Faculty Collaboration Database

Reduction of myocardial infarct size by the calcium antagonist fr 7534. Cardiology 1981;68(3):146-60

Date

01/01/1981

Pubmed ID

7317884

DOI

10.1159/000173276

Scopus ID

2-s2.0-0019481512 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

This study was conducted to determine the effect of FR 7534, a light-stable derivative of nifedipine on hemodynamics, coronary collateral blood flow and myocardial infarct size in the anesthetized dog. Myocardial infarction was produced by a 2-hour occlusion and reperfusion of the distal third of the left anterior descending coronary artery in control dogs, FR 7534-treated dogs and FR 7534-treated dogs with a constant aortic blood pressure. FR 7534 alone produced significant decreases in heart rate and mean aortic blood pressure, however, no change in collateral blood flow of central ischemic zones was observed. On the other hand, when aortic blood pressure was held constant, FR 7534 produced a significant increase in coronary collateral blood flow. With or without a constant aortic perfusion pressure, FR 7534 significantly reduced infarct size as compared to control experiments (33.5 to 4.3 and 7.5% of the area at risk infarcted, respectively). The present results demonstrate the efficacy of a new calcium antagonist, FR 7534, to protect ischemic myocardium with or without a change in oxygen supply via the coronary collateral circulation.

Author List

Meils CM, Gross GJ, Brooks HL, Warltier DC

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Collateral Circulation
Coronary Circulation
Dogs
Heart Rate
Myocardial Infarction
Nifedipine
Pyridines