Medical College of Wisconsin
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Ramani Ramchandran PhD

Ramani Ramchandran PhD


Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Developmental Biology
Program: Human Molecular Embryology


  • Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID 24324647
  • SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. (Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X) Hum Mol Genet 2014 Mar 15;23(6):1644-55 PMID 24203696
  • Mmp17b is essential for proper neural crest cell migration in vivo. (Leigh NR, Schupp MO, Li K, Padmanabhan V, Gastonguay A, Wang L, Chun CZ, Wilkinson GA, Ramchandran R) PLoS One 2013;8(10):e76484 PMID 24098510
  • Protein structure in context: the molecular landscape of angiogenesis. (Span EA, Goodsell DS, Ramchandran R, Franzen MA, Herman T, Sem DS) Biochem Mol Biol Educ 2013 Jul-Aug;41(4):213-23 PMID 23868376
  • Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA) J Biol Chem 2013 Apr 12;288(15):10265-74 PMID 23393131
  • Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 PMID 23172031
  • Studies on Axenfeld-Rieger syndrome patients and mice reveal Foxc1's role in corneal neovascularization. (François M, Ramchandran R) Proc Natl Acad Sci U S A 2012 Feb 7;109(6):1818-9 PMID 22308435
  • Reactive oxygen species driven angiogenesis by inorganic nanorods. (Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay D) Nano Lett 2011 Nov 9;11(11):4932-8 PMID 21967244
  • Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. (Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P, Ramchandran R) J Biol Chem 2011 Sep 2;286(35):30740-7 PMID 21730073
  • Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M) Blood 2011 Aug 18;118(7):2015-26 PMID 21636859
  • Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. (Chun CZ, Remadevi I, Schupp MO, Samant GV, Pramanik K, Wilkinson GA, Ramchandran R) PLoS One 2011;6(2):e14732 PMID 21364913
  • Natural antisense transcript: a concomitant engagement with protein-coding transcript. (Li K, Ramchandran R) Oncotarget 2010 Oct;1(6):447-52 PMID 21311100
  • Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. (Zhao B, Chun C, Liu Z, Horswill MA, Pramanik K, Wilkinson GA, Ramchandran R, Miao RQ) Blood 2010 Dec 9;116(24):5423-33 PMID 20813898
  • Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. (Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant GV, Horswill M, Chun CZ, Zhao B, Wang E, Miao RQ, Mukhopadhyay D, Ramchandran R, Wilkinson GA) Blood 2010 Jun 3;115(22):4614-22 PMID 20086248
  • A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh NR, Chun CZ, Samant GV, Zhao B, Garnaas MK, Horswill MA, Stanhope SA, North PE, Miao RQ, Wilkinson GA, Affolter M, Ramchandran R) Blood 2010 Jan 7;115(1):133-9 PMID 19880500
  • Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. (Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD) Cell Stress Chaperones 2010 Mar;15(2):165-81 PMID 19579057
  • Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. (Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC) Biochem Biophys Res Commun 2009 Aug 14;386(1):263-7 PMID 19523926
  • A whole-animal microplate assay for metabolic rate using zebrafish. (Makky K, Duvnjak P, Pramanik K, Ramchandran R, Mayer AN) J Biomol Screen 2008 Dec;13(10):960-7 PMID 19029015
  • Silencing of directional migration in roundabout4 knockdown endothelial cells. (Kaur S, Samant GV, Pramanik K, Loscombe PW, Pendrak ML, Roberts DD, Ramchandran R) BMC Cell Biol 2008;9:61 PMID 18980679
  • Dusp-5 and Snrk-1 coordinately function during vascular development and disease. (Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R) Blood 2009 Jan 29;113(5):1184-91 PMID 18927432
  • Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. (Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R) Circ Res 2008 Sep 26;103(7):710-6 PMID 18757825
  • Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. (Chun CZ, Kaur S, Samant GV, Wang L, Pramanik K, Garnaas MK, Li K, Field L, Mukhopadhyay D, Ramchandran R) Blood 2009 Jan 29;113(5):1192-9 PMID 18723694
  • Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. (Kaur S, Abu-Asab MS, Singla S, Yeo SY, Ramchandran R) Gene Expr 2007;13(6):321-7 PMID 17708418
  • Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD) Br J Pharmacol 2007 May;151(1):63-72 PMID 17351657
  • Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. (Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC) Neurosci Lett 2007 Feb 2;412(3):233-8 PMID 17178437
  • Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. (Arbiser JL, Kau T, Konar M, Narra K, Ramchandran R, Summers SA, Vlahos CJ, Ye K, Perry BN, Matter W, Fischl A, Cook J, Silver PA, Bain J, Cohen P, Whitmire D, Furness S, Govindarajan B, Bowen JP) Blood 2007 Jan 15;109(2):560-5 PMID 16990598
  • A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. (Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP) J Cell Sci 2006 Oct 1;119(Pt 19):4117-26 PMID 16968741
  • Robo4 signaling in endothelial cells implies attraction guidance mechanisms. (Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R) J Biol Chem 2006 Apr 21;281(16):11347-56 PMID 16481322
  • roundabout4 is essential for angiogenesis in vivo. (Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R) Proc Natl Acad Sci U S A 2005 May 3;102(18):6373-8 PMID 15849270
  • Critical roles of CD146 in zebrafish vascular development. (Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP) Dev Dyn 2005 Jan;232(1):232-44 PMID 15580611
  • Cellular actions and signaling by endostatin. (Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP) Crit Rev Eukaryot Gene Expr 2002;12(3):175-91 PMID 12449342
  • Endostatin is a potential inhibitor of Wnt signaling. (Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S) J Cell Biol 2002 Aug 5;158(3):529-39 PMID 12147676
  • Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. (Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP) J Biol Chem 2002 May 10;277(19):16464-9 PMID 11815623
  • Cell surface glypicans are low-affinity endostatin receptors. (Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP) Mol Cell 2001 Apr;7(4):811-22 PMID 11336704
  • Antitumor interaction of short-course endostatin and ionizing radiation. (Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR) Cancer J 2000 Sep-Oct;6(5):287-93 PMID 11079167
  • A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells. (Ramchandran R, Bengra C, Whitney B, Lanclos K, Tuan D) Am J Hematol 2000 Sep;65(1):14-24 PMID 10936858
  • Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. (Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R) J Biol Chem 2000 Jan 14;275(2):1209-15 PMID 10625665
  • Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. (Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 19;258(3):668-73 PMID 10329443
  • Cloning, expression, and in vitro activity of human endostatin. (Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 10;258(2):345-52 PMID 10329390
  • Endostatin induces endothelial cell apoptosis. (Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP) J Biol Chem 1999 Apr 23;274(17):11721-6 PMID 10206987
  • Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP) Biochem Biophys Res Commun 1999 Feb 24;255(3):735-9 PMID 10049780
  • Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. (Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP) Cancer Res 1999 Jan 1;59(1):189-97 PMID 9892206
  • Grants and Awards

