Medical College of Wisconsin
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Sang H. Lee PhD

Sang H. Lee PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development


  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 4;35(5):1892-904 PMID 25653350
  • SynPAnal: software for rapid quantification of the density and intensity of protein puncta from fluorescence microscopy images of neurons. (Danielson E, Lee SH) PLoS One 2014;9(12):e115298 PMID 25531531
  • GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. (Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH) Nat Neurosci 2012 Dec;15(12):1655-66 PMID 23143515
  • Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors. (Danielson E, Metallo J, Lee SH) Channels (Austin) 2012 Sep-Oct;6(5):393-7 PMID 22878254
  • S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. (Danielson E, Zhang N, Metallo J, Kaleka K, Shin SM, Gerges N, Lee SH) J Neurosci 2012 May 16;32(20):6967-80 PMID 22593065
  • Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. (Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT) Nat Neurosci 2010 Oct;13(10):1199-207 PMID 20802490
  • The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. (Okamoto K, Narayanan R, Lee SH, Murata K, Hayashi Y) Proc Natl Acad Sci U S A 2007 Apr 10;104(15):6418-23 PMID 17404223
  • Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. (Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V) Proc Natl Acad Sci U S A 2007 Feb 20;104(8):2991-6 PMID 17289840
  • Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. (Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT) J Neurochem 2007 Jan;100(1):118-31 PMID 17227435
  • Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. (Lee SH, Simonetta A, Sheng M) Neuron 2004 Jul 22;43(2):221-36 PMID 15260958
  • Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. (Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, Sheng M, Wang YT) EMBO J 2004 Mar 10;23(5):1040-50 PMID 14976558
  • Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. (Lee SH, Liu L, Wang YT, Sheng M) Neuron 2002 Nov 14;36(4):661-74 PMID 12441055
  • Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. (Lee SH, Valtschanoff JG, Kharazia VN, Weinberg R, Sheng M) Neuropharmacology 2001 Nov;41(6):680-92 PMID 11640922
  • AMPA receptor trafficking and the control of synaptic transmission. (Sheng M, Lee SH) Cell 2001 Jun 29;105(7):825-8 PMID 11439178
  • Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. (Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M) Nat Neurosci 2000 Dec;3(12):1282-90 PMID 11100149
  • Growth of the NMDA receptor industrial complex. (Sheng M, Lee SH) Nat Neurosci 2000 Jul;3(7):633-5 PMID 10862688
  • Development of neuron-neuron synapses. (Lee SH, Sheng M) Curr Opin Neurobiol 2000 Feb;10(1):125-31 PMID 10679427
  • Grants and Awards

  • Program for the Study of Neuronal Synaptic Plasticity in Health and Illness (#9520217 01/01/2012 - 12/31/2016) PI of Role of a Novel Chemokine-Like TAFA-2 in Synapse Regulation (#5520323)
  • Program for the Study of Neuronal Synaptic Plasticity in Health and Illness (#9520217 01/01/2012 - 12/31/2016) PI of Creation of Floxed S-SCAM Transgenic Mice as a New Animal Model of Schizophrenia (#5520291)
  • Last update: 03/27/2015