Faculty Collaboration Database

Temporal dependence of coronary collateral development. Cardiovasc Res 1997 May;34(2):306-12

Date

05/01/1997

Pubmed ID

9205544

DOI

10.1016/s0008-6363(97)00019-9

Scopus ID

2-s2.0-0031005004 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

OBJECTIVE: Previous evidence suggests that episodes of myocardial ischemia of sufficient duration and intensity are required to produce coronary collateral development during repetitive coronary occlusion. This investigation tested the hypothesis that coronary collateral development is also temporal-dependent.

METHODS: Chronically instrumented dogs (n = 16) were subjected to brief (2 min) left anterior descending coronary artery (LAD) occlusions, once every hour, 8 h a day, for 3 weeks or once every hour, 24 h a day for 1 week. Collateral perfusion (radioactive microspheres), LAD contractile function (ultrasonic crystals), and post-occlusive flow debt repayment (LAD flow probe) were measured during occlusions 1, 55, 105, and 155.

RESULTS: Increases (P < 0.05 in subendocardial collateral blood flow to ischemic myocardium, progressive normalization of contractile function during LAD occlusion, and successive reduction in flow debt repayment were observed in dogs receiving occlusions over 3 weeks. In contrast, dogs receiving the same number of coronary occlusions over 1 week demonstrated minimal increases in collateral blood flow, persistent regional contractile dysfunction, and sustained flow debt repayment.

CONCLUSIONS: The results demonstrate that LAD collateral development in response to repetitive coronary occlusion requires sufficient time for growth adaptation of the collateral circulation to occur.

Author List

Kersten JR, McGough MF, Pagel PS, Tessmer JP, Warltier DC

MESH terms used to index this publication - Major topics in bold

Animals
Collateral Circulation
Coronary Circulation
Dogs
Microspheres
Myocardial Contraction
Myocardial Ischemia
Myocardial Stunning
Random Allocation
Time Factors