Faculty Collaboration Database

Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett 2008 Dec 08;272(1):32-9

Date

08/13/2008

Pubmed ID

18694622

Pubmed Central ID

PMC3780599

DOI

10.1016/j.canlet.2008.06.022

Scopus ID

2-s2.0-53949083067 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

p21 and p27, members of the kinase inhibitor protein (KIP) family, bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell cycle arrest. The purpose of our study was to identify whether the p21 (C-to-A), and p27 (T-to-G) polymorphisms were associated with age at diagnosis of pancreatic cancer, either independently or jointly. Two hundred and five patients with a diagnosis of pancreatic cancer were genotyped for the p21 and p27 polymorphisms. We found patients with the p21 variant genotype (CA/AA) had an earlier age at diagnosis than those with the wild-type genotype (CC) (log-rank, P=0.001; HR=1.89; 95%CI, 1.28-2.78). The p21 and p27 polymorphisms combined had a joint effect on age-associated risk for early diagnosis of pancreatic cancer (log-rank, P=0.004; HR=2.91; 95%CI, 1.49-5.67). Our findings suggest that the p21 polymorphism independently and p21 and p27 polymorphisms jointly contribute to a significantly earlier age at diagnosis of pancreatic cancer.

Author List

Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML

Author

Douglas B. Evans MD Chair, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Age of Onset
Aged
Cyclin-Dependent Kinase Inhibitor p21
DNA Primers
Female
Genetic Variation
Humans
Male
Middle Aged
Pancreatic Neoplasms
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Proliferating Cell Nuclear Antigen
Proportional Hazards Models
Proteasome Endopeptidase Complex