Direct cardiac actions of the H2 receptor agonists, impromidine and dimaprit. Eur J Pharmacol 1985 Jan 08;107(3):379-84
Date
01/08/1985Pubmed ID
3156752DOI
10.1016/0014-2999(85)90266-3Scopus ID
2-s2.0-0021951650 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Intracoronary administration of the H2 receptor agonists impromidine and dimaprit at doses that did not alter systemic hemodynamics increased coronary blood flow but had no regional positive inotropic effects. Dose-related increases in myocardial blood flow were observed with both drugs. These effects were attenuated by prior administration of cimetidine. The results of this study demonstrate that H2 coronary receptor stimulation results in vasodilation of both subepicardial and subendocardial regions.
Author List
Pelc LR, Christensen CW, Gross GJ, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Dimaprit
Dogs
Female
Heart
Imidazoles
Impromidine
Male
Myocardial Contraction
Receptors, Histamine
Receptors, Histamine H2
Stimulation, Chemical
Thiourea
