Medical College of Wisconsin
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Roy L. Silverstein MD

Roy L. Silverstein MD

Chairman, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Administration
Program: Chairman

Member of the MCW Cancer Center


Publications

  • Platelet CD36 links not only α-granule-derived proteins to thrombus stability but also metabolic and oxidant stress to a prothrombotic phenotype. (Silverstein RL) Arterioscler Thromb Vasc Biol 2014 Jun;34(6):1120-1 PMID 24828516
  • Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression. (Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD) Stem Cells 2014 Jul;32(7):1746-58 PMID 24737733
  • Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. (Wang Y, Fang C, Gao H, Bilodeau ML, Zhang Z, Zhang Z, Liu S, Morooka T, Sakuma M, Nakajima K, Yoneda S, Shi C, Zidar D, Andre P, Stephens G, Silverstein RL, Hogg N, Schmaier AH, Simon DI) J Clin Invest 2014 May 1;124(5):2160-71 PMID 24691441
  • Proteasome proteolysis supports stimulated platelet function and thrombosis. (Gupta N, Li W, Willard B, Silverstein RL, McIntyre TM) Arterioscler Thromb Vasc Biol 2014 Jan;34(1):160-8 PMID 24177323
  • Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop. (Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM) J Immunol 2013 Nov 15;191(10):5196-203 PMID 24081990
  • Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. (Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS) Mucosal Immunol 2014 Mar;7(2):440-8 PMID 24045574
  • Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells. (Chu LY, Ramakrishnan DP, Silverstein RL) Blood 2013 Sep 5;122(10):1822-32 PMID 23896411
  • Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice. (Rahaman SO, Li W, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Sep;33(9):2053-7 PMID 23825362
  • Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. (Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L) Am J Physiol Heart Circ Physiol 2013 Aug 15;305(4):H563-74 PMID 23748423
  • Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36. (Klenotic PA, Page RC, Li W, Amick J, Misra S, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1655-62 PMID 23640500
  • Loci influencing blood pressure identified using a cardiovascular gene-centric array. (Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, CARDIOGRAM, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW) Hum Mol Genet 2013 Apr 15;22(8):1663-78 PMID 23303523
  • CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. (Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL) Hypertension 2013 Jan;61(1):216-24 PMID 23172921
  • Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH, LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F) Am J Hum Genet 2012 Nov 2;91(5):823-38 PMID 23063622
  • Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. (Hale JS, Li M, Sinyuk M, Jahnen-Dechent W, Lathia JD, Silverstein RL) PLoS One 2012;7(7):e40033 PMID 22808089
  • Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. (Park YM, Drazba JA, Vasanji A, Egelhoff T, Febbraio M, Silverstein RL) Mol Biol Cell 2012 Aug;23(16):3057-68 PMID 22718904
  • P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease. (Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P, Silverstein RL, Bhatt DL, Kottke-Marchant K) Int J Lab Hematol 2012 Oct;34(5):473-83 PMID 22574824
  • Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis. (Park YM, R Kashyap S, A Major J, Silverstein RL) Lab Invest 2012 Aug;92(8):1171-80 PMID 22525426
  • Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36. (Zhu W, Li W, Silverstein RL) Blood 2012 Jun 21;119(25):6136-44 PMID 22431576
  • CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C. (Chu LY, Silverstein RL) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):760-7 PMID 22247259
  • CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. (Huang W, Febbraio M, Silverstein RL) PLoS One 2011;6(12):e29092 PMID 22216174
