Robert L. Truitt PhD Online Profile
Clinical Professor
Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology
Research Experience
Adoptive TransferAlopeciaBiological TherapyBone Marrow TransplantationCell SeparationCell TransplantationCord Blood Stem Cell TransplantationDisease Models, AnimalEpidermisGraft RejectionGraft vs Host ReactionGraft vs Leukemia EffectGraft vs Tumor EffectHairHair FollicleHematopoietic Stem Cell TransplantationHistocompatibilityHost vs Graft ReactionImmune ToleranceImmunity, CellularImmunocompromised HostImmunologic TestsImmunomagnetic SeparationImmunotherapyImmunotherapy, AdoptiveLeukemiaLeukemia, ExperimentalMonitoring, ImmunologicNeoplasms, ExperimentalPeripheral Blood Stem Cell TransplantationRadiation ChimeraStem Cell TransplantationT-LymphocytesTissue TransplantationTransplantationTransplantation ChimeraTransplantation ConditioningTransplantation ImmunologyTransplantation ToleranceTransplantation, AutologousTransplantation, HeterologousMethodologies and Techniques
Bone Marrow TransplantationFlow CytometryGraft vs Leukemia EffectGraft vs Tumor EffectHematopoietic Stem Cell TransplantationImmunomagnetic SeparationImmunophenotypingTransplantation ConditioningLeadership Positions
Associate Director of Research Resources, MCW Cancer CenterEmeritus Professor of PediatricsCommunity Partnerships
Wisconsin Breast Cancer Showhouse for a Cure, Inc.American Cancer SocietyMidwest Athletes Against Childhood Cancer (MACC) FundPublications
Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis. (Keever-Taylor CA, Browning MB, Johnson BD, Truitt RL, Bredeson CN, Behn B, Tsao A) Cytotherapy 2007;9(2):144-57 PMID 17453966 Graft-versus-leukemia and graft-versus-host reactions after donor lymphocyte infusion are initiated by host-type antigen-presenting cells and regulated by regulatory T cells in early and long-term chimeras. (Xia G, Truitt RL, Johnson BD) Biol Blood Marrow Transplant 2006 Apr;12(4):397-407 PMID 16545723 CD200, a "no danger" signal for hair follicles. (Rosenblum MD, Yancey KB, Olasz EB, Truitt RL) J Dermatol Sci 2006 Mar;41(3):165-74 PMID 16386879 Characterization of CD 200-receptor expression in the murine epidermis. (Rosenblum MD, Woodliff JE, Madsen NA, McOlash LJ, Keller MR, Truitt RL) J Invest Dermatol 2005 Dec;125(6):1130-8 PMID 16354182 Tracking ex vivo-expanded CD4+CD25+ and CD8+CD25+ regulatory T cells after infusion to prevent donor lymphocyte infusion-induced lethal acute graft-versus-host disease. (Xia G, Kovochich M, Truitt RL, Johnson BD) Biol Blood Marrow Transplant 2004 Nov;10(11):748-60 PMID 15505606 Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? (Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL) J Invest Dermatol 2004 Nov;123(5):880-7 PMID 15482475 The Mortimer M. Bortin Lecture: to destroy by the reaction of immunity: the search for separation of graft-versus-leukemia and graft-versus-host. (Truitt RL) Biol Blood Marrow Transplant 2004 Aug;10(8):505-23 PMID 15282529 The T cell activation marker CD150 can be used to identify alloantigen-activated CD4(+)25+ regulatory T cells. (Browning MB, Woodliff JE, Konkol MC, Pati NT, Ghosh S, Truitt RL, Johnson BD) Cell Immunol 2004 Feb;227(2):129-39 PMID 15135295 CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. (Rosenblum MD, Olasz E, Woodliff JE, Johnson BD, Konkol MC, Gerber KA, Orentas RJ, Sandford G, Truitt RL) Blood 2004 Apr 1;103(7):2691-8 PMID 14644999 CD25+ immunoregulatory T-cells of donor origin suppress alloreactivity after BMT. (Johnson BD, Konkol MC, Truitt RL) Biol Blood Marrow Transplant 2002;8(10):525-35 PMID 12434947 Characterization of a murine NKT