Comparison of the sensitivity of commercial APTT reagents in the detection of mild coagulopathies. Am J Clin Pathol 1984 Oct;82(4):436-9
Date
10/01/1984Pubmed ID
6475840DOI
10.1093/ajcp/82.4.436Scopus ID
2-s2.0-0021137174 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
This study was undertaken to evaluate the precision and sensitivity of three different commercial APTT reagents containing the activators kaolin, micronized silica, or ellagic acid. These reagents varied greatly in their ability to detect mild coagulopathies. The ellagic acid reagent was able to detect the mildest deficiencies for the most common coagulopathies. This reagent was sensitive to 50% levels of Factor VIIIC, whereas the APTT with the kaolin reagent was not prolonged until levels of 35% or less were attained. The micronized silica reagent was the least sensitive to Factor IX deficiency, detecting levels of 12% or less. Precision was similar for all reagents when tested with normal and slightly abnormal plasmas. Since methods and instrumentation vary, each laboratory should evaluate their APTT reagent to determine its precision and sensitivity.
Author List
Marlar RA, Bauer PJ, Endres-Brooks JL, Montgomery RR, Miller CM, Schanen MMAuthor
Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood Coagulation DisordersBlood Coagulation Tests
Evaluation Studies as Topic
Female
Humans
Indicators and Reagents
Kaolin
Male
Partial Thromboplastin Time
Reference Values
