin-switch assay for the identification of S-nitrosated proteins. (Zhang Y, Keszler A, Broniowska KA, Hogg N) Free Radic Biol Med 2005 Apr 1;38(7):874-81 PMID 15749383
  • S-Nitrosothiols: cellular formation and transport. (Zhang Y, Hogg N) Free Radic Biol Med 2005 Apr 1;38(7):831-8 PMID 15749378
  • The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. (Kim-Shapiro DB, Gladwin MT, Patel RP, Hogg N) J Inorg Biochem 2005 Jan;99(1):237-46 PMID 15598504
  • Antioxidant defense responses to sleep loss and sleep recovery. (Everson CA, Laatsch CD, Hogg N) Am J Physiol Regul Integr Comp Physiol 2005 Feb;288(2):R374-83 PMID 15472007
  • Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID 15388508
  • How do red blood cells dilate blood vessels?--Reply. (Kim-Shapiro DB, Patel RP, Schechter AN, Gladwin MT, Cannon RO 3rd, Hogg N) Circ Res 2004 Aug 6;95(3):e10 PMID 15297387
  • Biological activity of nitric oxide in the plasmatic compartment. (Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT) Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11477-82 PMID 15258287
  • Impact of pulmonary arterial endothelial cells on duroquinone redox status. (Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH) Free Radic Biol Med 2004 Jul 1;37(1):86-103 PMID 15183197
  • Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease. (Crawford JH, Chacko BK, Pruitt HM, Piknova B, Hogg N, Patel RP) Blood 2004 Sep 1;104(5):1375-82 PMID 15150083
  • The mechanism of transmembrane S-nitrosothiol transport. (Zhang Y, Hogg N) Proc Natl Acad Sci U S A 2004 May 25;101(21):7891-6 PMID 15148403
  • S-nitrosohemoglobin: a biochemical perspective. (Zhang Y, Hogg N) Free Radic Biol Med 2004 Apr 15;36(8):947-58 PMID 15059635
  • Formation and stability of S-nitrosothiols in RAW 264.7 cells. (Zhang Y, Hogg N) Am J Physiol Lung Cell Mol Physiol 2004 Sep;287(3):L467-74 PMID 14672925
  • Oxidation and nitrosylation of oxyhemoglobin by S-nitrosoglutathione via nitroxyl anion. (Spencer NY, Patel NK, Keszler A, Hogg N) Free Radic Biol Med 2003 Dec 1;35(11):1515-26 PMID 14642399
  • Ischemic preconditioning: triggering role of nitric oxide-derived oxidants in isolated hearts. (Novalija E, Hogg N, Kevin LG, Camara AK, Stowe DF) J Cardiovasc Pharmacol 2003 Nov;42(5):593-600 PMID 14576506
  • Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. (Keszler A, Kalyanaraman B, Hogg N) Free Radic Biol Med 2003 Nov 1;35(9):1149-57 PMID 14572617
  • Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation. (Xu X, Cho M, Spencer NY, Patel N, Huang Z, Shields H, King SB, Gladwin MT, Hogg N, Kim-Shapiro DB) Proc Natl Acad Sci U S A 2003 Sep 30;100(20):11303-8 PMID 14500899
  • Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. (Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP) Free Radic Biol Med 2003 Apr 1;34(7):892-907 PMID 12654478
  • Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications. (Zhang H, Bhargava K, Keszler A, Feix J, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 2003 Mar 14;278(11):8969-78 PMID 12519728
  • Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. (Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO 3rd, Schechter AN, Gladwin MT) Nat Med 2002 Dec;8(12):1383-9 PMID 12426562
  • Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts. (Novalija E, Varadarajan SG, Camara AK, An J, Chen Q, Riess ML, Hogg N, Stowe DF) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H44-52 PMID 12063273
  • Mixing artifacts from the bolus addition of nitric oxide to oxymyoglobin: implications for S-nitrosothiol formation. (Zhang Y, Hogg N) Free Radic Biol Med 2002 Jun 1;32(11):1212-9 PMID 12031905
  • The biochemistry and physiology of S-nitrosothiols. (Hogg N) Annu Rev Pharmacol Toxicol 2002;42:585-600 PMID 11807184
  • Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. (Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B, Parks DA, Barnes S, Darley-Usmar V) Free Radic Biol Med 2001 Dec 15;31(12):1570-81 PMID 11744331
  • Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. (Vásquez-Vivar J, Whitsett J, Martásek P, Hogg N, Kalyanaraman B) Free Radic Biol Med 2001 Oct 15;31(8):975-85 PMID 11595382
  • Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution. (Zhang H, Joseph J, Feix J, Hogg N, Kalyanaraman B) Biochemistry 2001 Jun 26;40(25):7675-86 PMID 11412121
  • Metabolism of S-nitrosoglutathione by endothelial cells. (Zeng H, Spencer NY, Hogg N) Am J Physiol Heart Circ Physiol 2001 Jul;281(1):H432-9 PMID 11406512
  • Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. (Kotamraju S, Hogg N, Joseph J, Keefer LK, Kalyanaraman B) J Biol Chem 2001 May 18;276(20):17316-23 PMID 11278975
  • Reaction of S-nitrosoglutathione with the heme group of deoxyhemoglobin. (Spencer NY, Zeng H, Patel RP, Hogg N) J Biol Chem 2000 Nov 24;275(47):36562-7 PMID 10945989
  • Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation. (Konorev EA, Kalyanaraman B, Hogg N) Free Radic Biol Med 2000 Jun 1;28(11):1671-8 PMID 10938464
  • Biological chemistry and clinical potential of S-nitrosothiols. (Hogg N) Free Radic Biol Med 2000 May 15;28(10):1478-86 PMID 10927172
  • The use of NO gas in biological systems. (Hogg N, Kalyanaraman B) Methods Mol Biol 1998;100:231-6 PMID 10907008
  • Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):607-17 PMID 10630684
  • Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications. (Goss SP, Singh RJ, Hogg N, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):597-606 PMID 10630683
  • Mechanism of superoxide dismutase/H(2)O(2)-mediated nitric oxide release from S-nitrosoglutathione--role of glutamate. (Singh RJ, Hogg N, Goss SP, Antholine WE, Kalyanaraman B) Arch Biochem Biophys 1999 Dec 1;372(1):8-15 PMID 10562411
  • Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B) J Biol Chem 1999 Sep 17;274(38):26736-42 PMID 10480877
  • The effect of cyst(e)ine on the auto-oxidation of homocysteine. (Hogg N) Free Radic Biol Med 1999 Jul;27(1-2):28-33 PMID 10443916
  • The kinetics of S-transnitrosation--a reversible second-order reaction. (Hogg N) Anal Biochem 1999 Aug 1;272(2):257-62 PMID 10415097
  • Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. (Patel RP, Hogg N, Spencer NY, Kalyanaraman B, Matalon S, Darley-Usmar VM) J Biol Chem 1999 May 28;274(22):15487-92 PMID 10336440
  • Nitric oxide and lipid peroxidation. (Hogg N, Kalyanaraman B) Biochim Biophys Acta 1999 May 5;1411(2-3):378-84 PMID 10320670
  • Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. (Ferguson E, Hogg N, Antholine WE, Joseph J, Singh RJ, Parthasarathy S, Kalyanaraman B) Free Radic Biol Med 1999 Apr;26(7-8):968-77 PMID 10232841
  • Free radicals in disease. (Hogg N) Semin Reprod Endocrinol 1998;16(4):241-8 PMID 10101806
  • The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. (Goss SP, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1999 Mar 15;363(2):333-40 PMID 10068456
  • Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. (Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B) Methods Enzymol 1999;301:169-77 PMID 9919565
  • Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. (Goss SP, Kalyanaraman B, Hogg N) Methods Enzymol 1999;301:444-53 PMID 9919593
  • The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. (Singh RJ, Hogg N, Joseph J, Konorev E, Kalyanaraman B) Arch Biochem Biophys 1999 Jan 15;361(2):331-9 PMID 9882464
  • Nitric oxide and low-density lipoprotein oxidation. (Hogg N, Kalyanaraman B) Free Radic Res 1998 Jun;28(6):593-600 PMID 9736311
  • Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. (Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr) Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9220-5 PMID 9689061
  • Rapid and irreversible inhibition of creatine kinase by peroxynitrite. (Konorev EA, Hogg N, Kalyanaraman B) FEBS Lett 1998 May 8;427(2):171-4 PMID 9607305
  • Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. (Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3469-74 PMID 9437194
  • Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol. (O'Donnell VB, Chumley PH, Hogg N, Bloodsworth A, Darley-Usmar VM, Freeman BA) Biochemistry 1997 Dec 9;36(49):15216-23 PMID 9398249
  • Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. (Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B) Biochemistry 1997 Sep 23;36(38):11293-7 PMID 9333325
  • The effect of nitric oxide release rates on the oxidation of human low density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) J Biol Chem 1997 Aug 22;272(34):21647-53 PMID 9261188
  • The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein. (Ferguson E, Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1997 May 15;341(2):287-94 PMID 9169017
  • S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. (Hogg N, Singh RJ, Konorev E, Joseph J, Kalyanaraman B) Biochem J 1997 Apr 15;323 ( Pt 2):477-81 PMID 9163341
  • Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. (Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B) FEBS Lett 1997 Feb 17;403(2):127-30 PMID 9042951
  • Mechanism of nitric oxide release from S-nitrosothiols. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 1996 Aug 2;271(31):18596-603 PMID 8702510
  • The reaction between nitric oxide and alpha-tocopherol: a reappraisal. (Hogg N, Singh RJ, Goss SP, Kalyanaraman B) Biochem Biophys Res Commun 1996 Jul 25;224(3):696-702 PMID 8713109
  • Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study. (Karoui H, Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1996 Jun 1;330(1):115-24 PMID 8651684