cell tumor previously described as an acute myelogenous leukemia. (LaBelle JL, Truitt RL) Leuk Lymphoma 2002 Aug;43(8):1637-44 PMID 12400607 Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. (LaBelle JL, Hanke CA, Blazar BR, Truitt RL) Blood 2002 Mar 15;99(6):2146-53 PMID 11877291 Donor natural killer (NK1.1+) cells do not play a role in the suppression of GVHD or in the mediation of GVL reactions after DLI. (Johnson BD, Dagher N, Stankowski WC, Hanke CA, Truitt RL) Biol Blood Marrow Transplant 2001;7(11):589-95 PMID 11760146 Role of immunoregulatory donor T cells in suppression of graft-versus-host disease following donor leukocyte infusion therapy. (Johnson BD, Becker EE, LaBelle JL, Truitt RL) J Immunol 1999 Dec 15;163(12):6479-87 PMID 10586039 Photochemical treatment with S-59 psoralen and ultraviolet A light to control the fate of naive or primed T lymphocytes in vivo after allogeneic bone marrow transplantation. (Truitt RL, Johnson BD, Hanke C, Talib S, Hearst JE) J Immunol 1999 Nov 1;163(9):5145-56 PMID 10528221 Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets. (Johnson BD, Becker EE, Truitt RL) Biol Blood Marrow Transplant 1999;5(3):123-32 PMID 10392958 Sca1(+)/Mac1(+) nitric oxide-producing cells in the spleens of recipients early following bone marrow transplant suppress T cell responses in vitro. (Johnson BD, Hanke CA, Becker EE, Truitt RL) Cell Immunol 1998 Nov 1;189(2):149-59 PMID 9790729 Glycosphingolipids as novel targets for T-cell suppression by the B subunit of recombinant heat-labile enterotoxin. (Truitt RL, Hanke C, Radke J, Mueller R, Barbieri JT) Infect Immun 1998 Apr;66(4):1299-308 PMID 9529046 The graft-versus-leukemia effect of post-transplant donor leukocyte infusion. (Johnson BD, Hanke CA, Truitt RL) Leuk Lymphoma 1996 Sep;23(1-2):1-9 PMID 9021679 Human adenovirus-specific CD8+ T-cell responses are not inhibited by E3-19K in the presence of gamma interferon. (Flomenberg P, Piaskowski V, Truitt RL, Casper JT) J Virol 1996 Sep;70(9):6314-22 PMID 8709259 Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults. (Margolis D, Camitta B, Pietryga D, Keever-Taylor C, Baxter-Lowe LA, Pierce K, Kupst MJ, French J 3rd, Truitt R, Lawton C, Murray K, Garbrecht F, Flomenberg N, Casper J) Br J Haematol 1996 Jul;94(1):65-72 PMID 8757510 Hematologic and immunologic evaluation of recombinant human interleukin-6 in patients with advanced malignant disease: evidence for monocyte activation. (Keever-Taylor CA, Witt PL, Truitt RL, Ramanujam S, Borden EC, Ritch PS) J Immunother Emphasis Tumor Immunol 1996 May;19(3):231-43 PMID 8811498 Immunoregulatory properties of ISG15, an interferon-induced cytokine. (D'Cunha J, Knight E Jr, Haas AL, Truitt RL, Borden EC) Proc Natl Acad Sci U S A 1996 Jan 9;93(1):211-5 PMID 8552607 Principles of graft-vs.-leukemia reactivity. (Truitt RL, Johnson BD) Biol Blood Marrow Transplant 1995 Dec;1(2):61-8 PMID 9118293 Phase IA/IB evaluation of mammalian cell-derived glycosylated recombinant human interleukin (SIGOSIX) before and after cytotoxic chemotherapy. (Ritch PS, Keever C, Schiller J, Rivkin S, Witt PL, Grossberg SE, Truitt RL, Burris H, von Hoff DD, Vaickus L) Ann N Y Acad Sci 1995 Jul 21;762:359-60 PMID 7668536 Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease. (Johnson BD, Truitt RL) Blood 1995 Jun 1;85(11):3302-12 PMID 7756664 Use of anti-CD3 epsilon F(ab')2 fragments in vivo to modulate graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation. (Johnson BD, McCabe C, Hanke CA, Truitt RL) J Immunol 1995 May 15;154(10):5542-54 PMID 7730653 Characterization of human proliferative T cell responses to