Prophylaxis of experimental bone marrow transplant nephropathy. J Lab Clin Med 1994 Sep;124(3):371-80
Date
09/01/1994Pubmed ID
8083580Scopus ID
2-s2.0-0028504786 (requires institutional sign-in at Scopus site) 69 CitationsAbstract
Renal radiation injury is a known complication of both local kidney irradiation and total body irradiation (TBI). TBI is felt to play an important role in the late-onset chronic renal failure seen after bone marrow transplantation in human beings. Two-hundred and eleven WAG/Rij/MCW rats underwent 0 to 20 Gy TBI followed by syngeneic bone marrow transplant (BMT). Rats received either no drug or verapamil, enalapril, or captopril in the drinking water starting 9 days before TBI and continuing thereafter. Follow-up continued up to 55 weeks after TBI/BMT. No-drug irradiated animals developed significant proteinuria 6 weeks after TBI, were azotemic by 9 weeks after TBI, and were hypertensive by 13 weeks after TBI. Survival was inversely related to the dose of TBI. There was a dose-related reduction in proteinuria, blood pressure, and azotemia with increasing doses of captopril. At 500 mg/L, captopril was more effective than 50 mg/L enalapril in controlling proteinuria, blood pressure, and azotemia and in enhancing survival of irradiated animals. Verapamil, 700 mg/L, did not control proteinuria, blood pressure, or the development of renal failure and did not enhance survival when compared with no-drug irradiated animals. We conclude that angiotensin-converting enzyme inhibitors are beneficial in preventing radiation nephropathy and that control of proteinuria may be of particular importance in preventing progression of renal failure in this model.
Author List
Cohen EP, Moulder JE, Fish BL, Hill PMESH terms used to index this publication - Major topics in bold
Angiotensin-Converting Enzyme InhibitorsAnimals
Antihypertensive Agents
Blood Pressure
Bone Marrow Transplantation
Captopril
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Enalapril
Kidney
Kidney Diseases
Male
Proteinuria
Radiation Injuries, Experimental
Rats
Time Factors
Uremia
Verapamil
Whole-Body Irradiation
