Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett 1993 Sep 13;330(2):181-5
Date
09/13/1993Pubmed ID
8365489DOI
10.1016/0014-5793(93)80269-zScopus ID
2-s2.0-0027162279 (requires institutional sign-in at Scopus site) 258 CitationsAbstract
Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.
Author List
Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada SAuthors
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinBalaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Cell LineHumans
Lipoproteins, LDL
Macrophages
Membrane Proteins
Nitrates
Oxidation-Reduction
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scavenger Receptors, Class B
Vitamin E