adenovirus. (Flomenberg P, Piaskowski V, Truitt RL, Casper JT) J Infect Dis 1995 May;171(5):1090-6 PMID 7751682 Unrelated bone marrow donor transplants for children with leukemia or myelodysplasia. (Casper J, Camitta B, Truitt R, Baxter-Lowe LA, Bunin N, Lawton C, Murray K, Hunter J, Pietryga D, Garbrecht F) Blood 1995 May 1;85(9):2354-63 PMID 7727769 Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease. (Johnson BD, Drobyski WR, Truitt RL) Bone Marrow Transplant 1993 Apr;11(4):329-36 PMID 8485480 Detection of residual leukemia by the polymerase chain reaction and sequence-specific oligonucleotide probe hybridization after allogeneic bone marrow transplantation for AKR leukemia: a murine model for minimal residual disease. (Drobyski WR, Baxter-Lowe LA, Truitt RL) Blood 1993 Jan 15;81(2):551-9 PMID 8422472 A decrease in graft-vs.-host disease without loss of graft-vs.-leukemia reactivity after MHC-matched bone marrow transplantation by selective depletion of donor NK cells in vivo. (Johnson BD, Truitt RL) Transplantation 1992 Jul;54(1):104-12 PMID 1631918 Immunological evaluation of pediatric cancer patients receiving recombinant interleukin-2 in a phase I trial. (Truitt RL, Piaskowski V, Kirchner P, McOlash L, Camitta BM, Casper JT) J Immunother (1991) 1992 May;11(4):274-85 PMID 1599913 Regulation of lymphokine-activated killer activity in T-replete and T-cell-depleted human bone marrow by interleukin 4. (Drobyski WR, LeFever AV, Truitt RL) Exp Hematol 1991 Oct;19(9):950-7 PMID 1716592 Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. (Truitt RL, Atasoylu AA) Bone Marrow Transplant 1991 Jul;8(1):51-8 PMID 1833016 Impact of pretransplant conditioning and donor T cells on chimerism, graft-versus-host disease, graft-versus-leukemia reactivity, and tolerance after bone marrow transplantation. (Truitt RL, Atasoylu AA) Blood 1991 Jun 1;77(11):2515-23 PMID 2039833 Kinetic analysis of human IL-2 activated cytotoxic cells. (LeFever AV, Piaskowski VD, Casper JT, Truitt RL) Immunopharmacol Immunotoxicol 1991;13(1-2):147-68 PMID 1770217 Preservation of lymphokine-activated killer activity following T cell depletion of human bone marrow. (Drobyski WR, Piaskowski V, Ash RC, Casper JT, Truitt RL) Transplantation 1990 Oct;50(4):625-32 PMID 1699309 Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. (Ash RC, Casper JT, Chitambar CR, Hansen R, Bunin N, Truitt RL, Lawton C, Murray K, Hunter J, Baxter-Lowe LA) N Engl J Med 1990 Feb 22;322(8):485-94 PMID 2300120 Graft-versus-leukemia reactions after bone marrow transplantation. (Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb HJ, Rimm AA, Ringdén O, Rozman C, Speck B) Blood 1990 Feb 1;75(3):555-62 PMID 2297567 Third-party-mediated graft rejection and graft-versus-host disease after T-cell-depleted bone marrow transplantation, as demonstrated by hypervariable DNA probes and HLA-DR polymorphism. (Drobyski W, Thibodeau S, Truitt RL, Baxter-Lowe LA, Gorski J, Jenkins R, Gottschall J, Ash RC) Blood 1989 Nov 1;74(6):2285-94 PMID 2572285 T-cell depletion in allogeneic bone marrow transplantation: progress and problems. (Marmont AM, Gale RP, Butturini A, Goldman JM, Martelli MF, Prentice HG, Slavin S, Storb R, Truitt RL, Van Bekkum DW) Haematologica 1989 May-Jun;74(3):235-48 PMID 2511092 Serotonin modulated Ca++ dependent K+ channels in alloimmune effector cell lytic function. (Liepins A, LeFever A, Truitt RL) Immunopharmacol Immunotoxicol 1989;11(2-3):165-78 PMID 2559929 Role of K+ ion channels in lymphokine-activated killer (LAK) cell lytic function. (LeFever A, Liepins A, Truitt R) Immunopharmacol Immunotoxicol 1989;11(4):571-82 PMID 2560785 