A high-potency, single-donor cryoprecipitate of known factor VIII content dispensed in vials. Ann Intern Med 1987 Jan;106(1):35-40
Date
01/01/1987Pubmed ID
3098152DOI
10.7326/0003-4819-106-1-35Scopus ID
2-s2.0-0023119532 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Current factor VIII products expose recipients to many donors and hence to a high risk of acquiring blood-borne infections. Plasma-exchange donation of cryoprecipitate can reduce donor exposure by repeatedly obtaining large yields of factor VIII from individual donors. In this study, donor factor VIII levels were stimulated with desmopressin before donation. Mean yield per donation increased from 1399 +/- 425 IU in controls to 3818 +/- 1350 IU in stimulated donations (p less than 0.001), and mean factor VIII concentration in the cryoprecipitate increased from 8.2 +/- 3 IU/mL to 24 +/- 12 IU/mL (p less than 0.001). A new packaging system dispenses assayed aliquots of stimulated cryoprecipitate in plastic vials. The direct cost of production for this material is $.065 per unit. The cryoprecipitate is hemostatically active and convenient to use, and the aggregate yields from sequential donations by stimulated persons are high enough to allow long-term, single-donor support of many adults with hemophilia.
Author List
McLeod BC, Sassetti RJ, Cole ER, Scott JPMESH terms used to index this publication - Major topics in bold
Blood Component RemovalChemical Precipitation
Costs and Cost Analysis
Deamino Arginine Vasopressin
Drug Packaging
Factor VIII
Hemophilia A
Humans
Plasma Exchange