Disruption of primary and secondary esophageal peristalsis by afferent stimulation. Am J Physiol Gastrointest Liver Physiol 2000 Aug;279(2):G255-61
Date
08/01/2000Pubmed ID
10915632DOI
10.1152/ajpgi.2000.279.2.G255Scopus ID
2-s2.0-0033858101 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
Recent studies have shown that afferent signals originating from the pharynx inhibit progression of primary esophageal peristalsis. Our aim was to further elucidate the effect of esophageal and pharyngeal afferent stimulation on primary and secondary esophageal peristalsis. We studied the effect of esophageal air distension and pharyngeal water stimulation on progression of primary and secondary peristalsis in nine healthy volunteers aged 27 +/- 2 yr (4 men, 5 women). At a threshold volume, rapid injection of water into the pharynx, directed posteriorly, resulted in complete halt of the progressing secondary and primary esophageal peristalses in both the proximal and distal esophagus. The threshold volume of injected water for inducing inhibition was similar for secondary (0.6 +/- 0.2 ml) and primary (0.5 +/- 0.1 ml) esophageal peristalsis. Progression of primary peristalsis induced by a dry swallow and secondary peristalsis induced by intraesophageal air distension were completely inhibited by intraesophageal injection of 15 +/- 2 ml of air in 70% and 75% of the trials, respectively. We conclude that afferent signals induced by esophageal air distension and pharyngeal water stimulation inhibit propagation of both primary and secondary esophageal peristalsis, suggesting a shared neural control mechanism for these types of peristalsis.
Author List
Bardan E, Xie P, Aslam M, Kern M, Shaker RAuthor
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAir
Deglutition
Electric Stimulation
Esophagus
Female
Humans
Male
Neurons, Afferent
Peristalsis
Pharynx
Physical Stimulation
Pressure
Water