Partially matched bone marrow transplantation in patients with myelodysplastic syndromes. (Bunin NJ, Casper JT, Chitambar C, Hunter J, Truitt R, Menitove J, Camitta BM, Ash R) J Clin Oncol 1988 Dec;6(12):1851-5 PMID 3058877 Downregulation of L3T4+ cytotoxic T lymphocytes by interleukin-2. (Shih CC, Truitt RL) Science 1987 Oct 16;238(4825):344-7 PMID 2443976 Kinetic analysis of Qa-1-specific cloned cytotoxic T lymphocytes: lytic parameters and evaluation of cellular inhibition. (LeFever AV, Truitt RL) Scand J Immunol 1987 Jun;25(6):541-53 PMID 2440099 A class II antigen-specific T cell clone can suppress graft-versus-host reactivity in murine allogeneic bone marrow chimeras. (Shih CC, Truitt RL) Transplant Proc 1987 Feb;19(1 Pt 3):2664-7 PMID 2950639 Prophylaxis of graft-vs-host disease by adoptive transfer of a class II antigen-specific murine T-cell clone. (Shih CC, Truitt RL) Prog Clin Biol Res 1987;244:439-47 PMID 3116558 Manipulation of T-cell content in transplanted human bone marrow: effect on GVH and GVL reactions. (Truitt RL, Ash RC) Prog Clin Biol Res 1987;244:409-21 PMID 3310003 Migration of cytotoxic effector cells. (LeFever AV, Truitt RL) Prog Clin Biol Res 1987;244:313-24 PMID 3498956 Kinetic analysis of cloned cytotoxic T lymphocyte reactivity against normal and leukaemic target cells. (LeFever AV, Truitt RL) J Immunogenet 1986 Apr-Jun;13(2-3):275-85 PMID 3493298 Manipulation of graft-versus-host disease for a graft-versus-leukemia effect after allogeneic bone marrow transplantation in AKR mice with spontaneous leukemia/lymphoma. (Truitt RL, Shih CC, LeFever AV) Transplantation 1986 Mar;41(3):301-10 PMID 3513389 Reactivity of in-vitro-expanded alloimmune cytotoxic T lymphocytes and Qa-1-specific cytotoxic T lymphocytes against AKR leukemia in vivo. (LeFever AV, Truitt RL, Shih CC) Transplantation 1985 Nov;40(5):531-7 PMID 2414869 Isolation of suppressor-like T cells from bacteria-free allogeneic bone marrow chimeras. (Truitt RL, Shih CC) Prog Clin Biol Res 1985;181:451-4 PMID 3161091 Migration patterns and functional activity of cloned cytotoxic T lymphocytes in syngeneic and allogeneic mice. (LeFever AV, Truitt RL, Shih CC, Liepins A, Bortin MM) Transplantation 1984 Apr;37(4):410-7 PMID 6200972 Alloimmunization for induction of graft-versus-leukemia reactivity in H-2-compatible donors: critical role for incompatibility of donor and alloimmunizing strains at non-H-2 loci. (Bortin MM, Truitt RL, Shih CY, Tempelis LD, LeFever AV, Rimm AA) Transplant Proc 1983 Dec;15(4):2114-7 PMID 6673211 Characterization of alloimmunization-induced T lymphocytes reactive against AKR leukemia in vitro and correlation with graft-vs-leukemia activity in vivo. (Truitt RL, Shih CY, Lefever AV, Tempelis LD, Andreani M, Bortin MM) J Immunol 1983 Oct;131(4):2050-8 PMID 6194224 Growth of AKR T cell leukemia lymphoblasts in medium containing interleukin 2 (IL-2). (Shih CY, Truitt RL, Andreani M, Bortin MM) In Vitro 1983 Oct;19(10):759-66 PMID 6605296 Alloimmunization and adoptive immunotherapy of leukemia. (Truitt RL, Shih CY, Rimm AA, Tempelis LD, Bortin MM) Transplant Proc 1981 Dec;13(4):1910-4 PMID 6949385 Alloimmunization: induction of antileukemic reactivity without modification of anti-host reactivity in H-2-compatible mice. (Truitt RL, Bortin MM, Rimm AA) Transplant Proc 1980 Mar;12(1):143-6 PMID 6966095 Graft-versus-leukemia: allosensitization of MHC compatible donors induces antileukemic reactivity without amplification of antihost reactivity. (Bortin MM, Truitt RL, Shih CY, Rimm AA) Haematol Blood Transfus 1980;25:31-9 PMID 7021349 Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity. (Bortin