The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci 2008 May 01;13:3581-93
Date
05/30/2008Pubmed ID
18508457Pubmed Central ID
PMC4758212DOI
10.2741/2951Scopus ID
2-s2.0-42949102509 (requires institutional sign-in at Scopus site) 89 CitationsAbstract
p38 mitogen-activated protein kinases (p38 MAPKs) are a group of serine/threonine protein kinases that together with ERK (extracellular signal-regulated kinases) and JNK (c-Jun N-terminal kinases) MAPKs act to convert different extracellular signals into specific cellular responses through interacting with and phosphorylating downstream targets. In contrast to the mitogenic ERK pathway, mammalian p38 MAPK family proteins (alpha, beta, gamma, and delta), with and without JNK participation, predominantly regulate inflammatory and stress response. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. A selective activation of a stress pathway to block tumorigenesis may be a novel strategy to control human malignancies.
Author List
Loesch M, Chen GAuthor
Guan Chen MD, PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Death
Extracellular Signal-Regulated MAP Kinases
Genes, ras
Isoenzymes
Mammals
Neoplasms
Oncogenes
Protein Isoforms
p38 Mitogen-Activated Protein Kinases
