Medical College of Wisconsin
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Paul H. Goldspink PhD

Paul H. Goldspink PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology


Publications

  • Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy. (Koshman YE, Chu M, Kim T, Kalmanson O, Farjah M, Kumar M, Lewis W, Geenen DL, de Tombe P, Goldspink PH, Solaro RJ, Samarel AM) J Mol Cell Cardiol 2014 Jul;72:281-91 PMID 24713463
  • Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. (Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ) Arch Biochem Biophys 2014 Jun 15;552-553:50-9 PMID 24480308
  • The E-domain region of mechano-growth factor inhibits cellular apoptosis and preserves cardiac function during myocardial infarction. (Mavrommatis E, Shioura KM, Los T, Goldspink PH) Mol Cell Biochem 2013 Sep;381(1-2):69-83 PMID 23712705
  • Could interferon-gamma be a therapeutic target for treating heart failure? (Levick SP, Goldspink PH) Heart Fail Rev 2014 Mar;19(2):227-36 PMID 23589353
  • Genetic background influences adaptation to cardiac hypertrophy and Ca(2+) handling gene expression. (Waters SB, Diak DM, Zuckermann M, Goldspink PH, Leoni L, Roman BB) Front Physiol 2013;4:11 PMID 23508205
  • Mechano-Growth Factor: an important cog or a loose screw in the repair machinery? (Zabłocka B, Goldspink PH, Goldspink G, Górecki DC) Front Endocrinol (Lausanne) 2012;3:131 PMID 23125840
  • New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I. (Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi T, Solaro RJ) Biochim Biophys Acta 2013 Apr;1833(4):823-32 PMID 22940544
  • Myocardial infarction in mice alters sarcomeric function via post-translational protein modification. (Avner BS, Shioura KM, Scruggs SB, Grachoff M, Geenen DL, Helseth DL Jr, Farjah M, Goldspink PH, Solaro RJ) Mol Cell Biochem 2012 Apr;363(1-2):203-15 PMID 22160857
  • Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein. (Gaffin RD, Peña JR, Alves MS, Dias FA, Chowdhury SA, Heinrich LS, Goldspink PH, Kranias EG, Wieczorek DF, Wolska BM) J Mol Cell Cardiol 2011 Nov;51(5):812-20 PMID 21840315
  • Myofilament calcium sensitization delays decompensated hypertrophy differently between the sexes following myocardial infarction. (Shioura KM, Farjah M, Geenen DL, Solaro RJ, Goldspink PH) Am J Physiol Regul Integr Comp Physiol 2011 Feb;300(2):R361-8 PMID 21106909
  • Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone. (Collins JM, Goldspink PH, Russell B) J Mol Cell Cardiol 2010 Dec;49(6):1042-5 PMID 20875825
  • Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. (Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM) J Mol Cell Cardiol 2010 Dec;49(6):993-1002 PMID 20854827
  • Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension. (Dias FA, Urboniene D, Yuzhakova MA, Biesiadecki BJ, Pena JR, Goldspink PH, Geenen DL, Wolska BM) Front Biosci (Elite Ed) 2010;2:312-24 PMID 20036880
  • Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein. (Boateng SY, Senyo SE, Qi L, Goldspink PH, Russell B) J Mol Cell Cardiol 2009 Oct;47(4):426-35 PMID 19376126
  • Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes. (Koshman YE, Waters SB, Walker LA, Los T, de Tombe P, Goldspink PH, Russell B) J Mol Cell Cardiol 2008 Dec;45(6):853-6 PMID 18835396
  • Sex-related changes in cardiac function following myocardial infarction in mice. (Shioura KM, Geenen DL, Goldspink PH) Am J Physiol Regul Integr Comp Physiol 2008 Aug;295(2):R528-34 PMID 18550865
  • Maladaptation of calcium homoeostasis in aging cardiac myocytes. (Goldspink P, Ruch S, Los T, Buttrick P, García J) Pflugers Arch 2008 Jun;456(3):479-87 PMID 18172603
  • Assembly and maintenance of the sarcomere night and day. (Boateng SY, Goldspink PH) Cardiovasc Res 2008 Mar 1;77(4):667-75 PMID 18006451
  • Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. (Hankiewicz JH, Goldspink PH, Buttrick PM, Lewandowski ED) Am J Physiol Heart Circ Physiol 2008 Jan;294(1):H330-6 PMID 17965277
  • Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice. (Shioura KM, Geenen DL, Goldspink PH) Am J Physiol Heart Circ Physiol 2007 Nov;293(5):H2870-7 PMID 17720769
  • Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. (Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C) Heart Lung Circ 2008 Feb;17(1):33-9 PMID 17581790
  • Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart. (Chu SH, Goldspink P, Kowalski J, Beck J, Schwertz DW) Life Sci 2006 Aug 22;79(13):1257-67 PMID 16647722
  • Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. (Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H957-64 PMID 16603692
  • Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. (Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH) J Mol Cell Cardiol 2006 Apr;40(4):465-73 PMID 16445938
  • Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism. (Montgomery DE, Rundell VL, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM) Am J Physiol Heart Circ Physiol 2005 Nov;289(5):H1881-8 PMID 15951344
  • Sex differences in expression of calcium-handling proteins and beta-adrenergic receptors in rat heart ventricle. (Chu SH, Sutherland K, Beck J, Kowalski J, Goldspink P, Schwertz D) Life Sci 2005 Apr 22;76(23):2735-49 PMID 15792839
  • Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. (Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM) Circ Res 2004 Aug 20;95(4):424-32 PMID 15242976
  • Proteasome production in human muscle during nutritional inhibition of myofibrillar protein degradation. (Brodsky IG, Suzara D, Furman M, Goldspink P, Ford GC, Nair KS, Kukowski J, Bedno S) Metabolism 2004 Mar;53(3):340-7 PMID 15015147
  • Isoenergetic dietary protein restriction decreases myosin heavy chain IIx fraction and myosin heavy chain production in humans. (Brodsky IG, Suzara D, Hornberger TA, Goldspink P, Yarasheski KE, Smith S, Kukowski J, Esser K, Bedno S) J Nutr 2004 Feb;134(2):328-34 PMID 14747668
  • Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo. (Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM) Am J Physiol Heart Circ Physiol 2004 Jun;286(6):H2089-95 PMID 14726296
  • Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. (Alden KJ, Goldspink PH, Ruch SW, Buttrick PM, García J) Am J Physiol Cell Physiol 2002 Apr;282(4):C768-74 PMID 11880265
  • Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats. (Goldspink PH, McKinney RD, Kimball VA, Geenen DL, Buttrick PM) Mol Cell Biochem 2001 Oct;226(1-2):83-8 PMID 11768242
  • Localization of cardiac (alpha)-myosin heavy chain mRNA is regulated by its 3' untranslated region via mechanical activity and translational block. (Goldspink P, Sharp W, Russell B) J Cell Sci 1997 Dec;110 ( Pt 23):2969-78 PMID 9359883
  • Beating affects the posttranscriptional regulation of alpha-myosin mRNA in cardiac cultures. (Goldspink PH, Thomason DB, Russell B) Am J Physiol 1996 Dec;271(6 Pt 2):H2584-90 PMID 8997319
  • Physiological role of phosphorylation of the cyclic AMP response element binding protein in rat cardiac nuclei. (Goldspink PH, Russell B) Cell Tissue Res 1996 Sep;285(3):379-85 PMID 8772151
  • The cAMP response element binding protein is expressed and phosphorylated in cardiac myocytes. (Goldspink PH, Russell B) Circ Res 1994 Jun;74(6):1042-9 PMID 8187274
  • Remodeling of myofibrils: subcellular distribution of myosin heavy chain mRNA and protein. (Russell B, Wenderoth MP, Goldspink PH) Am J Physiol 1992 Mar;262(3 Pt 2):R339-45 PMID 1558205
  • Distribution of myosin heavy chain mRNA in normal and hyperthyroid heart. (Eisenberg BR, Goldspink PH, Wenderoth MP) J Mol Cell Cardiol 1991 Mar;23(3):287-96 PMID 1880813
  • Grants and Awards

  • Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds (#9206475 09/01/2010 - 05/31/2015) Sponsor: NIH Heart Lung and Blood Institute