Medical College of Wisconsin
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Parvaneh Rafiee PhD

Parvaneh Rafiee PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Colorectal Surgery
Program: Colorectal Surgery

Member of the Cancer Center


Publications

  • Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Schmidt J, Mackinnon A, Venu N, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Apr 1;306(7):G557-74 PMID 24481601
  • Glycosaminoglycan entrapment by fibrin in engineered heart valve tissues. (Alfonso AR, Rath S, Rafiee P, Hernandez-Espino M, Din M, George F, Ramaswamy S) Acta Biomater 2013 Sep;9(9):8149-57 PMID 23791855
  • Response. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Nov;26(11):4388-9 PMID 23118151
  • EUK-207 protects human intestinal microvascular endothelial cells (HIMEC) against irradiation-induced apoptosis through the Bcl2 pathway. (Otterson MF, Nie L, Schmidt JL, Link BJ, Jovanovic N, Lyros O, Rafiee P) Life Sci 2012 Oct 22;91(15-16):771-82 PMID 22940617
  • Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID 22247331
  • Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. (Rafiee P, Binion DG, Wellner M, Behmaram B, Floer M, Mitton E, Nie L, Zhang Z, Otterson MF) Am J Physiol Gastrointest Liver Physiol 2010 Jun;298(6):G865-77 PMID 20299603
  • Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC). (Rafiee P, Stein DJ, Nelson VM, Otterson MF, Shaker R, Binion DG) Am J Physiol Gastrointest Liver Physiol 2010 Feb;298(2):G167-76 PMID 19926820
  • Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. (Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2009 Aug;297(2):G259-68 PMID 19520742
  • Intramucosal distribution of WNT signaling components in human esophagus. (Ali I, Rafiee P, Zheng Y, Johnson C, Banerjee B, Haasler G, Jacob H, Shaker R) J Clin Gastroenterol 2009 Apr;43(4):327-37 PMID 19309775
  • Is inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease. (Binion DG, Rafiee P) Gastroenterology 2009 Feb;136(2):400-3 PMID 19111728
  • Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. (Rafiee P, Nelson VM, Manley S, Wellner M, Floer M, Binion DG, Shaker R) Am J Physiol Gastrointest Liver Physiol 2009 Feb;296(2):G388-98 PMID 19074641
  • Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn's disease stricture formation. (Floer M, Binion DG, Nelson VM, Manley S, Wellner M, Sadeghi S, Behmaram B, Sewell C, Otterson MF, Kucharzik T, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2008 Sep;295(3):G581-90 PMID 18635600
  • Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. (Binion DG, Otterson MF, Rafiee P) Gut 2008 Nov;57(11):1509-17 PMID 18596194
  • Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID 18006466
  • Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. (Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, Andrekopoulos C, Kalyanaraman B, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1323-36 PMID 17218473
  • Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls. (Ali I, Rafiee P, Hogan WJ, Jacob HJ, Komorowski RA, Haasler GB, Shaker R) Am J Gastroenterol 2006 Jul;101(7):1437-48 PMID 16863544
  • Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27. (Rafiee P, Theriot ME, Nelson VM, Heidemann J, Kanaa Y, Horowitz SA, Rogaczewski A, Johnson CP, Ali I, Shaker R, Binion DG) Am J Physiol Cell Physiol 2006 Nov;291(5):C931-45 PMID 16790501
  • Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium. (Heidemann J, Maaser C, Lügering A, Spahn TW, Zimmer KP, Herbst H, Rafiee P, Domschke W, Krieglstein CF, Binion DG, Kucharzik TF) Int J Oncol 2006 Jan;28(1):77-85 PMID 16327982
  • Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID 15808839
  • Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID 15611843
  • Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. (Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P) Am J Physiol Cell Physiol 2005 Feb;288(2):C272-81 PMID 15483224
  • Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling. (Rafiee P, Heidemann J, Ogawa H, Johnson NA, Fisher PJ, Li MS, Otterson MF, Johnson CP, Binion DG) Cell Commun Signal 2004 Jun 2;2(1):3 PMID 15175101
  • Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID 15088102
  • Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. (Heidemann J, Ogawa H, Rafiee P, Lügering N, Maaser C, Domschke W, Binion DG, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2004 Jun;286(6):G1059-68 PMID 14764445
  • Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. (Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG) FEBS Lett 2003 Nov 6;554(1-2):88-94 PMID 14596920
  • Butyrate modulates gene and protein expression in human intestinal endothelial cells. (Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG) Biochem Biophys Res Commun 2003 Sep 26;309(3):512-9 PMID 12963019
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID 12937165
  • Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. (Rafiee P, Ogawa H, Heidemann J, Li MS, Aslam M, Lamirand TH, Fisher PJ, Graewin SJ, Dwinell MB, Johnson CP, Shaker R, Binion DG) Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1277-92 PMID 12919942
  • Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID 12794122
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. (Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, Binion DG) J Biol Chem 2003 Mar 7;278(10):8508-15 PMID 12496258
  • Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. (Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG) J Biol Chem 2002 Sep 20;277(38):35605-15 PMID 12110686
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 9;106(2):239-45 PMID 12105165
  • Iron deficiency transiently suppresses biliary neuronal nitric oxide synthase. (Goldblatt MI, Swartz-Basile DA, Choi SH, Rafiee P, Nakeeb A, Sarna SK, Pitt HA) J Surg Res 2001 Jun 15;98(2):123-8 PMID 11397128
  • Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. (Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT) Free Radic Biol Med 2000 Nov 1;29(9):881-8 PMID 11063913
  • Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID 11053770
  • TNF-alpha induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils. (Rafiee P, Lee JK, Leung CC, Raffin TA) J Immunol 1995 May 1;154(9):4785-92 PMID 7722327
  • Characterization of the cytokeratins of human colonic, pancreatic, and gastric adenocarcinoma cell lines. (Rafiee P, Ho SB, Bresalier RS, Bloom EJ, Kim JH, Kim YS) Pancreas 1992;7(2):123-31 PMID 1372735
  • Synthesis of tubulin during early postgastrula development of Artemia: isotubulin generation and translational regulation. (Langdon CM, Rafiee P, MacRae TH) Dev Biol 1991 Nov;148(1):138-46 PMID 1718798
  • A sialoglycoprotein complex linked to the microvillus cytoskeleton acts as a receptor for pilus (AF/R1) mediated adhesion of enteropathogenic Escherichia coli (RDEC-1) in rabbit small intestine. (Rafiee P, Leffler H, Byrd JC, Cassels FJ, Boedeker EC, Kim YS) J Cell Biol 1991 Nov;115(4):1021-9 PMID 1683351
  • Cadmium and zinc reversibly arrest development of Artemia larvae. (Bagshaw JC, Rafiee P, Matthews CO, MacRae TH) Bull Environ Contam Toxicol 1986 Aug;37(2):289-96 PMID 3742084
  • Tubulin and associated proteins from developing brine shrimp, (Artemia). (Rafiee P, MacRae TH) Prog Clin Biol Res 1986;217A:419-22 PMID 2875465
  • Grants and Awards

  • Role of Noncanonical Wnt5A in Progression of Barrett?s Esophagus to Esophageal Adenocarcinoma (#9306450 10/01/2013 - 09/30/2014) Sponsor: Digestive Disease Center
  • Aanalysis of Epigenetic Mechanisms of IBD-Associated Fibrosis (#9305275 03/01/2011 - 12/01/2013) Sponsor: Digestive Disease Center