Allergic bronchopulmonary aspergillosis in corticosteroid-dependent asthmatics. J Allergy Clin Immunol 1981 Aug;68(2):98-102
Date
08/01/1981Pubmed ID
7252001DOI
10.1016/0091-6749(81)90165-2Scopus ID
2-s2.0-0019446115 (requires institutional sign-in at Scopus site) 88 CitationsAbstract
Forty-two corticosteroid-dependent asthmatics were studied to determine whether their underlying disease might be allergic bronchopulmonary aspergillosis (ABPA). The clinical and laboratory characteristics studied included age, sex, atopic status, mean corticosteroid doses, skin tests to Aspergillus fumigatus (Af), precipitins to Af, total serum IgE, and chest roentgenograms. Twelve patients had four or more of the seven primary criteria used and were considered as the ABPA suspect group. Further studies identified three patients who were considered to have definite ABPA and an additional three patients with probable ABPA. This study suggests that previously undiagnosed ABPA can be detected in populations of corticosteroid dependent asthmatics. Corticosteroid therapy may mask ABPA, and serial evaluations of these patients may be of value in detecting additional cases of the disease.
Author List
Basich JE, Graves TS, Baz MN, Scanlon G, Hoffmann RG, Patterson R, Fink JNMESH terms used to index this publication - Major topics in bold
AdolescentAdrenal Cortex Hormones
Adult
Aged
Aspergillosis, Allergic Bronchopulmonary
Asthma
Dose-Response Relationship, Drug
Female
Humans
Immunoglobulin E
Male
Middle Aged
Skin Tests
