Faculty Collaboration Database

Event-related fMRI of tasks involving brief motion. Hum Brain Mapp 1999;7(2):106-14

Date

02/09/1999

Pubmed ID

9950068

Pubmed Central ID

PMC6873311

DOI

10.1002/(SICI)1097-0193(1999)7:2<106::AID-HBM4>3.0.CO;2-O

Scopus ID

2-s2.0-0032902268 (requires institutional sign-in at Scopus site)   240 Citations

Abstract

The assessment of brain function by blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) for tasks involving motion near the field of view is compromised by artifacts arising from the motion. The aim of this study is to demonstrate that these artifacts can be reduced by acquiring the average response from a brief stimulus (a "single-trial," or "event-related," paradigm) as opposed to alternating blocks of repeated task with rest (a "block-trial" paradigm). The basis of this technique is that the NMR signal changes from neuronal activation are delayed relative to the motion due to a slow hemodynamic response. By acquiring the average response from a brief stimulus, motion-induced signal changes occur prior to neuronal activation-induced signal changes, and the two can thus be distinguished. This technique is applied to the tasks of speaking out loud, swallowing, jaw clenching, and tongue movement. Functional activation maps derived from the single-trial paradigm contain significantly less artifact than functional activation maps derived from a more traditional block-trial paradigm.

Author List

Birn RM, Bandettini PA, Cox RW, Shaker R

Author

Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Artifacts
Brain
Brain Mapping
Deglutition
Humans
Jaw
Magnetic Resonance Imaging
Movement
Muscle Contraction
Oxygen
Speech
Tongue