Faculty Collaboration Database

Initiation of esophageal secondary peristalsis by slow fluid infusion in the opossum: effect of hydrochloric acid. Am J Physiol 1996 Jun;270(6 Pt 1):G927-31

Date

06/01/1996

Pubmed ID

8764198

DOI

10.1152/ajpgi.1996.270.6.G927

Scopus ID

2-s2.0-0029838955 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

We investigated the mechanisms of slow fluid infusion-induced secondary peristalsis and the effects of hydrochloric acid on this response. In 13 chronically esophagostomized opossum, acidic and neutral barium sulfate were infused into the distal esophagus at a rate of 1.1 ml/min, while recording the esophageal dimension by videofluoroscopy and esophageal intraluminal pressure concurrently. The effects of atropine, tetrodotoxin, capsaicin, and bilateral cervical vagotomy on the response to slow fluid infusion were examined. Acidic barium initiated secondary peristalsis more frequently and at shorter latency with less increase of preperistaltic intraesophageal pressure than neutral barium (P < 0.05). Atropine abolished secondary peristalsis initiated by neutral barium. For acidic barium, atropine decreased the incidence of secondary peristalsis, increased the latency for initiation of secondary peristalsis, and initiated secondary peristalsis more distally (P < 0.05). Tetrodotoxin or vagotomy and capsaicin abolished activation of secondary peristalsis. We concluded that secondary peristalsis can be stimulated in response to slow distension by minute amounts of fluid. This peristalsis is atropine and capsaicin sensitive and vagally mediated. The presence of acid significantly lowers the threshold for stimulation of secondary peristalsis induced by slow fluid distension. This effect seems to be atropine resistant.

Author List

Kusano M, Hogan WJ, Lang IM, Bonnevier JL, Massey BT, Shaker R

Authors

Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of Wisconsin
Benson T. Massey MD Professor in the Medicine department at Medical College of Wisconsin
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Atropine
Capsaicin
Esophagostomy
Esophagus
Female
Fluoroscopy
Hydrochloric Acid
Hydrogen-Ion Concentration
Male
Opossums
Peristalsis
Physical Stimulation
Solutions
Television
Tetrodotoxin
Vagotomy