  • Teaching an old dog new tricks: potential antiatherothrombotic use for statins. (Silverstein RL) J Clin Invest 2012 Feb 1;122(2):478-81 PMID 22214843
  • Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes. (Rahaman SO, Zhou G, Silverstein RL) J Biol Chem 2011 Oct 14;286(41):36011-9 PMID 21865158
  • Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system. (Klenotic PA, Page RC, Misra S, Silverstein RL) Protein Expr Purif 2011 Dec;80(2):253-9 PMID 21821127
  • Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. (Jankowska AM, Szpurka H, Calabro M, Mohan S, Schade AE, Clemente M, Silverstein RL, Maciejewski JP) Haematologica 2011 Jul;96(7):954-62 PMID 21546506
  • Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. (Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant K, Barnard J, Silverstein RL) Blood 2011 Jun 9;117(23):6355-66 PMID 21478428
  • Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. (Ren B, Hale J, Srikanthan S, Silverstein RL) Blood 2011 Jun 2;117(22):6036-45 PMID 21441463
  • Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. (Chen K, Li W, Major J, Rahaman SO, Febbraio M, Silverstein RL) Blood 2011 May 26;117(21):5744-50 PMID 21427288
  • Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. (Rahaman SO, Swat W, Febbraio M, Silverstein RL) J Biol Chem 2011 Mar 4;286(9):7010-7 PMID 21209086
  • Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. (Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ) Am J Hum Genet 2011 Jan 7;88(1):6-18 PMID 21194676
  • A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. (Kennedy DJ, Kuchibhotla S, Westfall KM, Silverstein RL, Morton RE, Febbraio M) Cardiovasc Res 2011 Feb 15;89(3):604-13 PMID 21088116
  • CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. (Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL) J Clin Invest 2010 Nov;120(11):3996-4006 PMID 20978343
  • A novel broadband impedance method for detection of cell-derived microparticles. (Lvovich V, Srikanthan S, Silverstein RL) Biosens Bioelectron 2010 Oct 15;26(2):444-51 PMID 20729061
  • Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. (Silverstein RL, Li W, Park YM, Rahaman SO) Trans Am Clin Climatol Assoc 2010;121:206-20 PMID 20697562
  • Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. (Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL) Am J Pathol 2010 Apr;176(4):2039-50 PMID 20167858
  • Type 2 scavenger receptor CD36 in platelet activation: the role of hyperlipemia and oxidative stress. (Silverstein RL) Clin Lipidol 2009 Dec;4(6):767 PMID 20161667
  • Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL. (Kashyap SR, Ioachimescu AG, Gornik HL, Gopan T, Davidson MB, Makdissi A, Major J, Febbraio M, Silverstein RL) Obesity (Silver Spring) 2009 Dec;17(12):2142-8 PMID 19521352
  • CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. (Silverstein RL, Febbraio M) Sci Signal 2009;2(72):re3 PMID 19471024
  • Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36. (Silverstein RL) Cleve Clin J Med 2009 Apr;76 Suppl 2:S27-30 PMID 19376978
  • TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. (Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV) Cell Immunol 2009;258(1):29-37 PMID 19362712
  • Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG) Cancer Res 2009 Feb 1;69(3):1212-20 PMID 19176395
  • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. (Park YM, Febbraio M, Silverstein RL) J Clin Invest 2009 Jan;119(1):136-45 PMID 19065049
  • Biological surgery: synergetic angiogenic therapy using coadministration of two progenitor cell populations. (Li W, Silverstein RL) Circ Res 2008 Sep 26;103(7):684-6 PMID 18818411
  • Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. (Rege TA, Stewart J Jr, Dranka B, Benveniste EN, Silverstein RL, Gladson CL) J Cell Physiol 2009 Jan;218(1):94-103 PMID 18726995
  • Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis. (Robertson JO, Li W, Silverstein RL, Topol EJ, Smith JD) Thromb Res 2009 Feb;123(4):644-52 PMID 18706682
