Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury. J Investig Med 1996 Aug;44(6):375-81
Date
08/01/1996Pubmed ID
8795301Scopus ID
2-s2.0-0030209856 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
BACKGROUND: We assessed the effect of a cytokine inhibitor, compound SKF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (renal blood flow and glomerular filtration rate) that occur acutely following immune injury of glomerular mesangial cells.
METHODS: Injury was induced in Munich-Wistar rats by the administration of a monoclonal antibody against the mesangial cell membrane antigen Thy 1.1. An acute drop in renal blood flow (RBF) and glomerular filtration rate (GFR) occurred within one hour of injury.
RESULTS: Pretreatment of animals with the cytokine inhibitor SKF 86002 prevented this drop. SKF 86002 had no effect on glomerular synthesis of vasoconstrictor eicosanoids.
CONCLUSIONS: The observations indicate that in mesangial cell immune injury, cytokines mediate renal hemodynamic impairment.
Author List
Pan CG, Bresnahan BA, Albrightson CR, Griswold D, Lianos EAAuthors
Barbara A. Bresnahan MD Professor in the Medicine department at Medical College of WisconsinCynthia G. Pan MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAnti-Inflammatory Agents, Non-Steroidal
Antibodies, Monoclonal
Cytokines
Eicosanoids
Glomerular Filtration Rate
Glomerular Mesangium
Imidazoles
Inflammation Mediators
Male
Rats
Rats, Wistar
Renal Circulation
Thiazoles
Tumor Necrosis Factor-alpha
