Faculty Collaboration Database

Interferon-gamma secretion defects in haemophilia A patients receiving highly purified plasma-derived or recombinant factor VIII. Br J Haematol 1996 Dec;95(3):554-60

Date

12/01/1996

Pubmed ID

8943901

DOI

10.1046/j.1365-2141.1996.d01-1924.x

Scopus ID

2-s2.0-0029859034 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The outcome of developing immune responses is influenced by interactions among a large and complex network of secreted cytokines. T-cell secretion of interferon-gamma (IFN-gamma), tumour necrosis factor alpha (TNF-alpha) and TNF-beta, or lymphotoxin contributes to the development of cell-mediated immunity, whereas secretion of interleukin (IL)-4, IL-5 and IL-6 contributes to development of humoral immunity. Humoral immunity to factor VIII (FVIII) develops in approximately 25% of severe haemophilia A patients. The aim of our research was to understand the underlying immune response to FVIII in patients with FVIII inhibitors. We report a defect in IFN-gamma secretion by peripheral blood mononuclear cells (PBMC) derived from haemophilia A patients, which was accompanied by a low level of mitogen-induced proliferation and a significant decrease in the percentage of natural killer (NK) cells. All of the observed defects were found in haemophilia A patients, both with and without FVIII inhibitors, who were free of viral infection and had been treated predominantly or exclusively with monoclonal antibody-purified or recombinant FVIII.

Author List

Newton-Nash DK, Tollerud D, Guevarra L, Gill JC

Author

Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of Wisconsin

MESH terms used to index this publication - Major topics in bold

Child, Preschool
Factor VIII
Granulocyte-Macrophage Colony-Stimulating Factor
Hemophilia A
Humans
Infant
Interferon-gamma
Killer Cells, Natural
T-Lymphocytes