  • A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. (Chen K, Febbraio M, Li W, Silverstein RL) Circ Res 2008 Jun 20;102(12):1512-9 PMID 18497330
  • Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. (Ghosh A, Li W, Febbraio M, Espinola RG, McCrae KR, Cockrell E, Silverstein RL) J Clin Invest 2008 May;118(5):1934-43 PMID 18431509
  • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. (Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W) Gastroenterology 2008 Feb;134(2):556-67 PMID 18242221
  • CD36-TSP-HRGP interactions in the regulation of angiogenesis. (Silverstein RL, Febbraio M) Curr Pharm Des 2007;13(35):3559-67 PMID 18220792
  • Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. (Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL) Nat Med 2007 Sep;13(9):1086-95 PMID 17721545
  • Venous thrombosis in the elderly: more questions than answers. (Silverstein RL, Bauer KA, Cushman M, Esmon CT, Ershler WB, Tracy RP) Blood 2007 Nov 1;110(9):3097-101 PMID 17684155
  • CD36: implications in cardiovascular disease. (Febbraio M, Silverstein RL) Int J Biochem Cell Biol 2007;39(11):2012-30 PMID 17466567
  • A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. (Rahaman SO, Lennon DJ, Febbraio M, Podrez EA, Hazen SL, Silverstein RL) Cell Metab 2006 Sep;4(3):211-21 PMID 16950138
  • Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. (Goodman OB Jr, Febbraio M, Simantov R, Zheng R, Shen R, Silverstein RL, Nanus DM) J Biol Chem 2006 Nov 3;281(44):33597-605 PMID 16940054
  • Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. (Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, Silverstein RL, Hazen SL) J Biol Chem 2006 Feb 17;281(7):4222-30 PMID 16354659
  • EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. (Marleau S, Harb D, Bujold K, Avallone R, Iken K, Wang Y, Demers A, Sirois MG, Febbraio M, Silverstein RL, Tremblay A, Ong H) FASEB J 2005 Nov;19(13):1869-71 PMID 16123174
  • A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. (Ahn J, Febbraio M, Silverstein RL) J Cell Sci 2005 Apr 15;118(Pt 8):1725-31 PMID 15797922
  • The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. (Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL, Iadecola C) J Neurosci 2005 Mar 9;25(10):2504-12 PMID 15758158
  • The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. (Simantov R, Febbraio M, Silverstein RL) Matrix Biol 2005 Feb;24(1):27-34 PMID 15748999
  • Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis. (Febbraio M, Guy E, Silverstein RL) Arterioscler Thromb Vasc Biol 2004 Dec;24(12):2333-8 PMID 15486305
  • The second international congress on myeloproliferative and myelodysplastic syndromes. (Silver RT, Bennett JM, Deininger M, Feldman E, Rafii S, Silverstein RL, Solberg LA, Spivak JL) Leuk Res 2004 Sep;28(9):979-85 PMID 15234576
  • CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. (Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC) J Infect Dis 2004 Jan 15;189(2):204-13 PMID 14722884
  • Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. (Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA) J Clin Invest 2004 Jan;113(1):38-48 PMID 14702107
  • CD36: a critical anti-angiogenic receptor. (Simantov R, Silverstein RL) Front Biosci 2003 Sep 1;8:s874-82 PMID 12957861
  • Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. (Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, Silverstein RL, Rafii S, Mesri EA) Cancer Cell 2003 Feb;3(2):131-43 PMID 12620408
  • CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. (Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC) Infect Immun 2003 Jan;71(1):393-400 PMID 12496189
  • The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. (Febbraio M, Guy E, Coburn C, Knapp FF Jr, Beets AL, Abumrad NA, Silverstein RL) Mol Cell Biochem 2002 Oct;239(1-2):193-7 PMID 12479585
