Faculty Collaboration Database

Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men. Kidney Int 1985 Jan;27(1):66-73

Date

01/01/1985

Pubmed ID

3884880

DOI

10.1038/ki.1985.11

Scopus ID

2-s2.0-0021986704 (requires institutional sign-in at Scopus site)   83 Citations

Abstract

In contrast to other nonsteroidal anti-inflammatory drugs (NSAIDs), sulindac has been reported to inhibit systemic prostaglandins (PGs) while not affecting renal PGs. We studied 11 normal volunteers who received placebo, ibuprofen, naproxen, or sulindac in a randomized, double-blind fashion. After control periods assessing the effect of the NSAIDs alone, 40 mg of furosemide were administered. Overall, each of the drugs appeared similar. Renal function, plasma renin activity (PRA) and urinary PGs were not affected during control collections, while all three NSAIDs decreased thromboxane B2 (TxB2). After furosemide, all NSAIDs decreased fractional excretions of Na+ and Cl-, PRA, and TxB2 by equivalent degrees (P less than 0.05). Sulindac and ibuprofen decreased urinary PGE2 (P less than 0.05) while naproxen had no effect. None of these drugs affected the excretion of furosemide, but all decreased the pharmacodynamics of response to furosemide. In conclusion, the effects of these NSAIDs depended on the conditions of the study. In the basal state there were no renal effects but all decreased the renal response to furosemide.

Author List

Brater DC, Anderson S, Baird B, Campbell WB

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Clinical Trials as Topic
Double-Blind Method
Furosemide
Humans
Ibuprofen
Indenes
Kidney
Male
Naproxen
Prostaglandins
Random Allocation
Renin
Sulindac
Thromboxanes