Medical College of Wisconsin
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Thomas C. Abshire MD

Thomas C. Abshire MD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Hematology


Research Experience

  • Blood Coagulation Disorders, Inherited
  • Clinical Trial
  • Hemostasis
  • Thrombosis
  • von Willebrand Disease
  • Clinical trials in hemostasis and thrombosis including laboratory evaluation, therapeutic intervention and new product development.
  • Evaluation of mild bleeding disorders in children including the role of the clinical history and in clinical trials in Von Willebrand Disease.
  • Clinical Expertise

  • Blood Coagulation Disorders
  • Hematologic Diseases
  • Hemorrhagic Disorders
  • Thrombosis
  • von Willebrand Disease
  • Publications

  • A study of prospective surveillance for inhibitors among persons with haemophilia in the United States. (Soucie JM, Miller CH, Kelly FM, Payne AB, Creary M, Bockenstedt PL, Kempton CL, Manco-Johnson MJ, Neff AT, Haemophilia Inhibitor Research Study Investigators) Haemophilia 2014 Mar;20(2):230-7 PMID 24261612
  • Comparison of clot-based, chromogenic and fluorescence assays for measurement of factor VIII inhibitors in the US Hemophilia Inhibitor Research Study. (Miller CH, Rice AS, Boylan B, Shapiro AD, Lentz SR, Wicklund BM, Kelly FM, Soucie JM, Hemophilia Inhibitor Research Study Investigators) J Thromb Haemost 2013 Jul;11(7):1300-9 PMID 23601690
  • Evaluating for suspected child abuse: conditions that predispose to bleeding. (Carpenter SL, Abshire TC, Anderst JD, Section on Hematology/Oncology and Committee on Child Abuse and Neglect of the American Academy of Pediatrics) Pediatrics 2013 Apr;131(4):e1357-73 PMID 23530171
  • Evaluation for bleeding disorders in suspected child abuse. (Anderst JD, Carpenter SL, Abshire TC, Section on Hematology/Oncology and Committee on Child Abuse and Neglect of the American Academy of Pediatrics) Pediatrics 2013 Apr;131(4):e1314-22 PMID 23530182
  • No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation. (Flood VH, Friedman KD, Gill JC, Haberichter SL, Christopherson PA, Branchford BR, Hoffmann RG, Abshire TC, Dunn AL, Di Paola JA, Hoots WK, Brown DL, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR) Blood 2013 May 2;121(18):3742-4 PMID 23520336
  • Prophylaxis in severe forms of von Willebrand's disease: results from the von Willebrand Disease Prophylaxis Network (VWD PN). (Abshire TC, Federici AB, Alvárez MT, Bowen J, Carcao MD, Cox Gill J, Key NS, Kouides PA, Kurnik K, Lail AE, Leebeek FW, Makris M, Mannucci PM, Winikoff R, Berntorp E, VWD PN) Haemophilia 2013 Jan;19(1):76-81 PMID 22823000
  • Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A. (Kempton CL, Abshire TC, Deveras RA, Hoots WK, Gill JC, Kessler CM, Key NS, Konkle BA, Kuriakose P, Macfarlane DE, Bergman G) Haemophilia 2012 Sep;18(5):798-804 PMID 22512291
  • TAFI made stickier. (Abshire T) Blood 2012 Apr 12;119(15):3380-1 PMID 22500053
  • Validation of Nijmegen-Bethesda assay modifications to allow inhibitor measurement during replacement therapy and facilitate inhibitor surveillance. (Miller CH, Platt SJ, Rice AS, Kelly F, Soucie JM, Hemophilia Inhibitor Research Study Investigators) J Thromb Haemost 2012 Jun;10(6):1055-61 PMID 22435927
  • VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population. (Bellissimo DB, Christopherson PA, Flood VH, Gill JC, Friedman KD, Haberichter SL, Shapiro AD, Abshire TC, Leissinger C, Hoots WK, Lusher JM, Ragni MV, Montgomery RR) Blood 2012 Mar 1;119(9):2135-40 PMID 22197721
  • A community-based partnership to promote information infrastructure for bleeding disorders. (Aschman DJ, Abshire TC, Shapiro AD, Lusher JM, Forsberg AD, Kulkarni R) Am J Prev Med 2011 Dec;41(6 Suppl 4):S332-7 PMID 22099355
  • F8 and F9 mutations in US haemophilia patients: correlation with history of inhibitor and race/ethnicity. (Miller CH, Benson J, Ellingsen D, Driggers J, Payne A, Kelly FM, Soucie JM, Craig Hooper W, Hemophilia Inhibitor Research Study Investigators) Haemophilia 2012 May;18(3):375-82 PMID 22103590
  • The principal results of the International Immune Tolerance Study: a randomized dose comparison. (Hay CR, DiMichele DM, International Immune Tolerance Study) Blood 2012 Feb 9;119(6):1335-44 PMID 22101900
  • Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. (Li C, Narkbunnam N, Samulski RJ, Asokan A, Hu G, Jacobson LJ, Manco-Johnson MJ, Monahan PE, Joint Outcome Study Investigators) Gene Ther 2012 Mar;19(3):288-94 PMID 21697954
  • In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study. (Kempton CL, Soucie JM, Miller CH, Hooper C, Escobar MA, Cohen AJ, Key NS, Thompson AR, Abshire TC) J Thromb Haemost 2010 Oct;8(10):2224-31 PMID 20704648
  • Evaluation of factor VIII pharmacokinetics and anti-factor VIII antibodies in four boys with haemophilia A and a poor clinical response to factor VIII. (Kempton CL, Meeks SL, Donald Harvey R 3rd, Abshire TC) Haemophilia 2011 Jan;17(1):155-6 PMID 20579112
  • Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. (Flood VH, Gill JC, Morateck PA, Christopherson PA, Friedman KD, Haberichter SL, Branchford BR, Hoffmann RG, Abshire TC, Di Paola JA, Hoots WK, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR) Blood 2010 Jul 15;116(2):280-6 PMID 20231421
  • The "parallel-cohort RCT": Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism. (Goldenberg NA, Tripputi M, Crowther M, Abshire TC, DiMichele D, Manco-Johnson MJ, Hiatt WR) Contemp Clin Trials 2010 Jan;31(1):131-3 PMID 19941974
  • Inhibitors of factor VIII in black patients with hemophilia. (Viel KR, Ameri A, Abshire TC, Iyer RV, Watts RG, Lutcher C, Channell C, Cole SA, Fernstrom KM, Nakaya S, Kasper CK, Thompson AR, Almasy L, Howard TE) N Engl J Med 2009 Apr 16;360(16):1618-27 PMID 19369668
  • Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment. (Meeks SL, Abshire TC) Haemophilia 2008 Nov;14(6):1159-63 PMID 19141155
  • Diagnosis of type 1 VWD: can the clinical history trump laboratory findings? (Abshire TC) Pediatr Blood Cancer 2009 Jan;52(1):7-8 PMID 19006252
  • One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab. (Mueller BU, Bennett CM, Feldman HA, Bussel JB, Abshire TC, Moore TB, Sawaf H, Loh ML, Rogers ZR, Glader BE, McCarthy MC, Mahoney DH, Olson TA, Feig SA, Lorenzana AN, Mentzer WC, Buchanan GR, Neufeld EJ, Pediatric Rituximab/ITP Study Group, Glaser Pediatric Research Network) Pediatr Blood Cancer 2009 Feb;52(2):259-62 PMID 18937333
  • Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. (Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R, Ingram JD, Manco-Johnson ML, Funk S, Jacobson L, Valentino LA, Hoots WK, Buchanan GR, DiMichele D, Recht M, Brown D, Leissinger C, Bleak S, Cohen A, Mathew P, Matsunaga A, Medeiros D, Nugent D, Thomas GA, Thompson AA, McRedmond K, Soucie JM, Austin H, Evatt BL) N Engl J Med 2007 Aug 9;357(6):535-44 PMID 17687129
  • Recombinant tissue plasminogen activator may reduce frequency of central venous access device infection in hemophilia patients undergoing immune tolerance therapy. (Dunn AL, Abshire TC) Pediatr Blood Cancer 2008 Mar;50(3):627-9 PMID 17143876
  • Incidence of inhibitors in a cohort of 838 males with hemophilia A previously treated with factor VIII concentrates. (Kempton CL, Soucie JM, Abshire TC) J Thromb Haemost 2006 Dec;4(12):2576-81 PMID 17002659
  • Prophylaxis and von Willebrand's disease (vWD). (Abshire TC) Thromb Res 2006;118 Suppl 1:S3-7 PMID 16580053
  • Current issues in prophylactic therapy for persons with hemophilia. (Dunn AL, Abshire TC) Acta Haematol 2006;115(3-4):162-71 PMID 16549891
  • Clinical uses of plasma and plasma fractions: plasma-derived products for hemophilias A and B, and for von Willebrand disease. (Josephson CD, Abshire TC) Best Pract Res Clin Haematol 2006;19(1):35-49 PMID 16377540
  • Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. (Bennett CM, Rogers ZR, Kinnamon DD, Bussel JB, Mahoney DH, Abshire TC, Sawaf H, Moore TB, Loh ML, Glader BE, McCarthy MC, Mueller BU, Olson TA, Lorenzana AN, Mentzer WC, Buchanan GR, Feldman HA, Neufeld EJ) Blood 2006 Apr 1;107(7):2639-42 PMID 16352811
  • Leukemia and P32 radionuclide synovectomy for hemophilic arthropathy. (Dunn AL, Manco-Johnson M, Busch MT, Balark KL, Abshire TC) J Thromb Haemost 2005 Jul;3(7):1541-2 PMID 15978117
  • Recent advances in the management of the child who has hemophilia. (Dunn AL, Abshire TC) Hematol Oncol Clin North Am 2004 Dec;18(6):1249-76, viii PMID 15511615
  • The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. (Shapiro AD, Di Paola J, Cohen A, Pasi KJ, Heisel MA, Blanchette VS, Abshire TC, Hoots WK, Lusher JM, Negrier C, Rothschild C, Roth DA) Blood 2005 Jan 15;105(2):518-25 PMID 15383463
  • Arthroscopic synovectomy for hemophilic joint disease in a pediatric population. (Dunn AL, Busch MT, Wyly JB, Sullivan KM, Abshire TC) J Pediatr Orthop 2004 Jul-Aug;24(4):414-26 PMID 15205625
  • IGIV-C, a novel intravenous immunoglobulin: evaluation of safety, efficacy, mechanisms of action, and impact on quality of life. (Bussel JB, Eldor A, Kelton JG, Varon D, Brenner B, Gillis S, Angiolillo A, Kulkarni R, Abshire TC, Kelleher J, IGIV-C in ITP Study Group) Thromb Haemost 2004 Apr;91(4):771-8 PMID 15045139
  • An approach to the diagnosis and treatment of bleeding disorders in infants. (Abshire TC) Int J Hematol 2002 Aug;76 Suppl 2:265-70 PMID 12430935
  • Hepatitis C in adults and adolescents with hemophilia: a randomized, controlled trial of interferon alfa-2b and ribavirin. (Fried MW, Peter J, Hoots K, Gaglio PJ, Talbut D, Davis PC, Key NS, White GC, Lindblad L, Rickles FR, Abshire TC) Hepatology 2002 Oct;36(4 Pt 1):967-72 PMID 12297845
  • Radionuclide synovectomy for hemophilic arthropathy: a comprehensive review of safety and efficacy and recommendation for a standardized treatment protocol. (Dunn AL, Busch MT, Wyly JB, Abshire TC) Thromb Haemost 2002 Mar;87(3):383-93 PMID 11916068
  • Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. (Abshire TC, Pollock BH, Billett AL, Bradley P, Buchanan GR) Blood 2000 Sep 1;96(5):1709-15 PMID 10961868
  • Sucrose formulated recombinant human antihemophilic factor VIII is safe and efficacious for treatment of hemophilia A in home therapy--International Kogenate-FS Study Group. (Abshire TC, Brackmann HH, Scharrer I, Hoots K, Gazengel C, Powell JS, Gorina E, Kellermann E, Vosburgh E) Thromb Haemost 2000 Jun;83(6):811-6 PMID 10896230
  • Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. (Zhou M, Gu L, Abshire TC, Homans A, Billett AL, Yeager AM, Findley HW) Leukemia 2000 Jan;14(1):61-7 PMID 10637478
  • Determination of heparin-induced thrombocytopenia: a rapid flow cytometric assay for direct demonstration of antibody-mediated platelet activation. (Tomer A, Masalunga C, Abshire TC) Am J Hematol 1999 May;61(1):53-61 PMID 10331512
  • Coagulopathy in pediatric abusive head trauma. (Hymel KP, Abshire TC, Luckey DW, Jenny C) Pediatrics 1997 Mar;99(3):371-5 PMID 9041291
  • Idarubicin and cytosine arabinoside reinduction therapy for children with multiple recurrent or refractory acute lymphoblastic leukemia: a Pediatric Oncology Group study. (Bernstein ML, Abshire TC, Pollock BH, Devine S, Toledano S, Steuber CP, Bowman WP, Buchanan GR) J Pediatr Hematol Oncol 1997 Jan-Feb;19(1):68-72 PMID 9065722
  • The prolonged thrombin time of nephrotic syndrome. (Abshire TC, Fink LK, Christian J, Hathaway WE) J Pediatr Hematol Oncol 1995 May;17(2):156-62 PMID 7749766
  • Prevalence of von Willebrand disease in children: a multiethnic study. (Werner EJ, Broxson EH, Tucker EL, Giroux DS, Shults J, Abshire TC) J Pediatr 1993 Dec;123(6):893-8 PMID 8229521
  • Dysfunctional protein C deficiency (type II). A report of 11 cases in 3 American families and review of the literature. (Berdeaux DH, Abshire TC, Marlar RA) Am J Clin Pathol 1993 Jun;99(6):677-86 PMID 8322701
  • Philadelphia chromosome-positive chronic myeloid leukemia and thoracic ganglioneuroma. Previously undescribed association. (Shea MP, Abshire TC) Am J Pediatr Hematol Oncol 1993 Feb;15(1):111-4 PMID 8447551
  • Relative value of diagnostic studies for von Willebrand disease. (Werner EJ, Abshire TC, Giroux DS, Tucker EL, Broxson EH) J Pediatr 1992 Jul;121(1):34-8 PMID 1625090
  • Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. (Abshire TC, Buchanan GR, Jackson JF, Shuster JJ, Brock B, Head D, Behm F, Crist WM, Link M, Borowitz M) Leukemia 1992 May;6(5):357-62 PMID 1534389
  • Molecular genetic studies in black families with sickle cell anemia and unusually high levels of fetal hemoglobin. (Seltzer WK, Abshire TC, Lane PA, Roloff JS, Githens JH) Hemoglobin 1992;16(5):363-77 PMID 1385360
  • Severe neonatal protein C deficiency: prevalence and thrombotic risk. (Manco-Johnson MJ, Abshire TC, Jacobson LJ, Marlar RA) J Pediatr 1991 Nov;119(5):793-8 PMID 1834822
  • The coagulopathy of childhood leukemia. Thrombin activation or primary fibrinolysis? (Abshire TC, Gold SH, Odom LF, Carson SD, Hathaway WE) Cancer 1990 Aug 15;66(4):716-21 PMID 2386901
  • Zinc status in children and young adults with sickle cell disease. (Abshire TC, English JL, Githens JH, Hambidge M) Am J Dis Child 1988 Dec;142(12):1356-9 PMID 3195534
  • Anemia of acute inflammation in children. (Abshire TC, Reeves JD) J Pediatr 1983 Dec;103(6):868-71 PMID 6644420