Faculty Collaboration Database

Antibodies of different immunoglobulin classes against antigens causing farmer's lung. Am Rev Respir Dis 1976 Aug;114(2):315-24

Date

08/01/1976

Pubmed ID

823846

DOI

10.1164/arrd.1976.114.2.315

Scopus ID

2-s2.0-0017183698 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

A solid phase radioimmunoassay technique was used to demonstrate antibodies of various immunoglobulin classes in sera against farmer's lung antigens. IgG, IgA, and IgM antibody activity in normal patients and in patients with farmer's lung were detected against Micropolyspora faeni. Only the IgG and IgA antibody activity was different in farmers and in control subjects. An asymptomatic subject could not be differentiated from symptomatic farmers by IgG antibody activity. No IgE antibody activity was detected. The radioimmunoassay technique can be used to show antibody activity against carbohydrate antigens and as a method of evaluation of antigens by inhibition analysis. Certain types of hypersensitivity lung disease can be discriminated by in vitro analysis of serum antibody of various immunoglobulin classes. This is apparent for IgE and possibly true for IgM.

Author List

Patterson R, Roberts M, Roberts RC, Emanuel DA, Fink JN

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Antibodies, Bacterial
Antibody Specificity
Antigens, Bacterial
Cross Reactions
Farmer's Lung
Humans
Immunodiffusion
Immunoglobulin A
Immunoglobulin G
Immunoglobulins
Micromonosporaceae
Middle Aged
Precipitin Tests
Radioimmunoassay