  • The face of TSR revealed: an extracellular signaling domain is exposed. (Silverstein RL) J Cell Biol 2002 Oct 28;159(2):203-6 PMID 12403807
  • A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. (Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Febbraio M, Hajjar DP, Silverstein RL, Hoff HF, Salomon RG, Hazen SL) J Biol Chem 2002 Oct 11;277(41):38517-23 PMID 12145296
  • CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. (Bodart V, Febbraio M, Demers A, McNicoll N, Pohankova P, Perreault A, Sejlitz T, Escher E, Silverstein RL, Lamontagne D, Ong H) Circ Res 2002 May 3;90(8):844-9 PMID 11988484
  • Hematology grants workshop-2001. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2001:507-21 PMID 11723002
  • Hematology Grants Workshop-2000. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2000;():424-437 PMID 11701555
  • Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. (Finnemann SC, Silverstein RL) J Exp Med 2001 Nov 5;194(9):1289-98 PMID 11696594
  • CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. (Febbraio M, Hajjar DP, Silverstein RL) J Clin Invest 2001 Sep;108(6):785-91 PMID 11560944
  • Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL) J Clin Invest 2001 Jan;107(1):45-52 PMID 11134179
  • CD36 and atherosclerosis. (Silverstein RL, Febbraio M) Curr Opin Lipidol 2000 Oct;11(5):483-91 PMID 11048891
  • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. (Coburn CT, Knapp FF Jr, Febbraio M, Beets AL, Silverstein RL, Abumrad NA) J Biol Chem 2000 Oct 20;275(42):32523-9 PMID 10913136
  • CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor. (Nicholson AC, Febbraio M, Han J, Silverstein RL, Hajjar DP) Ann N Y Acad Sci 2000 May;902:128-31; discussion 131-3 PMID 10865832
  • Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. (Feng J, Han J, Pearce SF, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC) J Lipid Res 2000 May;41(5):688-96 PMID 10787429
  • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. (Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein RL, Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL) J Clin Invest 2000 Apr;105(8):1095-108 PMID 10772654
  • Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. (Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL) J Clin Invest 2000 Apr;105(8):1049-56 PMID 10772649
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. (Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N) Nat Med 2000 Jan;6(1):41-8 PMID 10613822
  • Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin. (Naiyer AJ, Jo DY, Ahn J, Mohle R, Peichev M, Lam G, Silverstein RL, Moore MA, Rafii S) Blood 1999 Dec 15;94(12):4011-9 PMID 10590044
  • Angiogenesis and atherosclerosis. The mandate broadens. (Silverstein RL, Nachman RL) Circulation 1999 Aug 24;100(8):783-5 PMID 10458710
  • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. (Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL) J Biol Chem 1999 Jul 2;274(27):19055-62 PMID 10383407
  • Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1. (Pijuan-Thompson V, Grammer JR, Stewart J, Silverstein RL, Pearce SF, Tuszynski GP, Murphy-Ullrich JE, Gladson CL) Exp Cell Res 1999 May 25;249(1):86-101 PMID 10328956
  • Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. (Dawson DW, Volpert OV, Pearce SF, Schneider AJ, Silverstein RL, Henkin J, Bouck NP) Mol Pharmacol 1999 Feb;55(2):332-8 PMID 9927626
  • Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain. (Pearce SF, Roy P, Nicholson AC, Hajjar DP, Febbraio M, Silverstein RL) J Biol Chem 1998 Dec 25;273(52):34875-81 PMID 9857015
  • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N) J Exp Med 1998 Oct 5;188(7):1359-68 PMID 9763615
  • Cell adhesion molecules: an overview. (Joseph-Silverstein J, Silverstein RL) Cancer Invest 1998;16(3):176-82 PMID 9541632
  • Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. (Crombie R, Silverstein RL, MacLow C, Pearce SF, Nachman RL, Laurence J) J Exp Med 1998 Jan 5;187(1):25-35 PMID 9419208
  • CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. (Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP) J Cell Biol 1997 Aug 11;138(3):707-17 PMID 9245797
  • CD36 expression is altered in retinal pigment epithelial cells of the RCS rat. (Sparrow JR, Ryeom SW, Abumrad NA, Ibrahimi A, Silverstein RL) Exp Eye Res 1997 Jan;64(1):45-56 PMID 9093020
  • Engagement of the Lewis X antigen (CD15) results in monocyte activation. (Lo SK, Golenbock DT, Sass PM, Maskati A, Xu H, Silverstein RL) Blood 1997 Jan 1;89(1):307-14 PMID 8978306
  • Factor V Leiden increases the risk of thrombosis in patients with antiphospholipid antibodies. (Simantov R, Lo SK, Salmon JE, Sammaritano LR, Silverstein RL) Thromb Res 1996 Dec 1;84(5):361-5 PMID 8948063
  • Antiphospholipid antibodies activate vascular endothelial cells. (Simantov R, Lo SK, Gharavi A, Sammaritano LR, Salmon JE, Silverstein RL) Lupus 1996 Oct;5(5):440-1 PMID 8902777
  • Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36. (Ryeom SW, Silverstein RL, Scotto A, Sparrow JR) J Biol Chem 1996 Aug 23;271(34):20536-9 PMID 8702796
  • Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. (Yesner LM, Huh HY, Pearce SF, Silverstein RL) Arterioscler Thromb Vasc Biol 1996 Aug;16(8):1019-25 PMID 8696941
  • Hypercoagulability in cancer. (Green KB, Silverstein RL) Hematol Oncol Clin North Am 1996 Apr;10(2):499-530 PMID 8707766
  • Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. (Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL) Blood 1996 Mar 1;87(5):2020-8 PMID 8634453
  • CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. (Ryeom SW, Sparrow JR, Silverstein RL) J Cell Sci 1996 Feb;109 ( Pt 2):387-95 PMID 8838662
  • Activation of cultured vascular endothelial cells by antiphospholipid antibodies. (Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL) J Clin Invest 1995 Nov;96(5):2211-9 PMID 7593607
  • Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. (Marcus AJ, Safier LB, Broekman MJ, Islam N, Fliessbach JH, Hajjar KA, Kaminski WE, Jendraschak E, Silverstein RL, von Schacky C) Thromb Haemost 1995 Jul;74(1):213-7 PMID 8578460
  • CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. (Ren Y, Silverstein RL, Allen J, Savill J) J Exp Med 1995 May 1;181(5):1857-62 PMID 7536797
  • Induction of tissue factor on monocytes by adhesion to endothelial cells. (Lo SK, Cheung A, Zheng Q, Silverstein RL) J Immunol 1995 May 1;154(9):4768-77 PMID 7536780
  • CD36 induction on human monocytes upon adhesion to tumor necrosis factor-activated endothelial cells. (Huh HY, Lo SK, Yesner LM, Silverstein RL) J Biol Chem 1995 Mar 17;270(11):6267-71 PMID 7534309
  • Recombinant GST/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36. (Frieda S, Pearce A, Wu J, Silverstein RL) J Biol Chem 1995 Feb 17;270(7):2981-6 PMID 7531696
  • Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site. (Nicholson AC, Frieda S, Pearce A, Silverstein RL) Arterioscler Thromb Vasc Biol 1995 Feb;15(2):269-75 PMID 7538425
  • Principles of thromboregulation: control of platelet reactivity in vascular disease. (Marcus AJ, Safier LB, Kaminski WE, Islam N, Hajjar KA, Jendraschak E, Silverstein RL, Broekman MJ, von Schacky C, Fliessbach JH) Adv Prostaglandin Thromboxane Leukot Res 1995;23:413-8 PMID 7732885
  • A carboxyl terminal truncation mutant of CD36 is secreted and binds thrombospondin: evidence for a single transmembrane domain. (Pearce SF, Wu J, Silverstein RL) Blood 1994 Jul 15;84(2):384-9 PMID 7517712
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Immunol Today 1994 Mar;15(3):98-9 PMID 7909665
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Blood 1994 Feb 15;83(4):879-80 PMID 8111060
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) J Immunol 1994 Jan 1;152(1):1-2 PMID 7902854
  • von Willebrand factor mediates platelet adhesion to virally infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5153-6 PMID 8389471
