Primary skeletal Ewing's sarcoma in Down syndrome. Cancer Genet Cytogenet 1990 Jul 01;47(1):61-8
Date
07/01/1990Pubmed ID
2141543DOI
10.1016/0165-4608(90)90263-aScopus ID
2-s2.0-0025372991 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.
Author List
Bridge JA, Neff JR, Borek DA, Hackbarth DAAuthor
Donald A. Hackbarth Jr MD Professor in the Orthopaedic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Bone Neoplasms
Chromosome Banding
Down Syndrome
Female
Humans
Karyotyping
Male
Sarcoma, Ewing