Faculty Collaboration Database

delta 9-Tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex. Brain Res 1982 Mar 11;235(2):370-7

Date

03/11/1982

Pubmed ID

6329417

DOI

10.1016/0006-8993(82)91016-2

Scopus ID

2-s2.0-0020059703 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

The effects of 3 cannabinoids, delta 9-tetrahydrocannabinol (delta 9-THC), 11-OH-delta 9-tetrahydrocannabinol (11-OH-delta 9-THC) and cannabidiol (CBD) on the binding of [3H]dihydroalprenolol [( 3H]DHA) to mouse brain beta-adrenergic receptors were determined. In vitro, delta 9-THC and 11-OH-delta 9-THC increased the specific binding of [3H]DHA. The increased specific binding of [3H]DHA was due to an increase in receptor affinity as indicated by a decrease in the dissociation constant (Kd). CBD had no effect on binding. Chronic administration of delta 9-THC in vivo caused a decrease in the number of [3H]DHA binding sites with no change in Kd.

Author List

Hillard CJ, Bloom AS

Author

Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cannabidiol
Cerebral Cortex
Dihydroalprenolol
Dronabinol
Male
Mice
Mice, Inbred ICR
Receptors, Adrenergic, beta