Effect of barium sulfate on wound healing in the gastrointestinal tract of the rat. Radiology 2000 Feb;214(2):563-7
Date
02/15/2000Pubmed ID
10671612DOI
10.1148/radiology.214.2.r00fe16563Scopus ID
2-s2.0-0033956760 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
PURPOSE: To study the effect of barium sulfate on wound healing in the gastrointestinal tract of the rat.
MATERIALS AND METHODS: Sixty rats weighing approximately 320 g were divided into four groups: Fifteen control rats had gastric, small-bowel, and colonic incisions; 15 rats had gastric incision; 15 rats had small-bowel incision; and 15 rats had colonic incision. Barium sulfate was placed into the incision before closure in all rats except those in the control group, and the effects were documented clinically and histopathologically for 3 months. Autopsy was performed in five rats from each group at 1, 4, and 12 weeks. The incisions in the rats receiving barium sulfate were compared with those in the control rats.
RESULTS: There was no difference in the clinical course (weight gain, activity, and viability) between the control and experimental groups. Early and late autopsy findings and histopathologic grading of healing and inflammatory response were similar for both the control and experimental groups.
CONCLUSION: Under the conditions of this study, the effect of barium sulfate on visceral transmural wound healing in the gastrointestinal tract of the rat was minimal.
Author List
Shackleton KL, Stewart ET, Henderson JD Jr, Demeure MJ, Telford GLMESH terms used to index this publication - Major topics in bold
Abdominal AbscessAnimals
Barium Sulfate
Biocompatible Materials
Colon
Contrast Media
Fibroblasts
Follow-Up Studies
Foreign-Body Reaction
Giant Cells
Intestine, Small
Lymphocytes
Macrophages
Motor Activity
Neutrophils
Peritonitis
Phagocytosis
Rats
Rats, Sprague-Dawley
Stomach
Survival Rate
Weight Gain
Wound Healing