MM, Truitt RL, Rimm AA, Bach FH) Nature 1979 Oct 11;281(5731):490-1 PMID 386133 Graft versus leukemia. VIII. Selective reduction in antihost reactivity without loss of antileukemic reactivity by treatment of donor mice with lipopolysaccharide. (Truitt RL, Rose WC, Rimm AA, Bortin MM) Exp Hematol 1978 May;6(5):488-98 PMID 26584 AKR T-cell acute lymphoblastic leukemia: a model for human T-cell leukemia. (Bortin-M, Truitt RL) Biomedicine 1977 Oct;26(5):309-11 PMID 303119 Growth of human tumors in lethally irradiated mice reconstituted with syngeneic fetal liver cells. (Saltzstein EC, Rose WC, Truitt RL, Rimm AA, Bortin MM, Patillo RA) Cancer 1977 Feb;39(2):581-6 PMID 319894 Graft-versus-leukemia for AKR spontaneous leukemia-lymphoma. (Truitt RL, Rimm AA, Saltzstein EC, Rose WC, Bortin MM) Transplant Proc 1976 Dec;8(4):569-74 PMID 11589 Mouse leukemia and solid tumors treated with bone marrow grafting. (Pollard M, Truitt RL, Ashman RB) Transplant Proc 1976 Dec;8(4):565-7 PMID 11588 Transplantation of hematopoietic and lymphoid cells in mice. (Bortin MM, Rimm AA, Rose WC, Truitt RL, Saltzstein EC) Transplantation 1976 Apr;21(4):331-6 PMID 7865 Mitigation of graft-versus-host disease in mice by treatment of donors with bacterial endotoxin. (Rose WC, Rodey GE, Rimm AA, Truitt RL, Bortin MM) Exp Hematol 1976 Mar;4(2):90-6 PMID 4335 Allogeneic bone marrow chimerism in germ-free mice. IV. Therapy of "Hodgkin's-like" reticulum cell sarcoma in SJL mice. (Truitt RL, Pollard M) Transplantation 1976 Jan;21(1):12-6 PMID 1108322 Adoptive immunotherapy of spontaneous leukemia-lymphoma in AKR mice. (Bortin MM, Truitt RL, Rose WC, Rimm AA, Saltzstein EC) Adv Exp Med Biol 1976;73 Pt B:331-9 PMID 793340 Graft versus leukemia. VI. Adoptive immunotherapy in combination with chemoradiotherapy for spontaneous leukemia-lymphoma in AKR mice. (Bortin MM, Rose WC, Truitt RL, Rimm AA, Saltzstein EC, Rodey GE) J Natl Cancer Inst 1975 Nov;55(5):1227-9 PMID 1546 Low-dose chemotherapy as a prelude to intensive treatment of spontaneous leukemia-lymphoma in AKR mice. (Rose WC, Rimm AA, Saltzstein EC, Truitt RL, Bortin MM) J Natl Cancer Inst 1975 Jul;55(1):219-21 PMID 1159816 Allogeneic bone marrow chimerism in germfree mice. 3. Therapy of leukemic AKR mice. (Truitt RL, Pollard M, Srivastava KK) Proc Soc Exp Biol Med 1974 May;146(1):153-8 PMID 4597165 Allogeneic bone marrow chimerism in germ-free mice. II. Prevention of reticulum cell sarcomas in SJL-J mice. (Pollard M, Truitt RL) Proc Soc Exp Biol Med 1974 Feb;145(2):488-92 PMID 4592169 Allogeneic bone marrow chimerism in germfree mice. 1. Prevention of spontaneous leukemia in AKR mice. (Pollard M, Truitt RL) Proc Soc Exp Biol Med 1973 Nov;144(2):659-65 PMID 4583624 Ultrastructural examination of phytohemagglutinin stimulated lymphocytes infected with vesicular stomatitis virus. (McFadden GK, Truitt RL, Shechmeister IL) Arch Gesamte Virusforsch 1973;41(3):229-37 PMID 4353796 The replication of bovine viral diarrhea-mucosal disease virus in bovine leukocytes in vitro. (Truitt RL, Schechmeister IL) Arch Gesamte Virusforsch 1973;42(1):78-87 PMID 4749260 Grants and Awards
Institutional Research Grant (#9202672 07/01/2002 - 06/30/2005) Sponsor: American Cancer Society NationalAllopecific Immunoregulatory T Cells in BMT Receipients (#9202191 08/20/2001 - 07/31/2005) Sponsor: NIH Heart Lung and Blood InstituteAmerican Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 12/31/2013) Sponsor: American Cancer Society NationalCD200 Expression on Apoptotic DCs and Immune Tolerance (#9203372 08/01/2004 - 07/31/2007) Sponsor: NIH Heart Lung and Blood Institute
