Optic chiasm glioma associated with inappropriate secretion of antidiuretic hormone, cerebral ischemia, nonobstructive hydrocephalus and chronic ascites following ventriculoperitoneal shunting. Childs Nerv Syst 1991 Dec;7(8):458-61
Date
12/01/1991Pubmed ID
1790531DOI
10.1007/BF00263189Scopus ID
2-s2.0-0026317599 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
An optic chiasm glioma may cause loss of vision, endocrine disturbances, hydrocephalus and cerebral ischemia due to its proximity to the pituitary, hypothalamus, III ventricle and internal carotids. A 3-month-old infant with optic chiasm glioma developed hypopituitarism and inappropriate secretion of antidiuretic hormone with plasma hypo-osmolality. The cerebrospinal fluid (CSF) protein concentration was markedly elevated. The impairment of fluid absorption via arachnoid villi and peritoneum by the high protein content, and reversed osmotic gradient between protein-rich CSF and hypo-osmolar plasma may have contributed to both nonobstructive hydrocephalus and recurrent ascites following ventriculoperitoneal shunting. Cerebral ischemia from carotid compression may have led to cerebral atrophy.
Author List
Tang TT, Whelan HT, Meyer GA, Strother DR, Blank EL, Camitta BM, Franciosi RAMESH terms used to index this publication - Major topics in bold
AscitesAstrocytoma
Biopsy
Cerebrospinal Fluid Shunts
Cranial Nerve Neoplasms
Female
Humans
Hydrocephalus
Inappropriate ADH Syndrome
Infant
Optic Chiasm
Postoperative Complications
Reoperation