  • Fully Automated Angiogenesis Drug Discovery Assay in Zebrafish (#9207450 04/01/2012 - 02/28/2015) Sponsor: Physical Sciences Inc.
  • Targeting DUSP-5 to Treat Vascular Anomalies (#9207396 02/21/2012 - 12/31/2016) Sponsor: NIH Heart Lung and Blood Institute
  • Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program: A Study to Identify Molecules (similar to RR505) that Targets Dual Specific Phosphatase5 (DUSP5) (#9208371 11/15/2013 - 11/14/2016) Sponsor: NIH Heart Lung and Blood Institute
  • Cystathionine Beta Synthase (CBS) and Angiogensis (#9208352 08/15/2013 - 06/30/2014) Sponsor: Oklahoma University Health Science Center
  • Rap1 in VEGF Signaling in Endothelial Cells (#9207459 04/16/2012 - 03/31/2016) Sponsor: BloodCenter of Wisconsin
  • Molecular Crosstalk and Matrix Metalloproteinases in Generalized Lymphatic Anomaly (GLA) and Gorham-stout Syndrome (GSS) Patients (#9207752 11/15/2012 - 03/31/2014) Sponsor: Lymphatic Malformation Institute
  • Snrk-1 and Dusp-5 Co-Ordinately Regulate Vascular Development in Vertebrates (#9207065 08/01/2011 - 07/31/2015) Sponsor: NIH Heart Lung and Blood Institute
  • Roundabout4 Signaling Endothelial Cells (#9205558 03/16/2009 - 02/28/2014) Sponsor: NIH Heart Lung and Blood Institute