  • The role of glutathione in the transport and catabolism of nitric oxide. (Hogg N, Singh RJ, Kalyanaraman B) FEBS Lett 1996 Mar 18;382(3):223-8 PMID 8605974
  • Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. (Karoui H, Hogg N, Fréjaville C, Tordo P, Kalyanaraman B) J Biol Chem 1996 Mar 15;271(11):6000-9 PMID 8626383
  • Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. (Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Dec 20;324(2):367-73 PMID 8554328
  • Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors. (Hogg N, Struck A, Goss SP, Santanam N, Joseph J, Parthasarathy S, Kalyanaraman B) J Lipid Res 1995 Aug;36(8):1756-62 PMID 7595096
  • The antioxidant effect of spermine NONOate in human low-density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) Chem Res Toxicol 1995 Jul-Aug;8(5):800-6 PMID 7548764
  • Spin-labeling study of the oxidative damage to low-density lipoprotein. (Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Jun 20;320(1):155-61 PMID 7793976
  • Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. (Kalyanaraman B, Darley-Usmar V, Struck A, Hogg N, Parthasarathy S) J Lipid Res 1995 May;36(5):1037-45 PMID 7658151
  • Trapping of nitric oxide formed during photolysis of sodium nitroprusside in aqueous and lipid phases: an electron spin resonance study. (Singh RJ, Hogg N, Neese F, Joseph J, Kalyanaraman B) Photochem Photobiol 1995 Apr;61(4):325-30 PMID 7740075
  • Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells. (Struck AT, Hogg N, Thomas JP, Kalyanaraman B) FEBS Lett 1995 Mar 20;361(2-3):291-4 PMID 7698340
  • Photosensitized decomposition of S-nitrosothiols and 2-methyl-2-nitrosopropane. Possible use for site-directed nitric oxide production. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) FEBS Lett 1995 Feb 20;360(1):47-51 PMID 7875299
  • Reactions of nitric oxide with nitronyl nitroxides and oxygen: prediction of nitrite and nitrate formation by kinetic simulation. (Hogg N, Singh RJ, Joseph J, Neese F, Kalyanaraman B) Free Radic Res 1995 Jan;22(1):47-56 PMID 7889147
  • Physical and chemical interactions between nitric oxide and nitroxides. (Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B) Biochim Biophys Acta 1994 Dec 15;1201(3):437-41 PMID 7803474
  • The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDL. (Hogg N, Rice-Evans C, Darley-Usmar V, Wilson MT, Paganga G, Bourne L) Arch Biochem Biophys 1994 Oct;314(1):39-44 PMID 7944405
  • The oxidation of alpha-tocopherol and trolox by peroxynitrite. (Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1994 Oct;314(1):153-8 PMID 7944387
  • The oxidation of cytochrome-c oxidase vesicles by hemoglobin. (Sarti P, Hogg N, Darley-Usmar VM, Sanna MT, Wilson MT) Biochim Biophys Acta 1994 Sep 21;1208(1):38-44 PMID 8086437
  • Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. (Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S) FEBS Lett 1993 Nov 15;334(2):170-4 PMID 8224243
  • Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. (Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S) FEBS Lett 1993 Sep 13;330(2):181-5 PMID 8365489
  • The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide. (Hogg N, Darley-Usmar VM, Wilson MT, Moncada S) FEBS Lett 1993 Jul 12;326(1-3):199-203 PMID 8391994
  • Peroxynitrite and atherosclerosis. (Hogg N, Darley-Usmar VM, Graham A, Moncada S) Biochem Soc Trans 1993 May;21(2):358-62 PMID 8359496
  • Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. (Hogg N, Darley-Usmar VM, Wilson MT, Moncada S) Biochem J 1992 Jan 15;281 ( Pt 2):419-24 PMID 1310595
  • The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. (Darley-Usmar VM, Hogg N, O'Leary VJ, Wilson MT, Moncada S) Free Radic Res Commun 1992;17(1):9-20 PMID 1332919
  • Reactions of reduced cellobiose oxidase with oxygen. Is cellobiose oxidase primarily an oxidase? (Wilson MT, Hogg N, Jones GD) Biochem J 1990 Aug 15;270(1):265-7 PMID 2396987
  • Grants and Awards

  • Development of Redox Biology Program at the Medical College of Wisconsin (#9520214 11/01/2011 - 06/30/2017) Sponsor: AHW-Research and Education Program
  • Hemolysis, Lipid Oxidation and Vascular Dysfunction in Sickle Cell Disease (#9205026 04/01/2008 - 07/03/2012) Sponsor: NIH Heart Lung and Blood Institute
  • Effects of Nitric Oxide in Sickle Cell Blood (#9207644 05/01/2012 - 04/30/2017) Sponsor: Wake Forest University
  • Mechanism if Metabolism of S-Nitrosothiols (#9202284 12/01/2001 - 11/30/2006) Sponsor: NIH General Medical Sciences
  • Nitric Oxide: A Modulator of Bioenergetics in Breast Cancer (#9305736 07/01/2012 - 06/30/2014) Sponsor: Cancer Center
  • Careers in Industry: Real World Training For PhD Scientists (#9207589 07/01/2012 - 06/30/2014) Sponsor: Burroughs Wellcome
  • Mechanism of Metabolism of S-Nitrosothiols (#9204557 05/01/2007 - 04/30/2012) Sponsor: NIH General Medical Sciences