The role and regulation of COX-2 during viral infection. Viral Immunol 2003;16(4):447-60
Date
01/22/2004Pubmed ID
14733733DOI
10.1089/088282403771926283Scopus ID
2-s2.0-0347362590 (requires institutional sign-in at Scopus site) 117 CitationsAbstract
Prostaglandins are lipid mediators, generated by cyclooxygenase (COX), that have been shown to participate in the regulation of virus replication and the modulation of inflammatory responses following infection. A number of studies support a role for PGE2 in the modulation of virus replication and virulence in a cell type and virus selective manner. Virus infection also stimulates the expression of a number of proinflammatory gene products, including COX-2, inducible nitric oxide synthase (iNOS) as well as proinflammatory cytokines. This review will focus on the mechanisms by which proinflammatory prostaglandin production regulates virus replication and virulence. In addition, the signaling pathways that are activated during a virus infection, and that regulate proinflammatory gene expression in macrophages will be reviewed. Specific attention will be placed on the ability of virus infection to activate multiple signaling cascades (such as PKR, MAPK, iPLA2, NF-kappaB) and how these pathways are integrated in the regulation of individual target gene expression.
Author List
Steer SA, Corbett JAAuthor
John A. Corbett PhD Chair, Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Line
Cyclooxygenase 2
Dinoprostone
Gene Expression Regulation
Humans
Isoenzymes
Membrane Proteins
Prostaglandin-Endoperoxide Synthases
Rats
Virulence
Virus Diseases
Virus Replication
Viruses