  • Cancer and clotting--Trousseau's warning. (Silverstein RL, Nachman RL) N Engl J Med 1992 Oct 15;327(16):1163-4 PMID 1308758
  • Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. (Silverstein RL, Febbraio M) Blood 1992 Sep 15;80(6):1470-5 PMID 1520873
  • Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor. (Silverstein RL, Baird M, Lo SK, Yesner LM) J Biol Chem 1992 Aug 15;267(23):16607-12 PMID 1379600
  • Identification of a monocyte receptor on herpesvirus-infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1991 Aug 15;88(16):7200-3 PMID 1714592
  • CD36-mediated signal transduction in human monocytes by anti-CD36 antibodies but not by anti-thrombospondin antibodies recognizing cell membrane-bound thrombospondin. (Schüepp BJ, Pfister H, Clemetson KJ, Silverstein RL, Jungi TW) Biochem Biophys Res Commun 1991 Feb 28;175(1):263-70 PMID 1998511
  • Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (Febbraio M, Silverstein RL) J Biol Chem 1990 Oct 25;265(30):18531-7 PMID 2211717
  • Thrombospondin forms complexes with single-chain and two-chain forms of urokinase. (Silverstein RL, Nachman RL, Pannell R, Gurewich V, Harpel PC) J Biol Chem 1990 Jul 5;265(19):11289-94 PMID 2141608
  • Viral activation of the coagulation cascade: molecular interactions at the surface of infected endothelial cells. (Etingin OR, Silverstein RL, Friedman HM, Hajjar DP) Cell 1990 May 18;61(4):657-62 PMID 2160855
  • Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. (Silverstein RL, Asch AS, Nachman RL) J Clin Invest 1989 Aug;84(2):546-52 PMID 2474571
  • Binding of Lys-plasminogen to monocytes/macrophages. (Silverstein RL, Friedlander RJ Jr, Nicholas RL, Nachman RL) J Clin Invest 1988 Dec;82(6):1948-55 PMID 2974046
  • Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. (Hajjar KA, Hajjar DP, Silverstein RL, Nachman RL) J Exp Med 1987 Jul 1;166(1):235-45 PMID 3598461
  • Thrombospondin-plasminogen interactions: modulation of plasmin generation. (Silverstein RL, Nachman RL) Semin Thromb Hemost 1987 Jul;13(3):335-42 PMID 2961063
  • Isolation of the thrombospondin membrane receptor. (Asch AS, Barnwell J, Silverstein RL, Nachman RL) J Clin Invest 1987 Apr;79(4):1054-61 PMID 2435757
  • Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. (Silverstein RL, Nachman RL) J Clin Invest 1987 Mar;79(3):867-74 PMID 3818952
  • Binding of plasminogen to extracellular matrix. (Knudsen BS, Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Biol Chem 1986 Aug 15;261(23):10765-71 PMID 3090040
  • Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin. (Silverstein RL, Harpel PC, Nachman RL) J Biol Chem 1986 Jul 25;261(21):9959-65 PMID 2942536
  • Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. (Nachman RL, Hajjar KA, Silverstein RL, Dinarello CA) J Exp Med 1986 Jun 1;163(6):1595-600 PMID 3086483
  • Thrombospondin: a versatile multifunctional glycoprotein. (Silverstein RL, Leung LL, Nachman RL) Arteriosclerosis 1986 May-Jun;6(3):245-53 PMID 3518684
  • Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation. (Silverstein RL, Nachman RL, Leung LL, Harpel PC) J Biol Chem 1985 Aug 25;260(18):10346-52 PMID 3160707
  • Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine-rich glycoprotein. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1985 Jun;75(6):2065-73 PMID 4008652
  • Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1984 Nov;74(5):1625-33 PMID 6438154
  • Grants and Awards

  • Mechanistic Role of CD36 in Thrombosis (#9208155 06/01/2013 - 05/31/2017) Sponsor: NIH Heart Lung and Blood Institute
  • Regulation of Angiogenesis by CD36/TSP/HRGP (#9207276 10/01/2011 - 05/31/2014) Sponsor: NIH Heart Lung and Blood Institute
  • Candidate Genes Affecting Adolescent Metabolic Syndrome (#9204606 07/01/2007 - 06/30/2013) Sponsor: NIH Diabetes, Digestive and Kidney Diseases
  • Red Cell Transfusion: Modifier of Lung and Systemic Inflammatory Responses (#9208327 04/05/2013 - 03/31/2018) Sponsor: University of Pittsburgh