Medical College of Wisconsin
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Scott P. Levick PhD

Scott P. Levick PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development


Publications

  • Substance P in heart failure: the good and the bad. (Dehlin HM, Levick SP) Int J Cardiol 2014 Jan 1;170(3):270-7 PMID 24286592
  • Estrogen modulates the influence of cardiac inflammatory cells on function of cardiac fibroblasts. (McLarty JL, Li J, Levick SP, Janicki JS) J Inflamm Res 2013;6:99-108 PMID 24062614
  • Substance P acting via the neurokinin-1 receptor regulates adverse myocardial remodeling in a rat model of hypertension. (Dehlin HM, Manteufel EJ, Monroe AL, Reimer MH Jr, Levick SP) Int J Cardiol 2013 Oct 12;168(5):4643-51 PMID 23962787
  • Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure. (Li J, Levick SP, DiPette DJ, Janicki JS, Supowit SC) Regul Pept 2013 Aug 10;185:20-8 PMID 23816470
  • Could interferon-gamma be a therapeutic target for treating heart failure? (Levick SP, Goldspink PH) Heart Fail Rev 2014 Mar;19(2):227-36 PMID 23589353
  • Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase. (Janicki JS, Spinale FG, Levick SP) Pflugers Arch 2013 May;465(5):687-97 PMID 23417570
  • Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart. (Li J, Lu H, Plante E, Meléndez GC, Levick SP, Janicki JS) J Mol Cell Cardiol 2012 Oct;53(4):469-74 PMID 22850284
  • Alterations in cardiac structure and function in a murine model of chronic alcohol consumption. (Law BA, Levick SP, Carver WE) Microsc Microanal 2012 Jun;18(3):453-61 PMID 22571914
  • Estrogenic modulation of inflammation-related genes in male rats following volume overload. (McLarty JL, Meléndez GC, Levick SP, Bennett S, Sabo-Attwood T, Brower GL, Janicki JS) Physiol Genomics 2012 Mar 19;44(6):362-73 PMID 22274565
  • The convergence of ancient chinese medicine with modern therapeutics to prevent cardiac fibrosis. (Janicki JS, Levick SP) Am J Hypertens 2012 Feb;25(2):139 PMID 22262254
  • Isolation of functional cardiac immune cells. (McLarty JL, Meléndez GC, Spencer WJ, Levick SP, Brower GL, Janicki JS) J Vis Exp 2011(58): PMID 22158428
  • Prevention of adverse cardiac remodeling to volume overload in female rats is the result of an estrogen-altered mast cell phenotype. (Lu H, Meléndez GC, Levick SP, Janicki JS) Am J Physiol Heart Circ Physiol 2012 Feb 1;302(3):H811-7 PMID 22160000
  • Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells. (Meléndez GC, Li J, Law BA, Janicki JS, Supowit SC, Levick SP) Cardiovasc Res 2011 Dec 1;92(3):420-9 PMID 21908647
  • Tryptase/Protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. (McLarty JL, Meléndez GC, Brower GL, Janicki JS, Levick SP) Hypertension 2011 Aug;58(2):264-70 PMID 21730297
  • Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats. (Chan V, Fenning A, Levick SP, Loch D, Chunduri P, Iyer A, Teo YL, Hoey A, Wilson K, Burstow D, Brown L) J Cardiovasc Pharmacol 2011 Apr;57(4):469-78 PMID 21283019
  • Cardiac mast cells: the centrepiece in adverse myocardial remodelling. (Levick SP, Meléndez GC, Plante E, McLarty JL, Brower GL, Janicki JS) Cardiovasc Res 2011 Jan 1;89(1):12-9 PMID 20736239
  • Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. (Meléndez GC, McLarty JL, Levick SP, Du Y, Janicki JS, Brower GL) Hypertension 2010 Aug;56(2):225-31 PMID 20606113
  • Inhibition of matrix metalloproteinase activity prevents increases in myocardial tumor necrosis factor-alpha. (Murray DB, Levick SP, Brower GL, Janicki JS) J Mol Cell Cardiol 2010 Aug;49(2):245-50 PMID 20403361
  • Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart. (Levick SP, Murray DB, Janicki JS, Brower GL) Hypertension 2010 Feb;55(2):270-6 PMID 20048196
  • TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload. (Jobe LJ, Meléndez GC, Levick SP, Du Y, Brower GL, Janicki JS) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1462-8 PMID 19666842
  • Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart. (Levick SP, McLarty JL, Murray DB, Freeman RM, Carver WE, Brower GL) Hypertension 2009 Jun;53(6):1041-7 PMID 19398662
  • Regulation of matrix metalloproteinases is at the heart of myocardial remodeling. (Levick SP, Brower GL) Am J Physiol Heart Circ Physiol 2008 Oct;295(4):H1375-6 PMID 18757475
  • Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats. (Levick SP, Gardner JD, Holland M, Hauer-Jensen M, Janicki JS, Brower GL) J Mol Cell Cardiol 2008 Jul;45(1):56-61 PMID 18538342
  • A novel technique for isolating functional mast cells from the heart. (Morgan LG, Levick SP, Voloshenyuk TG, Murray DB, Forman MF, Brower GL, Janicki JS) Inflamm Res 2008 May;57(5):241-6 PMID 18465084
  • Response of cardiac mast cells to atrial natriuretic peptide. (Murray DB, Gardner JD, Levick SP, Brower GL, Morgan LG, Janicki JS) Am J Physiol Heart Circ Physiol 2007 Aug;293(2):H1216-22 PMID 17434981
  • Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. (Brower GL, Levick SP, Janicki JS) Am J Physiol Heart Circ Physiol 2007 Jun;292(6):H3057-64 PMID 17308006
  • Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. (Levick SP, Loch DC, Taylor SM, Janicki JS) J Immunol 2007 Jan 15;178(2):641-6 PMID 17202322
  • The relationship between myocardial extracellular matrix remodeling and ventricular function. (Brower GL, Gardner JD, Forman MF, Murray DB, Voloshenyuk T, Levick SP, Janicki JS) Eur J Cardiothorac Surg 2006 Oct;30(4):604-10 PMID 16935520
  • Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. (Levick S, Loch D, Rolfe B, Reid RC, Fairlie DP, Taylor SM, Brown L) J Immunol 2006 Jun 1;176(11):7000-7 PMID 16709861
  • Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats. (Loch D, Levick S, Hoey A, Brown L) J Cardiovasc Pharmacol 2006 Mar;47(3):396-404 PMID 16633082
  • Reversal of cardiac dysfunction by selective ET-A receptor antagonism. (Allan A, Fenning A, Levick S, Hoey A, Brown L) Br J Pharmacol 2005 Nov;146(6):846-53 PMID 16151437
  • Increased calcium influx mediates increased cardiac stiffness in hyperthyroid rats. (Levick S, Fenning A, Brown L) Cell Biochem Biophys 2005;43(1):53-60 PMID 16043883
  • Grants and Awards

  • Neuro-Immune Modulation of Cardiac Mast Cell-Mediated Myocardial Remodeling (#9207084 08/20/2011 - 06/30/2015) Sponsor: NIH Heart Lung and Blood Institute